Gene DPYK3 (Slime mold)

DPYK3

Species: Slime mold
Alias: DdisK246, DPYK3, DDB0191218, pkyA, PYK3
External Links: DictyBase Link ,
Annotation: Secondary Group: TKL, Secondary Family: DPYK

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
DPYK3.AA Protein None 1338 None Fasta, JSON
DPYK3.kin_dom Protein Kinase Domain None 187 None Fasta, JSON
DPYK3.kin_dom2 Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of DPYK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DPYK3.AA TKL-Unique 813-1005 27 9.1e-86 291.24 In-house 144-383 (290) Show / Hide 
Range on Protein: 813-1005
Range on HMM: 144-383/290
Sequence Identity: 27% (65 aa)

MIQ-HKNLGLLVGWCG-------DSIIFESFKGMNSLHDLIH---------RDGLKIDMALFIKISKDIASVMGLLHSKD--VAHGNLTSRSIYLDRF--
... |.|. ...|.|        ...|. ... ..||.|..|         .. .|..|....|. .|||..|  ||...  ..|..|.|.....|..  
KLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSN

------QIVKVSFPKLNATDLNNPAIEP------------RYMAPEMTRMEEDQISCSIDVYAYAFVLWEALTSHL------PFRKFNDISVAAKVAY--
      .|......|.|.........|.            |.||||..||...|.|...|||....|||| .|...      |............|.|  
IAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYME

ENLRPKIPTSCPLIIRKLINRCWAPLPSDRPTFNDILKLF
||.||.||..|| ..|.||..||.. ||.||.|..|..  
ENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase DPYK3.AA TKL 5-1005 5 7.8e-40 138.66 In-house 50-364 (364) Show / Hide 
Range on Protein: 5-1005
Range on HMM: 50-364/364
Sequence Identity: 5% (65 aa)

NNNNNNNNNNNNNNNNINGEGITLRTLLNSCTNTSSNEQLIVNNVNKNSNIINNININNTPSPISTCINVNKIELRGSSNGIFLNSKIKVPLPNSTLLEQ
|. || |.                                                                                            
ND-NN-NY--------------------------------------------------------------------------------------------

QQDGADEQDKKQQSLSDKNILFSSGDKEFLNHGSNNIITDQNTLLYQLQQQQQKEKEKENDEIMNHDDIIGYNEENEDNFFNEGMDPILAHSIEHHLHNH
                                                                                                    
----------------------------------------------------------------------------------------------------

HHHHGEFDTQENEDTSGESSDESENIDEVLVYTEDIESEKEKKRERLITSPPSFDPHTLYSMSQSLLNCSLNNNNNNNNSISSPSSSINNSGNNINLNNS
                                                                                                    
----------------------------------------------------------------------------------------------------

GNNNVNSNNNTNIINNSNDNFISQPLFNPLSMPNNEQYELLPNPTTTTSTITSTTTTTTITNLPPALPSFPSSSSIKSLKNSFGSNSITSSGELNNVFSS
                                                                                                    
----------------------------------------------------------------------------------------------------

SMSPPMSPPNRNVRSLTFPGTNPINCINTSVINSITANTNCINHHHHHHQHNHHNHHQGHNNINNSGHIRKSADDTVTLSPTLSSGSSSTSSSNPHHPNH
                                                                                                    
----------------------------------------------------------------------------------------------------

NHQKGLNNKTLEKLSCTRKEIYELIEKKESLIEKQNLIDEGYSENADSFENLSEEIQKINEKIIELENLITSLSNSNSNWSLNGSSTSTISCNPLSPRSM
                                                                                                    
----------------------------------------------------------------------------------------------------

NPSSSTSSTSSNLTNSLRKFSQELKIELRPLDLRAELYSSINTSPRGSASISGGSGSGGGGNNNGCFKTSSNSSINSPIQFFENENESIDSYEKKNEEQF
                                                                                                    
----------------------------------------------------------------------------------------------------

ESLTQLIRENQLYTKPIEFKEIKLLEKLESNSKSSNIWQIEYKSTQLVLKQPKDQDSDKNIEKRKQLFNGSNVSGSNNSGSSGGNNHNHHHCNNSNGSNS
                                                                                            .  . .. 
--------------------------------------------------------------------------------------------SD-M-QLN

EVIPSKYTM-----------IQHKNLGLLVG---------WCGD-------SIIFESFKGMNSLHDLIHRDGLKIDMALFIKISKDIASVMGLLHSKD--
.  .|..             ..| |. ...|         .|..         |   .    ||....|       . .......|||. |  |||..  
DPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPK

------VAHGNLTSRSIYLDR-FQ-------------IVKVS-F-------------------------PKLNATDLNNPAIEPRYMAPEMTRMEED---
      ..| .|.|. | .|. ..              .|.. |                         . .|.. ....   ||.||||. |....   
WCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTE

-----------QISCSIDVYAYAFVLWEALTSHLPFRKFNDISVA---------AKVAYENLRPKIP------------TSCPLIIRKLINRCWAPLPSD
           . | ..|||... |||| ||  .|..... ...          ..|....||| ||            ..||  ..||. .||.. |..
KVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEK

RPTFNDILKLF
||.|..||| .
RPSFQEILKRL
Kinase DPYK3.AA MLK 913-1005 35 2.2e-30 102.66 In-house 197-291 (291) Show / Hide 
Range on Protein: 913-1005
Range on HMM: 197-291/291
Sequence Identity: 35% (34 aa)

PRYMAPEM-TRMEEDQISCSIDVYAYAFVLWEALTSHLPFR-KFNDISVAAKVAYENLRPKIPTSCPLIIRKLINRCWAPLPSDRPTFNDILKLF
...||||. .. .... | . ||. .. |||| ||  .|..   . . .|..|||..||| || .|| .. ||...|| . |..||.|  |.. .
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase DPYK3.AA HH498 913-1005 35 1.6e-26 80.8 In-house 189-284 (284) Show / Hide 
Range on Protein: 913-1005
Range on HMM: 189-284/284
Sequence Identity: 35% (34 aa)

PRYMAPEMTRMEEDQISCSIDVYAYAFVLWEALTSHLPFRKFNDISVAAKVAYENLRPKIPTS----CPLIIRKLINRCWAPLPSDRPTFNDILKLF
.|.|||| .     . |  .||. || ..|| .|  .||  .  .  ||..||   || || .     |  .  || .|| | |..||.| .|. . 
LRWMAPEVFS-QCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase DPYK3.AA Dicty4 933-1007 35 1.4e-19 62.14 In-house 199-277 (277) Show / Hide 
Range on Protein: 933-1007
Range on HMM: 199-277/277
Sequence Identity: 35% (28 aa)

DVYAYAFVLWEALTSHLPFR-KFNDI-SVAAKVAYENLRPKIPTSCPLIIRKLINRCWAPLPSDRPTFNDILKL--FDH
||| .. |||| ||   |.   . ..  ... |. . |||.|| .||  ...||..|| . |. ||.|. |..    .|
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase DPYK3.AA Dicty5 933-1009 37 1.8e-18 60.18 In-house 185-260 (260) Show / Hide 
Range on Protein: 933-1009
Range on HMM: 185-260/260
Sequence Identity: 37% (29 aa)

DVYAYAFVLWEALTSHLPFRKFNDISVAAKVAYENLRPKIPTSCPLIIRKLINRCWAPLPSDRPTFNDILKLFDHLE
|||... |||| .|   |.   | .. .  |.    || ||  ||  | .||  ||   |. ||.|  |.| |. . 
DVYSFGIVLWEMFTRKEPYDNINNWNIPVMVMKGE-RPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase DPYK3.AA Dicty4-Unclassified 933-1005 39 1.9e-18 59.77 In-house 190-263 (263) Show / Hide 
Range on Protein: 933-1005
Range on HMM: 190-263/263
Sequence Identity: 39% (29 aa)

DVYAYAFVLWEALTSHLPFRKFN-DISVAAKVAYENLRPKIPTSCPLIIRKLINRCWAPLPSDRPTFNDILKLF
||| || .|.| .|   |.      . .|  |.   |||||| .|.  ..|||  ||   |  |||.|.| .  
DVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase DPYK3.AA LRRK 913-1007 32 4.7e-18 60.45 In-house 243-351 (351) Show / Hide 
Range on Protein: 913-1007
Range on HMM: 243-351/351
Sequence Identity: 32% (35 aa)

PRYMAPEMTRME-EDQISCSIDVYAYAFVLWEALTSH-LPFRKFN--D----ISVAAKVAYENLRPKIPTS-CPL-----IIRKLINRCWAPLPSDRPTF
|..||||  | . | . .  .|.|... .||| ||   .||. ..  |    ..   .   | |||.|| . ||         .||. ||.  | .||.|
PGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHF

NDILKLFDH
..|.|    
SQIVKRLSQ
Kinase DPYK3.AA DRK 933-1007 33 4.1e-15 47.66 In-house 184-258 (258) Show / Hide 
Range on Protein: 933-1007
Range on HMM: 184-258/258
Sequence Identity: 33% (25 aa)

DVYAYAFVLWEALTSHLPFRKFNDISVAAKVAYENLRPKIPTSCPLIIRKLINRCWAPLPSDRPTFNDILKLFDH
||| .| |||| .|   |.   .   |   |  . .|| .|  ||    .|.|.||   |. ||.. ..|.  . 
DVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase DPYK3.AA Pkinase_Tyr 933-1005 29 5.4e-14 48.02 Pfam 196-270 (270) Show / Hide 
Range on Protein: 933-1005
Range on HMM: 196-270/270
Sequence Identity: 29% (22 aa)

DVYAYAFVLWEALT-SHLP-FRKFNDISVAAKVAYENLRPKIPTSCPLIIRKLINRCWAPLPSDRPTFNDILKLF
||...  ..|| .|    | .    .  | .... .. | ..|  ||  | .|. .||.. |.||||| .|.  .
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DPYK3.AA CZAK 933-1005 32 1.1e-13 46.17 In-house 204-279 (279) Show / Hide 
Range on Protein: 933-1005
Range on HMM: 204-279/279
Sequence Identity: 32% (25 aa)

DVYAYAFVLWEALTSHLPFRKFNDISVAAKVAYENLRPKIPTSCPLIIR---KLINRCWAPLPSDRPTFNDILKLF
||| .. .||. .|.  |      .  |   |||| || .|   .       .|| .||   |. ||.|  ||   
DVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase DPYK3.AA Pkinase 913-1005 20 3.1e-11 40.8 Pfam 175-293 (293) Show / Hide 
Range on Protein: 913-1005
Range on HMM: 175-293/293
Sequence Identity: 20% (25 aa)

PRYMAPEMTRMEEDQISCSIDVYAYAFVLWEALTSHLPFRKF------NDISVAAKVAYENLRPKIPTSCP-------------------LIIRKLINRC
|.|||||  | .   .. ..|....  .|.| |. ..||.        ... . ... .  |.  .|..|.                      ...|..|
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

WAPLPSDRPTFNDILKL--F
... |..|||. .||.   |
LCKDPKKRPTAEQILQHPWF
Kinase DPYK3.AA LRRK 840-883 31 4e-05 14.04 In-house 209-262 (351) Show / Hide 
Range on Protein: 840-883
Range on HMM: 209-262/351
Sequence Identity: 31% (17 aa)

SLHDLIH---RDGL-----KIDMALFIKISKDIASVMGLLHSKD--VAHGNLTS
.|....|   .||.     .|.  |..||. .||. |. |||..  . | .|.|
DLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKS
Kinase DPYK3.AA HH498 852-896 27 0.032766 2.36 In-house 222-269 (284) Show / Hide 
Range on Protein: 852-896
Range on HMM: 222-269/284
Sequence Identity: 27% (13 aa)

IDMALFIKISKDIASVMGLLHS---KDVAHGNLTSRSIYLDRFQIVKV
.| .    || |.|  |  ||.   . . |  |.|  | .... . .|
MDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVV
Kinase DPYK3.AA MLK 840-897 18 0.03427 3.56 In-house 96-175 (291) Show / Hide 
Range on Protein: 840-897
Range on HMM: 96-175/291
Sequence Identity: 18% (15 aa)

SLHDLIHR-DG------------LKIDMALFIKISKDIASVMGLLHSKD---VAHGNLTSRSIYLDR------FQIVKVS
||....|  ..              .|...........|. |  |||..   . |  | |. | .|.        ..|..
SLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKIC
Kinase DPYK3.AA Dicty4-Unclassified 841-896 30 0.161807 0.92 In-house 89-150 (263) Show / Hide 
Range on Protein: 841-896
Range on HMM: 89-150/263
Sequence Identity: 30% (19 aa)

LHDLIH------RDGLKIDMALFIKISKDIASVMGLLHSKDVAHGNLTSRSIYLDRFQIVKV
|  .||         .| |  | ||.  |||  |  ||.... |  . |  | .|.   .|.
LFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKI
Kinase DPYK3.AA Dicty4 840-865 22 0.233143 0.49 In-house 88-122 (277) Show / Hide 
Range on Protein: 840-865
Range on HMM: 88-122/277
Sequence Identity: 22% (8 aa)

SLHDLIHR------DGLKIDMALFIK---ISKDIA
.|. |.|       .  |.|  |...   . .|.|
NLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAA
Kinase DPYK3.AA TKL-Unique 1059-1301 41 1.7e-138 466.44 In-house 1-290 (290) Show / Hide 
Range on Protein: 1059-1301
Range on HMM: 1-290/290
Sequence Identity: 41% (119 aa)

IVEKVGAGSFANVFLGIWNGYKVAIKILK-NESISND--EKFIKEVSSLIKSH-HPNVVTFMGACI----DPP--CIFTEYLQGGSLYDVLH--------
...|.|.|....|. |.|.||.||||... ||..||.  ..|..||. . | | |||.|..||.|.    .||  ||..||..|||||||||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-IQKIKLNPLMMYKMIHDLSLGMEHLHSIQ--MLHRDLTSKNILLDEF-----KNIKIADFGLATTLS--DDMTLSGI---------TNPRWRSPELTKG
 ....|||.....||..| ..||..||. .  ..||||.|.|.|.|..      ||||.||||....|  ..||....         ...||..||....
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--LVYNEKVDVYSFGLVVYEIYTGKI------PFEGLDGTASAAKAAF--ENYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILTEL
    |.||.|||||| |..||.|.||      |..|.| .. ......  ||||| ||..|| ..|.||..||..||||||||.||...|
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase DPYK3.AA TKL 1063-1301 26 1.8e-98 333.47 In-house 1-364 (364) Show / Hide 
Range on Protein: 1063-1301
Range on HMM: 1-364/364
Sequence Identity: 26% (100 aa)

VGAGSFANVFLGIWNG----------YKVAIKILKN------ESISND---------------------EKFIKEVSSLIKSHHPNVVTFMG--------
.| |.|. |. |.|.|          . ||.|..|       ...|..                     .....|. .... .|||.| |||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-ACIDP------PCIFTEYLQGGSLYDVLHIQKIKLNPLMMYKMIHDLSLGMEHLHSIQ--------MLHRDLTSKNILLDEFKN--------------I
 .|..|      .|| .|| .||||...||       .  . ....| ..||..||| .        ..||||.|||||.||  .              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIADFGLATTLSDD---------------------MTLSGITNPRWRSPELTKGL----------------VYNEKVDVYSFGLVVYEIYTGKIPFEGLD
||.||||....| .                     .| . . .||| .||. .|                  |.||.||||||.| .||.|...|.....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

GTASA---------AKAAFENYRPAIP------------PDCPVSLRKLITKCWASDPSQRPSFTEILTEL
              .... ...|| ||            |||| |..||...||..||..||||.||| .|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase_Tyr DPYK3.AA Pkinase_Tyr 1057-1301 31 1.6e-89 303.77 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1057-1301
Range on HMM: 1-270/270
Sequence Identity: 31% (86 aa)

VAIVEKVGAGSFANVFLGIWN------GYKVAIKILKNESISND---EKFIKEVSSLIKS-HHPNVVTFMGACI---DP--PCIFTEYLQGGSLYDVLHI
. . .| |.|.| .|..|.|.      ...||.|.||. . . .   |.|..|.. . .  ||||.| ..|.|.   .|  ..| .|| ..|.|.| |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

Q---KIKLNPLMMYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTL-SDDMT----LSGITNPRWRSPELTKGLVYNEKVDVYSF
.   | .|.. .. .| .. . |||.|.|... ||||  .|.|..| . .||.||||| .. .||       .|    .| .||  .  ....| ||.||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GLVVYEIYT-GKIP-FEGLDGTASAAKAA-FENYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILTEL
| . .||.| |..| ..|.   .   ..   ..|| ..|..||  . .|...||. ||..||.|.||. .|
GVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DPYK3.AA Dicty4 1057-1303 38 1.1e-79 265.49 In-house 1-277 (277) Show / Hide 
Range on Protein: 1057-1303
Range on HMM: 1-277/277
Sequence Identity: 38% (108 aa)

VAIVEKVGAGSFANVFLGIWNGYKVAIKIL--KNESISNDE--KFIKEVSSLIKSHHPNVVTFMGACI----DP--PCIFTEYLQGGSLYDVLHI-----
 .| .. | |||. |..|.| | .||.|.|  .|.  . ..   | |||. . |  |||...|||||.     |  .|| |||.  |.|| .||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-QKIKLN-PLMMY--KMIHDLSLGMEHLHS-I-QMLHRDLTSKNILLDEFKNIKIADFGLAT------TLSD-DMTLSGITNPRWRSPELTKGLVYNEKV
 |.|||  ||.    .|  |  .|| .||. .   .|||| | |.| |. ...|..||||..      ...|  ||  |   | | .||   .  ||||.
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACG--TPCWMAPEVMMHQPYNEKA

DVYSFGLVVYEIYTGKIPFE-GLDGTASAAKAAFE-NYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILTE--LET
||||||.| .|| |...|.    . .  .. |  .   || ||..|| |...||..||  ||..|||| ||. .  ||.
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase DPYK3.AA LRRK 1057-1303 25 5e-78 265.53 In-house 1-351 (351) Show / Hide 
Range on Protein: 1057-1303
Range on HMM: 1-351/351
Sequence Identity: 25% (91 aa)

VAIVEKVGAGSFA-NVFLGIWNG----------------------------YKVAIKILKNE----------------------------------SISN
. | |..| |.|. .|. ..|.|                            ..||||... .                                  .. .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

DEKFIKEVSSLIKSHHPNVVTFMGACIDPPCIFTEYLQGGSLYDVLHIQK--------IKLNPLMMYKMIHDLSLGMEHLHSIQ--MLHRDLTSKNILLD
  .| .||. . . .|||.|  .| ||.|.|. .||.. |.||..||  |        ..... . .|   . . |||.|||     .||||.| |||| 
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

EFK------------NIKIADFGLAT---TLSDDMTLSGITNPRWRSPELTKG---LVYNEKVDVYSFGLVVYEIYTGK-IPFEGLD----G--TASAAK
...            ..||||||. .   ..    .    .||.|..||  ..    .|.||||.||||.. .|..|.. .||...|    .  .    .
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

AAFENYRPAIPPD-CPV-----SLRKLITKCWASDPSQRPSFTEILTELET
.  |  || ||.. ||      .. .||..||. || .||.|..|.  |..
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase DPYK3.AA MLK 1057-1301 31 3.1e-77 262.89 In-house 1-291 (291) Show / Hide 
Range on Protein: 1057-1301
Range on HMM: 1-291/291
Sequence Identity: 31% (93 aa)

VAIVEKVGAGSFANVFLGIWNGYK-----VAIKILK---NESISN----DEKFIKEVSSLIKSHHPN----VVTFMGACIDPPC---IFTEYLQGGSLYD
  . |..|.|||  |..| | .       ||.|. .     ..|     ...| .|.  | .  |||    .. |.|.|..|||   | .||..|||||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLHIQK-------------IKLNPLMMYKMIHDLSLGMEHLHSIQ---MLHRDLTSKNILLDE------FKNIKIADFGLATTLSDD---MTLSGITNPR
||| ..             .   .  . .  .. . ||. ||| .     |||| |.|||.||       .. ||.|||... ...    |. | . ...
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM-SNAGTYA

WRSPELT---KGLVYNEKVDVYSFGLVVYEIYTGKIPFE-GLDGTASAAKAAFENYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILTEL
|..|| .   ..  |.||.||.|.|.| .|. |...|.. ..|. | |...| .. ||.||..|| .. ||...|| .||..|||| .|...|
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase DPYK3.AA HH498 1057-1301 31 3.1e-76 241.09 In-house 1-284 (284) Show / Hide 
Range on Protein: 1057-1301
Range on HMM: 1-284/284
Sequence Identity: 31% (89 aa)

VAIVEKVGAGSFANVFLGIWNGYKVAIKILKNESISNDEK--------FIKEVSSLIKSHHPNVVTFMGACIDPP---CIFTEYLQGGSLYDVL------
.   ||.|.||| .|..| | .  ||.|  . . ..   .        |..||| . .  ||.|| |..||.| |    | |.| ..|||. .|      
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIG

--------HIQK---IKLNPLMMYKMIHDLSLGMEHLHS---IQMLHRDLTSKNILLDEFKNIKIADFGLA--TTLSDDMTLSG-ITNPRWRSPELTK-G
        | ||   . . .     .  |   ||. ||.    .  ||||.| |||..|.   ..||||        .| ..   . |.||..|| .. .
GAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQC

LVYNEKVDVYSFGLVVYEIYTGKIPFEGLDGTASAAKAAFENYRPAIPPD----CPVSLRKLITKCWASDPSQRPSFTEILTEL
  | .||||.|......|..|...||  .   | ||. |.   || ||       | .   ||  ||   |. ||.| .|.| |
QKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase DPYK3.AA DRK 1057-1303 37 8.3e-68 228.72 In-house 1-258 (258) Show / Hide 
Range on Protein: 1057-1303
Range on HMM: 1-258/258
Sequence Identity: 37% (96 aa)

VAIVEKVGAGSFANVFLGIWNGYKVAIKILKNESISNDEKFI----KEVSSLIKSHHPNVVTFMGACIDPP--CIFTEYLQGGSLYDVLHIQKIKLNPLM
..|   .| |... ||.| | | .||.| |.|  | |||.|.    .|.  . .  |||.. |||.|  ||  || .||.  |||| .|| ..|..    
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNI-NDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL

MYKMIHDLSLGMEHLHSIQ--MLHRDLTSKNILLDEFKNIKIADFGLAT----TLSDDMTLSGITNPRWRSPELTKGLVYNEKVDVYSFGLVVYEIYTGK
| .|  |   ||  ||.     .|||| | | | ||   .|.|||||.|     ..   .   .  | | .||      | || |||||. |  |. | .
MKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQ

IPFEGLDGTASAAKAAFENYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILTELET
.|. |            .  || .|. ||    .|.. ||  ||..|||. |.|  || 
DPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase DPYK3.AA Dicty4-Unclassified 1057-1301 35 4.1e-66 225.43 In-house 1-263 (263) Show / Hide 
Range on Protein: 1057-1301
Range on HMM: 1-263/263
Sequence Identity: 35% (93 aa)

VAIVEKVGAGSFANVFLGIWNGYKVAIKILKNESISND----EKFIKEVSSLIKSHHPNVVTFMGACIDP------PCIFTEYLQGGSLYDVLH------
. |   .| | |. |  |.| |  ||.|..   . .      . | |||  |    ||| |.  |.|| |       || .| .  | |  | |      
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

IQKIKLNPLMMYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTLSDDMTLSGIT-NPRWRSPELTKGLVYNEKVDVYSFGLVVYE
 | |||.  .  |.  |   || |||.  . |||. | |||.|   ||||||||..   .   ..  |   |.| |||  ..  || | ||||.... ||
QQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYE

IYTGKIPFEGLD-GTASAAKAAFENYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILTEL
  ||  |. .       |   .    || ||  |.  ..|||  ||  ||  ||.. .|   |
LATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase DPYK3.AA S_TKc 1057-1309 27 3e-61 210.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 1057-1309
Range on HMM: 1-231/231
Sequence Identity: 27% (74 aa)

VAIVEKVGAGSFANVFLGIWNG--YKVAIKILKNESISNDEKFIKEVSSLIKSHHPNVVTFMGACI-DPPCIFTEYLQG--GSLYDVLHIQKIK-----L
  |..|.| |.|. |.......   .|||||.|       |....|.. | | ||||.|.. ...  |  ....||. |  |.|.|... .. .     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NPLMMYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTLSDDMTLSGITNPRWRSPELTKGLVYNE-KVDVYSFGLVVYEIYTGKI
.. .  .... . ...|..|| . .||||   ||||||  .|||.|||||. |      . .  | ...||.     |.  |.|..|.| ..|| ..|. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP

PFEGLDGTASAAKAAFENYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILT-ELETMKSKFI
||.         .. |.. .       . ... .| ||.  ||..||.  |.|. |.. ..  ..
PFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DPYK3.AA TyrKc 1057-1301 30 1.3e-60 208.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 1057-1301
Range on HMM: 1-280/280
Sequence Identity: 30% (86 aa)

VAIVEKVGAGSFANVFLGIWNGYKVAIKILKNESISNDEKFIKEVSSLIKS--HHPNVVTFMGACI---------DPPCIFTEYLQGGSLYDVLHIQKIK
.   .| | | |  |..|.|. ..||.| ||...    | |..| . . |   ||||.| . |.|.         .|..| .||  .|.| | |.  . |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LNPLMMYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTLSDD--------MTL-----SGI--TNPRWRSPELTKGLVYNEKVDV
|..  . .. .. . |||.||| .  ||||   |.|..| . .||.||||.  . ||        .       .|      || .||  .  ....| ||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

YSFGLVVYEIYT-GKIPFEGL----DGTASAAKAAFENYRPAIPPD--------CPVSLRKLITKCWASDPSQRPSFTEILTEL
.||| . .||.| |. | .|        . . .   . ||. .||.        ||  . .....||. ||..||.|.||  ..
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DPYK3.AA CZAK 1060-1301 36 5.6e-55 188.96 In-house 3-279 (279) Show / Hide 
Range on Protein: 1060-1301
Range on HMM: 3-279/279
Sequence Identity: 36% (102 aa)

VEKV-GAGSFANVFLGIWNGYKVAIKILKNESISNDEK------FIKEVSSLIKSHHPNVVTFMGACIDPP----CIFTEYLQGGSLYDVL--HIQKIKL
.... | | |  |  . | |  |||||.  ..  |         | |||| . |  |||.| |.|||        || .|.  ||||   |  |   .| 
FGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQ

NPLMMYKMIHDLSLGMEHLHS-IQM---LHRDLTSKNILLDEFKN-------------IKIADFGLA---TTLSDDMTLSGITNPRWRSPELTKGLVYNE
|| .  .|  |   ||  ||        |||||.|.|||||.                 ||.||||         .|| . .    |  ||  ||  | |
NPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQT-MGCLCWMAPECFKGENYTE

KVDVYSFGLVVYEIYTGKIPFEGLDGTASAAKAAFENYRPAIPPDCPVSLR---KLITKCWASDPSQRPSFTEILTEL
||||||||.....| |.  |  ..     |  ||.||||| .|   .       .||..|| . |. |||| .||  |
KVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase DPYK3.AA Pkinase 1057-1301 24 3.9e-53 187.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1057-1301
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

VAIVEKVGAGSFANVFLGIWNGYK--VAIKILKNESISNDEK--FIK--EVSSLIKSHHPNVVTFMGACI--DPPCIFTEYLQGG----SLYDVLH-IQK
  |..|.|.|||. |..... |.   ||.||.| .... ...   ..  |.. . . .|||.|.. ...   | ... .||..||    .|.|...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

IKL--NPLMMYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNI----KIADFGLAT---TLSDDMTLSGITNPRWRSPELTK-GLVYNEKVDVYSF
 ..   .    ...  .  |.|..||   .|||| . |||.|.  .|    ||.|||||    . ..  . .    |....||. . |  |  |||..|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GLVVYEIYTGKIPFEGL---DGTASAAKAAFENYRPAIPPDCP-----------------------VSLRKLITKCWASDPSQRPSFTEILTE--L
|...|| ..|. || |    |. ..  .  ... .| .. |.|                        .....|..|.. ||..||....||    .
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DPYK3.AA Dicty5 1057-1305 35 2e-51 175.29 In-house 1-260 (260) Show / Hide 
Range on Protein: 1057-1305
Range on HMM: 1-260/260
Sequence Identity: 35% (93 aa)

VAIVEKVGAGSFANVFLGIWNGYKVAIKILKNES-ISND-EKFIKEVS--SLIKSHHPNVVTFMGACIDP---PCIFTEYLQGGSLYDVLHIQKIK--LN
|.. . . .|.   |. || .|  |||| .  |  .  | . | .||   |...| |||.. . ||       | . ||| . ||| . |  .. |    
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLN-DQRKTTGQ

PLMMYKMIH---DLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLAT--TLSDDMTL-SGITNPRWRSPELTKGLVYNEKVDVYSFGLVVYEIY
|.     .|   |   .|.||||.   |||| | |.|. |   ||| |||      .   ||.  |  .  | ..|| .|  | .|.|||||| | .|. 
PIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQC--WMACELFNGQPYHQKCDVYSFGIVLWEMF

TGKIPFEGLDGTASAAKAAFENYRPAIPPDCPVSLRKLITKCWASDPSQRPSFTEILTELETMK
| | |.. .    . .       || ||.||| .  .|| |||   |..||||.||.  .| . 
TRKEPYDNIN-NWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII