Gene HH498 (Slime mold)

HH498

Species: Slime mold
Alias: HH498, DDB0230019, DdisK238
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
HH498.AA Protein None 908 None Fasta, JSON
HH498.kin_dom Protein Kinase Domain None 275 None Fasta, JSON

Protein domain

Protein domains of HH498.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank HH498.AA Ank 362-394 33 5.7e-05 22.18 Pfam 1-33 (33) Show / Hide 
Range on Protein: 362-394
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

SNNTPLNLASLSGNLSLAKILLNSGARLSIDNL
  .||| ||...|... .| ||. || . . . 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 395-427 24 0.001314 17.27 Pfam 1-33 (33) Show / Hide 
Range on Protein: 395-427
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

NGRYPIHNACVNGNIDLIRYFLELYSKMNSTTL
.|. | | || .|... ....|.     | .. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 330-361 36 0.005893 14.92 Pfam 1-33 (33) Show / Hide 
Range on Protein: 330-361
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

KGMLPIHYHSLNGHVDVVKCLID-DSTINALDQ
 |. | |. ...||..|||.|..    .|| | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank HH498.AA Ank 495-518 25 32.565781 1.42 Pfam 1-24 (33) Show / Hide 
Range on Protein: 495-518
Range on HMM: 1-24/33
Sequence Identity: 25% (6 aa)

ENNTPIDLLVLNNHFTIAIELLKY
. .||  | ....|  .. .||..
DGFTPLHLACRCGHTEVVKMLLQH
Kinase HH498.AA HH498 530-805 52 5.5e-224 717.63 In-house 1-284 (284) Show / Hide 
Range on Protein: 530-805
Range on HMM: 1-284/284
Sequence Identity: 52% (149 aa)

FKTARKIGAGAFGDVYLVEWRNKNVAVKRVKIEKILESGKSYQWIRDKFILEAVLMVKLSNFSSFVKLYATCIEEKELLLVLEFCDNGSLYTILNTIPIG
.....|||.|.||.||..|||||.|||||...........|||||.|.|..|...|..|.........||.|........|...||||||..||||||||
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIG

GAGANNNNNNNNNNDIIQSLPSINTLSLNIANGMNYLHS-LKPQIIHRDLTSQNILIDRNGIAKIADFGISRFKNDIGDKTMTS-IGNPRFRSPEVTK-G
||||||||.|..||..|..|.|..|.|...|.||||||. ||..||||||.|.||||...|.|..||||.|||..|..|..||. .||.|...|||.. .
GAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQC

QKYSEKVDVFGFGMILYEMFTRRVPFHDYEQIAASFKIANAE-RPPLPQT----IDHRWSNLIQICWDQNPNNRPSFDQILTII
||||.|||||...|...||.||.||||.|...||....|... |||.|||    |.|.||||||.||...|.|||.||||.||.
QKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase HH498.AA MLK 530-805 35 1.6e-132 446.57 In-house 1-291 (291) Show / Hide 
Range on Protein: 530-805
Range on HMM: 1-291/291
Sequence Identity: 35% (105 aa)

FKTARKIGAGAFGDVYLVEWRNKN-----VAVKRVKIEKILESGKSY--QWIRDKFILEAVLMVKLSNFSSFVKLYATCIEE-KELLLVLEFCDNGSLYT
... ..||.|.||.|.. .||||.     ||||||..... .....|  ||  .... ..  . .. |.......|..|... .....|.|.|..||||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ILNTIPIGGAGANNNNNNNNNNDIIQSLPSINTLSLNIANGMNYLHSLKP-QIIHRDLTSQNILIDR------NGIAKIADFGISRFKNDIGDKTMTS-I
.|.........||   .|.. ||..... .... .|..|.||.||||..| .|||||| |.|||||.      .|..||.|||.||...... ..|.| .
VLHGARSKWMDAN---HNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA

GNPRFRSPEVT---KGQKYSEKVDVFGFGMILYEMFTRRVPFH-DYEQIAASFKIANAE-RPPLPQTIDHRWSNLIQICWDQNPNNRPSFDQILTII
|......|||.   ...|||||.||. .|..|.||.||.||.. .|...|. ...|. . |||.|.|....|..|...||.|.|..||||.||... 
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase HH498.AA TKL 536-805 27 6.8e-97 328.21 In-house 1-364 (364) Show / Hide 
Range on Protein: 536-805
Range on HMM: 1-364/364
Sequence Identity: 27% (105 aa)

IGAGAFGDVYLVEWRN----------KNVAVKRVKIEKILESGKSYQWI-----------------RDKFILEAVLMVKLS-NFSSFVKLYATCIEEKE-
|| |.|| ||  .||.          | ||||. |..   |. |. |..                 . .| .| ..|.... .    |.... |....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LLLVLEFCDNGSLYTILNTIPIGGAGANNNNNNNNNNDIIQSLPSINTLSLNIANGMNYLHSLK------PQIIHRDLTSQNILIDRN
            | .| |.|..|||. .|.                        .. .  ..| || ||||||| .      |.||||||.|.|||.|.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN

GI--------------AKIADFGISRFKNDIGD-------------------KTMTSIGNPRFRSPEVTKGQ----------------KYSEKVDVFGFG
.               .||.|||.|||..  |.                   .||| .|.||. .||| .||                .||||.||. ||
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

MILYEMFTRRVPFHDYEQ----------IAASFKIANAERPPLP------------QTIDHRWSNLIQICWDQNPNNRPSFDQILTII
..|.|..||..|..||            . ..  . . .|||.|             ........|.| |||..|..||||..|| ..
IVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase HH498.AA TKL-Unique 532-805 33 2e-79 270.15 In-house 1-290 (290) Show / Hide 
Range on Protein: 532-805
Range on HMM: 1-290/290
Sequence Identity: 33% (101 aa)

TARKIGAGAFGDVYLVEWRNKNVAVKRVKI-EKILESGKSYQWIRDKFILEAVLMVKLSNFSSFVKLYATCI----EEKELLLVLEFCDNGSLYTILNTI
   |||.|..| || ..|| . ||.|. .. |..  .      ....|. |  .| ||      |.....|.     .... .|.|.|. ||||  |.. 
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNE------MMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQ-

PIGGAGANNNNNNNNNNDIIQSLPSINTLSLNIANGMNYLHSLKPQIIHRDLTSQNILIDRN-----GIAKIADFGISRFKNDIGDKTMTSI--------
       |||||||||| .  ..  .... . || ||.|||...| ||||||.|.|.|.|.|       .||.|||.|.|.. | ..| . .        
-------NNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTR

-GNPRFRSPEVTKG--QKYSEKVDVFGFGMILYEMFTRRV------PFHDYEQIAASFKIAN---AERPPLPQTIDHRWSNLIQICWDQNPNNRPSFDQI
 |..| ..|||...   .||||.||. ||..|.|..|| .      |.....|..   ...      |||.|. .  . ..||| ||...| .|||||.|
CGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEI

LTII
.. .
IHRL
Kinase HH498.AA Dicty4 659-807 40 1.1e-56 187.7 In-house 121-277 (277) Show / Hide 
Range on Protein: 659-807
Range on HMM: 121-277/277
Sequence Identity: 40% (65 aa)

IANGMNYLHSLKPQIIHRDLTSQNILIDRNGIAKIADFGISR-FKNDI--GDKTMTSIGNPRFRSPEVTKGQKYSEKVDVFGFGMILYEMFTRRVPFH--
.| |||.||.  | |||||| | |.|.| |  .|..|||.|. .| ..  .|..|| .| |   .|||  .| | ||.||. ||..|.|..||  |.   
AARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKH

--DYEQIAASFKIAN-AERPPLPQTIDHRWSNLIQICWDQNPNNRPSFDQILTI--IQN
  .|.|....  ..|  .|||.|.  . .|. ||| ||| .|..|||| .|. .     
HMPYMQFVRA--VCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase HH498.AA Pkinase 530-805 26 2.1e-54 191.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 530-805
Range on HMM: 1-293/293
Sequence Identity: 26% (84 aa)

FKTARKIGAGAFGDVYLVEWRNKN--VAVKRVKIEKILESGKSYQWIRDKFILEAVLMVKLSNFSSFVKLYATCIEEKELLLVLEFCDNG----SLYTIL
... ||||.|.|| ||.  ... .  ||||..| ... .. . . . .     |. .| .| |    |.|| .. ..... .|.|.|..|    .|....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

NTIPIGGAGANNNNNNNNNNDIIQ--SLPSINTLSLNIANGMNYLHSLKPQIIHRDLTSQNILIDRNGIA----KIADFGISRFK-NDIGDKTMTSIGNP
 |                 ..     |   .    . |. |..|.||    |||||| ..|||||.||      ||.|||..... .  .  ..|  | |
ST----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP

RFRSPEVTK-GQKYSEKVDVFGFGMILYEMFTRRVPFHDY----EQIAASFKIANAERPPLPQTID-----------------------HRWSNLIQICW
....||| . ||.|. |||....| |||||...| || .     . .   ..|..  .|||.  ..                            .|  |.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

DQNPNNRPSFDQILTI--I
...|. ||...|||    .
CKDPKKRPTAEQILQHPWF
Kinase HH498.AA LRRK 655-807 36 2.6e-54 186.77 In-house 169-351 (351) Show / Hide 
Range on Protein: 655-807
Range on HMM: 169-351/351
Sequence Identity: 36% (68 aa)

LSLNIANGMNYLHSLKPQIIHRDLTSQNILI---D---------RNGIAKIADFGISR-FKNDIGDK-TMTSIGNPRFRSPEVTKGQ---KYSEKVDVFG
..|.|| ||.|||| .| ||||||.| |||.   .          . .|||||||||| |   .. . .... |||....||. ..     |.||||.. 
IALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYS

FGMILYEMFTRR-VPFHDYE-------QIAASFKIANAERPPLPQT-IDH-----RWSNLIQICWDQNPNNRPSFDQILTIIQN
|||||.|  ||.  || ...       ..  . || .  ||..||.   .     . ..||| ||...|..||.| ||. ..  
FGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase HH498.AA S_TKc 530-810 25 5.2e-50 173.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 530-810
Range on HMM: 1-231/231
Sequence Identity: 25% (75 aa)

FKTARKIGAGAFGDVYLVEWRN--KNVAVKRVKIEKILESGKSYQWIRDKFILEAVLMVKLSNFSSFVKLYATCIEEKELLLVLEFCDN--GSLYTILNT
..  |||| |||| ||.. ...  . ||.|..|               .... |  .. |  .    |||| .. . ..| .|.|.||.  |.|....  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

IPIGGAGANNNNNNNNNNDIIQSLPSINTLSLNIANGMNYLHSLKPQIIHRDLTSQNILIDRNGIAKIADFGISRFKNDIGDKTMTSIGNPRFRSPEVTK
 . .|            ..   .   .  .   |.....|.||.  .||||||  .|||.|.    ||.|||..|.        .| .| | ...|||  
RGRHG------------LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-

GQKYSE-KVDVFGFGMILYEMFTRRVPFHDYEQIAASFKIANAERPPLPQTIDHRWSNLIQICWDQNPNNRPSFDQILT----IIQNLPI
  .|.  |.|.  .| |||||.... ||.   |... ||.            ..   ..|. |.. .|..||.  ..|.    | .   .
--GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HH498.AA STE 530-804 23 6.5e-50 172.14 In-house 1-359 (359) Show / Hide 
Range on Protein: 530-804
Range on HMM: 1-359/359
Sequence Identity: 23% (87 aa)

FKTARKIGAGAFGDVYLVEWRN---KN--------------VAVKRVKIEKIL------ESGKSY-----QWIRDKFILEAVLMVKLSN-FSSFVKLYAT
..  .||| |||| ||.   ..    .              .|.|....|.        |. .       . ...... |  .| |...     || | .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

CIEE-------KELLLVLEFCDNGSLYTILNTIPIGGAGANNNNNNNNNNDIIQSLPSINTLSLNIANG-MNYLHSLKPQIIHRDLTSQNILIDRNGIAK
.. |        || ...|..|.|||  |...  . | . |.|.          . . | .    |  | ..||||..  |||||. ..|||.     .|
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ---H-QHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VK

IADFGISRFKNDIGD----------------KTMTSIGNPRFRSPEVTKG------QKYSEKVDVFGFGMILYEMFTRRVPFHDYEQIAASFKIANA---
..|||..   .|...                |. | .| | . .||| ..      ..|..|.|.  .|  . || | ..|.||.    | | |..    
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

------------ERPPLPQTID---------------HRWS----NLIQICWDQNPNNRPSFDQILT-----I
            . ||||....               |.||    . |. | . .||.||. .| |      |
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase HH498.AA Dicty5 657-809 40 5e-46 156.41 In-house 111-260 (260) Show / Hide 
Range on Protein: 657-809
Range on HMM: 111-260/260
Sequence Identity: 40% (62 aa)

LNIANGMNYLHSLKPQIIHRDLTSQNILIDRNGIAKIADFGISRFKNDIGDKTMTS-IGNPRFRSPEVTKGQKYSEKVDVFGFGMILYEMFTRRVPFHDY
. ||..| .|||    |||||| | |.||  |  .|| |||.|||      . ||  .| . . ..|. .|| | .|.||. || .|.|||||  |. . 
IDIAQSMRHLHSM--NIIHRDLKSMNFLITENWKIKIIDFGTSRFVDN--RYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNI

EQIAASFKIANAERPPLPQTIDHRWSNLIQICWDQNPNNRPSFDQILTIIQNLP
 ..     ..  ||| .| ..    ||||  || | | |||||  |. ... . 
NNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase HH498.AA Pkinase_Tyr 530-805 25 6.6e-46 156.1 Pfam 1-270 (270) Show / Hide 
Range on Protein: 530-805
Range on HMM: 1-270/270
Sequence Identity: 25% (75 aa)

FKTARKIGAGAFGDVYLVEWR------NKNVAVKRVKIEKILE-SGKSYQWIRDKFILEAVLMVKLSNFSSFVKLYATCI-EEKE--LLLVLEFCDNGSL
 .  .|.|.||||.||. .|.      .  |||| .|     |        .|..|. || .| .| .    |.||. |. ...   ...|.|.. .|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN------CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

YTILNTIPIGGAGANNNNNNNNNNDIIQSLPSINTLSLNIANGMNYLHSLKPQIIHRDLTSQNILIDRNGIAKIADFGISRFKNDIGDK-TMTS--IGNP
.. | .                ...   ... .   .. ||.||.||.| .  .|||||   |.|...|...||.||| .|   . .   ....      
LDYLRKHR--------------EDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPI

RFRSPEVTKGQKYSEKVDVFGFGMILYEMFT-RRVP-FHDYEQIAASFKI-ANAERPPLPQTIDHRWSNLIQICWDQNPNNRPSFDQILTII
.  .||. .  |...| ||  ||  ..|.||  . | . .        .|  . .| | |.       .|.. ||...|..||.| .|. ..
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HH498.AA CZAK 655-805 39 1.1e-45 158.14 In-house 110-279 (279) Show / Hide 
Range on Protein: 655-805
Range on HMM: 110-279/279
Sequence Identity: 39% (68 aa)

LSLNIANGMNYLHS-LKP-QIIHRDLTSQNILIDRN-G------------IAKIADFGISRFKNDIGDKTMTSIGNPRFRSPEVTKGQKYSEKVDVFGFG
. . || ||||||   ||  |.||||.|.||| | .              |.||.||| || .   .     ..|   .  ||. ||  |.|||||. ||
MAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYSFG

MILYEMFTRRVPFHDYEQIAASFKIANAE--RPPLPQTIDHRWS---NLIQICWDQNPNNRPSFDQILTII
|||... | . |  . . .   .  |  |  |||.||..|  |     ||  ||. ||  |||| ||| . 
MILWCIITCDQPYQNMQPMKMAH-LAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase HH498.AA Ciliate-E2-Unclassified 530-802 21 2.2e-45 155.37 In-house 1-347 (352) Show / Hide 
Range on Protein: 530-802
Range on HMM: 1-347/352
Sequence Identity: 21% (80 aa)

FKTARKIGAGAFGDVYLVEWRNKNVA-------VKRVKIEKILESGKSYQWIR--DKFILEAVLMVK---------LSNFSSFVKLYATCIEEKE--LLL
.|  ..|| |.||.||... .... .       .....  |. .. .   .      ....    ..         |.|. . ....   .....  . .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLEFCDNGSLYTILNT------IPIGGAGANNNNNNNNNNDIIQSLPS--------IN-----TLSLNIANGMNYLHSLKPQIIHRDLTSQNILIDRNG-
|.|.|..|.|  ...       .                ||. ... .        .      ..   | .| .|||. .  |||||.. .|||.| || 
VMEYCEGGDLWQYIKKRKKQKQK---------------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGK

--IAKIADFGISRFKNDI--------------GDKTMTSI-GNPRFR----SPEVTKGQKYS----EKVDVFGFGMILYEMFTRRVPFHDYE--------
    ||.|||||.. ..                .. |... |.|..     .||| .||.|.    .|.|....|.||||| . . || |.         
NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLI

----------QIAASFKIANAERPPLP-QTIDHRWS--------NLIQICWDQNPNNRPSFDQIL
          |.   .|  | . |. | | |...||        .|.| . . |||.|..|.|||
TQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase HH498.AA TyrKc 530-805 26 7e-43 149.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 530-805
Range on HMM: 1-280/280
Sequence Identity: 26% (83 aa)

FKTARKIGAGAFGDVYLVEWRNKNVAVKRVKIEKILESGKSYQWIRDKFILEAVLMVKL-SNFSSFVKLYATCIEE-------KELLLVLEFCDNGSLYT
 .  .|.| |||| ||. .|.  .|||| .| ..           |  |. || .| ||  .    |.||. |...       . |..|.|....|.|  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

IL-NTIPIGGAGANNNNNNNNNNDIIQSLPSINTLS--LNIANGMNYLHSLKPQIIHRDLTSQNILIDRNGIAKIADFGISRFKNDI-------GDKTMT
 | .. |                     |.    ||  . ||.||.||||   ..|||||   |.|...|...||.||| ||.  |          ....
YLRKHRPK--------------------LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKK

S--IGNP----RFRSPEVTKGQKYSEKVDVFGFGMILYEMFTR-RVPFHD-----YEQIAASFKIANAERPPLPQT--------IDHRWSNLIQICWDQN
.   |.     |  .||. .  |...| ||. ||  ..|.||.   |  .      . . .  .. . .|.| |.               .... ||. .
EHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

PNNRPSFDQILTII
|..||.| .|  ..
PEDRPTFSEIHECF
Kinase HH498.AA Dicty4 530-557 50 8.1e-08 22.34 In-house 1-28 (277) Show / Hide 
Range on Protein: 530-557
Range on HMM: 1-28/277
Sequence Identity: 50% (14 aa)

FKTARKIGAGAFGDVYLVEWRNKNVAVK
 ..  .|| |.|| ||.  || | ||||
INIEQRIGKGSFGEVYKGTWRGKEVAVK
Kinase HH498.AA CZAK 530-557 50 7e-06 17.56 In-house 1-28 (279) Show / Hide 
Range on Protein: 530-557
Range on HMM: 1-28/279
Sequence Identity: 50% (14 aa)

FKTARKIGAGAFGDVYLVEWRNKNVAVK
.|  . || | || ||   || | ||.|
LKFGQTIGQGFFGEVYKAYWRGKDVAIK
Kinase HH498.AA LRRK 530-565 35 7e-06 16.67 In-house 68-104 (351) Show / Hide 
Range on Protein: 530-565
Range on HMM: 68-104/351
Sequence Identity: 35% (13 aa)

FKTARKIGAGAFG-DVYLVEWRNKNVAVKRVKIEKIL
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LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQ