Gene Roco5 (Slime mold)

Roco5

Species: Slime mold
Alias: DdisK233, Roco5, DDB0184765
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
Roco5.AA Protein None 2800 None Fasta, JSON
Roco5.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of Roco5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RhoGEF Roco5.AA RhoGEF 247-351 25 1.9e-15 54.67 Pfam 17-131 (196) Show / Hide 
Range on Protein: 247-351
Range on HMM: 17-131/196
Sequence Identity: 25% (29 aa)

KVILDVFYQPLKK---ADLLSQEELKAIFSLIESISSFQQTILIDFKK--YISNWNSTTQAQ--LHSTF--LQ-FVGYLKLYKVYGLQYNYSLSSLCLLM
..|......||..    ..||..|.. ||| ||.| .|.|..|.|...   . .||  .. .  .   |  |. .  ..|.| .|   |..... |  ..
NIIIEHYMKPLRNCANPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMYSEYCNNYPKAMKLLKKCR

FDNQRFESFINNAES
 .|..|. |....|.
KKNPKFQQFLKWCEK
RhoGEF Roco5.AA RhoGEF 231-395 16 4.5e-05 -0.92 SMART 1-211 (211) Show / Hide 
Range on Protein: 231-395
Range on HMM: 1-211/211
Sequence Identity: 16% (35 aa)

LVEGFMKSLQGCSDAIKVILDVFYQPLKKAD------LLSQEELKAIFS-LIESISSFQQTILIDFKKYISNWN-------------STTQAQLHSTFLQ
 .  .| . .   .  ..|......|..| .      .||..|.. ||.  ||.| .|... |.. ...|..|.                . .. . |..
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK

F---VGYLKLYKVYGLQYNYSLSSLCLLM--FDNQRFESFINNAESKLVNE----HKYSLAPLVPT-----------------SSSSSCVKPVSLSEILG
.     ..|.|. |  ...|.|. |  .|   .| ||. |.. .||. ...    |...|  . ..                  .....     | . |.
WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSNSEHRLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKALD

SQYDQTTSQST
.  | ...  .
CMKDVAQHCNE
PH Roco5.AA PH 541-649 18 2.6e-09 36.25 Pfam 1-92 (92) Show / Hide 
Range on Protein: 541-649
Range on HMM: 1-92/92
Sequence Identity: 18% (20 aa)

FLKEGILIEQF-NNQRISYYTFLFSDIILFTEKIEDTSTINNNTMMAYDGSFYLLKKLERIVNIQVDDPELGFEYRKGFQIKTKES-SIFYMTSSEKEKS
  ||| |  .  . ..  .. .||.. ... ..                   | .|.   . ..||.... . . . .|||.| .  ...  ..||.|. 
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK-----------------YRPKGSIPLSDCQVTKVPDN-KRPHCFQIRT-DRRTYYFQAESEEEMN

TWFQVLSQASL
.| | ...|. 
DWMQAIQSACR
PH Roco5.AA PH 541-651 15 4.7e-09 37.31 SMART 1-82 (82) Show / Hide 
Range on Protein: 541-651
Range on HMM: 1-82/82
Sequence Identity: 15% (17 aa)

FLKEGILIEQFNNQRISYYTFLFSDIILFTEKIEDTSTINNNTMMAYDGSFYLLKKLERIVNIQVDDPELGFEYRKGFQIKTKESSIFYMTSSEKEKSTW
..||| |  . . ..  .. .||.| ......                     .|.   . ...|.. .       .|.|.. . ...  ..||.|.  |
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK-------------------KPKGSIPLSDCTVRE-P-------CFEIHH-DRTYYFQCESEEEMQEW

FQVLSQASLKS
.| . .|. ..
MQAIQKAIHNN
LRR_1 Roco5.AA LRR_1 779-801 18 15.145318 2.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 779-801
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

SITHLTLSQ-N--SIN-DPCAVALGDM
...|| ||  |  ..  .    ..  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco5.AA LRR_1 835-860 12 70.873274 0.18 Pfam 1-26 (26) Show / Hide 
Range on Protein: 835-860
Range on HMM: 1-26/26
Sequence Identity: 12% (4 aa)

SITVVILTQ-N--QITDTGAKHISK--LLKF
....  |   |  ..|..    |..  . ..
NLQHLDLSGCNCCNLTGH----IPPSCF-NL
LRR_1 Roco5.AA LRR_1 1010-1031 37 5.6e-05 21.82 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1010-1031
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLQILDLSN-N--QLS-SLPSE-ISEM
|||.||||. |  .|. ..|.. .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco5.AA LRR_TYP 1008-1030 54 6.6e-05 23.55 SMART 1-24 (24) Show / Hide 
Range on Protein: 1008-1030
Range on HMM: 1-24/24
Sequence Identity: 54% (13 aa)

LKNLQILDLSNNQLSSLPSEI-SE
| ||. ||||||||..||... . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco5.AA LRR_1 986-1008 29 0.001069 17.28 Pfam 1-26 (26) Show / Hide 
Range on Protein: 986-1008
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

DLKELYLDH-N--CIS-SIPVSILKEL
 |..|.|.. |  ... .|| |..  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco5.AA LRR_TYP 1078-1101 33 0.00849 16.54 SMART 1-24 (24) Show / Hide 
Range on Protein: 1078-1101
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LVNLKVLMMQRNYFNRLPIEIFTR
|.||..|  ..| . .|| ..|  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco5.AA LRR_1 1056-1078 29 0.011295 13.65 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1056-1078
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

KLNHLDISF-N--FIE-TINVNSLSQL
.| |||.|  |   .. .|  ... .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco5.AA LRR_1 1033-1054 29 0.017452 12.98 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1033-1054
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ELKLLNVSH-N--NLS-SLPIE-LGTL
 |. |..|. |  ||. ..| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco5.AA LRR_TYP 984-1007 25 0.019361 13.89 SMART 1-24 (24) Show / Hide 
Range on Protein: 984-1007
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

ISDLKELYLDHNCISSIPVSILKE
 . |.||.|..| ....|  ..  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP Roco5.AA LRR_TYP 1031-1052 33 0.050198 10.5 SMART 1-24 (24) Show / Hide 
Range on Protein: 1031-1052
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

MKELKLLNVSHNNLSSLPIEL--G
. .|. |. |.|.|..|| ..  |
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP Roco5.AA LRR_TYP 1054-1077 25 0.08278 8.72 SMART 1-24 (24) Show / Hide 
Range on Protein: 1054-1077
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

LCKLNHLDISFNFIETINVNSLSQ
| .| .|| |.| ....  . .. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco5.AA LRR_1 1080-1102 25 0.130653 9.88 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1080-1102
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

NLKVLMMQR-N--YFN-RLPIEIFTRL
||..| ... |   .   .| ..|  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco5.AA LRR_TYP 1174-1197 41 0.000162 22.25 SMART 1-24 (24) Show / Hide 
Range on Protein: 1174-1197
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LSSLQTLNLSNNAIESLPWQLSQL
|..|..|.||||....|| .. | 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco5.AA LRR_1 1153-1174 29 0.000624 18.11 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1153-1174
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLIELDLTN-N--RI-KDLPPQ-IGKL
.| .||| . |  .. ...||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco5.AA LRR_1 1176-1197 29 0.001022 17.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1176-1197
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLQTLNLSN-N--AIE-SLPWQ-LSQL
.||.|.||. |   .. ..|   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco5.AA LRR_TYP 1151-1173 41 0.028454 12.52 SMART 1-24 (24) Show / Hide 
Range on Protein: 1151-1173
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

ISSLIELDLTNNRIKDLPPQI-GK
 ..| |||| ||... |||.. . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco5.AA LRR_1 1130-1151 25 0.922579 6.87 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1130-1151
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KATKLDLSDC---GLS-ALPIE-IGSI
. ..||||.|    |.  .| . . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco5.AA LRR_1 1199-1226 20 5.155807 4.22 Pfam 1-26 (26) Show / Hide 
Range on Protein: 1199-1226
Range on HMM: 1-26/26
Sequence Identity: 20% (7 aa)

TLKVLNITG-N--PIS-FDGASNAKISIPD---VL
.|..|.. | |  ...           ||.    |
NLQHLDLSGCNCCNLTGH---------IPPSCFNL
ROC Roco5.AA ROC 1248-1456 26 5.6e-54 178.95 In-house 1-215 (215) Show / Hide 
Range on Protein: 1248-1456
Range on HMM: 1-215/215
Sequence Identity: 26% (68 aa)

CMRMKLMLVGQENVGKTSIAKCLKKEIIP------VGKKLRQTIGLGTKKSKTPTLTEANGSIDFNAPQSINPLNTSLNISTDGIN-MDDWRPPSEDQ--
| .|||||.||..|||||  |.|...  .                                               . . .|.||.  ..|  . .|.  
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSC--------------------------------------DKGNHPTTHGIEPIQQWVLDCKDMMF

---SPPVTFSIWDFAGQEVYYSTHQFFISS-RSVFIVVFDMSV--------YNPDETSR--VPYWLQCIEAFGGN--------SPVILVGTHLDDLPNGV
   .  ..|..|||.|||.|..||||| .. |||...|.| .            .. ..  . |||. |...|..        ||||.||||.|  |   
RKKEDEIKFNVWDFGGQEIYHATHQFFLTNHRSVYLLVWDCRTKCCDGQPEMI-VRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQD

----DVNQITQDIHSKYFTKFPNV----------KFFLPVSCKSG-KNINKLQNH
    .. |.   . .|.  ||||.          ..|. |.|..| |.|.||..|
NKVYQHKQCC-RMWQKLRNKFPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH
COR Roco5.AA COR 1453-1802 14 3.1e-51 164.24 In-house 1-302 (434) Show / Hide 
Range on Protein: 1453-1802
Range on HMM: 1-302/434
Sequence Identity: 14% (61 aa)

LQNHIVKLGK----AEKKLGDLFSRSYFQLENLILSER----EMNTPPIITLSEFTEMAISCG-----------IPQTSITAAADFLKELGVIVYFD--D
..... |. .    ..  ... . .|.. ... . ..|    . |. | ....||.......|           |  ... ..|..| .||.|..|.  |
IRKTAKKIKHKQMFED-YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIWD

PKSGLDQFIFIDPPWLTRLMATIITSKPNF-----VQSGV-LDQSNLHQIWKPP----------DFPQHLHHVLLAILQKFEIVHPLPDPKATISSSSSS
. ..| .|...|| |..  |..|...|         ..|. .. . |..||.||           .|.|.|  |. ...|||.  |... . . .     
HDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFW-----

PSTTQKSLNNSGSNLKSSGSAISTSSSSTTNGNKTLHRTNSTTNTTSLLNVSRFGNGSISKGSSLSIIKKINDQSTSPSNSTTPSPNTSSNNFSDSITLV
                                                                                                    
----------------------------------------------------------------------------------------------------

PKSSTKHLVPILLSEERPNSIEKLYDQILLKS------QQQQPFLERIYQF------EFLPIGFFSKLMIRTMHFTTVKE------------FWKNGLLV
.   |  |.| ||...||.. |      ...       ....  | |.|..       ||| ||..... |. ||                 .|.||.. 
HQETTTYLIPQLLPDDRPQHWE------WWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRNGMVL

EKDDS---QCLIES
.. .    ..|...
KWEGHNKNEALVKC
Miro Roco5.AA Miro 1344-1410 29 2e-11 43.01 Pfam 70-140 (140) Show / Hide 
Range on Protein: 1344-1410
Range on HMM: 70-140/140
Sequence Identity: 29% (21 aa)

FSIWDFAGQEVYYSTHQFF--ISSRSVFIVVFDMSVYN-PDETSRVPYWLQCIEAFGGN-SPVILVGTHLD
|.|||..|.|  ...|..|  .  ......|.| . |.  .. |..  ||. ... |.. .|||.||...|
FHIWDCGGREYWKFEHMHFACMKWADAICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
RAB Roco5.AA RAB 1251-1464 17 0.000106 -83.98 SMART 1-172 (172) Show / Hide 
Range on Protein: 1251-1464
Range on HMM: 1-172/172
Sequence Identity: 17% (40 aa)

MKLMLVGQENVGKTSIAKCLKKEIIPVGKKLRQTIGLGTKKSKTPTLTEANGSIDFNAPQSINPLNTSLNISTDGINMDDWRPPSEDQSPPVTFSIWDFA
.|..|.|  .|||...    ..   .   .   |||    |.|| ..                                      ...   |.  ||| |
FKIILIGDSGVGKSCLLHRFTDDKFS--EQYKHTIGV-DFKTKTIEV--------------------------------------DGKR--VKLQIWDTA

GQEVYYSTHQFFISSRSVFIVVFDMSVYNPDETSRVPYWLQCIEAFGGN----SPVILVGTHLDDLPN--GVDVNQITQDIHSKYF----TKFPNVKFFL
||| . |  . .  .   .|.|.| .  |..   .|. ||  |.   ..     ...|||    || .   |. ..       . |     .  ...|..
GQERFRSITSSYYRGAHGCILVYDIT--NRESFENVKNWLKEIRMHANPPPENVVIMLVGNKC-DLEHQRQVSTEE------AQKFCCDCAEKHGMPFMF

PVSCKSGKNINKLQNHIVKLGKAE
 .| | . |..    ....  .. 
ETSAKTNTNVEEAFQCLARKIYQR
Miro Roco5.AA Miro 1252-1266 33 0.376359 6.32 Pfam 1-15 (140) Show / Hide 
Range on Protein: 1252-1266
Range on HMM: 1-15/140
Sequence Identity: 33% (5 aa)

KLMLVGQENVGKTSI
|....| . .||.|.
KVVVCGDKGCGKSSF
Kinase Roco5.AA LRRK 2175-2442 38 1e-152 513.65 In-house 1-351 (351) Show / Hide 
Range on Protein: 2175-2442
Range on HMM: 1-351/351
Sequence Identity: 38% (137 aa)

LEIIEKVGEGGFG-IVYKGKLRG----------------------------QLVAIKQITID---------------------SGQAEAAS--------E
|.| |..|.|||| .||..|.||                            | ||||....|                     |.|.|. .        .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVED-MDQNHEDCCR

IYREFRREVWLSNTLTHPSIVSLKGYCLDPCCIVMEYIPNGTLYSHLRKSFSS--------ITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILM
..||||.|||. ..|.||.||||||.|..|.|.||||.|.|.||..|......        |.|.||||||..||......| ..|.|.||||||||||.
AFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

LSDMN--------AAVVCKVSDFGETR--AVVTSALGRDKLSNPIWLSPEIMRGD---EYTEKADVYSFGIVLWEILTGL-LPFDEYP-VAHSSFMYQLE
 | ..        |.|..|..||| .|  ....... .... ||.|..|||||..   |||||.|.||||..|||.||.. .||||.. ..|...|.|.|
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

DEITNGLRPTIPQNSVCGH----PDFITLITDCWQNDPLKRPTFIDIHSRLLI
|.|..||||||||. .|..    ... .||..|||.||.|||.|..| .||  
DKIIEGLRPTIPQH-YCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Roco5.AA TKL 2181-2440 29 1.8e-96 326.82 In-house 1-364 (364) Show / Hide 
Range on Protein: 2181-2440
Range on HMM: 1-364/364
Sequence Identity: 29% (108 aa)

VGEGGFGIVYKGKLRG----------QLVAIKQITIDSGQA--------------------EAASEIYREFRREVW-LSNTLTHPSIVSLKG--------
.|.||||.|||||.||          . ||.|.. ... .                     .  .. .|.|..|.. . . | || ||...|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YCLDP------CCIVMEYIPNGTLYSHLRKSFSSITWQLKLKIAINIADAIKHMHGFT------PKICHRDLKSPNILMLSDMN----------AAVVC
 .|..|      .||||||.|.|.|...|        |......|. || .. ..|  .      |.| ||||||.|||  ....          | ..|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVSDFGETRAVVTSALGRD--------------------KLSNPIWLSPEIMRGD----------------EYTEKADVYSFGIVLWEILTGLLPFDEYP
|..|||  | . .|    |                    .  .| |..||..||.                ||.||.||||||||||||||. .|...||
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

VAHSSFM----YQLEDEITNGLRPTIPQNSVC------GHPD---FITLITDCWQNDPLKRPTFIDIHSRL
     |.      ..  . .||||.||    .       ..    .. |..|||. || |||.| .| .||
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Roco5.AA TKL-Unique 2177-2440 34 3.8e-77 262.62 In-house 1-290 (290) Show / Hide 
Range on Protein: 2177-2440
Range on HMM: 1-290/290
Sequence Identity: 34% (102 aa)

IIEKVGEGGFGIVYKGKLRGQLVAIKQITIDSGQAEAASEIYREFRREVWLSNTLT-HPSIVSLKGYCL----DPC--CIVMEYIPNGTLYSHLR-----
...|.||||.| ||||| ||  |||||. .   ...  .|. .||..|| ....|  || || . |||     .|   ||||||.| |.||..|      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP---NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

----KSFSSITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLSD-MNAAVVCKVSDFGETRAVVTS---ALGR-------DKLSNPIWLSPEI
    .. . ...|...|.|| ||..  . |   |.| ||||||.|.|  ..   | .  |..|||  .   ..    ...       .......|..||.
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

MRG--DEYTEKADVYSFGIVLWEILTGLL------PFDEYPVAHSSFMYQLEDEITNGLRPTIPQNSVCGHPDFITLITDCWQNDPLKRPTFIDIHSRL
.|.  . |.||.||||||||||||.|. .      |....    . . ......   ..||.||..     ...  ||..||  || .||.|..| .||
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM---DQEQWCEMVHYMEENYRPPIPNH---CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Roco5.AA MLK 2175-2440 31 5.6e-64 218.87 In-house 1-291 (291) Show / Hide 
Range on Protein: 2175-2440
Range on HMM: 1-291/291
Sequence Identity: 31% (96 aa)

LEIIEKVGEGGFGIVYKGKLRGQL-----VAIKQITIDSGQAEAASEIYREFRREVWLSNTLTHPS----IVSLKGYCLDP-C--CIVMEYIPNGTLYSH
... |..|.|.|| |.||. |...     ||.|.....   .  .... ..|..|. . . | ||     |. ..| ||.| |  ||||||...| ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L--RKSFSS-----------ITWQLKLKIAINIADAIKHMHGFTP-KICHRDLKSPNILMLS---DMNAAVVCKVSDFGETR---AV---VTSALGRDKL
|  ..| ..           .. ......| ..| ..   |   | .| ||||||.||| .    || .  ..|..|||. |         .|. |    
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDM-HHGTLKICDFGTSRDWHQMCTNMMSNAG----

SNPIWLSPEIM---RGDEYTEKADVYSFGIVLWEILTGLLPFDEYPVAHSSFMYQLEDEITNGLRPTIPQNSVCGHPDFITLITDCWQNDPLKRPTFIDI
 ...| .||.    |.. |.||.||.|.|.||||.||. .|..     | . |. .   . |||||.||..  | .. .  |...||. || |||.|  |
-TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK----QHYDPMAIAWWVAYNGLRPPIPST--CPEH-WKKLMKQCWNQDPHKRPSFRQI

HSRL
 . |
VQHL
Kinase Roco5.AA TK 2175-2440 17 2e-52 173.68 In-house 1-486 (486) Show / Hide 
Range on Protein: 2175-2440
Range on HMM: 1-486/486
Sequence Identity: 17% (84 aa)

LEIIEKVGEGGFG---IVYKGKLRG---------------------------QLVAIKQITIDSGQAEAASEIY------------REFRREVWLSN-TL
.....| ||| ||    ||||..||                           . ||.|... ........ . .            .| . .  ...  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

THPSIVSLKGYCLDP--------------CCIVMEYIPNGT----LYSHLRKS-----------------------------------------------
 || ||.| |.|...              ..||||| |.|     | ..|||.                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------FSSITWQLKLKIAINIADAIKHMHGFTP----KICHRDLKSPNILMLSDMNAA-------VVCKVSDFG---
                             . .| . .| ..  ||..  ..|        .. ||||   |.|  .... .        |||..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----ETRAVV-----TSALGRDKLSNPIW-----------------------LSPEIMRGDE---------YTEKADVYSFGIVLWEILT-G-LLPFDE
      .|..      ... ....  .. |                       ..|| ... .         .|.| ||.|||...|||.| |   .  .
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

YP---VAH-SSFMYQLEDEITN------------GLRPTIPQNSVCGH-------------PDFITLITDCWQNDPLKRPTFIDIHSRL
 .   |..    . .. . ...            | |   ||   |               ...  |...||. || .|||| ..|..|
MSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Roco5.AA DRK 2175-2442 35 2.3e-52 175.64 In-house 1-258 (258) Show / Hide 
Range on Protein: 2175-2442
Range on HMM: 1-258/258
Sequence Identity: 35% (97 aa)

LEIIEKVGEGGFGIVYKGKLRGQLVAIKQITIDSGQAEAASEIYREFRREVWLSNTLTHPSIVSLKGYCLDPC--CIVMEYIPNGTLYSHLRKSFSSITW
  |   .| |..| |. |  ||  ||.|    .    |   ..  ||.||. |   | || |.   | |. |   ||.|||.| | ||. |     .. |
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDE---NFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDW

QLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLSDMNAAVVCKVSDFG-ET--RAVVTSALGRDKLSNPIWLSPEIMRGDEYTEKADVYSFGIVLW
 | ..... .|  .   |. .| | |||||| | |   | .  |  ||.|||  |  . .      .     | | .||. | . ||||||||||.||||
PLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLV--DEHWQV--KVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLW

EILTGLLPFDEYPVAHSSFMYQLEDEITN-GLRPTIPQNSVCGHPDFITLITDCWQNDPLKRPTFIDIHSRLLI
|..| . |.   |        |    .   |.|| .||.   . | .| |..|||  ||  ||.. ..  ||  
ECVTRQDPYFGMP------TFQVVFSVGRHGMRPPMPQW---CPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Roco5.AA Dicty4-Unclassified 2175-2440 32 3.5e-52 177.01 In-house 1-263 (263) Show / Hide 
Range on Protein: 2175-2440
Range on HMM: 1-263/263
Sequence Identity: 32% (91 aa)

LEIIEKVGEGGFGIVYKGKLRGQLVAIKQITIDSGQAEAASEIYREFRREVWLSNTLTHPSIVSLKGYCLDP------CCIVMEYIPNGTLYSHLR----
. |   .|.| |  |.||  .|  ||.|   . ...  .  |.  .|..|| .   . ||  | ..|||. |       ||||| .. |.|         
IQIDQFIGKGHFSKVHKGNWKGKDVAVKK--FNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPS

---KSFSSITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLSDMNAAVVCKVSDFGETRAVVTSALGRDKLS-NPIWLSPEIMRGDEYTEKAD
   ..  .    | .|.|. ||  . |.|  |  . |||.|| ||||  . |.    |. |||  | |.            | | |||....  |. |.|
EQQQPI-KLDDTLIIKYAFDIAQGMQHLH--TRNFIHRDIKSSNILMDKHFNI----KIADFGISR-VIDFNFNMTTIAGTPKWESPECLMHESYNQKSD

VYSFGIVLWEILTGLLPFDEYPVAHSSFMYQLEDEITNGLRPTIPQNSVCGHPDFITLITDCWQNDPLKRPTFIDIHSRL
|||....|.| .||  |. | .    | |         .||| || |     . .  || .|| ||| ||||. .|  .|
VYSYAMMLYELATGDEPYQEIQ----SIMNAARSVCDKKLRPKIPDNC---DNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Roco5.AA TyrKc 2175-2440 29 1.3e-48 168.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 2175-2440
Range on HMM: 1-280/280
Sequence Identity: 29% (89 aa)

LEIIEKVGEGGFGIVYKGKLRGQLVAIKQITIDSGQAEAASEIYREFRREVWLSNTL--THPSIVSLKGYCL---------DPCCIVMEYIPNGTLYSHL
.. ..| ||| ||.||||... . ||.| .  |.          ..|.||  .   |   || || | |.|.         .| .||||| |.| | ..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RKSFSSITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLSDMNAAVVCKVSDFGETRAVVTS-------ALGRDK---LSN---PI-WLSPEI
||.   .... .|.... ||.   . |    .. ||||   |.|  ..     ..|.|||| .|..             | |    ..   || |..|| 
RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

MRGDEYTEKADVYSFGIVLWEILT-GLLPFDE---YPVAHSSFMYQLEDEITNGLRPTIPQN-----SVCGHPDFITLITDCWQNDPLKRPTFIDIHSRL
..  ..|.| ||.|||...|||.| |  |  .    ..  .  . ...    .| |. .|.|     .|| ...  .....||. || .|||| .||...
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK----QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Roco5.AA HH498 2175-2440 30 2.2e-48 151.25 In-house 1-284 (284) Show / Hide 
Range on Protein: 2175-2440
Range on HMM: 1-284/284
Sequence Identity: 30% (92 aa)

LEIIEKVGEGGFGIVYKGKLRGQLVAIKQITIDSGQAEAASE----IYREFRREVWLSNTLTHPSIVSLKGYCLD---PCCIVMEYIPNGTLYSHL----
.|  ||.| | || ||||. |. .||.|   .      . |.    |   | ||| .   | ||. |   . |.|      || .|. || |.| |    
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAM--AFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIP

-------------RKSFSSITWQLKLKIAINIADAIKHMHG-FTPKICHRDLKSPNILMLSDMNAAVVCKVSDFGETRAVVTSALGRDKL-S---NPIWL
             ..    .  | |. |....|      |   .. | |||| | |||.  |  |    .| |||| | |    .. | . .   |. | 
IGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHA----VVADFGESRFV--CDMHDDNMTKQPGNLRWM

SPEIMR-GDEYTEKADVYSFGIVLWEILTGLLPFDEYPVAHSSFMYQLEDEITNGL-RPTIPQNSVCGHPDFIT-LITDCWQNDPLKRPTFIDIHSRL
.||.   .  |..|.||.|.....||..|. .||  |  |  ..      |...   ||.|||      |  .  ||  ||.  |  ||.| .|   |
APEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAA------EMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase Roco5.AA S_TKc 2175-2442 25 9e-48 165.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 2175-2442
Range on HMM: 1-231/231
Sequence Identity: 25% (74 aa)

LEIIEKVGEGGFGIVYKGKLRG--QLVAIKQITIDSGQAEAASEIYREFRREVWLSNTLTHPSIVSLKGYCL-DPCCIVMEYIPN--GTLYSHLRKSFSS
 ||..|.|.|.|| |||.. ..  ..||||.|              . .|||. .     || || |....  |  ..||||...  |.|.....|  . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRH

-----ITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLSDMNAAVVCKVSDFGETRAVVTSALGRDKLSNPIWLSPEIMRGDEYTE-KADVYS
     ..     ...  |..|....|    .|.|||||  |||. .      . |..|||  | .      .     | ...||..    |.  |.|..|
GLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

FGIVLWEILTGLLPFDEYPVAHSSFMYQLEDEITNGLRPTIPQNSVCGHPDFITLITDCWQNDPLKRPTFIDIHS-------RLLI
.|..|.| |.|  ||.         |... . |                |... .|  |.| || ||||  ..            .
CGCILYEMLCGYPPFP--------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Roco5.AA TK-Unique 2175-2440 27 7.4e-45 152.63 In-house 1-294 (294) Show / Hide 
Range on Protein: 2175-2440
Range on HMM: 1-294/294
Sequence Identity: 27% (86 aa)

LEIIEKVGEGGFGIVYKGKLRG--------QLVAIKQITIDSGQAEAASEIYREFRREVWLSNTLT-HPSIVSLKGYCL---DPCCIVMEYIPNGTLYSH
||. ...||| || |..|...|        . ||.|.  ... . . .     .| .|  . . |. || ||.. |.|    .| .|.|||.|.|.| ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQ-----DFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHY

LRKSF-------------------------SSITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLSDMNAAVVCKVSDFGETR-----AVVTS
||..                          ..|. .. . .|. || . .....   || |||| . |.|. .      |||..||| .|      |. .
LRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSM

ALGRDKLSNPIWLSPEIMR--GDEY-TEKADVYSFGIVLWEILT-GLLPFDEYPVAHSSFMYQLEDEITNGLRPTIPQNSVCGHPDFITLITDCWQNDPL
  .. ....  |..||...  .  | |.| ||.|||...|||.| |  |. ..| .       ....|..| |.  |..  |  ...  |.  ||| .| 
MCSQGRIPI-RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD------IMECIRDGYRMPQPEH--CCSHEMYNLMKSCWQWEPE

KRPTFIDIHSRL
.||.| .| .||
ERPSFRQIKHRL
Kinase Roco5.AA Dicty4 2342-2444 42 7.4e-34 110.43 In-house 181-277 (277) Show / Hide 
Range on Protein: 2342-2444
Range on HMM: 181-277/277
Sequence Identity: 42% (45 aa)

PIWLSPEIMRGDEYTEKADVYSFGIVLWEILTGLLPFD-EYPVAHSSFMYQLEDEITN-GLRPTIPQNSVCGHPDFITLITDCWQNDPLKRPTFIDIHSR
| | .||.|....|.|||||||||||||||||.  |.  .    |...| |. . . | .||| ||..   . | ...||..|| .|| .||.|  | .|
PCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKH----HMPYM-QFVRAVCNKKLRPPIPDW---CPPSWKHLIQWCWDHDPQHRPSFEEIIQR

LLIMS
..  .
RILEH
Kinase Roco5.AA Dicty4 2175-2324 33 4.7e-33 107.69 In-house 1-159 (277) Show / Hide 
Range on Protein: 2175-2324
Range on HMM: 1-159/277
Sequence Identity: 33% (56 aa)

LEIIEKVGEGGFGIVYKGKLRGQLVAIKQITIDSGQAEAASEIYREFRREVWLSNTLTHPSIVSLKGYCL----DP--CCIVMEYIPNGTLYSHLRK---
. | .. |.|.|| ||||. ||. ||.|    .  .  . ...  |||.|| .   . || |. ..|.|.     |  .|||.|| | |.||| |..   
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNH--NQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---SFSSITWQLKLK---IAINIADAIKHMHGFTPKICHRDLKSPNILMLSDMNAAVVCKVSDFG
   .  .. | | ..   .|. .|  . . |. .| | |||||| |.|.  ....    ||.|||
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRV----KVCDFG
Kinase Roco5.AA Pkinase 2175-2324 28 7.1e-26 92.58 Pfam 1-157 (293) Show / Hide 
Range on Protein: 2175-2324
Range on HMM: 1-157/293
Sequence Identity: 28% (46 aa)

LEIIEKVGEGGFGIVYKGKLRGQ--LVAIKQITIDSGQAEAASEIYREFR-REVWLSNTLTHPSIVSLKGYCL--DPCCIVMEYIPNG----TLYSHLR-
..|..|.|.|.|| |||.. .|   .||.|.|  ..   |  .. .. .| .|. . . | || || |....   | ...|||| ..|     |..... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRH---EKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

---KSFSSITWQLKLKIAINIADAIKHMHGFTPKICHRDLKSPNILMLSDMNAAVVCKVSDFG
   ..|.  ...   ...  |. .....|    .|.|||||. |||. .... .   |..|||
WRHGCFY-FSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFG
Kinase Roco5.AA Pkinase_Tyr 2175-2290 30 1.5e-23 80.41 Pfam 1-128 (270) Show / Hide 
Range on Protein: 2175-2290
Range on HMM: 1-128/270
Sequence Identity: 30% (40 aa)

LEIIEKVGEGGFGIVYKGKLR------GQLVAIKQITIDSGQAEAASEIYREFRREVWLSNTL-THPSIVSLKGYCL---DP--CCIVMEYIPNGTLYSH
.....| ||| || ||||...      .. ||.| .  .. . .    . ..| ||. .  .|  || ||.| | |.   .|   .||||| |.| |...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LRKS---FSSITWQLKLKIAINIADAIKHMH
|||      ..| . .|.... ||..  . .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase Roco5.AA Pkinase_Tyr 2317-2440 31 6.6e-22 74.82 Pfam 149-270 (270) Show / Hide 
Range on Protein: 2317-2440
Range on HMM: 149-270/270
Sequence Identity: 31% (41 aa)

VCKVSDFGETRAV----VT-SALGRDKLSNPIWLSPEIMRGDEYTEKADVYSFGIVLWEILT-GLLP-FDEYPVAHSSFMYQLEDEI-TNGLRPTIPQNS
|.|..||| .|..        . |  |     |..|| ..  ..|.| ||.|||...|||.| |  | . . . .       . . |  .| |  .|.| 
VVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE------VYEYIYEDGYRMPCPENC

VCGHPDFITLITDCWQNDPLKRPTFIDIHSRL
   ...  .|...||. || .|||| .||..|
---PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Roco5.AA Pkinase 2344-2442 22 8.7e-13 46.3 Pfam 177-293 (293) Show / Hide 
Range on Protein: 2344-2442
Range on HMM: 177-293/293
Sequence Identity: 22% (27 aa)

WLSPEIMR-GDEYTEKADVYSFGIVLWEILTGLLPFDEYPVAHSSFMYQLE--DEITNGLRPTIPQNSVCGH-----------------PDFITLITDCW
...||. | | .|. |.|..|.|..|.| |.| .||.. .  | . . |..  ..|  .  .   ... ..                  .... .|..|.
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

QNDPLKRPTFIDIHSRLLI
. || ||||. .|     .
CKDPKKRPTAEQILQHPWF