Gene DDB0229853 (Slime mold)

DDB0229853

Species: Slime mold
Alias: DdisK219, DDB0229853
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: LISK-DD1

Sequence

Name Sequence Type Origin Length Description Download
DDB0229853.AA Protein None 527 None Fasta, JSON
DDB0229853.kin_dom Protein Kinase Domain None 248 None Fasta, JSON

Protein domain

Protein domains of DDB0229853.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0229853.AA LISK-DD1 38-291 50 4.6e-180 604.49 In-house 1-290 (290) Show / Hide 
Range on Protein: 38-291
Range on HMM: 1-290/290
Sequence Identity: 50% (146 aa)

EIGRGSFGQVQKASYFGTDVAVKQLST--LVSIDPDYFKFMLREIKILKG---MRHPNIVQYIGACCH-------------EGRYMIVTEYIKGGDLHQF
|||.||||.|.|..||||.||.|....  ....||||.||| ||||.||.   .|||||||.||.|.|             |....||||.|.|||||..
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

IKARG-----------VSNISWTLRMKLALDIASAFSYLHSKKVIFRDLKAKNILVDEIGDGLYRAKVIDFGFARIFDGK--DTNN--LTICGSENTMSP
.|...           ...|.|.||.|.|||||.|..|||||..|.||||.|||||||.||...|.||.||||||.|..|  ..||  .||||..|.|.|
LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTICGTDNWMAP

EVIVGSSYNDSCDVYSYGVLLLELICGSRVVKTQLKRTPMNAFDMNLEKAEH-LAPES--CPRAFMDLAKWCCSYNPKDRPTFKIVVEGL
|||.|.||..||||.|.|..|||||......|....|.|||.||...|.... ..|..  |||.||||..|||.|.|..||.|| .|. |
EVILGMSYDWSCDVFSFGMVLLELITRKKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL
Kinase DDB0229853.AA LISK 38-291 39 3e-162 531.15 In-house 1-296 (296) Show / Hide 
Range on Protein: 38-291
Range on HMM: 1-296/296
Sequence Identity: 39% (118 aa)

EIGRGSFGQVQKASYF--GTDVAVKQLST--LVSIDPDYFKFMLREIKILKGMRHPNIVQYIGACCH-EGRYMIVTEYIKGGDLHQFIKARG--VSNISW
|||.|.||.|.| ...  |...|.|....  ....||.|.||||||....| .|||||||..|.|.| .|...||||||.||||||..|...  .....|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

TLRMKLALDIASAFSYLHSKKVIFRDLKAKNILVDEIGDGLYRAKVIDFGFARIFDGKD--------------------------------TNN--LTIC
..|.|.|||||...|||||...|.||||.||.||.|.... .|.||.||||||..| ..                                ...  .|||
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GSENTMSPEVIVGSSYNDSCDVYSYGVLLLELICGSRVVKTQLKRTPMNAFDMNLEKAEHLAPES-CPRAFMDLAKWCCSYNPKDRPTFKIVVEGL
|....|.||...|.||..||||.|.|..|.|.|..... .....|||...|....|..... ... ||..|.||. .||.|.||.||.|| .|. |
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase DDB0229853.AA TKL 39-291 24 5.4e-87 295.33 In-house 1-364 (364) Show / Hide 
Range on Protein: 39-291
Range on HMM: 1-364/364
Sequence Identity: 24% (93 aa)

IGRGSFGQVQKASYFG----------TDVAVKQLSTLVS---------------------IDPDYFKFMLREIKILKGMR---HPNIVQYIGACCHEGR-
||.|.||.| |. . |          .|||||....  .                     .||.. .|. .|.. .. |.   ||||||..|.|| ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YMIVTEYIKGGD-LHQFIKARGVSNISWTLRMKLALDIASAFSYLHS--------KKVIFRDLKAKNILVDEIGD----------GLY
            ..||.||..||. ||...         | .|...|||||.. .||||        ...| |||| ||||||| .             .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

RAKVIDFGFARIFDGKDT-------------------NNLTICGSENTMSPEVIVGS----------------SYNDSCDVYSYGVLLLELICGSRVVKT
..|. |||..| ....                     .. |.||. . |.|||. |.                .|. .|||||.|..| |.... |. . 
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

QLKRTPM------NAFDMNLEKAEHLAP-------------ESCPRAFMDLAKWCCSYNPKDRPTFKIVVEGL
.  ....        | |. .| ... .             ..||. . .|...|....|..||.|. ... |
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase DDB0229853.AA S_TKc 33-299 27 2.4e-55 191.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 33-299
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LFMDVEIGRGSFGQVQKASYFG--TDVAVKQLSTLVSIDPDYFKFMLREIKILKGMRHPNIVQYIGACCHEGRYMIVTEYIKG--GDLHQFIKARGV---
  .  .||.|.||.| |.   .    ||.|...          . ..|||.|||  .|||||...... . ... .|.||. |  |||...|| ||    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-SNISWTLRMKLALDIASAFSYLHSKKVIFRDLKAKNILVDEIGDGLYRAKVIDFGFARIFDGKDTNNLTICGSENTMSPEVIVGSSYND-SCDVYSYGV
 . ..     ...  |..|  |.||...| ||||  |||.||      . |..|||.||..        |.||. . |.|||.   .|.  .||..| |.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LLLELICGSRVVKTQLKRTPMNAFDMNLEKAEHLAPESCPRAFMDLAKWCCSYNPKDRPTFKIVVE-GLKVLTNQQL
.| |..||          ...  |.. .           .. . |. . |. ..|..|||   . . ....   . .
ILYEMLCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0229853.AA Pkinase 39-291 28 9.2e-55 193.04 Pfam 7-293 (293) Show / Hide 
Range on Protein: 39-291
Range on HMM: 7-293/293
Sequence Identity: 28% (83 aa)

IGRGSFGQVQKASYFGTD--VAVKQLSTLVSIDPDYFKFMLR--EIKILKGMRHPNIVQYIGACCHEGRYMIVTEYIKGG----DLHQFIK---ARGVSN
||.||||.| |.   ||   ||||...   .....  .  .|  ||.|.| ..|||||......  .... .|.||  ||    ||. .|.    .... 
IGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-

ISWTLRMKLALDIASAFSYLHSKKVIFRDLKAKNILVD---EIGDGLYRAKVIDFGFARIF-DGKDTNNLTICGSENTMSPEVIV-GSSYNDSCDVYSYG
 |.    . .. |...  |.||...| ||||  |||.|   .|..   . |..|||.|. |   ... . |.||. . |.||||  |. |  ..|..|.|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG

VLLLELICGSRVVKTQ----LKRTPMNAFDMNLEKAEHLA-PESCP-------------------RAFMDLAKWCCSYNPKDRPTFKIVVEG--L
..| |..||    . .      ...|  .......  |   |..|.                   ... |. |||. ..||.|||.. ...   .
CILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDB0229853.AA TK 33-291 16 2.2e-49 163.26 In-house 1-486 (486) Show / Hide 
Range on Protein: 33-291
Range on HMM: 1-486/486
Sequence Identity: 16% (82 aa)

LFMDVEIGRGSFG---QVQKASYFG---------------------------TDVAVKQLSTLVSIDPD-YFK-FML---------REIKILKGMR----
. .  ..|.| ||   .| |. ..|                           |.||||.|    . ...  |  .|          .|  ..| |.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVQYIGACCHE------------GRYMIVTEYIKGGD----LHQFIKARGV---------------------------------------------
 |||||. .|.|...            . .|||.|| ..||    |... ...                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------SNISWTLRMKLALDIASAFSYLHSK------KVIFRDLKAKNILVDEIGDG-------LYRAKVIDFGFA-
                             ....   ..  ...||.. .|||||      ... ||| | |.||.| .          . .|. ||| . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RIFDGKDTNNLTICGSENT----------------------------MSPEVIVGSS---------YNDSCDVYSYGVLLLELIC-G-SRVVKTQ
     .  |  .  . .  .|. |                            |.||.. .           .    ||.|.|||. |.   |        
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

LK------RTPMNAFDMNLEK---------------AEHLAPESCP--------------RAFMDLAKWCCSYNPKDRPTFKIVVEGL
          ..  .  .|..                .  .|. ||               ...|| . |..|.|.|||||. ..| |
SNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDB0229853.AA TKL-Unique 38-229 30 2.4e-49 170.27 In-house 4-222 (290) Show / Hide 
Range on Protein: 38-229
Range on HMM: 4-222/290
Sequence Identity: 30% (66 aa)

EIGRGSFGQVQKASYFGTDVAVKQLSTLVSIDPDYFKFMLREIKILKGMR-HPNIVQYIGACC----HEGRYMIVTEYIKGGDLHQFIKA--------RG
 ||.|..||| |. . |..||.||.. . .. ..  .   .|....|  . |||||.|.|.|     ..... ||.||. || |.  .          . 
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNN

VSNISWTLRMKLALDIASAFSYLHSKK--VIFRDLKAKNILVDEI-GDGLYRAKVIDFGFARIFDGKDTNNLT-I--------CGSENTMSPEVIVG--S
 ..... .|.|.|.|||..  |||...  .| |||| .|.|||.      ...|..|||.... .  ...... .        ||| . |.|||. .  .
NCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFC

SYNDSCDVYSYGVLLLELI
 |. ..||||.|. | |..
QYSEKSDVYSFGIVLWEIA
Kinase DDB0229853.AA Dicty4 33-228 34 1.1e-46 153.77 In-house 1-210 (277) Show / Hide 
Range on Protein: 33-228
Range on HMM: 1-210/277
Sequence Identity: 34% (73 aa)

LFMDVEIGRGSFGQVQKASYFGTDVAVKQL-STLVSIDPDYFKFMLREIKILKGMRHPNIVQYIGACC----HEGRYMIVTEYIKGGDLHQFIKA-----
.  ...||.||||.| |..  |..|||| | .. .  | .  .  ..|..|..  |||||..  |||     | |. .|||||   |.|.  . .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

RGVSNISWTLRMK---LALDIASAFSYLHS--KKVIFRDLKAKNILVDEIGDGLYRAKVIDFGFAR-IFDGKDTNN--LTICGSENTMSPEVIVGSSYND
     ..|.|. .   .|.|.|    .||.    .| ||||. |.|||.     .|.|| |||... .  ..| .    | ||.   |.||| .. .|| 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKN----WRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

SCDVYSYGVLLLEL
. ||||.| .| |.
KADVYSFGIVLWEI
Kinase DDB0229853.AA MLK 33-229 30 1.8e-44 152.15 In-house 1-230 (291) Show / Hide 
Range on Protein: 33-229
Range on HMM: 1-230/291
Sequence Identity: 30% (72 aa)

LFMDVEIGRGSFGQVQKASYFGTD-----VAVKQLSTLVSIDPDY----FKFMLREIKILKGMRHPN----IVQYIGACCHEGR-YMIVTEYIKGGDLHQ
.     || ||||.| |. . ..|     ||||.  .    |        . . .|...|. ..|||    |.|  |.|  ..  . ||.||. || |. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

FIKA-RGVSN-----------ISWTLRMKLALDIASAFSYLHSKK---VIFRDLKAKNILVDE----IGDGLYRAKVIDFGFARIFDGKDTNNLTICGSE
.... |. ..           ..  . |. ||..|.. .||||..   .| |||| .|||.||    ...|   .|. ||| .| .  ..||    .|. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHG--TLKICDFGTSRDWHQMCTNMMSNAGTY

NTMSPEVI---VGSSYNDSCDVYSYGVLLLELI
 .|.||||    .. |. .|||.|.||.| |..
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase DDB0229853.AA TyrKc 33-291 25 1.5e-42 148.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 33-291
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

LFMDVEIGRGSFGQVQKASYFGTDVAVKQLSTLVSIDPDYFKFMLREIKILKGM--RHPNIVQYIGACCHE-------GRYMIVTEYIKGGDLHQFIKAR
. .. ..|.| ||.| |. .  ..|||| |           . ..||..|..    .|||||. .|.| ..       . .|||.|| ..|||.......
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GVSNISWTLRMKLALDIASAFSYLHSKKVIFRDLKAKNILVDEIGDGLYRAKVIDFGFARIFDGK-------DTNNLTICGSENT------MSPEVIVGS
.   ...    . ...||.  .|||||..| ||| | |.||.| .    ..|. ||| .|  . .       |.   .  ....|      |.||.|  .
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

SYNDSCDVYSYGVLLLELICGSRVVKTQ-LKRTPMNAFDMNLEKAEHL----APES--------CPRAFMDLAKWCCSYNPKDRPTFKIVVEGL
 ..   ||.|.||.. |.            .. .|..... .|. ..      |..        || .  .. |.|. ..|.|||||. ..| .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEV-IEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DDB0229853.AA STE 34-285 21 4e-41 142.93 In-house 1-349 (359) Show / Hide 
Range on Protein: 34-285
Range on HMM: 1-349/359
Sequence Identity: 21% (78 aa)

FMD-VEIGRGSFGQVQKASYF-----------------GTDVAVKQLST--------------LVSIDPDYFKFMLREIKILKGMR--HPNIVQYIGACC
. .  .||.|.||.| || .                  |. .|.||..               | ..... ..  |.||||.| ..  |||||.|.|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HEG-------RYMIVTEYIKGGDLHQFIK-ARGVSN-----------ISWTLRMKLALDIASA-FSYLHSKKVIFRDLKAKNILVDEIGDGLYRAKVIDF
.||          |. ||. || | ..||   |. .           .. ..  . . .|  .  .||||...| ||.|. |||.         .| .||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF

GFARIFDGK----------------DTNNLTICGSENTMSPEVIVG------SSYNDSCDVYSYGVLLLELICGSRVVKTQLKRTPMNAFDMNL------
|.. ... .                . .. |..|.   |.|||| .      . |. .||..| | ...|...|     .      | .. .|       
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

-------EKAEHLA------------------PESCPRAFMDLAKWCCSYNPKDRPTFK
       ..   |                   |...   | |  . |. ..|..||| .
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS
Kinase DDB0229853.AA LRRK 28-233 24 6e-40 139.01 In-house 1-281 (351) Show / Hide 
Range on Protein: 28-233
Range on HMM: 1-281/351
Sequence Identity: 24% (72 aa)

LDYSDLFMDVEIGRGSFG-QVQKASYFG----------------------------TDVAVKQLST------------------------------LVSI
| .  .     ||||.||  | .| . |                            ..||.|.. .                              ....
LKIEEQ-----IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHE

D-PDYFKFMLREIKILKGMRHPNIVQYIGACCHEGRYMIVTEYIKGGDLHQFIKARG-VS------NISWTLRMKLALDIASAFSYLHSKK--VIFRDLK
| .  |    .|. |. ...|||||. .| | |   ...|.||.  |||..|....   .      .|||.|. |.||.||..  ||||..  .|.||||
DCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLK

AKNILVDEI--GD------GLYRAKVIDFGFARIFDGKDTN--NLTICGSENTMSPEVIVG---SSYNDSCDVYSYGVLLLELICGS-R
  |||. ..  ..        . ||..|||  |.|   ...    .  | .  |.||.. .   ..|..  |.||.|..| ||. .. .
SPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHH
Kinase DDB0229853.AA Pkinase_Tyr 33-183 30 1.1e-37 128.31 Pfam 1-159 (270) Show / Hide 
Range on Protein: 33-183
Range on HMM: 1-159/270
Sequence Identity: 30% (51 aa)

LFMDVEIGRGSFGQVQKASYF------GTDVAVKQLSTLVSIDPDY--FKFMLREIKILKGM-RHPNIVQYIGACC-HEGR--YMIVTEYIKGGDLHQFI
. .. ..|.|.||.| |. ..      ...|||| |    . ...    . ..||.||.| . .|||||...|.|  ...   ..||.|| ..|||. . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KAR--GVSNISWTLRMKLALDIASAFSYLHSKKVIFRDLKAKNILVDEIGDGLYRAKVIDFGFAR
...  .  ...     . ...||.. .||.||. | ||| |.|.||.|   ..  .|. ||| ||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NN-VVKICDFGLAR
Kinase DDB0229853.AA TESK 76-185 45 2e-36 112.2 In-house 40-148 (292) Show / Hide 
Range on Protein: 76-185
Range on HMM: 40-148/292
Sequence Identity: 45% (50 aa)

MLREIKILKGMRHPNIVQYIGACCHEGRYMIVTEYIKGGDLHQFIKARGVSNISWTLRMKLALDIASAFSYLHSKKVIFRDLKAKNILVDEIGDGLYRAK
||||.. .  ..||||. . |.| |.|.   .|||| || | |      .   ||| ...||.|||   |||||| |  |||  ||.|| .  .  | | 
MLREVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCLEQLLADSEL-HLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQYEAV

VIDFGFARIF
| ||| ||..
VGDFGLARVL
Kinase DDB0229853.AA TESK 193-293 32 5.2e-19 56.25 In-house 194-292 (292) Show / Hide 
Range on Protein: 193-293
Range on HMM: 194-292/292
Sequence Identity: 32% (33 aa)

LTICGSENTMSPEVIVGSSYNDSCDVYSYGVLLLELICGSRVVKTQLKRTPMNAFDMNLEKAEHLAPESCPRAFMDLAKWCCSYNPKDRPTFKIVVEGLK
. . ||   |.|||  |  |.   ||.|.|. | |.|         . ||    | . ..   .. |. ||  |. ||  ||...|||||.|. ..  |.
MAVVGSPYWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPRT--EKFGLDYQAFKEMCPMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHLE

V
.
W
Kinase DDB0229853.AA Pkinase_Tyr 258-291 50 6.4e-08 27.44 Pfam 237-270 (270) Show / Hide 
Range on Protein: 258-291
Range on HMM: 237-270/270
Sequence Identity: 50% (17 aa)

APESCPRAFMDLAKWCCSYNPKDRPTFKIVVEGL
.|| ||    || | |  |.|.|||||. ..| |
CPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DDB0229853.AA TKL-Unique 259-291 33 1.1e-05 16.28 In-house 258-290 (290) Show / Hide 
Range on Protein: 259-291
Range on HMM: 258-290/290
Sequence Identity: 33% (11 aa)

PESCPRAFMDLAKWCCSYNPKDRPTFKIVVEGL
|..||  . || . |.  .| .||.|  ... |
PNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase DDB0229853.AA MLK 259-291 36 1.6e-05 15.23 In-house 259-291 (291) Show / Hide 
Range on Protein: 259-291
Range on HMM: 259-291/291
Sequence Identity: 36% (12 aa)

PESCPRAFMDLAKWCCSYNPKDRPTFKIVVEGL
| .||. .  | | | . .|..||.|. .|. |
PSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase DDB0229853.AA LRRK 259-293 31 2.9e-05 14.56 In-house 311-351 (351) Show / Hide 
Range on Protein: 259-293
Range on HMM: 311-351/351
Sequence Identity: 31% (13 aa)

PES-CPR-----AFMDLAKWCCSYNPKDRPTFKIVVEGLKV
|.. ||.      . || ..| . .||.||.|  .|. |. 
PQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase DDB0229853.AA Dicty4 259-293 29 7.2e-05 12.36 In-house 241-277 (277) Show / Hide 
Range on Protein: 259-293
Range on HMM: 241-277/277
Sequence Identity: 29% (11 aa)

PESCPRAFMDLAKWCCSYNPKDRPTFKIVVEG--LKV
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PDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase DDB0229853.AA Pkinase_Tyr 202-229 39 0.005023 10.87 Pfam 181-208 (270) Show / Hide 
Range on Protein: 202-229
Range on HMM: 181-208/270
Sequence Identity: 39% (11 aa)

MSPEVIVGSSYNDSCDVYSYGVLLLELI
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MAPECINYGKFTTKSDVWSFGVLMWEIF