Roco7

Species: Slime mold
Alias: DDB0191295, DdisK235, Roco7
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
Roco7.AA Protein None 2615 None Fasta, JSON
Roco7.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of Roco7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
COR Roco7.AA COR 1468-1746 18 9.6e-26 80.2 In-house 74-434 (434) Show / Hide
Range on Protein: 1468-1746
Range on HMM: 74-434/434
Sequence Identity: 18% (69 aa)

IEPRDSEAAIKYLYEIGEVLYYR-YEANDQLLNELVFLDSMWMSKLISAVLALKT--------QNGM-TVVDQITQAWAS-----------LFPHCKTSS
|..   .....|| . |.....  .. ...| ...|.||  |... .. ..  |.        ..|    .......|              .|.     
IDEDELHTVAMYLHDLGHIIHFKIWDHDPML-KDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEY

LLFLLEKFELVYISAED---------SSVIIPQLFGGERPMVM-RDLWSP---TAHANNEYLRIYEF------QFLPKGFFSRLSVRV--LQHYDPLC--
|. |.||||| |  ..|         . ..||||   .||    .  |..   . |  ..  |.|..      .||| ||..|. ||   ..|... |  
LVELMEKFELCYPIDPDWTHFWHQETTTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFY

--------IWQNGMVLQPAGQLWGGAAKSFDSQCLIEYDSVNFILKVSIRDDNK-----QQQLLKSIVDLVSSFILWYF--PGRL-------SNVRVACT
        .|.|||||.     |.|. |    ..|...|  .  ... .| . .       ||. .| ... ..   ..  ||          .. . | 
ERSCCEWMYWRNGMVLK-----WEGHNK---NEALVKCDNHDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCP

HCTNQHIE-NPT--MYTLDYLENQASLGQTNVICKAQL------------------------GGIIHETLSP
||   | . ..   .| .|....... |.....|. .                           |    .| 
HCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWI-Q-RISD

Kinase Roco7.AA LRRK 1775-2037 35 5.3e-152 511.28 In-house 1-351 (351) Show / Hide
Range on Protein: 1775-2037
Range on HMM: 1-351/351
Sequence Identity: 35% (125 aa)

LKFGPQLGSGSYA-NVYRGIWNG----------------------------SEVAIKVLNFD-----------DG------------------HANTTEK
||...|.|.|... .|||..|.|                            ..||||..|.|           ..                  |......
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YREFRNEAHITGELRHANTVSLMGVSLSPFCLVTELLQYGDLAKFIRNTAET--------FSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLG
.||||.|..|. .|.| | |||.|....|.|.|.|....||| .|..|....        .||...||.|...||||..|||..|.|.|||||| |||| 
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

GSSMD--------NLVAKVGDFGLSI--KPIGKEVKGRKVWNWRWLAPECMGDG---QYTEKIDIYSYAIVLWEIITRD-LPFEEYV--DQLKWNSIIED
.|...        . .||..|||.|   ......|  ..|.|..|.|||.|...   .||||.|.||....|||..||. .||.|..  |...|...|||
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

KIMKGLRPTIPNE-CPP-----DMKQLITDCWSGDPKKRPSFNSILERLST
||..|||||||.. |||     ....||..||..||||||.|..|..|||.
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase Roco7.AA TKL 1781-2035 27 2e-101 343.26 In-house 1-364 (364) Show / Hide
Range on Protein: 1781-2035
Range on HMM: 1-364/364
Sequence Identity: 27% (103 aa)

LGSGSYANVYRGIWNG----------SEVAIKVLNFDDG---------------------HANTTEKYREFRNEAH-ITGELRHANTVSLMG--------
.|||... ||.|.|.|           .||.|... ..                      ........|.|..|   .   ||| | |..||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VSLSP------FCLVTELLQYGDLAKFIRNTAETFSWGTVLKLAIDVAKGMNFLHSCK------PMIVHRDLKSANILLGGSSM----------DNLVA
 |...|      .|.|.|. . |.|  ..        |   ...|.|.|.|||.|||..      | |.||||||.|||.               .. ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KVGDFGLSI---------------------KPIGKEVKGRKVWNWRWLAPECMGDG----------------QYTEKIDIYSYAIVLWEIITRDLPFEEY
|..|||||                      .  ... ..... . ||.|||.. .                 .|.||.|.||..||||||.|| .|...|
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

V-DQLKWN----SIIEDKIMKGLRPTIP------------NECPPDMKQLITDCWSGDPKKRPSFNSILERL
  .. ...     ...  . |||||.||            . |||.||.|..|||. ||.|||||. ||.||
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase Roco7.AA TKL-Unique 1777-2035 35 9e-81 274.65 In-house 1-290 (290) Show / Hide
Range on Protein: 1777-2035
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)

FGPQLGSGSYANVYRGIWNGSEVAIKVLNF-DDGHANTTEKYREFRNEAHITGELR-HANTVSLMGVSL----SPF--CLVTELLQYGDLAKFIR-----
|.  .|.|.|..||.|.|.|..||||....  | .    |. .||.||  .   |. |.| | .||..     .|   |.|.| .. | | . .      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSN---EMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

----NTAETFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGS-SMDNLVAKVGDFGLSI--KPIGKEVKGRK--------VWNWRWLAPEC
    |   ....  ..|.|||.|.||..||.|.| | |||||| |.|.        . .|. |||||.  . | |. ....        . . ||.||| 
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

MGD--GQYTEKIDIYSYAIVLWEIITRDL------PFEEYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERL
. .   ||.||.|.||..||||||.||..      |.... || .| ... .   ...||.|||.||.. . ||..||  || .||||..|..||
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYM-EENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase Roco7.AA MLK 1775-2035 30 8.5e-73 248.15 In-house 1-291 (291) Show / Hide
Range on Protein: 1775-2035
Range on HMM: 1-291/291
Sequence Identity: 30% (90 aa)

LKFGPQLGSGSYANVYRGIWNGSE-----VAIKVLN--FDDGHANTTEKYREFRNEAHITGELRHAN----TVSLMGVSLSP---FCLVTELLQYGDLAK
..|   .||||.  |..| | . .     ||.|  .  ..   . | .  ..|. |. .   |.| |     . ..||.|.|   ||.|.| ...| |. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

FIRN-TAETF------------SWGTVLKLAIDVAKGMNFLHSCKP-MIVHRDLKSANILLG---GSSMDNLVAKVGDFGLSIKPIGK-EVKGRKVWNWR
.... . . .            . . ... | ..|.||..||| .| .|.|||||| |||.    .  |.....|. |||.| .   . . .  .  . .
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA

WLAPECM---GDGQYTEKIDIYSYAIVLWEIITRDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERL
| |||       ..|.|| |..|...||||..|| .|.....|..    |.   ...||||.||..||. .|.|...||. ||.||||| .|.. |
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPM---AIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase Roco7.AA Pkinase_Tyr 1775-2035 29 3.2e-69 235.07 Pfam 1-270 (270) Show / Hide
Range on Protein: 1775-2035
Range on HMM: 1-270/270
Sequence Identity: 29% (84 aa)

LKFGPQLGSGSYANVYRGIWN------GSEVAIKVLNFDDGHANTTEKY---REFRNEAHITGEL-RHANTVSLMGVSL---SP--FCLVTELLQYGDLA
..|| .||.|.. .||.|.|.      . .||.|.|.      .....    ..| .|| |  .| .| | |.|.|| .    |   ..|.|. ..||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KFIRNT---AETFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSI--KPIGKE--VKGRKVWNWRWLAPECMGDG
.. |.     . ..  . |. ....||||..|.| .  ..||||   |.|..     |.|.|..||||.    . .    ..|   .  .|.||||. .|
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG

QYTEKIDIYSYAIVLWEIIT-RDLP-FEEYVDQLKWNSIIEDKI-MKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERL
 .|.| |..|. ...|||.|  . | ...  ..      . ..|  .| |  .|  ||... .|...||  ||..||.|  |.|.|
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-----VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase Roco7.AA TK 1775-2035 17 1.7e-65 218.27 In-house 1-486 (486) Show / Hide
Range on Protein: 1775-2035
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)

LKFGPQLGSGSYA---NVYRGIWNG---------------------------SEVAIKVLNFDDGHANTTEKYREFR---------NEAHITGELR----
...| .||.| .     ||.|.|.|                            .||.|.|  .|... . .. .|..         .||..   ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HANTVSLMGVSLSP--------------FCLVTELLQYGD----LAKFIRNTAET--------------------------------------------
 | | |.| ||.. .              ...|.|. ..||    | .. |.  ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FSWGTVLKLAIDVAKGMNFLHSCKP----MIVHRDLKSANILLGGSS-------MDNLVAKVGDFGLS-
                               ..  . |  . ..|.|| .|||..      .|||||   |.|.| .        .. .|.|..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

------IKPIGK----EVKG------------------------RKVWNWRWLAPECMG---------DGQYTEKIDIYSYAIVLWEIITRD-LPFEE-Y
       . |..     .|.                        .  .  ||.||||.          .| .|.| |..|. ...||| |.   |. .  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

VDQLKWN----SIIEDKIMKG--------------LRPTIPNECP--------------PDMKQLITDCWSGDPKKRPSFNSILERL
 .|  |.      . ... .|              .|.  |  ||              ... .|...||. ||..||.|  ..|.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase Roco7.AA Dicty4-Unclassified 1775-2035 32 7.7e-64 217.51 In-house 1-263 (263) Show / Hide
Range on Protein: 1775-2035
Range on HMM: 1-263/263
Sequence Identity: 32% (88 aa)

LKFGPQLGSGSYANVYRGIWNGSEVAIKVLNFDDGHANTTEKYREFRNEAHITGELRHANTVSLMGVSLSP------FCLVTELLQYGDLAKFIR----N
..    .| |  . |..|.| | .||.| .|     .   |   .|. |  | | . | | | . | .. |      .| |.|..  | |   |      
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFR-EEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSE

TAETFSWGT--VLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMD-NLVAKVGDFGLSIKPIGKEVKGRKVW-NWRWLAPECMGDGQYTEKIDI
     .     ..| |.|.|.|| .||.    ..|||.||.|||     || .  .|..|||.|   |        .    .| .|||.    |. | |.
QQQPIKLDDTLIIKYAFDIAQGMQHLHTRN--FIHRDIKSSNIL-----MDKHFNIKIADFGIS-RVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDV

YSYAIVLWEIITRDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERL
||||..|.| .| | |. |    .     . |   |.||| ||  |.. .|.|| .||. ||.|||..| | ..|
YSYAMMLYELATGDEPYQEIQSIMNAARSVCD---KKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL

Kinase Roco7.AA TyrKc 1775-2035 29 1.9e-61 211.38 SMART 1-280 (280) Show / Hide
Range on Protein: 1775-2035
Range on HMM: 1-280/280
Sequence Identity: 29% (87 aa)

LKFGPQLGSGSYANVYRGIWNGSEVAIKVLNFDDGHANTTEKYREFRNEAHITGEL--RHANTVSLMGVSL---------SPFCLVTELLQYGDLAKFIR
...| .||.| .  ||.|.|.  .||.|.|. |          ..|..|| |  .|  .| | | | || .          | ..|.|.  .||| ...|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NTAETFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSIKPIGK-------EVK-------GRKVWNWRWLAPECM
.. ..... . |. ....|.||..|||    ..||||   |.|.|    .|...|..||||| .   .       ...       |. ..  ||.||||.
KHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVG----ENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

GDGQYTEKIDIYSYAIVLWEIITR-DLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNE--------CPPDMKQLITDCWSGDPKKRPSFNSILERL
 .| .|.| |..|. ...||| |. . | .. . | . |. .  ....| |. .| .        ||..| |....||  ||..||.|. | |..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase Roco7.AA TK-Unique 1775-2035 26 1.6e-54 186.4 In-house 1-294 (294) Show / Hide
Range on Protein: 1775-2035
Range on HMM: 1-294/294
Sequence Identity: 26% (83 aa)

LKFGPQLGSGSYANVYRGIWNG--------SEVAIKVLNFDDGHANTTEKYREFRNEAHITGELR-HANTVSLMGVSL---SPFCLVTELLQYGDLAKFI
|..| ..|.|..  |.||   |        . ||.| |.      .| .. ..| .|. .  ||  | | |...|..     |.... | ...|.| ...
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK----DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL

RNTAET-------------------------FSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSI-----KPIGKE
|... .                          | ....  |...|.||..|.| . .|||||| . |.||..    ..|.|..|||..      ... ..
RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMM

VK-GRKVWNWRWLAPECMG--DGQY-TEKIDIYSYAIVLWEIIT--RDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNEC-PPDMKQLITDCWSGDPKKR
 . ||     ||.||| .   .|.| |.| |..|.....||| |     |. .. .       |...| .| |.  |..| ...| .|.  ||. .|..|
CSQGRIP--IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKD-----IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEER

PSFNSILERL
||| .|. ||
PSFRQIKHRL

Kinase Roco7.AA DRK 1775-1977 36 4.7e-51 171.15 In-house 1-202 (258) Show / Hide
Range on Protein: 1775-1977
Range on HMM: 1-202/258
Sequence Identity: 36% (77 aa)

LKFGPQLGSGSYANVYRGIWNGSEVAIKVLNFDDGHANTT-EKY-REFRNEAHITGELRHANTVSLMGVSLSP--FCLVTELLQYGDLAKFIRNTAETFS
 | |   | |.|. |.|| | |..||.| |  .    |   |.   ||. |. .   ||| | .  ||  . |   | ..| .  | |..   . .   .
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNH----NINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMD

WGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSI---KPIGKEVKGRKVWNWRWLAPECMGDGQYTEKIDIYSYAIVL
|. ......|.||||..||.| | |.|||||| | |      ..   || |||||    |   .      .    | |||   .  |||| |.||.||||
WPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVD----EHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVL

WEIITRDLPF
||..||  |.
WECVTRQDPY

Kinase Roco7.AA Dicty4 1775-1925 35 8.4e-50 164.35 In-house 1-161 (277) Show / Hide
Range on Protein: 1775-1925
Range on HMM: 1-161/277
Sequence Identity: 35% (60 aa)

LKFGPQLGSGSYANVYRGIWNGSEVAIKVL--NFDDGHANTTEKYREFRNEAHITGELRHANTVSLMGVSL----SP--FCLVTELLQYGDLAKFIRN--
....  .|.||.. ||.|.| |.|||.|.|  . ..  .|. .   |||.|.|| . .|| | . .|| ..     |  .| |||..  |.|.. ...  
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLN---EFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

----TAETFSWGTVLK---LAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLS
       . .|.....   .|.|.|.||| ||.| | |.||||||.|.|      .|...||.|||||
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVD----KNWRVKVCDFGLS

Kinase Roco7.AA UTK 1775-2035 27 2.5e-49 166.91 In-house 1-296 (296) Show / Hide
Range on Protein: 1775-2035
Range on HMM: 1-296/296
Sequence Identity: 27% (85 aa)

LKFGPQLGSGSYANVYRGIWNG-------SEVAIKVLNFDDGHANTTEKYR---EFRNEAH---ITGELR-HANTVSLMGVSLS--PFCLVTELLQYGDL
...| |||.| . .|... ..        . ||.||..    ||... . .   .|..||    . . .. | | . | || ..  |...|||. . |||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDL

AKFIRNTAETFS-------WGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDN----LVAKVGDFG---LSIKPIGK--------EV---
... |. ..|.          . |. | |.| ||..||||.  .|||||   |.|.. ..|      .|.|..|||   .| . ..         |    
RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG--FVHRDLAARNCLVHMHRM-MWHCMMVCKIADFGRGGMS-RRVNTFHFSNRYWESYYY

--KGRKVWNWRWLAPECMGDG-QYTEKIDIYSYAIVLWEIITR-DLPFEEYVDQLKWNSIIEDKIMKG--LRPTIPNECPPDMKQLITDCWSGDPKKRPS
   ... | .|| |||.. .. ..|.| |..|. .|.||| |.  ||....     .|  .   ...|  .|.  | .|| .. .| ..||  || .||.
MAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM-----SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPD

FNSILERL
|  .....
FEDLVQQM

Kinase Roco7.AA Pkinase 1775-2035 24 2.5e-44 157.79 Pfam 1-293 (293) Show / Hide
Range on Protein: 1775-2035
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

LKFGPQLGSGSYANVYRGIWNGSE--VAIKVLNFDDGHANTTEKYREFR-NEAHITGELRHANTVSLMGVSL--SPFCLVTELLQYG----DLAKFIR-N
...| ..||||.. ||.... |..  ||.|... .  |..  .... .| .|..|  .|.| | | | ..    .  ..|.|... |    ||. .|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

TAETF--SWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVA----KVGDFGLSI---KPIGKEVKGRKVWNWRWLAPECMG-DGQY
   .|  |. .. . .  ...|....||.   |.|||||..|||.     .| .     |..||||.       .   ... .  | ..|||    .  |
RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILI----DNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW-YMAPEVIRGGQYY

TEKIDIYSYAIVLWEIITRDLPFE------EYVDQLKWNSIIEDKIMKGLRPTIPNECP-------------------PDMKQLITDCWSGDPKKRPSFN
. |.|..|. ..|.| ... .||       . .||..   .|. . .. |.  .|..|.                   ...|..|..|.  ||||||.. 
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQ---MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

SILER--L
 ||.   .
QILQHPWF

Kinase Roco7.AA S_TKc 1775-2042 22 2e-39 138.25 SMART 1-231 (231) Show / Hide
Range on Protein: 1775-2042
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

LKFGPQLGSGSYANVYRGIWNG--SEVAIKVLNFDDGHANTTEKYREFRNEAHITGELRHANTVSLMGVSL-SPFCLVTELLQY--GDLAKFIRNTAE--
 ... ..|.|... ||......   .||||...            . .|.|  |  . .| | | | .|   . ...|.|..    ||| ..|..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

---TFSWGTVLKLAIDVAKGMNFLHSCKPMIVHRDLKSANILLGGSSMDNLVAKVGDFGLSIKPIGKEVKGRKVWNWRWLAPECMGDGQYTE-KIDIYSY
    |.  .. ...  ........||    |.||||| .||||        . |..||||. .          .    ..||| .   .|.  |.|..| 
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

AIVLWEIITRDLPFEEYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILE--RLSTMQKTF
 ..|.| ...  ||.            .....| ..       .|..|..|  |.  ||.|||.   .|.  ..  .   |
GCILYEMLCGYPPFP-----------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Roco7.AA Dicty4 1943-2037 43 2.8e-35 115.25 In-house 183-277 (277) Show / Hide
Range on Protein: 1943-2037
Range on HMM: 183-277/277
Sequence Identity: 43% (43 aa)

WLAPECMGDGQYTEKIDIYSYAIVLWEIITRDLPFE-EYVDQLKWNSIIEDKIMKGLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILER--LST
| |||.|    |.|| | ||..|||||| ||. |.  .. .  .   ...    |.||| ||. |||  |.||..||. ||..||||. |..|  | .
WMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQ---FVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase Roco7.AA DRK 1997-2037 51 1.4e-16 52.75 In-house 218-258 (258) Show / Hide
Range on Protein: 1997-2037
Range on HMM: 218-258/258
Sequence Identity: 51% (21 aa)

GLRPTIPNECPPDMKQLITDCWSGDPKKRPSFNSILERLST
|.|| .|  |||   ||..|||. ||  |||.  .||||  
GMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA

WD40 Roco7.AA WD40 2472-2488 27 6.401916 2.39 Pfam 22-39 (39) Show / Hide
Range on Protein: 2472-2488
Range on HMM: 22-39/39
Sequence Identity: 27% (5 aa)

MDRFVITCSE-RVICIFD
| ......|. . |.|.|
MGHYLASGSRDGTIRIWD

WD40 Roco7.AA WD40 2491-2527 22 6.2e-05 16.82 Pfam 1-39 (39) Show / Hide
Range on Protein: 2491-2527
Range on HMM: 1-39/39
Sequence Identity: 22% (9 aa)

GIIKKRLDGLASRVLSLLILDT---YIIGACYDSTILVWD
.  |. . |  . | .. . .    |.. .. |.|| .||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD

WD40 Roco7.AA WD40 2532-2574 16 0.01237 10.2 Pfam 1-39 (39) Show / Hide
Range on Protein: 2532-2574
Range on HMM: 1-39/39
Sequence Identity: 16% (7 aa)

FRMVQSLKKKHTDAISSLAFALSPQGKPQLWVGGWDKKITTYS
   ....   ||......|.. .  . . |  |..|..|  ..
WKCKHTF--GHTHWVTCCAWHPD--MGHYLASGSRDGTIRIWD