Gene Gdt6 (Slime mold)
Gdt6
Sequence
Protein domains of Gdt6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Gdt6.AA | Gdt | 1194-1434 | 45 | 6.6e-170 | 570.75 | In-house | 1-289 (289) | Show / Hide |
Range on Protein: 1194-1434
Range on HMM: 1-289/289
Sequence Identity: 45% (132 aa)
IEVKELISQNNLSTVNIANYRGLQVVLRKIKTHSANYTKTYSQAIKKFYTEMDILSKLKNKNIVSFIGCTHDSSHLWIVTEYAPLGSLSSLIHQKK----
|..||..||.....|.....|..||.....|.|..||||||||.....|.|||||||.|..||||||||.|.|||..|||||.|.|||...|||||
IDFKEYCSQGTFGMVYKGIWRSSQVAVKMFKHHYVNYTKTYSQSCDEIYREMDILSKIKHQNIVSFIGCVHFSSHHCIVTEYCPRGSLGYYIHQKKNQKK
------------------------EKLSLIQKVKLMLDTAKGCEFLHSNDITNCNIKSNNLLLFSTMEKDDVCVKISDFG----IKKFEVQNQNE-----
.|.|.|||...|.|.||||.|||.|.|.....|..|.|.|||.|...||.||.||| |..|...|.|.
SNTNTITNTITNTNTNTNTSTSTSIKMSMIQKIRIMIDIAKGCQFLHQNGIIHRDLKPDNILIFSTNENSEVCAKICDFGTSKEINEFHCKNTNCGTMNY
--KEIFKDEKDQKLIDVYEFGITFYETMLEETP------ENLSNLILEGERPTLDLEKLDA-DIRNIIERCWNQ--NKRSTFSEISISL
.|||..|..||..|||.|||.|||.|.|..| ....|....|.|||||....|. |||||||.|||. .||.||.|||..|
MSNEIFEGENYQKSTDVYSFGILFYEMMIERIPFHEICHWEIPNFVQDGWRPTLDQDIFDDNDIRNIIECCWNKNPHKRPTFDEISKHL
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| Kinase | Gdt6.AA | TKL | 1200-1434 | 18 | 5.5e-55 | 188.98 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 1200-1434
Range on HMM: 1-364/364
Sequence Identity: 18% (68 aa)
ISQNNLSTVNIANYRG----------LQVVLRKIKTHSANY--------------------TKTYSQAIKKFYTEMDILSKLKNKNIVSFIGCTHDSSH-
| . ..| ...|| |. |.|.|. . ...|.. ... |. ..|.|. |||.|.|. ....
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------LWIVTEYAPLGSLSSLIHQKKEKLSLIQKVKLMLDTAKGCEFLHSND--------ITNCNIKSNNLLLFSTME---------KDDVCV
|.||.||.| ||| ...| . |.....||.|.|...|||.. | ...||.|.|... .. ..|.|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC
KISDFGIKKFEV-----------------------QNQNEK--------EIFKDE----------------KDQKLIDVYEFGITFYETMLEETPE--NL
||.|||. .| .. .. |..... . . .||| ||| ..| . ..|. .
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
--------------SNLILEGERPTLD-----------LEKLDADIRNIIERCWNQ--NKRSTFSEISISL
. ...|.||... . . ........||.. .|| .|.|| |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | Gdt6.AA | TKL-Unique | 1238-1380 | 26 | 1.9e-26 | 90.39 | In-house | 39-220 (290) | Show / Hide |
Range on Protein: 1238-1380 Range on HMM: 39-220/290 Sequence Identity: 26% (49 aa) IKKFYTEMDILSKLK-NKNIVSFIGCTH----DSSHLWIVTEYAPLGSLSSLIH---------QKKEKLSLIQKVKLMLDTAKGCEFLHSND--ITNCNI ...|. | ...||. .||| ..| .. . ... ||.|| |.||| ...| .. ||.. |.||. .| |.|...||... |. ... MQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDL KSNNLLLFSTMEKDDVCVKISDFGIKKFEVQN----QNEK-----------------EIFKD--EKDQKLIDVYEFGITFYE || |.|. . . .||.|||. || .. ||. |.... .. .. .||| ||| .| KSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWE |
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| Kinase | Gdt6.AA | LRRK | 1244-1346 | 38 | 3.6e-22 | 75.22 | In-house | 107-224 (351) | Show / Hide |
Range on Protein: 1244-1346
Range on HMM: 107-224/351
Sequence Identity: 38% (46 aa)
EMDILSKLKNKNIVSFIGCTHDSSHLWIVTEYAPLGSLSSLIHQKKE--------KLSLIQKVKLMLDTAKGCEFLHSND--ITNCNIKSNNLLLFSTME
|. |.|.|. |||| .| ... .| .|.||||.|.|....| ||. ..| | |..|. ||| |.|||.. | .. || | ||.| ..
EVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQ
K-------DDVCVKISDFGI
..||.||.||||
NHSPNYPNAHVCAKIADFGI
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| Kinase | Gdt6.AA | MLK | 1194-1349 | 21 | 3.4e-20 | 66.83 | In-house | 1-182 (291) | Show / Hide |
Range on Protein: 1194-1349 Range on HMM: 1-182/291 Sequence Identity: 21% (40 aa) IEVKELISQNNLSTVNIANYRGLQVVLRKIKTHSANYTKTYSQAI-----KKFYTEMDILSKLKNKN----IVSFIGCTHDS-SHLWIVTEYAPLGSLSS |...| | | ...|. .| . .. .. .. . .. ..| .| .|..|. .| |. | |. ... .|. ||.||.. |||.. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN LIHQKKE-------------KLSLIQKVKLMLDTAKGCEFLHSND---ITNCNIKSNNLLLFSTMEKDDVC---VKISDFGIKKF ..| .. .. .... .|. |.| ..|||.. | .|| |.|. .. | . .||.|||.... VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRD |
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| Kinase | Gdt6.AA | Pkinase_Tyr | 1235-1314 | 28 | 2e-19 | 66.43 | Pfam | 42-130 (270) | Show / Hide |
Range on Protein: 1235-1314 Range on HMM: 42-130/270 Sequence Identity: 28% (25 aa) SQA--IKKFYTEMDILSKL-KNKNIVSFIG-CTHDSSH--LWIVTEYAPLGSLSSLIHQK---KEKLSLIQKVKLMLDTAKGCEFLHSN ... ...| |. |...| ...|||...| ||... . ..||.||.|.|.| . ... |..|.. .... .. |||.|.|.|. HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK |
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| Kinase | Gdt6.AA | TK | 1240-1345 | 14 | 1.3e-17 | 54.94 | In-house | 84-296 (486) | Show / Hide |
Range on Protein: 1240-1345
Range on HMM: 84-296/486
Sequence Identity: 14% (31 aa)
KFYTEMDILSKLK-----NKNIVSFIG-CTHDS-----------SHLWIVTEYAPLGS----LSSLIHQKKEK---------------------------
.|. |. ...... .|||...| ||.. ...||.||.|.|. | . .....|
DFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGD
------------------------------------------------LSLIQKVKLMLDTAKGCEFLHSNDI------TNCNIKSNNLLLFSTME----
|.. |.. ... |.|.|.|||. . .. | |... .
ITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWH
--KDDVCVKISDFG
. ..||.|||
FDGCGPVCKIADFG
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| Kinase | Gdt6.AA | ULK | 1236-1345 | 23 | 2.3e-17 | 58.22 | In-house | 52-183 (324) | Show / Hide |
Range on Protein: 1236-1345 Range on HMM: 52-183/324 Sequence Identity: 23% (31 aa) QAIKKFYTEMDILSKLK---NKN--IVSFIGCTHDS--SHLWIVTEYAPLGSLSSLIHQKKE--------KLSLIQKVKLMLDTAKGCEFLHSNDITNCN ...... | |. ||| ..| || .. .. .| ...|..|| . | |...|...|. .|| . .. . . . |. .||.. | . YMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRD IKSNNLLLFST--------MEKDDVCVKISDFG || |.|. . ...||.||| IKPQNILIHNGQPKTDSKKVHP-NGVLKIADFG |
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| Kinase | Gdt6.AA | ULK | 1236-1345 | 22 | 6.8e-17 | 55.57 | In-house | 52-187 (329) | Show / Hide |
Range on Protein: 1236-1345 Range on HMM: 52-187/329 Sequence Identity: 22% (31 aa) QAIKKFYTEMDILSKLK--------NKNIVSFIGCTHDS--SHLWIVTEYAPLGSLSSLIHQKKE---------KLSLIQKVKLMLDTAKGCEFLHSNDI .... . | .|. ||| ..||| .. .. .| ...|..|| . | |...|...|. .|| . .. . . . |. .||.. | YMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNI TNCNIKSNNLLLFST--------MEKDDVCVKISDFG . || | |. . ...||.||| IHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFG |
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| Kinase | Gdt6.AA | DRK | 1214-1345 | 29 | 1.5e-16 | 52.65 | In-house | 21-145 (258) | Show / Hide |
Range on Protein: 1214-1345 Range on HMM: 21-145/258 Sequence Identity: 29% (39 aa) RGLQVVLRKIKTHSANYTKTYSQAIKKFYTEMDILSKLKNKNIVSFIGCTHDSSHLWIVTEYAPLGSLSSLIHQKKEKLSLIQKVKLMLDTAKGCEFLHS || || . . | | . .. | | .....| ||. |.| .. |..|| |.||| . | . ... ..|.| ||| .||. RGTQVAVKMLFNHNINDEN----FLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHC ND--ITNCNIKSNNLLLFSTMEKDDVCVKISDFG . | || ||| . ||..||| CNPIIIHRDLKSHNLLV-----DEHWQVKVADFG |
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| Kinase | Gdt6.AA | Pkinase | 1215-1346 | 26 | 2.5e-16 | 58.83 | Pfam | 24-158 (293) | Show / Hide |
Range on Protein: 1215-1346 Range on HMM: 24-158/293 Sequence Identity: 26% (37 aa) GLQVVLRKIKTHSANYTKTYSQA-IKKFYTEMDILSKLKNKNIVSFIGCTHDSSHLWIVTEYAPLG----SLSSLIH-QKKEKL--SLIQKVKLMLDTAK | .|.. .|| .... | .. . . .| |. .|. .||| .... .|..|...|.||.. | .|...|. ... .. | . . |. ... GKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILR GCEFLHSNDITNCNIKSNNLLLFSTMEKDDVCVKISDFGI | |..||. | . .|. |.|. .... |. ||||.|||. GLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGL |
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| Kinase | Gdt6.AA | Jak | 1236-1345 | 22 | 3.1e-16 | 53.71 | In-house | 51-166 (299) | Show / Hide |
Range on Protein: 1236-1345 Range on HMM: 51-166/299 Sequence Identity: 22% (27 aa) QAIKKFYTEMDILSKLKNKNIVSFIGCT--HDSSHLWIVTEYAPLGSLSSLIH----QKKEKLSL--IQKVKLMLDTAKGCEFLHSNDITNCNIKSNNLL | ...|. | .|.|.. .|.|| . |.. . . .|.||...|.| . | .|..... .|.... . ..| ..|..... .... |.| QHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNIL LFSTMEKDDVCVKISDFG . . |... ||||..|. V--DREGHWCCVKIPFFK |
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| Kinase | Gdt6.AA | TyrKc | 1194-1434 | 19 | 3.1e-15 | 23.6 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1194-1434
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)
IEVKELISQNNLSTVNIANYRGLQVVLRKIKTHSANYTKTYSQAIKKFYTEMDILSKL--KNKNIVSFIGCTHDS-------SHLWIVTEYAPLGSLSSL
|. .. . . .| . .. .|| ..| .. .. |. |. |..|| ...||| ..|. .. |.||.||.|.|.| .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY
IHQKKEKLSLIQKVKLMLDTAKGCEFLHSNDITNC---NIKSNNLLLFSTMEKDDVCVKISDFGIKKFEVQN----QNEKEIFK----DEKD--------
.. ...||.. .... ... |.|.|.|||. || . | |. . .||||||| .. ... . | ..|.
LRKHRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA
----QKLI-----DVYEFGITFYETM-------LE-----ETPENLSNLILEGERPTLDLE-------KLDADIRNIIERCWNQ--NKRSTFSEISISL
.. . ||. ||.. .| . . ... . ... .|.|. . ... .|...||. ..| ||||| .
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | Gdt6.AA | S_TKc | 1194-1439 | 18 | 4.1e-15 | 44.77 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1194-1439 Range on HMM: 1-231/231 Sequence Identity: 18% (49 aa) IEVKELISQNNLSTVNIANYRG--LQVVLRKIKTHSANYTKTYSQAIKKFYTEMDILSKLKNKNIVSFIGCTHDSSHLWIVTEYAPL--GSLSSLIHQKK |. ..| . ..| . .. .| . .|| .... |..||.| . .||| .... .| .||..|.||.. |.| ..|.... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG EK-----LSLIQKVKLMLDTAKGCEFLHSNDITNCNIKSNNLLLFSTMEKDDVCVKISDFGIKKFEVQNQNEK--------EIFKDEKDQK-LIDVYEFG . .. . ..| .... |..||. | . .| |.|| . ..||.|||. .. |.. . | .|.. .| RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCG ITFYETMLEETPENLSNLILEGERPTLDLEKLDADIRNIIERCWNQN--KRSTFSEISI----SLKEKYT ...|| . ..| .. . .. . . ...|..|.. . || | |. . . CILYEMLCGYPPFP--QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Gdt6.AA | LRRK | 1388-1436 | 28 | 0.000537 | 10.01 | In-house | 296-351 (351) | Show / Hide |
Range on Protein: 1388-1436 Range on HMM: 296-351/351 Sequence Identity: 28% (16 aa) ENLSNLILEGERPTLDLE-KLDA----DIRNIIERCWNQ--NKRSTFSEISISLKE | ....|.|| |||. . . . . |. ||.. .|| .||.| |.. EQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | Gdt6.AA | TK | 1370-1434 | 17 | 0.000548 | 8.41 | In-house | 376-486 (486) | Show / Hide |
Range on Protein: 1370-1434 Range on HMM: 376-486/486 Sequence Identity: 17% (19 aa) DVYEFGITFYETML--EETPEN-LSN---------------LILE-----------GERPTLD--LEKLD-------------ADIRNIIERCWNQN--K ||. ||.. .| . .|.. .|| | . |.| . | ... .. .||. . . DVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPED RSTFSEISISL | |||.. | RPTFSQLHEQL |
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| Kinase | Gdt6.AA | MLK | 1394-1434 | 27 | 0.001907 | 7.97 | In-house | 250-291 (291) | Show / Hide |
Range on Protein: 1394-1434 Range on HMM: 250-291/291 Sequence Identity: 27% (12 aa) ILEGERPTLDLEKLDADIRNIIERCWNQN--KRSTFSEISISL ...|.||.. . .. . . ...||||. || .|..| | AYNGLRPPIPST-CPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | Gdt6.AA | TKL-Unique | 1410-1434 | 33 | 0.002768 | 7.65 | In-house | 264-290 (290) | Show / Hide |
Range on Protein: 1410-1434 Range on HMM: 264-290/290 Sequence Identity: 33% (9 aa) DIRNIIERCWNQN--KRSTFSEISISL ..|..|..||... .| .|.|| .| EYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | Gdt6.AA | Pkinase_Tyr | 1409-1434 | 35 | 1.221059 | 2.79 | Pfam | 243-270 (270) | Show / Hide |
Range on Protein: 1409-1434 Range on HMM: 243-270/270 Sequence Identity: 35% (10 aa) ADIRNIIERCW--NQNKRSTFSEISISL ..| ... .|| . ..| ||||| | DEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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