DDB0229963

Species: Slime mold
Alias: DdisK196, DDB0229963
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: Dicty4

Sequence

Name Sequence Type Origin Length Description Download
DDB0229963.AA Protein None 2165 None Fasta, JSON
DDB0229963.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of DDB0229963.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PX DDB0229963.AA PX 645-737 22 5.1e-07 26.6 Pfam 1-103 (120) Show / Hide
Range on Protein: 645-737
Range on HMM: 1-103/120
Sequence Identity: 22% (24 aa)

TAWDISIRIVGFF-----QIDDHIEYKLQVISNSN-----EWFVCRRYNNFLMLDKKLKSSGIIDKKDLGL-TLPPKK-LKV---ASNQVAKARQLPLQS
. ... ...|...     . ..| .|. ..  |.|     ||.| |||. |. | |.||.       .. . .||||. ..     . .... |.  |..
DHFLQ-VHVVDPETHKHYGDKMHYYYVYEIHMNTNPFQKKEWHVWRRYSDFHWLHKQLKRHFP----MCIIPPLPPKHWFGRYNNFDEEFIEKRRQMLEQ

YLVHLLSN
|| .....
YLQRVCQH

PX DDB0229963.AA PX 645-753 20 0.000119 17.36 SMART 1-142 (142) Show / Hide
Range on Protein: 645-753
Range on HMM: 1-142/142
Sequence Identity: 20% (29 aa)

TAWDISIRIVGFF------QIDDHIEYKLQVISNSN----EWFVCRRYNNFLMLDKKLKSSGIIDKKDLGLTLPPKKLKV--------------------
....| | .|.||      . ..|  |  ..  ..|    .| |.|||. |. |...||    ..|   ....|| . |.                    
DHIFI-ITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEK--RMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSF

--ASNQVAKARQLPLQSYLVHLLSNYQGIF--YNNNIVAT--TNS
   . ...  |.. |..|| .|... . |    ....|..  ..|
NNFDEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS

Kelch_1 DDB0229963.AA Kelch_1 1487-1505 42 0.05054 11.02 Pfam 1-19 (45) Show / Hide
Range on Protein: 1487-1505
Range on HMM: 1-19/45
Sequence Identity: 42% (8 aa)

PRSSHSVTVYGSSLVLIGG
||..|.|.|..  .  |||
PRCGHGVCVHNGKIYVIGG

Kelch_2 DDB0229963.AA Kelch_2 1487-1505 36 0.151487 10.0 Pfam 1-19 (51) Show / Hide
Range on Protein: 1487-1505
Range on HMM: 1-19/51
Sequence Identity: 36% (7 aa)

PRSSHSVTVYGSSLVLIGG
||..|...|.|. ....||
PRYCHASCVPGGKIYVFGG

Kelch_2 DDB0229963.AA Kelch_2 1538-1585 29 0.001849 17.27 Pfam 1-51 (51) Show / Hide
Range on Protein: 1538-1585
Range on HMM: 1-51/51
Sequence Identity: 29% (15 aa)

SIYNHDYCRIGNKFYLFGGY--VAGKLSNKLYVLTIMDDSTVHWSS-PRIS
. |.| .| .|.| |.||||   ..  .  . .. ..|..| .|.  ||. 
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP

Kelch_1 DDB0229963.AA Kelch_1 1538-1575 18 5.930471 3.6 Pfam 1-37 (45) Show / Hide
Range on Protein: 1538-1575
Range on HMM: 1-37/45
Sequence Identity: 18% (7 aa)

SIYNHDYCRIGNKFYLFGGYVAGKLSNKLYVLTIMDDS
  ..|  | ...| | .||.     .|. ...  ....
PRCGHGVCVHNGKIYVIGGCDG-QYLNSVECYDPETNQ

Kelch_2 DDB0229963.AA Kelch_2 1592-1637 29 1e-08 37.23 Pfam 1-51 (51) Show / Hide
Range on Protein: 1592-1637
Range on HMM: 1-51/51
Sequence Identity: 29% (15 aa)

PRYGHTFTRYGNRFLLFGGY-----DGEQCLNDLYILEPETMCWSTVTNIK
|||.|... .|.. ..||||     ..   ..|.... ||| .|. |. ..
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP

Kelch_1 DDB0229963.AA Kelch_1 1592-1637 32 1e-08 34.98 Pfam 1-45 (45) Show / Hide
Range on Protein: 1592-1637
Range on HMM: 1-45/45
Sequence Identity: 32% (15 aa)

PRYGHTFTRYGNRFLLFGGYDGEQCLNDLYILEPETMCWSTVTNIK
||.||. . ....   .||.|| |.||. ... ||| .|. ... .
PRCGHGVCVHNGKIYVIGGCDG-QYLNSVECYDPETNQWTRCPPMP

Kelch_2 DDB0229963.AA Kelch_2 1644-1662 42 0.158051 9.93 Pfam 1-19 (51) Show / Hide
Range on Protein: 1644-1662
Range on HMM: 1-19/51
Sequence Identity: 42% (8 aa)

ERFGHTSTILGEKLIIFGG
 |..|.|. .|.|...|||
PRYCHASCVPGGKIYVFGG

Kelch_1 DDB0229963.AA Kelch_1 1644-1662 31 1.269918 6.0 Pfam 1-19 (45) Show / Hide
Range on Protein: 1644-1662
Range on HMM: 1-19/45
Sequence Identity: 31% (6 aa)

ERFGHTSTILGEKLIIFGG
 | ||... .. |. ..||
PRCGHGVCVHNGKIYVIGG

Kelch_1 DDB0229963.AA Kelch_1 1731-1780 15 0.009395 13.64 Pfam 1-45 (45) Show / Hide
Range on Protein: 1731-1780
Range on HMM: 1-45/45
Sequence Identity: 15% (8 aa)

ERSFHSATRVGRNIVMVGGKKDDSNGNPIALRDCWVLSYR-MQWSKVSGVQ
 |..|... ..  |  .||  .       .|....... .  ||....  .
PRCGHGVCVHNGKIYVIGGCDG------QYLNSVECYDPETNQWTRCPPMP

Kelch_2 DDB0229963.AA Kelch_2 1731-1780 21 4.849959 4.28 Pfam 1-51 (51) Show / Hide
Range on Protein: 1731-1780
Range on HMM: 1-51/51
Sequence Identity: 21% (11 aa)

ERSFHSATRVGRNIVMVGGKKDDSNGNPIALRDCWVLSYR-MQWSKVSGVQ
 |. |... .|  |...|| .... .|. ...| |..  .  .|..|... 
PRYCHASCVPGGKIYVFGGYCRHTHNNDCWSMDIWWWDPETHRWTCVPRMP

Kelch_1 DDB0229963.AA Kelch_1 1784-1811 25 1.319805 5.94 Pfam 1-27 (45) Show / Hide
Range on Protein: 1784-1811
Range on HMM: 1-27/45
Sequence Identity: 25% (7 aa)

PRYNFGLIKNGSKLFILGGKGNNNNINN
||...|    . |... ||  . .  |.
PRCGHGVCVHNGKIYVIGGCDG-QYLNS

Kelch_2 DDB0229963.AA Kelch_2 1784-1802 36 18.055938 2.11 Pfam 1-19 (51) Show / Hide
Range on Protein: 1784-1802
Range on HMM: 1-19/51
Sequence Identity: 36% (7 aa)

PRYNFGLIKNGSKLFILGG
|||.   .  |.|... ||
PRYCHASCVPGGKIYVFGG

Kinase DDB0229963.AA Dicty4-Unclassified 1907-2161 69 6.6e-217 726.89 In-house 1-263 (263) Show / Hide
Range on Protein: 1907-2161
Range on HMM: 1-263/263
Sequence Identity: 69% (184 aa)

IKIDKEIGKGHFSKVLKGNWKGKDVAVKKLNSNKDKAREEMIQEFKAEVELLGSLQHPNLVTCYGYSLNP------MCIVMEFLPSGNLFELIHSKPSEQ
|.||..|||||||||.|||||||||||||.|.||.|.||||||.||.|||.|||.||||||.||||..||      |||||||...|||||.||||||||
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

QQSIKLDSTLILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMTTIG-TVAWTAPEILRHESYNQKADVYSYAIVLYE
||.||||.|||...|||||.|||||||||.||||.||||.||||||||||||.||.|...|...||||. |..|..||.|.|||||||.||||||..|||
QQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYE

LLTGEEPYQGIP-PMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYL
|.||.||||.|. .|||...|..|.|||..|||||..||||..|||..||||||....|..||
LATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL

Kinase DDB0229963.AA Dicty4 1907-2163 49 1.3e-176 593.02 In-house 1-277 (277) Show / Hide
Range on Protein: 1907-2163
Range on HMM: 1-277/277
Sequence Identity: 49% (136 aa)

IKIDKEIGKGHFSKVLKGNWKGKDVAVKKLNSNKDKAREEMIQEFKAEVELLGSLQHPNLVTCYGYSL----NP--MCIVMEFLPSGNLFELIHSKPSEQ
|.|...||||.|..|.||.|.||.|||||||.......|.|..||..||.......|||.....|...    .|  ||||.|..|.|||..|.|.|||||
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

QQSIKLDSTLILA---IAFDIARGMQHLHTRN--IIHRDLKSSNLLMDKHFNIKIADLGIAR----ETSFTQ-TMTTIGTVAWTAPEILRHESYNQKADV
|||||||..||..   .|||.||||..||..|  ||||||||.|||.||....|..|.|...    ...... .||..||..|.|||...|..||.||||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSYAIVLYELLTGEEPYQ--GIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNY--LTK
||..|||.|.||..||||  ..|.|.....|..|.|||..||.|.|.||.|..|||..||..|||||||...  |  
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase DDB0229963.AA TKL 1913-2161 30 1.5e-107 363.57 In-house 1-364 (364) Show / Hide
Range on Protein: 1913-2161
Range on HMM: 1-364/364
Sequence Identity: 30% (116 aa)

IGKGHFSKVLKGNWKG----------KDVAVKKLNSNKDKAREEMIQE---------------------FKAEVELLGSLQ--HPNLVTCYG--------
||.|.|..| ||.|.|          |||||||..|. |. .....||                     |. |.|..  ..  |||.| ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YSLNP------MCIVMEFLPSGNLFELIHSKPSEQQQSIKLDSTLILAIAFDIARGMQHLHTRN--------IIHRDLKSSNLLMDKHFN---------
 ....|      .|||||. | |.|....|               ... .| ||||||..||..|        ||||||||.|.| |....         
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

-----IKIADLGIARETSFT---------------------QTMTTIGTVAWTAPEILRHE----------------SYNQKADVYSYAIVLYELLTGEE
     .||.|.|..|. | .                     .||| .|| .| |||.|| .                .|..|.||||..|||.|.||...
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

PYQGIPPMNAG---------ILVASKGLRPELP------------DNCDPNWKKLVVWCWSEDPNKRPSFEEITNYL
||...|.|            ..|..|||||..|            ..|.| .|||  .||..||.|||||.||. .|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase DDB0229963.AA MLK 1907-2161 38 5.9e-95 321.76 In-house 1-291 (291) Show / Hide
Range on Protein: 1907-2161
Range on HMM: 1-291/291
Sequence Identity: 38% (111 aa)

IKIDKEIGKGHFSKVLKGNWKGKD-----VAVKKLNSNK-DKAR-EEMIQEFKAEVELLGSLQHPN----LVTCYGYSLNP---MCIVMEFLPSGNLFEL
|.. . ||.|.| || ||.|..||     ||||. .... ||.. .. ...|. |...|  |.|||     .  || .|.|    |||||... | |...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IHSKPSEQQ-------QSIKLDSTLILAIAFDIARGMQHLHTRN---IIHRDLKSSNLLMD------KHFNIKIADLGIARETSFT-QTMTT-IGTVAWT
.|...|.          ..  |  ... .|...||||. ||      ||||||||.|.| |      .| . ||.| |..|. . . ..|.  .||.|| 
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEIL---RHESYNQKADVYSYAIVLYELLTGEEPYQ-GIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYL
|||..   |.| |. |.||.|...||.|.||.|.||. .. || ... || .|||| .| .|.. ||||   ||..||.||||| .|  .|
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase DDB0229963.AA TKL-Unique 1909-2161 36 1.2e-91 310.77 In-house 1-290 (290) Show / Hide
Range on Protein: 1909-2161
Range on HMM: 1-290/290
Sequence Identity: 36% (105 aa)

IDKEIGKGHFSKVLKGNWKGKDVAVKKLNSNKDKAREEMIQEFKAEVELLGSLQ-HPNLVTCYGYSL------NPMCIVMEFLPSGNLFELIH-SKPSE-
. . || | ...| || |.|..||.|...  . . . ||.|||. || ..  |. |||.|...||.       . ||||||..| |.| ...| . .   
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

-QQQSIKLDSTLILAIAFDIARGMQHLHTRN--IIHRDLKSSNLLMDKH-----FNIKIADLGIARETSFTQTMTTI-----------GTVAWTAPEILR
   ...||.  ... .| |||.|| .||...  ||||||||||.| | .     .||||.| |...  |   .||..           |.  | |||.||
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

H--ESYNQKADVYSYAIVLYELLTGEE------PYQGIPPMNAGILVAS--KGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYL
   . |..|.||||..|||.|..|..       ||||. .     .|..  ...||..|..| .. ..|   ||  || .||||.|| ..|
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase DDB0229963.AA DRK 1907-2163 42 1.1e-89 303.85 In-house 1-258 (258) Show / Hide
Range on Protein: 1907-2163
Range on HMM: 1-258/258
Sequence Identity: 42% (112 aa)

IKIDKEIGKGHFSKVLKGNWKGKDVAVKKL-NSNKDKAREEMIQEFKAEVELLGSLQHPNLVTCYGYSLNP--MCIVMEFLPSGNLFELIHSKPSEQQQS
|||   ||.| .  |  | | |  ||||.| | | .   |....||. |..|.  | ||| .   |  .||   ||.||..| | |    |       .|
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNIND--ENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH------DES

IKLDSTLILAIAFDIARGMQHLHTRN--IIHRDLKSSNLLMDKHFNIKIADLGIAR----ETSFTQTMTTIGTVAWTAPEILRHESYNQKADVYSYAIVL
|..|  |.. ..||.|.||  || .|  |||||||| ||| | |. .|.|| | .       . . .|| .||  |||||.|| . |  ||||||.||||
IEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVL

YELLTGEEPYQGIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYLTK
 |..| . ||.|.|..   . |   |.||  | .| | . .|   ||.|||  |||..|.   |  
WECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA

Kinase DDB0229963.AA LRRK 1907-2163 29 7.3e-86 291.57 In-house 1-351 (351) Show / Hide
Range on Protein: 1907-2163
Range on HMM: 1-351/351
Sequence Identity: 29% (103 aa)

IKIDKEIGKGHFS-KVLKGNWKG----------------------------KDVAVKKLNSNK------------------------------DKAREEM
.|| ..||.| |  .| ...|.|                            ..||.||.|                                 .  . . 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

IQEFKAEVELLGSLQHPNLVTCYGYSLNPMCIVMEFLPSGNLFELIHSKPSEQQQSIK--LDSTLILAIAFDIARGMQHLHTRN--IIHRDLKSSNLLM-
 .||  || .. .|.|||.|  .|....|.|.|||..| |.| ...|.| . ..  .|  .. .|.| || .||.||..|| .|  |||||||| | |. 
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

--D---------KHFNIKIADLGIAR-ETSFTQ--TMTTIGTVAWTAPEILR---HESYNQKADVYSYAIVLYELLTGE-EPYQGIP-P-----MNAGIL
  .          | ..|||| || |  ..|.   ...  |.  | ||||.|    |.|..|.|.||....|.||||..  |..... .     |.   .
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

VASKGLRPELPDN-CDP-----NWKKLVVWCWSEDPNKRPSFEEITNYLTK
  ..|||| .| . | |       ..| ..||..||.|||.|..|.  |  
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase DDB0229963.AA Pkinase_Tyr 1907-2161 31 5.3e-74 251.26 Pfam 1-270 (270) Show / Hide
Range on Protein: 1907-2161
Range on HMM: 1-270/270
Sequence Identity: 31% (87 aa)

IKIDKEIGKGHFSKVLKGNWK------GKDVAVKKLNSNKDKAREEM--IQEFKAEVELLGSL-QHPNLVTCYGYSL---NP--MCIVMEFLPSGNLFEL
|...|..|.|.| .| || ||      . .||||.|   |..| .|   ...| .|.... .| .|||.| .||  .    |  ..||||. | |.| . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML---KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IHSKPSEQQQSIKLDSTLILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARET-----SFTQTMTTIGTVAWTAPEILRHESYNQK
 ...     .  .|.   .| ....||.||..|. .|.|||||   | | .. . .||.| | ||        ....  .   . |.||| ...  .. |
LRKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

ADVYSYAIVLYELLT-GEEP-YQGIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYL
 ||.|. ....|..| ||.| |.|...     ... .| | . |.|| .   .|   || .||..||.|.|| . |
SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase DDB0229963.AA TyrKc 1907-2161 28 2.3e-72 247.66 SMART 1-280 (280) Show / Hide
Range on Protein: 1907-2161
Range on HMM: 1-280/280
Sequence Identity: 28% (83 aa)

IKIDKEIGKGHFSKVLKGNWKGKDVAVKKLNSNKDKAREEMIQEFKAEVELLGSL--QHPNLVTCYGYSL---------NPMCIVMEFLPSGNLFELIHS
|. .|..| |.| .| || ||  .||||.|....       ...|  | ... .|  .|||.| .||. .          |..||||. | |.| . ...
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KPSEQQQSIKLDSTLILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFT-------QTMT------TI--GTVAWTAPEILR
.  .      |     | ....||.||..|| .|.|||||   | | .. . .||.| | .|.           .. .      .     . |.||| ..
HRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

HESYNQKADVYSYAIVLYELLT-GEEPYQGI----PPMNAGILVASKGLRPELPDN--------CDPNWKKLVVWCWSEDPNKRPSFEEITNYL
.  .. | ||.|. ....|..| |..|| |.     .    |    .| |.. |.|        | .   ..  .|| |||..||.|.||  ..
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase DDB0229963.AA TK 1907-2161 17 1.2e-68 228.95 In-house 1-486 (486) Show / Hide
Range on Protein: 1907-2161
Range on HMM: 1-486/486
Sequence Identity: 17% (83 aa)

IKIDKEIGKGHFS---KVLKGNWKGK---------------------------DVAVKKLNSNKDKAREEMIQ-------------EFKAEVELLGS--L
|.. |..|.|.|    .| || |.|.                           .|||| | .  . . ||...             |. .| ... .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNLVTCYGYSLNP--------------MCIVMEFLPSGN----LFELIHSKPSEQQQSIK--------------------------------------
.|||.| .||... .              ..||||. | |.    | .  .... . |..                                        
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDSTLILAIAFDIARGMQHLHTR------NIIHRDLKSSNLLMDKHFN-----------IKIADLGIA-
                               |.    | ....||.||..|| .      |..||||   | | ... .           .|||| | . 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RETSFTQTMTTIGT----------------------------VAWTAPEILRHES---------YNQKADVYSYAIVLYELLT-GEEPYQGIP
       |.    .  .. ..                            . |.||| |..           .  | ||.|. ....|..| |.||| |  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PM--------NAGILVASK---------------GLRPELPDNCD--------------PNWKKLVVWCWSEDPNKRPSFEEITNYL
.         |. ..   .               ..|.. |..|               . .  |   ||..||..||.|... ..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase DDB0229963.AA TK-Unique 1907-2161 29 6.7e-67 228.57 In-house 1-294 (294) Show / Hide
Range on Protein: 1907-2161
Range on HMM: 1-294/294
Sequence Identity: 29% (88 aa)

IKIDKEIGKGHFSKVLKGNWKG--------KDVAVKKLNSNKDKAREEMIQEFKAEVELLGSLQ-HPNLVTCYGYSL---NPMCIVMEFLPSGNLFELIH
......||.| |. | .|  .|        | ||||.|   ||.|...  |.|. | ... .|  |||.|.|.|..    .|..|.||..| |||  ...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKML---KDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

SKPSEQQQS-----IK--------------LDSTLILAIAFDIARGMQHLHT--RNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMTTIGT---
..  .. |.     .|              ... . . .|..||.||..|.   ..|.|||| ..| |.  ....||.|.|.||... ..   ....   
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

--VAWTAPEILR--HESY-NQKADVYSYAIVLYELLT-GEEPYQGIPPMNAGILVA-SKGLRPELPDNC-DPNWKKLVVWCWSEDPNKRPSFEEITNYL
  ..| |||.|.  |. | . | ||.|......|..| |. || |.|. .  |. .  .| |...|..|  .   .|   ||...| .||||..|.. |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD--IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase DDB0229963.AA Dicty5 1907-2165 36 1.1e-66 227.87 In-house 1-260 (260) Show / Hide
Range on Protein: 1907-2165
Range on HMM: 1-260/260
Sequence Identity: 36% (98 aa)

IKIDKEIGKGHFSKVLKGNWKGKDVAVKKLNSNK----DKAREEMIQEFKAEVELLGSLQ--HPNLVTCYG---YSLNPMCIVMEFLPSGNLFELIHSKP
. . . |  |   .| .|  ||.|||.| . .      |      ..||. || ..   |  |||.. |||   |  .   .| |.  .| ||..   . 
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFD------WNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQR

SEQQQSIKLDSTLILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMTT-IGTVAWTAPEILRHESYNQKADVYSYAIV
    | |     ..| .| |||..|.|||  ||||||||| | |  . . ||| | |. |       ||. .|| .| |.|.     | ||.||||..||
KTTGQPIAY--FQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIV

LYELLTGEEPYQGIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYLTKTF
|.|..|  |||  |   |  ..|. || ||..|  |     .|.  || . | .|||| ||  |. .  
LWEMFTRKEPYDNINNWNIPVMVM-KGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII

Kinase DDB0229963.AA Pkinase 1907-2161 26 1.4e-65 228.99 Pfam 1-293 (293) Show / Hide
Range on Protein: 1907-2161
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

IKIDKEIGKGHFSKVLKGNWKGKD--VAVKKLNSNKDKAREEMIQEFKA--EVELLGSLQHPNLVTCYGYSL--NPMCIVMEFLPSG----NLFELIHSK
..| . ||.| |..| |. .||    ||||..  .|....... |.     |.... .|.||| |..|..    . ...|||... |     ||..|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKII--KKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

PSEQQQSIKL--DSTLILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNI----KIADLGIAR---ETSFTQTMTTIGTVAWTAPEILR-HESYNQ
    ... ..  .   .  ..  |.||....| ..|||||||..|.|.|.. .|    ||.| |.|.   . . . ..|  ||  . |||..| .. | .
----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KADVYSYAIVLYELLTGEEPYQGI---PPMNAGILVASKGLRPELPDNCD-----------------------PNWKKLVVWCWSEDPNKRPSFEEITNY
|.|..|. ..|||.|.|. |..|    .. .  . .  . ..|.|. ...                       .. |... ||.  ||.|||..|.| . 
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF

Kinase DDB0229963.AA S_TKc 1907-2161 27 2.4e-63 217.66 SMART 1-231 (231) Show / Hide
Range on Protein: 1907-2161
Range on HMM: 1-231/231
Sequence Identity: 27% (73 aa)

IKIDKEIGKGHFSKVLKGNWKG--KDVAVKKLNSNKDKAREEMIQEFKAEVELLGSLQHPNLVTCYGYSL-NPMCIVMEFLPS--GNLFELIHSKPSEQQ
 .| ..|||| |.|| |. .|.  . ||.|...           . .. |...| . .|||.|..|..   . ...|||...   |.||..|......  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGL

QSIKLDSTLILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMTTIGTVAWTAPEILRHESYNQ-KADVYSYAIVLYEL
.  ...   .  ..  |.......| ..||||||| .|.|.|.  .|||.| |.||.      .| .||  . |||.|   .|.  |.|..|  ..|||.
R-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTGEEPYQGIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITN---------YL
|.|. |..        . .  | ..       .|  | ..  |.  ||.|||.  |. .         ..
LCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF