Gene DDB0229854 (Slime mold)

DDB0229854

Species: Slime mold
Alias: DDB0229854, DdisK220, gefX
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: LISK-DD1

Sequence

Name Sequence Type Origin Length Description Download
DDB0229854.AA Protein None 960 None Fasta, JSON
DDB0229854.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of DDB0229854.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0229854.AA LISK-DD1 26-272 52 8.10000000001e-179 600.35 In-house 1-290 (290) Show / Hide 
Range on Protein: 26-272
Range on HMM: 1-290/290
Sequence Identity: 52% (152 aa)

KIGKGSFGSVFRGCYLGLDVAIKKIEK----ADDPEYLKYIDREVSMLQS---LRHPFIVNFSGICVH-------------SSGLYIVTEFVSGGDVRQL
.|||||||.|..|||.| .||||||.|    ..||.|.|...||..||..   .|||.||.|.|||.|             .|.|||||||..|||....
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

LKKTP-------------PIGWDKRVSIAVDLAKAMVFLHAKKIIHRDLKSKNILLDEF----QRIRLCDFGFARMSEQTKKS---RHMTMCGTEGWVAP
||.||             ||.|..||.||.|.|.||..||.|.||||||||||||.||.     ||..||||||||.||.|..   ||||.|||..|.||
LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTICGTDNWMAP

EILLGMSYDTSCDVFSYGVVLAELITGRKPGVDLWVRSPETCFDINPEELKQKSIPG---CPSELISVCVECCLYEPLTRPKFDEILSQL
|..||||||.||||||.|.||.||||..||....|.|||..||||..||..|..||.   ||.|....|..|| |.| .||.|.||...|
EVILGMSYDWSCDVFSFGMVLLELITRKKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPNNRPSFKEIVQTL
Kinase DDB0229854.AA LISK 26-272 43 1.5e-161 528.8 In-house 1-296 (296) Show / Hide 
Range on Protein: 26-272
Range on HMM: 1-296/296
Sequence Identity: 43% (129 aa)

KIGKGSFGSVFRGCYL--GLDVAIKKIEK----ADDPEYLKYIDREVSMLQSLRHPFIVNFSGICVH-SSGLYIVTEFVSGGDVRQLLKKTP----PIGW
.||||.||.|..|...  | ..|||.|..    ..||||.|...||| |...||||.||.| |.|.| ...|.||||...|||..|.||...    |. |
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

DKRVSIAVDLAKAMVFLHAKKIIHRDLKSKNILLDEF----QRIRLCDFGFARMSEQTKKS---------------------------------RHMTMC
..||.||.| |..| .||...||||||||||.|..|.     ||..|||||||| .....|                                 |.||.|
PQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMNQRKRRMTIC

GTEGWVAPEILLGMSYDTSCDVFSYGVVLAELITGRKPGVDLWVRSPETCFDINPEELKQKSIPG-CPSELISVCVECCLYEPLTRPKFDEILSQL
||. |.|||.|||.|||.||||||.|.|| |.||..|.. |.|.|.|...|....||..|| .|  ||.... .|..|| |.| .||.|.||...|
GTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase DDB0229854.AA TKL 27-272 26 7.3e-87 294.88 In-house 1-364 (364) Show / Hide 
Range on Protein: 27-272
Range on HMM: 1-364/364
Sequence Identity: 26% (99 aa)

IGKGSFGSVFRGCYLG----------LDVAIKKIEKAD-----------------------DPEYLKYIDREVSMLQS---LRHPFIVNFSGICVHSSG-
||.|.|| |..| . |           |||.||. . .                       |||. .. ..|.  . .   |||| || | |.|  ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LYIVTEFVSGGD-VRQLLKKTPPIGWDKRVSIAVDLAKAMVFLHA--------KKIIHRDLKSKNILLDEFQR--------------I
            |.||.|...||.   .|.       |..|...| | |..| .||.        ..||||||||||||.||  .              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

RLCDFGFAR-MSEQTKKSR-----------------HMTMCGTEGWVAPEILLGM----------------SYDTSCDVFSYGVVLAELITGRKPGVDLW
 .||||..| ||. .....                 .|| ||| .| |||.| |.                .|...|||.|.|.|| |..|...|  |..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

VRSPE------TCFDINPEELKQKSIP-------------GCPSELISVCVECCLYEPLTRPKFDEILSQL
 ....        | .. .. ..  ||              || .... . .|. ..|  || |.|||..|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase DDB0229854.AA Pkinase 21-272 24 6e-63 220.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 21-272
Range on HMM: 1-293/293
Sequence Identity: 24% (74 aa)

LEFNEKIGKGSFGSVFRGCYLGLD--VAIKKIEKADDPEYLKYIDR---EVSMLQSLRHPFIVNFSGICVHSSGLYIVTEFVSGG----DVRQLLK--KT
... .|||.||||.|....  |    ||.|.|.| .. .  ....|   |......|.||.|| . ...  .. .|.|.|.. ||    |   ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PPI--GWDKRVSIAVDLAKAMVFLHAKKIIHRDLKSKNILLDEFQRI----RLCDFGFAR-MSEQTKKSRHMTMCGTEGWVAPEILL-GMSYDTSCDVFS
 ..   ..   ...  ..... ..|...|||||||. |||.|.   |    ..||||.|. ..   ..|  .| ||| ...|||... |  |....|..|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

YGVVLAELITG--RKPGV---DLWVRSPETCFDINPEELKQKSIPGCP-------------------SELISVCVECCLYEPLTRPKFDEILSQ--L
.|..|.|...|    ||    |  ..  .  . | . .|.  .   |.                   .|.....  |. . |  || ...||    .
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc DDB0229854.AA S_TKc 21-273 28 1.4e-61 211.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-273
Range on HMM: 1-231/231
Sequence Identity: 28% (78 aa)

LEFNEKIGKGSFGSVFRGCYLG--LDVAIKKIEKADDPEYLKYIDREVSMLQSLRHPFIVNFSGICVHSSGLYIVTEFVSG--GDVRQLLKKTPP-----
 |. .|||||.||.|...   .    ||||.|         . | ||...|.. .||.||.. ..... . ||.|.|...|  ||.....|| ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IGWDKRVSIAVDLAKAMVFLHAKKIIHRDLKSKNILLDEFQRIRLCDFGFARMSEQTKKSRHMTMCGTEGWVAPEILLGMSYDT-SCDVFSYGVVLAEL
 .      ...  ...|. ..| ..|||||||  ||||||  .| .||||.||          .|.|||  ..|||.|   .|.. .||. | |..|.|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ITGRKPGVDLWVRSPETCFDINPEELKQKSIPGCPSELISVCVECCLYEPLTRPKFDEILS--------QLK
..|. |               ..... .|     ..|...    |. ..|  ||   |.|         .  
LCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0229854.AA MLK 21-215 31 1e-56 194.74 In-house 1-235 (291) Show / Hide 
Range on Protein: 21-215
Range on HMM: 1-235/291
Sequence Identity: 31% (75 aa)

LEFNEKIGKGSFGSVFRGCYLGLD-----VAIKKIE-----KADDPEYLKYIDREVSMLQSLRHPF----IVNFSGICVHS-SGLYIVTEFVSGGDVRQL
..| |.||.||||.|..| . . |     ||.|...     |.|  .  . ...|.  |  |.||     |. | |.|  . ....||.|...||    .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LKKTPP--------------IGWDKRVSIAVDLAKAMVFLHAKK---IIHRDLKSKNILLDE------FQRIRLCDFGFARMSEQTKKSRHMTMCGTEGW
|.  ..              .  |  ...|.. |..| .||...   ||||||||.|||.||          . |||| .|.  |.. . .| ..||  |
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAW

VAPEIL---LGMSYDTSCDVFSYGVVLAELITGRKP
 |||..    .  |. .|||.|.|||| |..|.. |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase DDB0229854.AA TK 21-272 15 2.9e-56 186.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 21-272
Range on HMM: 1-486/486
Sequence Identity: 15% (76 aa)

LEFNEKIGKGSFG---SVFRGCYLGL---------------------------DVAIKKIEKADDPEYLKYID----------------REVSMLQS--L
... .|.|.| ||    |..| . |.                           .||.| . . |. .    .|                .| .|...  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPFIVNFSGICVHSSG------------LYIVTEFVSGGD----VRQLLKKTPP---------------------------------------------
.|| ||.. |.|... .            ..||.|....||     |. |.| .|                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IGWDKRVSIAVDLAKAMVFLHAK------KIIHRDLKSKNILLDEFQR-----------IRLCDFGFAR
                               .    .. .....|..| .||.|      ...||||   |.|..|  .           ....||| .|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

M------------SEQTKKSRHMTMCGTEG----------------------WVAPEILLGMS---------YDTSCDVFSYGVVLAELIT-G-RKPGVD
.            .. ..|| . |...                         | ||| |..           . |  ||.|.||.. |. | |   .. .
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

LWVRS-------PETCFDINPE-------------ELKQKSIPGCPS-------------ELISV-CVECCLYEPLTRPKFDEILSQL
.  .         | .  .  .              . ..  |.||.             |..   . .|. |.|  || |.....||
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDB0229854.AA Dicty4 21-215 35 1.4e-55 183.87 In-house 1-216 (277) Show / Hide 
Range on Protein: 21-215
Range on HMM: 1-216/277
Sequence Identity: 35% (76 aa)

LEFNEKIGKGSFGSVFRGCYLGLDVAIKKI--EKAD-DPEYLKYIDREVSMLQSLRHPFIVNFSGICV----HSSGLYIVTEFVSGGDVRQLLKK-----
. . ..|||||||.|..|   | .||.||    . . | . |.   .||. . ..||| |. | | |     |.. . ||||... |..  || .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--TPPIGWDKRVS---IAVDLAKAMVFLHA--KKIIHRDLKSKNILLDEFQRIRLCDFGFAR-MSEQTKKSR-HMTMCGTEGWVAPEILLGMSYDTSCDV
    .. |  . .   .| | |. |  ||.    |||||||| |.| |.  |.  ||||... | . . ..   ||.||| .|.|||.. . .|. . ||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

FSYGVVLAELITGRKP
.|.| || |. |.  |
YSFGIVLWEILTRQEP
Kinase DDB0229854.AA TKL-Unique 23-212 32 3.5e-55 189.65 In-house 1-224 (290) Show / Hide 
Range on Protein: 23-212
Range on HMM: 1-224/290
Sequence Identity: 32% (72 aa)

FNEKIGKGSFGSVFRGCYLGLDVAIKKIEK-ADDP-EYLKYIDREVSMLQSLR-HPFIVNFSGICV----HSSGLYIVTEFVSGGDVRQLLK--------
| .||| |..|.|..| . | .||||.... .|   | ..   .||. .  |. ||.|| . |.|.    . . ..||.|...||  . .|         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--KTPPIGWDKRVSIAVDLAKAMVFLHAKK--IIHRDLKSKNILLDEF-----QRIRLCDFGFARMSEQT---KKSRH-----MTMCGTEGWVAPEILLG
  .  .. . .||..| | |..| .|| ..  ||||||||.|.|.|..      .|..||||... . .    ....|      | ||.  |.|||.| .
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--MSYDTSCDVFSYGVVLAELITG
    |....||.|.|.|| |..|.
NFCQYSEKSDVYSFGIVLWEIATR
Kinase DDB0229854.AA STE 21-213 24 2.9e-54 186.61 In-house 1-265 (359) Show / Hide 
Range on Protein: 21-213
Range on HMM: 1-265/359
Sequence Identity: 24% (66 aa)

LEFNEKIGKGSFGSVFRGCYL-----------------GLDVAIKKIEKADD----------------PEYLKYIDREVSMLQSLR--HPFIVNFSGICV
.|. ||||||.||.|.....                  |  .|||.... ..                .| .. | .|..... ..  ||.||.. | ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

HS-------SGLYIVTEFVSGGDVRQLLKKTPPIG--------------WDKRVSIAVDLAKA-MVFLHAKKIIHRDLKSKNILLDEFQRIRLCDFGFAR
.        . |.|. |...|| .....|..  .|               .    |.... |. . .|| ..|||||.|. ||||     . |||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

MSEQ---------------TKKSRHMTMCGTEGWVAPEILLGMS------YDTSCDVFSYGVVLAELITGR
  ..               | ...  |..||  | |||......      |||.||. | | .. |..||.
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase DDB0229854.AA Pkinase_Tyr 21-215 30 1.1e-52 179.05 Pfam 1-214 (270) Show / Hide 
Range on Protein: 21-215
Range on HMM: 1-214/270
Sequence Identity: 30% (65 aa)

LEFNEKIGKGSFGSVFRGCYL------GLDVAIKKI-EKADDPE-YLKYIDREVSMLQSL-RHPFIVNFSGICV-HSSG--LYIVTEFVSGGDVRQLLKK
..|..|.|.|.||.|..| .       ...||.|.. |.|.... ...   ||.... .| .|| ||.. |.|. ..    .|||.|.. .|| .  |.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TPPIGWDKRVSIAVDLAKAMVFLHAKKIIHRDLKSKNILLDEFQRIRLCDFGFARMSEQTKKSRH-MTMCGTEG---WVAPEILLGMSYDTSCDVF
     .|.     ...... ||.| .|..|..|||||  .|.|..|   .. |||| ||    ....    .  |.     | ||| .  . . |  || 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SYGVVLAELIT-GRKP
|.||.. |..| |..|
SFGVLMWEIFTYGEQP
Kinase DDB0229854.AA TyrKc 21-272 25 7.2e-51 176.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-272
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

LEFNEKIGKGSFGSVFRGCYLGLDVAIKKIEKADDPEYLKYIDREVSMLQSL--RHPFIVNFSGICVHS-------SGLYIVTEFVSGGDVRQLLKKTPP
.....|.| | || |..| .  ..||.|.. .      .. . || ... .|  .|| ||.. |.|...         |.||.|....|| .. |.|. |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-IGWDKRVSIAVDLAKAMVFLHAKKIIHRDLKSKNILLDEFQRIRLCDFGFARMSEQT-----KKSRHMTMC--GTEG-----WVAPEILLGMSYDTSCD
 . ... .|.... |. | .|| |..|||||   |.|..| .... .||| .|  .        |.  ...   |. .     | ||| .    . |  |
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VFSYGVVLAELIT-GRKPGVD---LWVRSPETCFDINPEELKQKSIPG--------CPSELISVCVECCLYEPLTRPKFDEILSQL
|.|.||.. |. | | .|  .     . |..  .    .    .  |         ||.|. ..  .|. ..|  || | || ...
VWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DDB0229854.AA LRRK 21-215 26 7.5e-51 175.25 In-house 1-282 (351) Show / Hide 
Range on Protein: 21-215
Range on HMM: 1-282/351
Sequence Identity: 26% (75 aa)

LEFNEKIGKGSFG-SVFRGCYLG----------------------------LDVAIKKIEK---------------------------------ADDPEY
|...|.||.|.|| .|.|. . |                             .|||||...                                 .| .. 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LKYIDREVSMLQSLRHPFIVNFSGICVHSSGLYIVTEFVSGGDVRQLLK---KTP------PIGWDKRVSIAVDLAKAMVFLHAKK--IIHRDLKSKNIL
.    .||... .|.|| ||.  |.| |   | .|.|... ||  ..|.   ...       |.|  .  ||.. ||.| .|| ..  |||||||| |||
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNIL

L---D---------EFQRIRLCDFGFARMSEQTKKSR-HMTMCGTEGWVAPEILLGM---SYDTSCDVFSYGVVLAELITGR-KP
|   .         ... . ..|||  ||  |. ..   ... |..||.||||. ..   .|..  |..|.|..| ||.|..  |
LWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase DDB0229854.AA DRK 21-211 35 2.9e-46 154.7 In-house 1-197 (258) Show / Hide 
Range on Protein: 21-211
Range on HMM: 1-197/258
Sequence Identity: 35% (70 aa)

LEFNEKIGKGSFGSVFRGCYLGLDVAIKKIEKA--DDPEYLKYIDREVSMLQSLRHPFIVNFSGICVHSSGLYIVTEFVSGGDV-RQLLKKTPPIGWDKR
      ||.|..| ||||   |  ||.|.      .| . |.   ||. ..  |||| |. | | |  ..   |..|. . |   . |.     . |  .
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

VSIAVDLAKAMVFLHAKK--IIHRDLKSKNILLDEFQRIRLCDFGFA-RMSEQTKKSRHMTMCGTEGWVAPEILLGMSYDTSCDVFSYGVVLAELIT
 ... | || | .||     |||||||| | | ||  ..   ||| . |      .   |||||| .|.|||.|    |    ||.|...|| |..|
KQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVT
Kinase DDB0229854.AA TKL-Unique 253-272 45 0.000641 9.92 In-house 271-290 (290) Show / Hide 
Range on Protein: 253-272
Range on HMM: 271-290/290
Sequence Identity: 45% (9 aa)

ECCLYEPLTRPKFDEILSQL
.|.  .|  || ||||.. |
QCWHHDPSQRPSFDEIIHRL
Kinase DDB0229854.AA Pkinase_Tyr 241-272 40 0.000754 13.66 Pfam 239-270 (270) Show / Hide 
Range on Protein: 241-272
Range on HMM: 239-270/270
Sequence Identity: 40% (13 aa)

PGCPSELISVCVECCLYEPLTRPKFDEILSQL
..|| |. ..  .|  |.|  || | ||..||
ENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DDB0229854.AA MLK 262-272 45 0.001752 8.1 In-house 281-291 (291) Show / Hide 
Range on Protein: 262-272
Range on HMM: 281-291/291
Sequence Identity: 45% (5 aa)

RPKFDEILSQL
||.|..|...|
RPSFRQIVQHL
Kinase DDB0229854.AA LRRK 258-274 35 0.010488 5.38 In-house 335-351 (351) Show / Hide 
Range on Protein: 258-274
Range on HMM: 335-351/351
Sequence Identity: 35% (6 aa)

EPLTRPKFDEILSQLKV
.|. ||.| .|...|. 
DPKKRPHFSQIVKRLSQ
Kinase DDB0229854.AA RasGEF_N 448-541 29 4.3e-20 66.56 Pfam 9-104 (104) Show / Hide 
Range on Protein: 448-541
Range on HMM: 9-104/104
Sequence Identity: 29% (29 aa)

KMIERAT--SDYYYDTSYIQDFLLAYRCFAPPQQIFELLLSRYIANSPDNFTNDINGWKKVQRVIQLRVIIFFKRWIDYY-PQ-DFLEE-AMEDNLNEF
|..|. |  .....|......||| || |..| ...|.|. ||   .| |  ..   .|| .  ||.||. ... |.. . .. || .. .. ..|.||
KLVEHCTHHHFHDPDPTFVETFLLTYRSFTTP-ELLEKLIQRYHWPPP-NNHYNSKWNKKYV-PIQIRVCNVLRHWVENHSWYQDFDDDPQLLQRLEEF
Kinase DDB0229854.AA RasGEFN 436-564 19 1.9e-09 38.6 SMART 1-172 (172) Show / Hide 
Range on Protein: 436-564
Range on HMM: 1-172/172
Sequence Identity: 19% (34 aa)

GPCYAALTSHITKMIERATSDYY-------YDTSYIQDFLLAYRCFAPPQQIFELLLSRYIANSPD-------------------------------NFT
   .   .    |.||..|.. .        | .....||. || | .||. ...|..|| . .|                                . .
CDGHRIKGGTLEKLIEHLTHHFDKGMVQFCDDPQFCETFLMTYRSFCTPQELCQKLIHRYNCIPPYIHYRSKELQQTEAREGLCFEDYSHNHFYCWFQTW

NDINGWKKVQRVIQLRVIIFFKRWIDYYPQDFLEEA-MEDNLNE-FDKISAQQ---NSSTALLLGTTISNNE
|..|  |. .| ||.||. . . |.. ..||| ... |  .|.| | .   |.    .  . .|  .. .. 
NIWNKEKHNPRRIQNRVCNIMRHWVENHWQDFYDDPKMNMMLWELFIHVVDQYHDKYPQWHKSLQNILCRLS
Kinase DDB0229854.AA LRRK 320-474 10 0.074253 2.33 In-house 71-104 (351) Show / Hide 
Range on Protein: 320-474
Range on HMM: 71-104/351
Sequence Identity: 10% (17 aa)

NNSNNNNNNNNNISNISPDITTGIQQINLSSSGGSNNSSPSTPPQGSQLVSLAQSRRNTMSLHRKSMELNLVDGQLSTTPPPTSPIQSRPHKPSDSIWKI
|||||||| |||                                                                                        
NNSNNNNNLNNNN---------------------------------------------------------------------------------------

AAKPKHVGYQTLKRKQGPCYAALTSHITKMIERATSDYYYDTS--YIQDFLLAYRCF
                                   |   .| .   ..|.. |.| |
-----------------------------------SEQVED-MDQNHEDCCRAFREF
RasGEF DDB0229854.AA RasGEF 709-908 30 3.2e-66 231.11 Pfam 1-204 (204) Show / Hide 
Range on Protein: 709-908
Range on HMM: 1-204/204
Sequence Identity: 30% (64 aa)

KDIHSTELARQITIINSFY-FNRIKAREFIEYIWEKCGEESTTTPYVGTSFVEVVPAENIHKFVRKCNNLARFVSTEILKQTKLQKRVATIERFIEAAEK
 |....|.|||.|.| . . |..|. ||.. ..| || |... . .          . ||..... .|.|...|.||||......||...|...|. |..
LDFDPEEIARQLTLIEWELWFCAIHPRECLDCAWTKC-EKDKKHRT--------HNSPNIERMINHFNHLSNWVATEILSEEDPKKRAKVIKKWIKIAQH

CLANNDYAAVFSIVEPLVDQSIERLSDTWRNVSQRNLATFEHLKSIVSKENDHKKYR--ELLP-DA--KP--PC-IPNIHLLLDELSFIETSSP-RLLPG
|.  |.......|.  |   .| ||. ||  |... . |||.|....| |...|.||  |.|   .  .|  || || . ..|  | ||... |   ...
CRELNNFNSMMAIISGLNHSPIYRLKKTWEKVPKKYKKTFEELEKLMSPEKNFKNYRHDEALKGKCKHNPQKPCFIPFFGVYLKDLTFIHEGNPKDFINN

G--IVNFFHY-RQ
|  ..||  . |.
GTKLINFEKRFRM
RasGEF DDB0229854.AA RasGEF 708-958 28 2.2e-50 174.64 SMART 1-261 (261) Show / Hide 
Range on Protein: 708-958
Range on HMM: 1-261/261
Sequence Identity: 28% (76 aa)

VKDIHSTELARQITIINSFYFNRIKAREFIEYIWEKCGEESTTTPYVGTSFVEVVPAENIHKFVRKCNNLARFVSTEILKQTK--LQKRVATIERFIEAA
. .... |||.|.|..    |..|.  |.. ..| .| ..| ..              |||.|.| .|... .|.|.|||.|.  ..||...||..|. |
FLHFDPWELAEQLTLMDWELFCKIHPFECLDCVWHHCHKKSPSHLCP----------QNIHRFIRRFNCVSNWVATMILKCTTMHPKKRAQVIEKWIQVA

EKCLANNDYAAVFSIVEPLVDQSIERLSDTWRNVSQRNLATFEHLKSIVSKE-NDHKKYRELLPDAK------PPCIPNIHLLLDELSFIETSSPRLLPG
..|.  |..  ...|.  |   .| ||. ||. |... . .|| |..... . . .|.|||.|  ..      ||||| . ..|  | ||..  | .|. 
KHCRELNNFNSMMAIMSALQSSPIYRLKKTWEHVPHKYKKLFEELCELMDPSERNYKNYREHLKSCNWMPNQQPPCIPFFGVYLKDLTFIHEGNPDWLEN

---GIVNFFHYRQLSRKILQSQQLQS----HCFRPI-PSIQKVLTK-PPSELFDDE--LIKNNSLKCEPPV
   . .||   |.... | . .|.||    ..|.|  ..||..|..  ... .. |   ... ||..||.|
HTKNLINFEKRRMMFNIIREIRQWQSACQHYNFQPNHMDIQWWLQQWRYLDHLPEENDEQYQLSLRIEPRV