Gene Mek1 (Slime mold)

Mek1

Species: Slime mold
Alias: DdMEK1, Mek1, mekA, DDB0191164, DdisK178
External Links: DictyBase Link ,
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
Mek1.AA Protein None 660 None Fasta, JSON
Mek1.kin_dom Protein Kinase Domain None 350 None Fasta, JSON

Protein domain

Protein domains of Mek1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Mek1.AA STE7-Unclassified 292-641 39 4.90000000001e-176 591.12 In-house 1-301 (301) Show / Hide 
Range on Protein: 292-641
Range on HMM: 1-301/301
Sequence Identity: 39% (152 aa)

LKIIRVLGRGAGGVVKLAYHET------SGTYIALKVITLDIQ-ENIRKQIILELKTLHKTS-YPYIVSFYDAFYTEGS---IFIALEFMELGSLS---D
|.....||.|..|.|....|..      .|...|.|||..... ....|||. |||||||.. .||||..|.|.|.|..   |.|..|.|..|||.   |
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

IMKKT--------STIPEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGR-----
|.||.        ..||||||||||.||..||.|||.|.|.|||||||.|||||.||..||.||||.|||..||..|.||||...|||||||.|.     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

SYSFDSEIWSLGLTILECAIGKFPYGSNLPHQQQQPLQQQQQQQQQQQQPLQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNN
|||..|.||||||||.|||.||.||..|        .|..|..|..|.                                                    
SYSVKSDIWSLGLTIWECATGKYPYEYN--------FQSEQYNQNFQP----------------------------------------------------

NNNNNVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPS-----TFSKEFRSFISECLQKEPTERPTASNLLN-HEFV
                      |.|.||.||.|||...||.||.     ..||||..|||.|..|.|.|||....||| |...
----------------------ENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase Mek1.AA STE7 292-641 36 2.8e-162 545.42 In-house 1-288 (288) Show / Hide 
Range on Protein: 292-641
Range on HMM: 1-288/288
Sequence Identity: 36% (133 aa)

LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQE-NIRKQIILELKTLHKTS-YPYIVSFYDAFYTEGS--IFIALEFMELGSLS---DIMKKT--
|..| .||.|..|||. ..|. ||...|.|.| |.... ...|||. ||..|||.. .|||| || ||||||.  |.|..|.| .|.|    ...||.  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----STIPEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISG--RSYSFDSEIWSLG
    ..|||..|||||..|..|| |||.|.. ||||.|||||||| .|. |..|||..|||......|.|.||...||.||||.|   .|.  |..||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LTI-LECAIGKFPYGSNLPHQQQQPLQQQQQQQQQQQQPLQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNNNNNNNVLDISN
.|. .|.|.|..||... .|    |..|.|.....|                                                                
ITMGIEMATGRYPYPNWNTH----PPDQKQYNNMFQ----------------------------------------------------------------

GGLVDSGSSVPEGMGFWVLLDCIVKE-EVPILPSTFSKEFRSFISECLQKEPTERPTASNLLN-HEFV
          || |... .|.|||.| . |.|| .||.||..|.. ||||.|.|||. ..|.. |.|.
----------PE-MAIFEQLTCIVNENPPPRLP-KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase Mek1.AA STE 292-641 25 1.3e-109 370.41 In-house 1-359 (359) Show / Hide 
Range on Protein: 292-641
Range on HMM: 1-359/359
Sequence Identity: 25% (113 aa)

LKIIRVLGRGAGG-VVKLAYHETS--------------GTYIALKVITLDIQE----------------NIRKQIILELKTLHKTS--YPYIVSFYDAFY
...|...|.||.| |.| ..|...              |...| |.. |. ..                ....||. |.|...| .   |.|| .|....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TEG-------SIFIALEFMELGSLSDIMK---KT-----------STIPEPVLGKIAFQVLQG-LVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVS
 ||       ...|..|.|. |||.||.|   ..           ...||.....|..|.|.| | |||..   |||||||.|||.     .|..||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GQLQH---------------TLS-KAVTWVGTVTYMSPERISG------RSYSFDSEIWSLGLTILECAIGKFPYGSNLPHQQQQPLQQQQQQQQQQQQP
|||..               | . |  |.|||  .|.||.|..        |.. . |||||.||.| | || |.    |..   . .. .  || |   
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ-Q---

LQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNNNNNNNVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPS------
                                                                             . .| |||... | ||.      
-----------------------------------------------------------------------------FEQL-CIVNGPPPPLPDHLSQNE

-------------TFSKEFRSFISECLQKEPTERPTASNLLN--HEFV
              .|.||. ||. ||||.| .||||| ||.  |.|.
MISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Mek1.AA S_TKc 292-641 22 1.4e-79 271.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 292-641
Range on HMM: 1-231/231
Sequence Identity: 22% (81 aa)

LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKTSYPYIVSFYDAFYTEGSIFIALEFMEL--GSLSDIMKKTST-----
 .|.|..|.|| |.|....|  .| . |.|.|         ..|. |.. |.|   |.|| .||.|.. ..... .|...   |.| |..||  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGRSYSF-DSEIWSLGLTILEC
 .|| .  ... |....| |.|.. . ||||.||.|||...  . ||.|||.. ||        | .||  ||.|| .   .|..  . .||.| .. |.
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

AIGKFPYGSNLPHQQQQPLQQQQQQQQQQQQPLQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNNNNNNNVLDISNGGLVDSG
. |. |.      |.|. ...                                                                               
LCGYPPFP-----QMQMMFKKIG-----------------------------------------------------------------------------

SSVPEGMGFWVLLDCIVKEEVPILPSTFSKEFRSFISECLQKEPTERPTASNLLN-------HEFV
                            |.|...||. ||||.|..||||  .|.       |...
----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Mek1.AA STE20 292-641 25 4.1e-78 265.81 In-house 1-288 (288) Show / Hide 
Range on Protein: 292-641
Range on HMM: 1-288/288
Sequence Identity: 25% (101 aa)

LKIIRVLGRGAGGVVKLAYHETSGTY----IALKVITLDIQE---NIRKQIILELKTLHKTSYPYIVSFYDAFYTE----GSIFIALEFMELGSLSDIMK
 ......|.|. |.| .|||  .| |    .| |.. |. ..   . .. |. |   . .   |.||..|.... .     ...|. |... |||.||||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---KTS------TIPEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQH----TLS-KAVTWVGTVTYMSPERISG---
   |.       .. |.    |  .||||| |||.. | ||||||  |||.. .||.|.|||||..||..    | . |  | |||  .|.|| |..   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--RSYSFDSEIWSLGLTILECAIGKFPYGS--------NLP--HQQQQPLQQQQQQQQQQQQPLQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNN
    | . . ||||| |..| | |. ||            |    .  .|...                                               
PDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDD-K---------------------------------------------

NNNNNNNNNNNNNNNNNNVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPSTFSKEFRSFISECLQKEPTERPTASNLLNHEFV
                                                       |...|.||. |.. ||||.| .||||| ||.|.|.
-------------------------------------------------------PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Mek1.AA MEK1 292-488 51 1.4e-77 264.03 In-house 1-195 (297) Show / Hide 
Range on Protein: 292-488
Range on HMM: 1-195/297
Sequence Identity: 51% (102 aa)

LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKTSYPYIVSFYDAFYTEGSIFIALEFMELGSLSDIMKKTSTIPEPVLG
.. |  || | ||||  . |. .|  .| |.| |.|.  ||.||| ||. ||.  .|||| || ||| .| | | .|.|. |||  ..||   ||| .||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

KIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGRSYSFDSEIWSLGLTILECAIGKFP
|..  ||.||.||. | ...|||.|||||||| .|| |. ||||||||    | |  .|||  ||||||. |  |. .|.|||.|| . | |||..|
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--SMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYP
Kinase Mek1.AA MEK5 292-505 45 6e-67 228.73 In-house 1-208 (254) Show / Hide 
Range on Protein: 292-505
Range on HMM: 1-208/254
Sequence Identity: 45% (98 aa)

LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKTSYPYIVSFYDAFYTEGSIFIALEFMELGSLSDIMKKTSTIPEPVLG
..    || | || |  |||  ||  .|.||| |||  ...|||. ||. |.|   |||. || ||..|  | |  |||. ||| |. ..   ||| .||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSL-DMYRC---IPEHILG

KIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGRSYSFDSEIWSLGLTILECAIGKFPYGS
...  . .|| ||   | ..|||.||||.||| .|. |. ||||| ||   ...  |..||  || ||||||  |   |..||||. ..| |.|.|||  
RMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITR--TYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQ

NLPHQ-QQQPLQQQQ
    | .  |.|  |
IQRDQGELMPIQLLQ
Kinase Mek1.AA Pkinase 292-503 29 4.3e-57 200.8 Pfam 1-229 (293) Show / Hide 
Range on Protein: 292-503
Range on HMM: 1-229/293
Sequence Identity: 29% (70 aa)

LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIIL----ELKTLHKTSYPYIVSFYDAFYTEGSIFIALEFMELG----SLSDIMK--K
..|.|..|.|. |.|....|  .|   |.|.| ..  |.  |....    |.. ... . |.|| .||.|.....| . .|..| |    .|.|...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

TSTI--PEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEA----KIADFGVSGQL-QHTLSKAVTWVGTVTYMSPERIS-GRSYSFDSEIW
  ..  .| .. ... |.|.|| |.|.    ||||.||.|||..|.|.     ||.|||.. |.     | . | .||  ||.|| |  |. |.  . .|
HGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGLTILECAIGKFPYGSN----LPHQQQQPLQQ
|.|... | . |..|. .       | |.| ...
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICR
Kinase Mek1.AA Ciliate-E2-Unclassified 293-641 21 3.1e-54 186.52 In-house 2-352 (352) Show / Hide 
Range on Protein: 293-641
Range on HMM: 2-352/352
Sequence Identity: 21% (95 aa)

KIIRVLGRGAGGVVKLAYHETSGTYI-----ALKVITLD--IQENIRKQIILELKTLHKTS-------------------YPYIVSFYDAFYTEGSIFIA
|||...|.|. |.|....|.  . ..     . |..  .  ...|   .|..|.|.. . .                    |.|| ....| ..  |.| 
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEFMELGSLSDIMKKTST-----------------IPEPVLG-----KIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKG---EAKIADFGVSGQLQ-
.|..| |.|....|| ..                 ..|         ... |.|||| |||.|.. |||||||.|||..|.|   . ||.||| | ..| 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-----HTL---------SKAVTWVGTVTYM----SPERISGRSYS----FDSEIWSLGLTILECAIGKFPYGSNLPHQQQQPLQQ-------QQQQQQQQ
     ..           .. | .||  ||    .|| . |  |.    . . |||||  . |.  |..|...|   |.||  .|       .|..|...
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

QQPLQQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNNNNNNNVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPSTFS
|...|.. . .||                                                                                  | . |
QKNIQFPKFPWQQ---------------------------------------------------------------------------------IPKHWS

KEFRSFIS----ECLQKEPTERPTASNLLNHEFV
.|   ||.     .|.| | .|.|.. .||| . 
PEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Mek1.AA MEK3 292-489 38 1.5e-51 173.59 In-house 1-206 (264) Show / Hide 
Range on Protein: 292-489
Range on HMM: 1-206/264
Sequence Identity: 38% (81 aa)

LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKTSY-PYIVSFYDAFYTEGSIFIALEFMELGSL----SDIMK-KTSTI
.  |  ||||| |.|    |. ||| .| | |   .     |... ..     .|  || | || | . || . |  | |   .|       .| .  .|
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGMHI

PEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISG----RSYSFDSEIWSLGLTILE
||..|||||. . ..| |.| .| .||||.||||.|.| .|  |. |||.||.|     | .   |   || |||| .    . |.  | .|||| |. |
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTID-AGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIE

CAIGKFPY
 ||| .||
MAIGRYPY
Kinase Mek1.AA MST 293-490 40 5.3e-46 144.17 In-house 2-198 (254) Show / Hide 
Range on Protein: 293-490
Range on HMM: 2-198/254
Sequence Identity: 40% (83 aa)

KIIRVLGRGAGGVVKLAYHETSGTYIALKVITL--DIQENIRKQIILELKTLHKTSYPYIVSFYDAFY--TEGSIFIALEFMELGSLSDIMKKTS-TIPE
 |.  ||.|. |.|  | |  .| . | |..    |.||     || |  ..     .||| .|. ..   .  . |  |. . ||..|||| |  |  |
DIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQE-----IIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNE

PVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGRSYSFDSEIWSLGLTILECAIGKF
     |  ..|||| ||| . . ||||||. |||.|..||.| ||||||||| .|  |. | .||  .|.|| |    |     ||||| |..| | |. 
QQIACILYDTLQGLQYLH-DNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMP

PYG
||.
PYS
Kinase Mek1.AA PAKA 293-489 31 1.2e-42 147.39 In-house 2-203 (260) Show / Hide 
Range on Protein: 293-489
Range on HMM: 2-203/260
Sequence Identity: 31% (65 aa)

KIIRVLGRGAGGVVKLAYHETSGTY--IALKVITLDIQENIRKQIILELKTLHKTSYPYIVSFYDAFYTEGSIFIALEFMELGSLSDIMKKTS-----TI
| .  .| || | | .|.    ..   .| |.. .. ...    || |.... .   . || ..|..  .  .....|.|| |.| |. ...      ..
KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMK-NQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

PEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGRSYSFDSEIWSLGLTILECAIG
.|   . .  ..|||| ..|.| | ||||||  |||..  |. ||.|||   ||.   .|  | |||  .|.|| |... |.    |||||  ..| . |
DEGQIAYVCRECLQGLEFIHSK-HRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEG

KFPY
  ||
EPPY
Kinase Mek1.AA Pkinase_Tyr 292-436 26 4e-21 72.18 Pfam 1-158 (270) Show / Hide 
Range on Protein: 292-436
Range on HMM: 1-158/270
Sequence Identity: 26% (42 aa)

LKIIRVLGRGAGGVVKLAYHE----TSGTYIALKVI--TLDIQENIRKQIILELKTLHKT-SYPYIVSFYDAFY-TEGS--IFIALEFMELGSLSDIMKK
......||.|| |.|....        ..  | |..  . . ..|.|.  . |.|....  . | ||..| . .  ...  |.| .|.|..|.| |  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TSTIPEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVS
       .. . | ....|. .|. ||..| ..||||.   |.||.... .||.||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESK-NCIHRDLAARNCLVTENNVVKICDFGLA
Kinase Mek1.AA TyrKc 292-641 17 1.7e-16 44.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 292-641
Range on HMM: 1-280/280
Sequence Identity: 17% (68 aa)

LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKT--SYPYIVSFYDAFYTE-------GSIFIALEFMELGSLSDIMKKT
.. ...||.|| |.| ..      .  | |..  |     |. .. |.. ..|   . | || .| .  ..       . ..| .|.|..|.| |  .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ST-IPEPVLGKIAFQVLQGLVYLHRKLHLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHT-------LSKAV-----TW-VGTVTYMSPERISGRSYSF
   .. . | ....|. .|  |||.| ..||||.   |.||.... .||.||| |  . .          . .     .  .  .  |.|| |  . ...
RPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

DSEIWSLGLTILE-CAIGKFPYGS---NLPHQQQQPLQQQQQQQQQQQQPL----QQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNN
 | .|| | .. | .  |. ||     . .   |. ... .|     | |                                                  
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------------

NNNNNNNNNVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPSTFSKEFRSFISECLQKEPTERPTASNLLNHEFV
                                                . ..|  . ...| . .| .||| |..  ||. 
---------------------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Mek1.AA MST 607-641 48 1.9e-16 48.73 In-house 220-254 (254) Show / Hide 
Range on Protein: 607-641
Range on HMM: 220-254/254
Sequence Identity: 48% (17 aa)

PSTFSKEFRSFISECLQKEPTERPTASNLLNHEFV
|. .| ||  |.. ||||.| .|.||  ||.|.|.
PEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase Mek1.AA MEK5 594-641 46 2.8e-14 48.61 In-house 206-254 (254) Show / Hide 
Range on Protein: 594-641
Range on HMM: 206-254/254
Sequence Identity: 46% (23 aa)

LLDCIVKEEVPILPS-TFSKEFRSFISECLQKEPTERPTASNLLNHEFV
|| ||| |. | ||.  ||. |  ||  |.|| | .||   .|..| |.
LLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase Mek1.AA MEK3 598-641 39 3e-14 44.87 In-house 219-264 (264) Show / Hide 
Range on Protein: 598-641
Range on HMM: 219-264/264
Sequence Identity: 39% (18 aa)

IVKEEVPILPS-T-FSKEFRSFISECLQKEPTERPTASNLLNHEFV
.|.|  | ||  . || ..  ||. ||.|...|||.   |. |.|.
VVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase Mek1.AA MEK1 554-641 31 1.5e-13 42.21 In-house 209-297 (297) Show / Hide 
Range on Protein: 554-641
Range on HMM: 209-297/297
Sequence Identity: 31% (28 aa)

NNNNNNNNNNNNNNNNVLDISNGGLVDSGSSVPEGMGFWVLLDCIVKEEVPILPS-TFSKEFRSFISECLQKEPTERPTASNLLNHEFV
..|  ...... .| . ..  |.  .  |   |. |  . .|| ||.|  | ||.  ||.||. |.. ||.|.| || .  .|..| |.
GDNVYCEQEGEPHNIDPRERPNYHPISHGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase Mek1.AA PAKA 607-641 37 2.8e-12 39.51 In-house 226-260 (260) Show / Hide 
Range on Protein: 607-641
Range on HMM: 226-260/260
Sequence Identity: 37% (13 aa)

PSTFSKEFRSFISECLQKEPTERPTASNLLNHEFV
|  .|.||. | . ||.... .|..|. ||.|.| 
PDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase Mek1.AA Pkinase 611-641 45 1.6e-08 31.2 Pfam 263-293 (293) Show / Hide 
Range on Protein: 611-641
Range on HMM: 263-293/293
Sequence Identity: 45% (14 aa)

SKEFRSFISECLQKEPTERPTASNLLNHEFV
|.|...||. ||.| |..||||  .|.|...
SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Mek1.AA Pkinase_Tyr 611-641 29 1.938676 2.11 Pfam 242-270 (270) Show / Hide 
Range on Protein: 611-641
Range on HMM: 242-270/270
Sequence Identity: 29% (9 aa)

SKEFRSFISECLQKEPTERPTASNLLNHEFV
..|  . . .| ...| .||| | .  ||. 
PDEIYDLMKQCWHYDPEDRPTFSEI--HEQL