Gene Gdt9 (Slime mold)

Gdt9

Species: Slime mold
Alias: Gdt9, DDB0206258c, DdisK217
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: Gdt

Sequence

Name Sequence Type Origin Length Description Download
Gdt9.AA Protein None 1577 None Fasta, JSON
Gdt9.kin_dom Protein Kinase Domain None 277 None Fasta, JSON

Protein domain

Protein domains of Gdt9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Gdt9.AA Gdt 1290-1569 63 7.80000000001e-219 733.28 In-house 1-289 (289) Show / Hide 
Range on Protein: 1290-1569
Range on HMM: 1-289/289
Sequence Identity: 63% (186 aa)

LDFDEICGQGTYGMVYKGKWRSQVVAIKMMRVGTVN--------CDEVYREMDIMGKIRHQNVISFIGCVVSLEHLCIVTEFSPIGSLGDLIHGDNNQKK
.||.|.|.|||.||||||.|||..||.||.....||        |||.||||||..||.|||..||||||....|.|||||..|.||||..||...||||
IDFKEYCSQGTFGMVYKGIWRSSQVAVKMFKHHYVNYTKTYSQSCDEIYREMDILSKIKHQNIVSFIGCVHFSSHHCIVTEYCPRGSLGYYIHQKKNQKK

SNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCGIIHRDLKPDNVLVFDINHNAPVCAKISDFGTSKETNEFSNKNTNCVGTPI
||||||||||||||||||||||||.|....||.||.||||.|||||||.|||||||||||.|.|..|.|..|||||.|||||||.|||..|||||. |..
SNTNTITNTITNTNTNTNTSTSTSIKMSMIQKIRIMIDIAKGCQFLHQNGIIHRDLKPDNILIFSTNENSEVCAKICDFGTSKEINEFHCKNTNCG-TMN

YMSNEILEKKTYDNSTDVYSFAVLFYEMMIEEVPFSEIDEKWEIPSKVISGWRPTKGLNSLDR-DIKNLINICWAP--HSLPSFDEIVFSL
||||||.|...|..|||||||..||||||||..||.|| ..||||..|..|||||......|. ||.|.|..||..  |..|.||||. .|
YMSNEIFEGENYQKSTDVYSFGILFYEMMIERIPFHEI-CHWEIPNFVQDGWRPTLDQDIFDDNDIRNIIECCWNKNPHKRPTFDEISKHL
Kinase Gdt9.AA TKL 1296-1569 21 2.9e-89 302.85 In-house 1-364 (364) Show / Hide 
Range on Protein: 1296-1569
Range on HMM: 1-364/364
Sequence Identity: 21% (87 aa)

CGQGTYGMVYKGKWRS----------QVVAIKMMRVGTVNC----------------------------DEVYREMDIMGKIRHQNVISFIGCVVSLEH-
 |.|..| |||||||           ..||.|....  ...                            ..  .|. .| ..||.|...|.|.. . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCIVTEFSPIGSLGDLIHGDNNQKKSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCG--------IIHRD
            ||||.|. | ||| ...|                                     |..|.|.|||||...||...        |||||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRD

LKPDNVLVFDINH---------NAPVCAKISDFGTSKETNEFSN-------------------KNTNCVGTPIYMSNEILEKK----------------T
||..|.||.. ..         ||..|.||.|||.|.. .. .|                   .. ...||| .|. |.|...                .
LKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFE

YDNSTDVYSFAVLFYEMMIEEVPFSEIDEK---------WEIPSKVISGWRPTKG-----------LNSLDRDIKNLINICWAP--HSLPSFDEIVFSL
|. ..|||||.....|..  ..|......          ...   .  | ||.              .. ....|.|.  ||..  .. |||.||.  |
YSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Gdt9.AA LRRK 1290-1571 24 2.6e-57 196.7 In-house 1-351 (351) Show / Hide 
Range on Protein: 1290-1571
Range on HMM: 1-351/351
Sequence Identity: 24% (94 aa)

LDFDEICGQGTYG-MVYKGKWRS----------------------------QVVAIKMMRVG-----TVNCD---------------------------E
| . |  |.|..|  ||..|||.                            | |||| . ..     .  |.                           .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDND-CNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

VY----REMDIMGKIRHQNVISFIGCVVSLEHLCIVTEFSPIGSLGDLIHGDNNQK----KSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDI
..    .|. || . .| |..| .|  .....||.|.|. |.|.| ...|   . .    |                        ....   ||.||..|
AFREFRHEVWIMSHLNHPNIVSLKG--FCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMK------------------------AHISWMLKLKIALQI

ARGCQFLHQCG--IIHRDLKPDNVLVFDINHN-------APVCAKISDFGTSK----ETNEFSNKNTNCVGTPIYMSNEILEK---KTYDNSTDVYSFAV
|.| ..|| .   |||||||..|.|.. .. |       |.|||||.|||.|      .... ..   |||.|..|. ||. .   ..|.  .|.|||..
AKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKG---CVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGM

LFYEMMIEE-VPFSEID--EKW----EIPSKVISGWRPTKGLN-SLDR----DIKNLINICWAPHSL--PSFDEIVFSLVK
. .| .  .  || |.|   .     .|  |.|.| |||   .  . .    . ..||. ||. . .  |.| .||  |  
ILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Gdt9.AA MLK 1290-1569 26 2e-56 193.78 In-house 1-291 (291) Show / Hide 
Range on Protein: 1290-1569
Range on HMM: 1-291/291
Sequence Identity: 26% (82 aa)

LDFDEICGQGTYGMVYKGKWRSQV-----VAIKMMR-------VGTVNCDEVYREMDIMGKIRHQN----VISFIGCVVSLEH-LCIVTEFSPIGSLGDL
..| |..| |..| |.||.|| .      ||.|. |       .     ... .|  .  ...|.|    .| | |.  . .. .|||.|. . ||| ..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IHG-DNNQKKSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCG---IIHRDLKPDNVLVFD--INHNAPVCAKISDFGTSKET
.|| ...   .|               .     .   .. .....| ..||| ..||.     |||||||. |.|. .    . .   .||.|||||.. 
LHGARSKWMDAN---------------HNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDW

NEFSNK-NTNCVGTPIYMSNEIL---EKKTYDNSTDVYSFAVLFYEMMIEEVPFS-EIDEKWEIPSKVISGWRPTKGLNSLDRDIKNLINICWA--PHSL
..   .  ..  ||...|. |..   .  .|. . ||.|..|...||.  |||.. ..|.   .   .  | ||. . .  .. .|.|...||   ||. 
HQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST-CPEHWKKLMKQCWNQDPHKR

PSFDEIVFSL
|||..||  |
PSFRQIVQHL
Kinase Gdt9.AA S_TKc 1290-1576 22 2.1e-46 161.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 1290-1576
Range on HMM: 1-231/231
Sequence Identity: 22% (68 aa)

LDFDEICGQGTYGMVYKGKWRS--QVVAIKMMRVGTVNCDEVYREMDIMGKIRHQNVISFIGCVVSLEHLCIVTEFSPI--GSLGDLIHGDNNQKKSNTN
 .. .. |.|..| |||.....  ..||||...      . ..||..|. | .| |.. .... .. .||..|.|. .   |.| |.|.  . ...    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR---

TITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCGIIHRDLKPDNVLVFDINHNAPVCAKISDFGTSKETNEFSNKNTNCVGTPIYMSN
                     ...  .  ...  |... ...|. |||||||||.|.|. .       . ||.||| ...        | ..||| ||. 
--------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------TTFCGTPWYMAP

EILEKKTYDN-STDVYSFAVLFYEMMIEEVPFSEIDEKWEIPSKVISGWRPTKGLNSLDRDIKNLINICWA--PHSLPSFDEIVF--SLVKIFKRF
|.|    |.  . |..|. ...|||.  . ||.      .   |.|            ... |..|. |.   |   |.  |.    ...|.   |
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Gdt9.AA Pkinase 1290-1525 23 1.1e-42 152.02 Pfam 1-227 (293) Show / Hide 
Range on Protein: 1290-1525
Range on HMM: 1-227/293
Sequence Identity: 23% (61 aa)

LDFDEICGQGTYGMVYKGKWRSQV--VAIKMMRVGTVNCDEVYR-----EMDIMGKIRHQNVISFIGCVVSLEHLCIVTEFSPIG----SLGDLIHGDNN
. . .. |.|..| |||.....    ||.| ... . .... ..     |  || ...| |.. ..... .  |...|.|. . |    .| |.|..   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

QKKSNTNTITNTITNTNTNTNTSTSTSTKL--TVKQKLRIAIDIARGCQFLHQCGIIHRDLKPDNVLVFDINHNAPVCAKISDFGTSKET-NEFSNKNTN
                        . ....  . ..  ...  |.|| ...|..|||||||||.|.|. . .|... | ||.||| .|   .  .  .| 
------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTT

CVGTPIYMSNEILE-KKTYDNSTDVYSFAVLFYEMMIEEVPFSEI------DEKWEI
 .||| ||. |..   . |. . |..|. ...|||.  . ||..       |... |
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMI
Kinase Gdt9.AA TyrKc 1290-1569 23 1.4e-42 148.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 1290-1569
Range on HMM: 1-280/280
Sequence Identity: 23% (75 aa)

LDFDEICGQGTYGMVYKGKWRSQVVAIKMMRVGTVNCDEVYREMDIMGKI--RHQNVISFIGCVVSL-------EHLCIVTEFSPIGSLGDLIHGDNNQK
. .... | | .| ||||.|. . ||.||.. ..    . .||. || |.  .|.|.. ..|....        | |.||.|. | |.| | ..   .. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

KSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCGIIHRDLKPDNVLVFDINHNAPVCAKISDFGTSKETNEF-------SNKN
                           |..|..| ....||.|...||. ..|||||   |.|| . .     ..|||||| |..  .        . . 
---------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYR

T----NCVG-TPI-YMSNEILEKKTYDNSTDVYSFAVLFYEMM-IEEVPFSEI----DEKWEIPSKVISGWRPTKGLN--------SLDRDIKNLINICW
.    .. .  ||  |. | . ....   .||.|| |. .|..   . | ...     .  |.  .| .| |. .  |          |   . ..  ||
KKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCW

APHSL--PSFDEIVFSL
.      |.| ||.  .
HEDPEDRPTFSEIHECF
Kinase Gdt9.AA STE 1290-1535 19 1.4e-42 147.83 In-house 1-299 (359) Show / Hide 
Range on Protein: 1290-1535
Range on HMM: 1-299/359
Sequence Identity: 19% (66 aa)

LDFDEICGQGTYGMVYKGKWR-----------------SQVVAIKMMRVGTVN------------------CDEVYREMDIMGKIR--HQNVISFIGCVV
... |. |.|..| |||.. .                  ...||| |.. . |                   ... .|..|| | .  |.|.. ..|| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SL-------EHLCIVTEFSPIGSLGDLIH-------GDNNQKKSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARG-CQFLHQCGIIHRDL
         ..|.|. |. . ||| |.|.       ..|....                       ....  .|  .|. .| .|  ..||. .|||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ---------------------H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDI

KPDNVLVFDINHNAPVCAKISDFGTSKETNE----------------FSNKNTNCVGTPIYMSNEILEK------KTYDNSTDVYSFAVLFYEMMIEEVP
||.|.|.          .|..|||...  ..                 . |.. .|||| .|. |....      | || . |..|.  .  ||   ..|
KPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP

FSEIDEK---WEIPSKVISGW---------RP
...       ..|| . ....          |
WHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGP
Kinase Gdt9.AA TK 1290-1510 16 5.1e-42 138.15 In-house 1-388 (486) Show / Hide 
Range on Protein: 1290-1510
Range on HMM: 1-388/486
Sequence Identity: 16% (66 aa)

LDFDEICGQGTYG---MVYKGKWRS---------------------------QVVAIKMMRVG-TVNCDEVYR--------------EMDIMGKIR----
. . .  |.| .|   .||||.||.                           . ||.||.. | . . .|                 |. .| . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HQNVISFIGCVVSL------------EHLCIVTEFSPIGS----LGDLIH--GDNNQKKSNTNT------------ITNTITNTNTNTNTSTSTSTK--
 |.|.....|...              |...||.|. | |.    | |  .   .. |. ....             ..               .  |  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC---------------M--KGD

------------------------------------------------LTVKQKLRIAIDIARGCQFLHQC------GIIHRDLKPDNVLVFDINH----
                                                ||..|.| .. .||.|...||..      ...||||   |.||.. |.    
ITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWH

--NAPVCAKISDFGTSK-----------ETNEFSNKNTNCVGTPI-----------------------YMSNEILE---------KKTYDNSTDVYSFAV
  . . ..||.||| |.           .  .   |..  .|.|.                       .|. | |.         ....   .||.|| |
FDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGV

LFYEMM
| .|..
LMWEIF
Kinase Gdt9.AA Pkinase_Tyr 1290-1510 25 3.3e-39 133.42 Pfam 1-208 (270) Show / Hide 
Range on Protein: 1290-1510
Range on HMM: 1-208/270
Sequence Identity: 25% (62 aa)

LDFDEICGQGTYGMVYKGKWR------SQVVAIKMMRVGTVNC----DEVYREMDIMGKI-RHQNVISFIGCVV-SLEH--LCIVTEFSPIGSLGDLIHG
. |..  |.| .|.||||.|.       . ||.||.. |.       ..  ||. || .. .|.|.....|...   |.  ..||.|. | |.| |  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

DNNQKKSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCGIIHRDLKPDNVLVFDINHNAPVCAKISDFGTSKET--NEFS-NK
                           .   .||.|..| ....||.|...|.. ..|||||   |.|| .     . ..||.||| ..     .    |
HR-------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----NNVVKICDFGLARDIYNDDYYYRK

NTNCVGTPI-YMSNEILEKKTYDNSTDVYSFAVLFYEMM
 ...   ||  |. | .  . .   .||.|| || .|..
RGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF
Kinase Gdt9.AA ULK 1290-1518 22 1.6e-38 132.09 In-house 1-258 (329) Show / Hide 
Range on Protein: 1290-1518
Range on HMM: 1-258/329
Sequence Identity: 22% (64 aa)

LDFDEICGQGTYGMVYKGK-WRS-----QVVAIKMMRVGTVNCDE-----------VYREMDIMGKIR--------HQNVISFIGCVVSLEH--LCIVTE
   ... |.|..| ||||.  ..     ..||.||.   . | ..           . .| .|| |.         |.|.. .. .  .  |  . |..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FSPIGSLGDLIH---------GDNNQKKSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCGIIHRDLKPDNVLVFD-------
. . | | ..|.                                      .  .|. .. . . ..|. |...||. .|||||.||.|.|. .       
YCNGGDLEQYIKKNKKLPEDTE----------------------------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDS

--INHNAPVCAKISDFGTSKETNEF---SNKNTNCV------GTPIYMSNEILE----KKTYDNS-TDVYSFAVLFYEMMIEEVPFSE
    |   ...||.||| .|  ...    . .. ||      |||.||. .||.    .| |... .|..|. ..||||   ..||..
KKV-HP-NGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYA
Kinase Gdt9.AA ULK 1290-1518 22 2.4e-37 130.11 In-house 1-254 (324) Show / Hide 
Range on Protein: 1290-1518
Range on HMM: 1-254/324
Sequence Identity: 22% (65 aa)

LDFDEICGQGTYG-MVYKGK-WRS----QVVAIKMMRVGTVNCDEV-----------YREMDIMGKIR---HQN--VISFIGCVVSLEH--LCIVTEFSP
   ... |.|..|  ||||.  ..    |.||.||.     | ..             .|  || |.    |.|  .. .. .  .  |  ..|..|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

IGSLGDLIH--------GDNNQKKSNTNTITNTITNTNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCGIIHRDLKPDNVLVFD---------IN
 | | ..|.                                     .  .|. .. . . ..|. |...||. .|||||.||.| |. .           
GGDLEQYIKKNKKLPETE----------------------------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKV-

HNAPVCAKISDFGTSKETNEFS---NKNTNCV------GTPIYMSNEILE----KKTYDNS-TDVYSFAVLFYEMMIEEVPFSE
|   ...||.||| .|  .. .   .... ||      |||.||. .||.    .| |... .|..|. ..||||   ..||..
HP-NGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFS
Kinase Gdt9.AA TKL-Unique 1394-1569 32 2.5e-37 129.24 In-house 93-290 (290) Show / Hide 
Range on Protein: 1394-1569
Range on HMM: 93-290/290
Sequence Identity: 32% (66 aa)

TNTNTNTSTSTSTKLTVKQKLRIAIDIARGCQFLHQCG--IIHRDLKPDNVLVFDINHNAPVCAKISDFGTSKETNEFSNKNTNC----------VGTPI
.| | |   . ..||. .|....|||||.|. .|| |.  |||||||. |.||   .  |.. .||.|||.|| .|  .||.||           .|...
QNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK-FNSKINKMTNNEHKGTRNQTRCGSFR

YMSNEILEK--KTYDNSTDVYSFAVLFYEMMIEEV------PFSEIDEK--WEIPSKVISGWRPTKGL-NSLDRDIKNLINICWAPHSL--PSFDEIVFS
.|. |.|.   ..|... |||||..  .|.   ..      |....| .   |.  ..  . ||.  . |..  ....||. ||.. .   ||||||. .
WMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPP--IPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHR

L
|
L
Kinase Gdt9.AA Dicty4 1409-1571 31 2.5e-26 84.97 In-house 110-277 (277) Show / Hide 
Range on Protein: 1409-1571
Range on HMM: 110-277/277
Sequence Identity: 31% (54 aa)

TVKQKLRIAIDIARGCQFLHQ--CGIIHRDLKPDNVLVFDINHNAPVCAKISDFGTSK---ETNEFSNKNTNCVGTPIYMSNEILEKKTYDNSTDVYSFA
..|. .|.|.|.||| . ||   . |||||||..| || |.| .    .|..||| |.   .  ... . .  .||| .|. |.. .. |. . |||||.
LIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV-DKNWR----VKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFG

VLFYEMMIEEVPFS-EIDEKWEIPSKVIS-GWRPTKGLNSLDRDIKNLINICW--APHSLPSFDEIVFS--LVK
 . .|.   . |.. ....  ..   | . . ||    . ... .| ||. ||   | . ||| ||..   |  
IVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPS-WKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Gdt9.AA Dicty4 1290-1374 35 6.6e-19 59.85 In-house 1-94 (277) Show / Hide 
Range on Protein: 1290-1374
Range on HMM: 1-94/277
Sequence Identity: 35% (33 aa)

LDFDEICGQGTYGMVYKGKWRSQVVAIKMM---RVG--TVNCDEVYREMDIMGKIRHQNVISFIGCVV----SLEHLCIVTEFSPIGSLGDLIH
...... |.| .| ||||.|| . ||.|..    ..       |  .| .||.|||| |.. | |         . .|||||. | |.|  |.|
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH
Kinase Gdt9.AA TKL-Unique 1292-1385 33 2.1e-17 58.06 In-house 1-109 (290) Show / Hide 
Range on Protein: 1292-1385
Range on HMM: 1-109/290
Sequence Identity: 33% (36 aa)

FDEICGQGTYGMVYKGKWRSQVVAIKMMRV--GTVNC--DEVYREMDIMGKIR-HQNVISFIGCVV----SLEHLCIVTEFSPIGSLGDLIH------GD
| .  |.|.|| |||||||.  ||||   .  .  |   .| ..|  .| |.. | |.  ..|  .    .  ..|||.|. | ||| |..|        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

NNQKKSNTN
||... ...
NNNNCKLNM
Kinase Gdt9.AA TK 1543-1569 19 0.099109 0.71 In-house 445-486 (486) Show / Hide 
Range on Protein: 1543-1569
Range on HMM: 445-486/486
Sequence Identity: 19% (8 aa)

D-------------RDIKNLINICWA--PHSLPSFDEIVFSL
|              ..  |.  ||.  |   |.|....  |
DWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL