Gene DDB0229866 (Slime mold)

DDB0229866

Species: Slime mold
Alias: DdisK223, DDB0229866
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LISK
Subfamily: LISK-DD1

Sequence

Name Sequence Type Origin Length Description Download
DDB0229866.AA Protein None 765 None Fasta, JSON
DDB0229866.kin_dom Protein Kinase Domain None 290 None Fasta, JSON

Protein domain

Protein domains of DDB0229866.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0229866.AA LISK-DD1 40-325 49 5.9e-196 657.28 In-house 1-290 (290) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-290/290
Sequence Identity: 49% (153 aa)

EIGKGAYGKIFKGEYFGTPVAIKEISLQPNDVKYKDLTKFIQREVAMLR----FSHPNLVQFIGVSER-------------GSSLYIVTEFVQGGDLAYY
|||||..||..||.|||||||||.|. ||||....|..||.|||..||.    ..|||.|||||..|.             .|||||||||..||||..|
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

LFRNKFDDTPEQYIHRKVNVGSSSTPDLSDPTVHNGEKLVQLAWPLRIKIAYDVACAMAYLHSRNVIHRDLKSTNLLVGDN----WRIKVCDMGFARTAQ
|....||||||||||                      ......|.||.|||.|.|||||||||.|.|||||||.|.||..|    |||||||.||||...
LKNTPFDDTPEQYIH----------------------HKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFE

VGGGSRAKRTMTICGTTNCMAPEVVLGQDYNEACDVFSYGIVLSEIITRMDTTNNLRPSSL--KYGLDVDVLLP-LVPKD--CPPPFLKLVLDCTEYDPD
........|.||||||.|.|||||.||..|...|||||.|.||.|.|||..........|.  ....|...... ..|||  ||..|..|...|..|||.
QKKNQQNNRHMTICGTDNWMAPEVILGMSYDWSCDVFSFGMVLLELITRKKPDKRMWQRSPMNCFDIDQEEFRQQKIPKDNDCPREFMDLCMWCCKYDPN

NRPTFKEITERL
|||.||||...|
NRPSFKEIVQTL
Kinase DDB0229866.AA LISK 40-325 42 5.1e-169 553.5 In-house 1-296 (296) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-296/296
Sequence Identity: 42% (138 aa)

EIGKGAYGKIFKGEYF--GTPVAIKEISLQPNDVKYKDLTKFIQREVAMLR-FSHPNLVQFIGVSER-GSSLYIVTEFVQGGDLAYYLFRNKFDDTPEQY
|||||..||..||...  |...|||.|. ||||.......||..|||.|.. ..||| |||.||...  ..|.||||...|||| .||.....       
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK-------

IHRKVNVGSSSTPDLSDPTVHNGEKLVQLAWPLRIKIAYDVACAMAYLHSRNVIHRDLKSTNLLVGDN----WRIKVCDMGFARTAQVGGGS--------
                        . ..| ||.|.|||.|.||.|.||||.|.|||||||.|.||..|    |||||||.||||...   .|        
------------------------HKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPRED

----------------------RAKRTMTICGTTNCMAPEVVLGQDYNEACDVFSYGIVLSEIITRMDTTN--NLRPSSLKYGLDVDVLLPLVPKD-CPP
                      ..||.||||||...||||..|||.|.|.|||||.|||| |||||.....  ..|......|||..........| |||
ESDPCMDNDMPMKRKIPKKCMNQRKRRMTICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWPRTPQHDFGLDYEEFWQKICPDDCPP

PFLKLVLDCTEYDPDNRPTFKEITERL
|||.|..||..|||.|||.||||...|
PFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase DDB0229866.AA TKL 41-325 27 1.2e-96 327.34 In-house 1-364 (364) Show / Hide 
Range on Protein: 41-325
Range on HMM: 1-364/364
Sequence Identity: 27% (112 aa)

IGKGAYGKIFKGEYFG----------TPVAIKEISLQP----------------------NDVKYKDLTKFIQREV-AMLRFSHPNLVQFIGVSERGSS-
||.|..|...||.. |          ..||.| .. .                       || ... . .|. .|.  |.|..|||.|||.|.. .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LYIVTEFVQGGDLAYYLFRNKFDDTPEQYIHRKVNVGSSSTPDLSDPTVHNGEKLVQLAWPLRIKIAYDVACAMAYLHSRN-------
            |.||.|...||.| .||                                          |..|...|.|.|..|.||||.|       
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKP

-VIHRDLKSTNLLVGDNWR--------------IKVCDMGFARTAQVGGG---------------SRAKRTMTICGTTNCMAPEVVLGQ-----------
 .||||||| |.|| .||.              .|.||.|..|. .  |.               ...|.|||.|||.. |||||  ||           
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

-----DYNEACDVFSYGIVLSEIITRMDTTNNLRPSS-LKY-------------GLDVD-VLLPLVP------------KDCPPPFLKLVLDCTEYDPDN
     .|.|.|||.|.|||| ||.||        | . ..|              ...|  | |..|            .||||.. ||  || ..||..
FCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEK

RPTFKEITERL
||.|.||..||
RPSFQEILKRL
Pkinase DDB0229866.AA Pkinase 35-325 21 5.5e-58 203.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 35-325
Range on HMM: 1-293/293
Sequence Identity: 21% (72 aa)

LEFGQEIGKGAYGKIFKGEYFGTP--VAIKEISLQPNDVKYKDLTKFIQREVAMLRFS-HPNLVQFIGVSERGSSLYIVTEFVQGG----DLAYYLFRNK
...|. ||.|..|. .|.   ||.  ||.|.|... .. . .     . .|.....   ||| |..... |.....|.|.|...||    ||. |. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

FDDTPEQYIHRKVNVGSSSTPDLSDPTVHNGEKLVQL--AWPLRIKIAYDVACAMAYLHSRNVIHRDLKSTNLLVGDNWRI----KVCDMGFARTAQVGG
                               ..   .   .   ....| ......|.||...||||||. |.|. .|  |    |.|| |.|. ..   
-------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---

GSRAKRTMTICGTTNCMAPEVVL-GQDYNEACDVFSYGIVLSEIITRMDTTNNLRPSSL-------KYGLDVDVLLPLVPKDCP----------------
  .   ..|.||| . |||||.. ||.|  ..|..|.|..| | ..      ..  ..        .. . . .. | .. |.|                
Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-----GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFH

-------PPFLKLVLDCTEYDPDNRPTFKEITER--L
       ....... .| ..||  |||...| .   .
WTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDB0229866.AA TK 35-325 17 1.4e-55 184.39 In-house 1-486 (486) Show / Hide 
Range on Protein: 35-325
Range on HMM: 1-486/486
Sequence Identity: 17% (88 aa)

LEFGQEIGKGAYG---KIFKGEYFG---------------------------TPVAIKEISLQ-PNDVK-YKD---------LTKFIQREVAMLRFS---
...|...|.|..|   ...|||..|                           ||||.| . .  ... .  .|         . .| .   .|  ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGE-DFLEEAEEMKMMCHSL

--HPNLVQFIGVSERGSS------------LYIVTEFVQGGD----LAYYLF--RNKFDDTPEQYIHRKVNVGSSST-----------------------
  |||.|...||. .| .            ..||.|....||    |  ||   |.|| . .. . ...  . .|..                       
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

-----PDLSDPTVHNGEKLV-----------QLAWPLRIKIAYDVACAMAYLHSR------NVIHRDLKSTNLLVGDNWR-----------IKVCDMG--
     .... |...  . |            ||  . .. .....||.|.||||.      |..||||   | |||.| .           .|..| |  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------FARTAQVGGGSRAKRTMTI------------CGTTNC----------MAPEVVLGQD---------YNEACDVFSYGIVLSEIITRMD------
       ||  . ..  ..|.. .                .            ||||.....          . .. ||.|.|... || |. .      
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

TTN------NLRPSSLKYGLDVD-------------VLLPLVPKDCPP-------------PFLKL-VLDCTEYDPDNRPTFKEITERL
 .|      .  .  .   |                 . .  |..||.             ... .  ..| .|||. ||||... |.|
MSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DDB0229866.AA TyrKc 35-325 24 2.3e-48 167.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 35-325
Range on HMM: 1-280/280
Sequence Identity: 24% (80 aa)

LEFGQEIGKGAYGKIFKGEYFGTPVAIKEISLQPNDVKYKDLTKFIQREVAMLRF--SHPNLVQFIGVSERG-------SSLYIVTEFVQGGDLAYYLFR
...|...| ||.|...||..  ..||.| .           .  |..    | ..  .|||.|...||   .         |.||.|.. .|||  || .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NKFDDTPEQYIHRKVNVGSSSTPDLSDPTVHNGEKLVQLAWPLRIKIAYDVACAMAYLHSRNVIHRDLKSTNLLVGDNWRIKVCDMGFARTAQVG---GG
.. .                                  | ..  .......|| |.||||.|.|||||   | |||.| ..|..| | .|    .   | 
HRPK----------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-

SRAKRTMTI----CGTT----NCMAPEVVLGQDYNEACDVFSYGIVLSEIITRMDTTNN------LRPSSLKYGLDVDVLLPLVPKD-------CPPPFL
  .| . .     .| |      ||||.     .... ||.|.|... || |. ..         . .. .   ..    .|  | |       ||.   
-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMY

KLVLDCTEYDPDNRPTFKEITERL
.. ..| ..||..||||.|| |..
QIMKQCWHEDPEDRPTFSEIHECF
Kinase DDB0229866.AA Dicty4 162-267 50 6.1e-43 141.14 In-house 104-213 (277) Show / Hide 
Range on Protein: 162-267
Range on HMM: 104-213/277
Sequence Identity: 50% (56 aa)

VQLAWPLRIK---IAYDVACAMAYLHSRN--VIHRDLKSTNLLVGDNWRIKVCDMGFARTAQVGGGSRAKR-TMTICGTTNCMAPEVVLGQDYNEACDVF
..| |||...   .| |.|  |..||..|  .||||||| |||| .|||.|||| |...  .   ..  |  .|| |||.  |||||  .| |||. ||.
IKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKK--HEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVY

SYGIVLSEIITR
|.|||| || ||
SFGIVLWEILTR
Kinase DDB0229866.AA TKL-Unique 157-325 35 5.8e-42 145.74 In-house 100-290 (290) Show / Hide 
Range on Protein: 157-325
Range on HMM: 100-290/290
Sequence Identity: 35% (67 aa)

NGEKLVQLAWPLRIKIAYDVACAMAYLHSRN--VIHRDLKSTNLLVGDN-----WRIKVCDMGFARTAQVGGGSRAKRT-----MTICGTTNCMAPEVVL
| ..   | . .|.|.| |.| .| |||...  .|||||||.|.||  |     |.||.|| |.....     . ...       | ||... |||||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

G--QDYNEACDVFSYGIVLSEIITRMDTTNNLRP----SSLKYGLDVDV----LLPLVPKDCPPPFLKLVLDCTEYDPDNRPTFKEITERL
.   .|.| .||.|.|||| ||.||. |    .|    .. ..   |..    . | .| .||. . .|  .|   ||..||.| || .||
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase DDB0229866.AA S_TKc 35-329 25 8.8e-41 142.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 35-329
Range on HMM: 1-231/231
Sequence Identity: 25% (79 aa)

LEFGQEIGKGAYGKIFKGEYFG--TPVAIKEISLQPNDVKYKDLTKFIQREVAMLRFSHPNLVQFIGVSERGSSLYIVTEFVQG--GDLAYYLFRNKFDD
 |....|||||.|| .|.   .    ||||.|.            . |.||...|.  |||.|....| .  ..||.|.|.. |  |||  |. ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----TPEQYIHRKVNVGSSSTPDLSDPTVHNGEKLVQLAWPLRIKIAYDVACAMAYLHSRNVIHRDLKSTNLLVGDNWRIKVCDMGFARTAQVGGGSRAK
     ||  .                                  ...| ..||..|.||...||||||  |.|. .  .||.|| |.||           
LRFPFPE-HA---------------------------------RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------

RTMTICGTTNCMAPEVVLGQDYNE-ACDVFSYGIVLSEIIT-------RMDTTNNLRPSSLKYGLDVDVLLPLVPKDCPPPFLKLVLDCTEYDPDNRPTF
  .|.||| . |||||.    |.  .||. | |..| | ..        . . ....                     .|... ..  | ..||..||| 
--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA

KEITE-----RLKSLT
 |. .     ..    
-EALQDEWDIKCHPWF
Kinase DDB0229866.AA Pkinase_Tyr 35-224 26 1.1e-40 138.4 Pfam 1-175 (270) Show / Hide 
Range on Protein: 35-224
Range on HMM: 1-175/270
Sequence Identity: 26% (55 aa)

LEFGQEIGKGAYGKIFKGEYF------GTPVAIKEISLQPNDVKYKD--LTKFIQREVAMLR-F-SHPNLVQFIGVSE-RGSS--LYIVTEFVQGGDLAY
..||...|.||.|...||...      ..|||.| .  .  .   ..  . .|.. |..... . .|||.|...||   .| .  .|||.|....|||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YLFRNKFDDTPEQYIHRKVNVGSSSTPDLSDPTVHNGEKLVQLAWPLRIKIAYDVACAMAYLHSRNVIHRDLKSTNLLVGDNWRIKVCDMGFARTA----
|| ...                               |   .|  .  .......|..|.||.|.| |||||   | ||..|  .|.|| | ||.     
YLRKHR-------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD

---QVGGGSR
   ...||..
YYYRKRGGGK
Kinase DDB0229866.AA MLK 35-267 28 3.6e-39 133.54 In-house 1-232 (291) Show / Hide 
Range on Protein: 35-267
Range on HMM: 1-232/291
Sequence Identity: 28% (75 aa)

LEFGQEIGKGAYGKIFKGEYFGTP-----VAIKEISLQP-----NDVKYKDLTKFIQREVAMLRFSHPN----LVQFIGV-SERGSSLYIVTEFVQGGDL
..| . ||.|..|| .||.. ..      ||.|..   .      .   .|. ... |....|  ||||     .|| || .. .. ..||.|...|| |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMEC-RHLRIL--SHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSL

AYYL--FRNKFDDTPEQYIHRKVNVGSSSTPDLSDPTVHNGEKLVQLAWPLRIKIAYDVACAMAYLHSRN---VIHRDLKSTNLLVGD------NWRIKV
. .|   |.| .|                         ||.   .     . ...|...| .|.||||     .||||||| |.|. .      .   |.
YNVLHGARSKWMDAN-----------------------HNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKI

CDMGFARTAQVGGGSRAKRTMTI-CGTTNCMAPEVV---LGQDYNEACDVFSYGIVLSEIITR
|| | .|  .    ..   .|.  .||   |||||     .. |.|.|||.|.|.|| |..||
CDFGTSRDWH----QMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase DDB0229866.AA Dicty5 164-267 43 3.4e-38 129.04 In-house 101-199 (260) Show / Hide 
Range on Protein: 164-267
Range on HMM: 101-199/260
Sequence Identity: 43% (46 aa)

LAWPLRIKIAYDVACAMAYLHSRNVIHRDLKSTNLLVGDNWRIKVCDMGFARTAQVGGGSRAKRTMTI-CGTTNCMAPEVVLGQDYNEACDVFSYGIVLS
.|..... .| |.| .| .||| |.||||||| | |.  || ||. | |  |         ..  ||.  || . ||.|.  || | . |||.|.|||| 
IAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVD------NRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLW

EIITR
|..||
EMFTR
Kinase DDB0229866.AA TESK 226-327 45 1.8e-36 112.4 In-house 191-292 (292) Show / Hide 
Range on Protein: 226-327
Range on HMM: 191-292/292
Sequence Identity: 45% (46 aa)

KRTMTICGTTNCMAPEVVLGQDYNEACDVFSYGIVLSEIITRMDTTNNLRPSSLKYGLDVDVLLPLVPKDCPPPFLKLVLDCTEYDPDNRPTFKEITERL
|  | . |.   |||||  |. |.|  ||||.|||| ||| |        |   |.|||..    ..|.|||.|||.|  .|  .||  ||.|.||| .|
KEKMAVVGSPYWMAPEVLRGEWYDEKADVFSFGIVLCEIIARIQADPDYMPRTEKFGLDYQAFKEMCPMDCPEPFLQLAFHCCNMDPKDRPVFHEITKHL

KS
. 
EW
Kinase DDB0229866.AA DRK 162-269 43 1.9e-36 120.95 In-house 93-200 (258) Show / Hide 
Range on Protein: 162-269
Range on HMM: 93-200/258
Sequence Identity: 43% (50 aa)

VQLAWPLRIKIAYDVACAMAYLHSRN--VIHRDLKSTNLLVGDNWRIKVCDMGFAR----TAQVGGGSRAKRTMTICGTTNCMAPEVVLGQDYNEACDVF
... |||..... |.|  | |||..|  .||||||| |||| ..|..|| | | .       |       | .|| |||.   ||||   | | |  ||.
IEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQ------HKFAMTMCGTPCWTAPEVLRNQRYTEKADVY

SYGIVLSEIITRMD
|..||| |..|| |
SFAIVLWECVTRQD
Kinase DDB0229866.AA TKL-Unique 37-137 28 1.3e-17 58.83 In-house 1-114 (290) Show / Hide 
Range on Protein: 37-137
Range on HMM: 1-114/290
Sequence Identity: 28% (33 aa)

FGQEIGKGAYGKIFKGEYFGTPVAIKEISLQPNDVKYKDLTKFIQREV-AMLRFS-HPNLVQFIGVSE----RGSSLYIVTEFVQGGDLAYYLF------
|.  || |.||...||.. |.||||| ...  .|.  . . .|. .||  | ..  |||.|...|..       . ..||.|...|| |  .|       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFE-NEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---RNKFDDTPEQYIH
   .|. . ...|...
NNNNNNCKLNMQQRVK
Kinase DDB0229866.AA TESK 159-200 50 1.3e-14 42.1 In-house 86-127 (292) Show / Hide 
Range on Protein: 159-200
Range on HMM: 86-127/292
Sequence Identity: 50% (21 aa)

EKLVQLAWPLRIKIAYDVACAMAYLHSRNVIHRDLKSTNLLV
.. . | |. .|. |||.|  | ||||..| |||| | | ||
DSELHLSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLV
Kinase DDB0229866.AA DRK 290-327 42 2.1e-13 41.82 In-house 221-258 (258) Show / Hide 
Range on Protein: 290-327
Range on HMM: 221-258/258
Sequence Identity: 42% (16 aa)

PLVPKDCPPPFLKLVLDCTEYDPDNRPTFKEITERLKS
| .|. |||.. .|  || . ||  ||.. |. ||| .
PPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase DDB0229866.AA Dicty4 35-116 29 5.9e-13 39.72 In-house 1-87 (277) Show / Hide 
Range on Protein: 35-116
Range on HMM: 1-87/277
Sequence Identity: 29% (26 aa)

LEFGQEIGKGAYGKIFKGEYFGTPVAIKEISLQPNDVKYKDLTKFIQREVAML-RFSHPNLVQFIGVSE----RGSSLYIVTEFV-QG
. ..|.||||..|. .||   |. ||.|   .   ..  . |. |  .||. .   .|||...| | .       ... ||||.. .|
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEF-RKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKG
Kinase DDB0229866.AA Dicty4 290-327 40 1.4e-11 35.1 In-house 238-277 (277) Show / Hide 
Range on Protein: 290-327
Range on HMM: 238-277/277
Sequence Identity: 40% (16 aa)

PLVPKDCPPPFLKLVLDCTEYDPDNRPTFKEITER--LKS
| .|..|||.. .|. .| . || .||.|.||..|  | .
PPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase DDB0229866.AA MLK 288-325 39 5.5e-11 34.48 In-house 254-291 (291) Show / Hide 
Range on Protein: 288-325
Range on HMM: 254-291/291
Sequence Identity: 39% (15 aa)

LLPLVPKDCPPPFLKLVLDCTEYDPDNRPTFKEITERL
| | .|..||... ||  .| . || .||.|..| . |
LRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase DDB0229866.AA DRK 35-120 28 6.1e-10 29.89 In-house 1-85 (258) Show / Hide 
Range on Protein: 35-120
Range on HMM: 1-85/258
Sequence Identity: 28% (25 aa)

LEFGQEIGKGAYGKIFKGEYFGTPVAIKEISLQPNDVKYKDLTKFIQREVAML-RFSHPNLVQFIGVSERGSSLYIVTEFVQGGDLA
   |  ||.| || .| |   || ||.|   .    .   .. .  .||. .. .  ||| .||.|     ..  |..|.   | |.
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNH--NINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLY
Kinase DDB0229866.AA Dicty5 35-123 32 3.2e-08 24.39 In-house 1-90 (260) Show / Hide 
Range on Protein: 35-123
Range on HMM: 1-90/260
Sequence Identity: 32% (31 aa)

LEFGQEIGKGAYGKIFKGEYFGTPVAIKEISLQPNDV-KYKDLTKFIQREVA-MLRFS--HPNLVQFIGVSERGSSL-YIVTEFVQGGDLAYYL
  |.. |  || |....| | |  ||||. |    ..    |.  | .|||. |  |   |||.. . |   .     ..|||... | |  ||
VSFHDWIASGASGRVYNGIYKGMDVAIKVYS---QENCMCFDWNEF-YREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYL
Kinase DDB0229866.AA Dicty5 290-329 42 1.9e-07 21.69 In-house 221-260 (260) Show / Hide 
Range on Protein: 290-329
Range on HMM: 221-260/260
Sequence Identity: 42% (17 aa)

PLVPKDCPPPFLKLVLDCTEYDPDNRPTFKEITERLKSLT
| .|||||  . .|.  |    | |||.|||| . ..|. 
PTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase DDB0229866.AA Pkinase_Tyr 293-325 48 1e-06 23.09 Pfam 238-270 (270) Show / Hide 
Range on Protein: 293-325
Range on HMM: 238-270/270
Sequence Identity: 48% (16 aa)

PKDCPPPFLKLVLDCTEYDPDNRPTFKEITERL
|..||..  .| ..| .|||..||||.|| |.|
PENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DDB0229866.AA Pkinase_Tyr 238-267 36 3.4e-05 18.22 Pfam 181-210 (270) Show / Hide 
Range on Protein: 238-267
Range on HMM: 181-210/270
Sequence Identity: 36% (11 aa)

MAPEVVLGQDYNEACDVFSYGIVLSEIITR
||||.     .... || |.|... ||.|.
MAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase DDB0229866.AA TESK 82-119 38 0.000183 9.51 In-house 42-80 (292) Show / Hide 
Range on Protein: 82-119
Range on HMM: 42-80/292
Sequence Identity: 38% (15 aa)

REVAML-RFSHPNLVQFIGVSERGSSLYIVTEFVQGGDL
||| .. . .||| . | ||  .   |  .||.. || |
REVQLMNKLQHPNILRFMGVCVHQGQLHALTEYINGGCL