Gene MkcE (Slime mold)

MkcE

Species: Slime mold
Alias: DDB0230009, DdisK161, MkcE
External Links: DictyBase Link ,
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MKC

Sequence

Name Sequence Type Origin Length Description Download
MkcE.AA Protein None 715 None Fasta, JSON
MkcE.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of MkcE.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MkcE.AA MKC 435-683 57 3.6e-195 654.67 In-house 9-260 (260) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-260/260
Sequence Identity: 57% (145 aa)

KGAFGTVYQVFYVN--GQYNNVDVALKKMDHKSEKKRRNNLNEISILRYLKHPNIVTYINSYEKNDEEIWMVMEYMDGGTIRDAISN-FTFTEKYVAYIT
||.|||||...|.|  ..|....||.|||.|...|..|||||||..|.|..|||||.|..|..|.|.|||||||.|.|||...|..| ..|.|...||..
KGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFCESCIAYVC

KEILHSLEYLASLNIAHRDLKSSNIMINSKAEVKLIDFGFSIDLTHLKQDINMCGSPFYMSPEQIQDKAHGLAVDIWSLGIVVAEMVRGRVPHHKSKIKA
||.|..|.||...||.||||||.|||.|...|.||||||..||..|.|..|.||||||.||||.||.|.|....||||.||...||..||.|||||..||
KEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHEKEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRPPHHKSRMKA

MFLAGTVGVKFSKEKKYSCHWSPELFDFLNVCLQMDPTKRPTPTQLLQHPFI
||...|.|.||.||....||||....|||..||||||.||||..|||.||||
MFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase MkcE.AA STE20 435-683 38 6.5e-119 401.35 In-house 9-288 (288) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-288/288
Sequence Identity: 38% (108 aa)

KGAFGTVYQVFYVN--GQYNNVDVALKKMDHKSE----KKRRNNLNEISILRYLKHPNIVTYINSYEKN---DEEIWMVMEYMDGGTIRDAISN------
.|..|.|| . | .  |.|.|..|| |||.....    ........||||.. .||||||.|..|| |.   |.|.|.||||..||...|....      
QGSYGKVYKA-YHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGK

----FTFTEKYVAYITKEILHSLEYLASLNIAHRDLKSSNIMINSKAEVKLIDFGFSIDLTH-----LK-QDINMCGSPFYMSPEQIQD-----KAHGLA
    ....|...|||..|.|  |.|| | .| |||.|. ||......||||.|||.. .||.      . .  ...|.|..|.|| ||      | ..  
NHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYK

VDIWSLGIVVAEMVRGRVPHHK-SKIKAMFLAGTVGVKFSKEKKY-SCHWSPELFDFLNVCLQMDPTKRPTPTQLLQHPFI
.|||||||   ||. |..|... .  .|||.  . . .. . |.. . .||||. ||...|||.|| ||||..|||.||||
CDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MkcE.AA STE 8-683 12 7.5e-96 324.74 In-house 33-359 (359) Show / Hide 
Range on Protein: 8-683
Range on HMM: 33-359/359
Sequence Identity: 12% (99 aa)

LKKKKEPNSWSNFDRSDDKSKSLSKKGSLYANGNYDGGGSGSGSGGSSSNSSGSSRKINTGGNNRNGGGMVHSPSNSSISSTSSNNSNSTTASSSSKLKG
..                                                                                                  
EN--------------------------------------------------------------------------------------------------

NKNRNSSGKQKNSSSQHQQYGNTYYLDDECDSDDFIPGEVRSISKTIDFSKSERKWLTSLNIPQELLDGNINVLLNVLNFLSKKEGILYIQTPTNIINNT
                                                                                                    
----------------------------------------------------------------------------------------------------

GKKNFQQQQLQQLQQQQQQQQLQQQQHQQHNHQIYGNGNNNNLNVNVNVNGNNNNSNNNNGNYTSYVNSRSNSIASNNSSITPSTSCSNLNNDNNNNNNN
                                                                                                    
----------------------------------------------------------------------------------------------------

NCTDNNSNNNNNNNNNNSTTTTTTITNTNVNMIGASNINSSKSNLNSLLLSGGSNGNGGVDNLSSTTTSLSQNPPIQPMRRSDYNRIFIEPGKFYIFPES
                                                                                                    
----------------------------------------------------------------------------------------------------

ESFALARLVVEEEDPSKLFRIGENAEVKGAFGTVYQVFYVNGQYNNVD------VALKKMDHKSE-----------------KKRRNNLNEISILRYLK-
                                               .      .| |.|.....                 ... . |.||.|.. .. 
-----------------------------------------------NGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH

-HPNIVTYINSYEKN------DEEIWMVMEYMDGGTIRDAISN---------------FTFTEKYVAYITKEILHS-LEYLASLNIAHRDLKSSNIMINS
 |||||.|. .|.|.      |.|.|..|||||||...| | .               ..| |. .|||...||.  |.|| |..| |||.|..||..  
MHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--

KAEVKLIDFGFSIDLTH-----------------LKQDINMCGSPFYMSPEQIQ------DKAHGLAVDIWSLGIVVAEMVRGRVPHHK-SKIKAMFLAG
   |||.|||..  ||.                  ..   ..|.| .|.|| ||      || ..  .||||||... ||. |..|.|. .  .|||.. 
---VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIP

TVGVKFS---------KEK---KY-----------------SCHWSPELFDFLNVCLQMDPTKRPTPTQLLQ--HPFI
. .....         ..    .                  . .||||. ||.| |||.|| ||||..|||.  ||||
FNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MkcE.AA S_TKc 426-683 30 5.8e-83 282.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 426-683
Range on HMM: 1-231/231
Sequence Identity: 30% (85 aa)

FRIGENAEVKGAFGTVYQVFYVNGQYNNVDVALKKMDHKSEKKRRNNLNEISILRYLKHPNIVTYINSYEKNDEEIWMVMEYMDG--GTIRDAISNFT--
..|..    |||||.||..  ..    .  ||.|...       .. ..||.||.  .|||||... ...   ....|||||.||  |. .| | .    
YEILRKIG-KGAFGKVYKCRHKK---TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEKYVAYITKEILHSLEYLASLNIAHRDLKSSNIMINSKAEVKLIDFGFSIDLTHLKQDINMCGSPFYMSPEQIQDKAHGL-AVDIWSLGIVVA
     |.|  .......|.  |||. |..| ||||| .||....  ..|..|||..  |        .||.|.||.|| .    .|  ..|.||.|....
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMVRGRVPHHKSKIKAMFLAGTVGVKFSKEKKYSCHWSPELFDFLNVCLQMDPTKRPTPTQLLQ-------HPFI
||. |. | .    . . . |                |||. ||.. |||.||.||||  ..||       ||..
EMLCGYPPFP-QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MkcE.AA Pkinase 435-683 31 2.2e-76 264.84 Pfam 9-293 (293) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-293/293
Sequence Identity: 31% (91 aa)

KGAFGTVYQVFYVNGQYNNVDVALKKMDHKSEKK--RRNNLN--EISILRYLKHPNIVTYINSYEKNDEEIWMVMEYMDGG----TIRDAIS---NFTF-
.|.||.||.   .. .     ||.|... ..||.  ......  ||.|.. |.|||||... ..|  . .|.|||||..||       | ||   . .| 
SGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY

-TEKYVAYITKEILHSLEYLASLNIAHRDLKSSNIMINSKAEV----KLIDFGFSID--LTHLKQDINMCGSPFYMSPEQIQ-DKAHGLAVDIWSLGIVV
 .|. .  . ..||  |||. | .| |||||..||.|... ..    |..|||..    . .       ||.|.||.|| |. .. .| .||.||.|...
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

AEMVRGRVPHHKS-------KIKAMFLAGTVGVKFSKEKKYSCH---------------WSPELFDFLNVCLQMDPTKRPTPTQLLQHPFI
.||. || |   .       ... ... .   ..|. ....|                 ||.|. ||.. ||..||.||||..|.||||..
YEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MkcE.AA PAKA 435-683 39 8.3e-73 248.19 In-house 9-260 (260) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-260/260
Sequence Identity: 39% (103 aa)

KGAFGTVYQVFYVNGQYNNVD-VALKKMDHKSEKKRRNNLNEISILRYLKHPNIVTYINSYEKNDEEIWMVMEYMDGGTIRDAISNFT------FTEKYV
.|| |.|| .   | . |. . || |.|. | . |  . .|||....  ||.||| || ||   |.|.|.|||||.||   | |...       ..|. .
QGASGEVYVA--TNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLV-DDELWVVMEYMEGGCLTDVITQCCNIQCNYMDEGQI

AYITKEILHSLEYLASLNIAHRDLKSSNIMINSKAEVKLIDFGFSIDLTHLKQDIN-MCGSPFYMSPEQIQDKAHGLAVDIWSLGIVVAEMVRGRVPHHK
||. .|.|  ||.. | ...|||.|| || ... ..||. ||||   ||  .|  | | | | .|.|| |. |  .  |||||||| . ||. |  |. .
AYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEPPYLN

SK-IKAMFLAGTVGVKFSKEKKYSCHWSPELFDFLNVCLQMDPTKRPTPTQLLQHPFI
 .  .||.|  | |.   |..     ||.|. |||. ||..|. .|.. ..||.|||.
EPPLRAMYLIATNGKPDIKDPD---KWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase MkcE.AA Ciliate-E2 435-683 24 4.8e-63 215.26 In-house 9-365 (365) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-365/365
Sequence Identity: 24% (94 aa)

KGAFGTVYQV--FYVNGQYN---------------NVDVALKKMDHKSEKKRRNNLNEISILR----------------YLKHPNIVTYINSYE-KNDEE
.|.||.||..    |. |..                |.. .. |  ..... .. ..||.|.|                 |.||||. .. ... |.|. 
QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN

IWMVMEYMDGGTIRDAISNF------------TFTEKYVAYITKEILH---------------SLEYLASLN-IAHRDLKSSNIMINSKAEVKLIDFGFS
| .|||| .||. .| | |.             |||| ..||.|.||                 |||| | | | |||.| .||..     .|.||||.|
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLS

IDLTHLKQDINM--------------------------------CGSPFYMSPEQIQDKA---------HGLAVDIWSLGIVVAEMVRGRVPHHKSKIKA
 ...   |.. .                                ||.| ||.|| .. |          .. ..||||||..  ||. |. |        
KKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------

MFLAGTVGVKFSKEKK----YSCH------------------WSPELFDFLNV----CLQMDPTKRPT-PTQLLQHPFI
          . . |.    ..|                   ||.|  |...     .|| || ||.| . |.|.||..
----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MkcE.AA CAMK 435-683 19 6.2e-61 194.77 In-house 4-425 (425) Show / Hide 
Range on Protein: 435-683
Range on HMM: 4-425/425
Sequence Identity: 19% (83 aa)

KGAFGTVYQVFYV-NG-QYN-------NVDVALKKMDHK----------------------------SEKKRRNNLNEISILRY-------LKHPNIVTY
.|.||.|. ..   .. . .       .. || | .| |                            ..|.|.| ..||.|..        |.||||.  
RGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKL

INSYEKN------------------DEEIWMVM---EYMDGG----TIRDAISN----------------FTFTEKYVAYITKEILHSLEYLASLNIAHR
.  || .                  |....|||   ||..||     . | |                  . |||. .... . |.  ..|. |.||.||
YEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHR

DLKSSNIMINSK-----------------AEVKLIDFGFSIDLTHLKQDIN------------------------MCGSPFYMS-PEQIQD---------
|||  ||.....                 . .|.|||||.. ... ... .                        .||.| ||. || ..          
DLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNA

-----KAHGLAVDIWSLGIVVAEMVRGRVPHHKS----------------KIKAMFLAGTVGVKFSKEKK-----YSCHWS-----------PELFDFLN
     . .| ..|.||.|..   |. |. |   .                ... . ..|      .. ..     ... |.           .|  |...
TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIR

VCLQMDPTKRPTPTQLLQHPFI
 .|| ||.||.| .| |.||..
KMLQVDPEKRMTIEQCLNHPWM
Kinase MkcE.AA STE11 475-683 33 2.4e-51 176.89 In-house 60-303 (303) Show / Hide 
Range on Protein: 475-683
Range on HMM: 60-303/303
Sequence Identity: 33% (84 aa)

EISILRYLKHPNIVTYINSYE-KN-DEEIWMVMEYMDGGTIRDAIS-NF-T--FTEKYVAYITKEILHSLEYLASLNIAHRDLKSSNIMINSKAE-VKLI
||.... |.|.||| |. .   .| ....   |||. ||.... .. .. .  |.|. . . || ||  | || | .| |||.|  ||...|.   .||.
EIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLA

DFGFSIDLT-HLKQDIN----------MCGSPF--------YMSPEQIQDKA---HGLAVDIWSLGIVVAEMVRGRVPHHKSK---IKAMFLAGTV-G--
||| .  |  .. .  |          | |.|.        .|.|| |       .| ..|||||| .| ||. |. | |  .   . ||| .|.  .  
DFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPH

----VKFSKEKKYSCHWS---PELFDFLNVCLQMDPTKRPTPTQLLQHPFI
     ..|         |   .|. |||. |.. || ||||  ||||||||
PPIPEHMSP-------ISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase MkcE.AA ULK 435-683 26 3.6e-51 176.31 In-house 9-324 (324) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-324/324
Sequence Identity: 26% (83 aa)

KGAFG-TVYQVF-YVNGQYNNVDVALKKMDHKSEKKRRNN----------LNEISILRYLK---HPN--IVTYINSYEKNDE-EIWMVMEYMDGGTIRDA
||.|| .||. .   ..   |..|| |..| |. .|  |.           |||.|.. ||   |||  || ..  .|  ..  |...||| .||. .. 
KGSFGVKVYKGRNKKTNT-QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQY

IS----------NFTFTEKYVAYITKEILHSLEYLASLNIAHRDLKSSNIMINSK------------AEVKLIDFGFSIDLTHLKQDINMC---------
|           . ...|. .  . | |.  . .| . || |||.| .||.|. .              .|. ||||.  .    .. .||         
IKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRI

-GSPFYMSPEQIQ----DKAHG-LAVDIWSLGIVVAEMVRGRVP---HHKSKIK--AMFLAG----------TVGVKFSKEKKYSCHWSPELFDFLNVCL
 |.| ||.|. .|     | ..   .||||||..  ||. |..|     ... .   . |            .  ..| | . .. . |||. |..  .|
KGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRML

QMDPTKRPTPTQLLQHPFI
| |...| . .....||..
QYDEKDRISWEEIFNHPWF
Kinase MkcE.AA ULK 435-683 25 1.5e-50 174.22 In-house 9-329 (329) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-329/329
Sequence Identity: 25% (82 aa)

KGAFGTVYQVF-YVNGQYNNVDVALKKMDHKSEKKRRNN----------LNEISILRYLK--------HPNIVTYINSYEKNDE-EIWMVMEYMDGGTIR
||.||.||. .   ...| |..|| |..| .....  |.           ||| |.. ||        ||||| ..  .|  ..  |...||| .||. .
KGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLE

DAIS-----------NFTFTEKYVAYITKEILHSLEYLASLNIAHRDLKSSNIMINSK------------AEVKLIDFGFSIDLTH-------LKQDIN-
. |.           . ...|. .  . | ||  . .| . || |||.| .||.|. .              .|. ||||.  ..        ..   | 
QYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE

--MCGSPFYMSPEQIQ----DKAHG-LAVDIWSLGIVVAEMVRGRVP---HHKSKIKAMFLAGTVGV---------KFSKEKK---YSCHWSPELFDFLN
   ||.| ||.|. .|     | ..   .||||||..  ||. |..|     ... . ...   .           |.  . .   .. . |||. |.. 
KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIR

VCLQMDPTKRPTPTQLLQHPFI
 .|| |...| . ..|..||..
RMLQYDEKDRISWEELFNHPWF
Kinase MkcE.AA Ciliate-E2-Unclassified 435-683 24 1.5e-50 173.52 In-house 9-352 (352) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-352/352
Sequence Identity: 24% (86 aa)

KGAFGTVYQVFYVNGQYNNVDVALKKMDHKSEKKRRNN---------LNEIS-------------ILRYLKHPNIVTYINSYEKNDEEIWMVMEYMDGGT
.|.||.||..   . .. ..   .||. ... |. .|.         .|...             ||. ..||.|| .   ...... | .||||..||.
QGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIV-KMFYCFQDKQNIYIVMEYCEGGD

IRDAISNFT------------------FTEKYVA-----YITKEILHSLEYLASLN-IAHRDLKSSNIMINSKA---EVKLIDFGFSIDLTHL-------
 .. |...                   |||. ..     .....||  |||| . | | |||.| .||.....    ..|.||||.|. .          
LWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQ

-------KQDIN--MCGSPFYM----SPEQIQDKAHG----LAVDIWSLGIVVAEMVRGRVPH-HKSKIK---------------AMFLAG-TVGVKFSK
       ||..   .||.| ||    .|| .| . ..     ..||||||..  ||. |. |   .....                ..       ..|.|
QQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPK

EKK--YSCHWSPELFDFLN----VCLQMDPTKRPTPTQLLQHPFI
...   ..|||||  ||.|     .|. .| ||.|. |.|.||..
FPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MkcE.AA TyrKc 435-683 24 3.7e-15 22.32 SMART 9-280 (280) Show / Hide 
Range on Protein: 435-683
Range on HMM: 9-280/280
Sequence Identity: 24% (68 aa)

KGAFGTVYQVFYVNGQYNNVDVALKKMDHKSEKKRRNNLNEISILRYL--KHPNIVTYINSYEKN------DEEIWMVMEYMDGGTIRDAISNFT--FTE
 ||||.||.  .       ..|| |.. . .   |.  ..|..|.. |  .|||||  .    .       .| ...|||||..|  .| . .    .. 
EGAFGEVYKGTWK------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

KYVAYITKEILHSLEYLASLNIAHRDLKSSNIMINSKAEVKLIDFGFSIDLTHL-----KQDINMC----GSP-----FYMSPEQIQDKAHGLAVDIWSL
|   ..   |    |||.| |. ||||   |......  ||  ||| | |...       .|  .     |.        |.|| |...    . |.|| 
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF

GIVVAEMV-RGRVPHH------KSKIKAMFLAGTVGVKFSKEKKY---SCHWSPELFDFLNVCLQMDPTKRPTPTQLLQHPFI
|..  |.  .|  |.       .| . .. .  . .     .  |   . . ..|...    | . || .||| ...  | ..
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MkcE.AA Pkinase_Tyr 435-511 30 5.8e-12 41.14 Pfam 104-187 (270) Show / Hide 
Range on Protein: 435-511
Range on HMM: 104-187/270
Sequence Identity: 30% (26 aa)

KGAFGTVYQVFYV-NGQYNNVDVALKKMDHKSEKK---RRNNLNEISILRYL-KHPNIVTYINSYEKNDEE--IWMVMEYMDGG
.||||.||.  .   .. ....|| |.. ... ..   |.  ..|..|.. | .||||| ..    . .|   |..||||| .|
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG
Kinase MkcE.AA Pkinase_Tyr 538-623 30 0.001993 12.23 Pfam 124-214 (270) Show / Hide 
Range on Protein: 538-623
Range on HMM: 124-214/270
Sequence Identity: 30% (28 aa)

LEYLASLNIAHRDLKSSNIMINSKAEVKLIDFGFSIDL----TH-LKQDINMCGSPFYMSPEQIQDKAHGLAVDIWSLGIVVAEMVR-GRVP
.|||.| |. ||||   |......  ||  ||| . |.    .   |..  .    . |.|| |...    . |.|| |..  |..  |. |
MEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP