Gene Roco8 (Slime mold)

Roco8

Species: Slime mold
Alias: Roco8, DdisK236, DDB0191480
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
Roco8.AA Protein None 1867 None Fasta, JSON
Roco8.kin_dom Protein Kinase Domain None 401 None Fasta, JSON

Protein domain

Protein domains of Roco8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DEP Roco8.AA DEP 19-91 40 1.4e-23 89.5 Pfam 1-75 (75) Show / Hide 
Range on Protein: 19-91
Range on HMM: 1-75/75
Sequence Identity: 40% (31 aa)

GLQIKDRTYLYKTYRSVFVGYECVDWIF-GNCPD-IKTREDAIKLGQTLFDAGIICNVTSGADPIFKDD-YIFYQF
|....||... |||...|.| |.|||.   .|.| |..|| |..||| | |.|.|  |.   .. |.|. . ||.|
GVKMRDRRWHWKTYPNCFTGSEAVDWLMNDCCEDFIIDREEAVHLGQDLMDHGYIHHVQDHHRG-FQDSDHYFYRF
DEP Roco8.AA DEP 16-93 27 1.7e-15 58.75 SMART 1-90 (90) Show / Hide 
Range on Protein: 16-93
Range on HMM: 1-90/90
Sequence Identity: 27% (25 aa)

SSDGLQIKDRTYLYKTYRSVFVGYECVDWIFGNCPD-----------IKTREDAIKLGQTLFDAGIICNVTSGADPIFKDD-YIFYQFDN
 ..|....|.... |||...|.|.| |||.  . ..           |..|| |....| . |.| |. |.   .  |.|| . .|.|  
PETGVKMDDHRWHMKTYPNCFTGSELVDWLMDHFEGQSNFCPTCTTFIHDREEAVHICQAMLDHGYIHHVNDWHKHTFQDDWQCYYRFQD
DEP Roco8.AA DEP 267-322 25 9.8e-09 35.82 Pfam 1-59 (75) Show / Hide 
Range on Protein: 267-322
Range on HMM: 1-59/75
Sequence Identity: 25% (15 aa)

GLKLQKKKKGAAGTTISCFSGSQLIDWLV----KKLEVTRKESIQIASALMHLNIFIEVG
|.|... ..   .|  .||.||...|||.    ... ..|.| ......||  ...  |.
GVKMRDRRW-HWKTYPNCFTGSEAVDWLMNDCCEDFIIDREEAVHLGQDLMDHGYIHHVQ
DEP Roco8.AA DEP 264-361 16 0.000801 12.61 SMART 1-90 (90) Show / Hide 
Range on Protein: 264-361
Range on HMM: 1-90/90
Sequence Identity: 16% (18 aa)

GDKGLKLQKKKKGAAGTTISCFSGSQLIDWLVKKLE-------------VTRKESIQIASALMHLNIFIEVGTIFNSSNNNNNNNNGGGGVMSSTLSTTI
 ..|.|.. ...    |  .||.||.|.|||.. .|              .|.| . |..|... . .  |.                      . . | 
PETGVKMD-DHRWHMKTYPNCFTGSELVDWLMDHFEGQSNFCPTCTTFIHDREEAVHICQAMLDHGYIHHVND---------------------WHKHTF

PSS-ISLQQLSN
. .  .. ... 
QDDWQCYYRFQD
LRR_1 Roco8.AA LRR_1 540-561 37 0.000573 18.24 Pfam 1-26 (26) Show / Hide 
Range on Protein: 540-561
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLESCNLSH-N--QLS-TLPSS-FSRL
||.. .||. |  .|. ..|.| |  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco8.AA LRR_TYP 561-584 37 0.00072 20.1 SMART 1-24 (24) Show / Hide 
Range on Protein: 561-584
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LELLTKLILSHNCFQVIPNVVFQL
|  |..| ||.| .. .|. .|| 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco8.AA LRR_1 586-607 33 0.003353 15.52 Pfam 1-26 (26) Show / Hide 
Range on Protein: 586-607
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

NLEELSLAA-N--QLS-SISES-IGSL
||..|.|   |  .|. .|..| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco8.AA LRR_TYP 538-560 45 0.01256 15.43 SMART 1-24 (24) Show / Hide 
Range on Protein: 538-560
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LYNLESCNLSHNQLSTLPSS-FSR
| ||.. .||.|||..||.  |. 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_TYP Roco8.AA LRR_TYP 585-607 34 0.034835 11.8 SMART 2-24 (24) Show / Hide 
Range on Protein: 585-607
Range on HMM: 2-24/24
Sequence Identity: 34% (8 aa)

SNLEELSLAANQLSSISESIGSL
.||.||.|  |||... . . . 
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 Roco8.AA LRR_1 563-584 29 0.355169 8.34 Pfam 1-26 (26) Show / Hide 
Range on Protein: 563-584
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

LLTKLILSH-N--CFQ-VIPNV-VFQL
 |..| ||. |  ...  ||.    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 Roco8.AA LRR_1 515-538 23 0.383953 8.22 Pfam 1-26 (26) Show / Hide 
Range on Protein: 515-538
Range on HMM: 1-26/26
Sequence Identity: 23% (7 aa)

FLRIIDLSF-N--QLS-ESNQLES--IATL
 |...|||  |  .|. .   . .  .  |
NLQHLDLSGCNCCNLTGH---IPPSCF-NL
LRR_1 Roco8.AA LRR_1 609-631 33 0.002115 16.23 Pfam 1-26 (26) Show / Hide 
Range on Protein: 609-631
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLEKLDLSF-N-KQIN-KIPKE-LGLL
.|..||||  |  ..  .||.. .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP Roco8.AA LRR_TYP 631-655 28 0.274811 4.45 SMART 1-24 (24) Show / Hide 
Range on Protein: 631-655
Range on HMM: 1-24/24
Sequence Identity: 28% (7 aa)

LVRLKSLNVLGSNKINELPSFLSTL
|. |..|. |..|.. .||. .   
LPNLRELD-LSNNQLTHLPPGAFQG
LRR_1 Roco8.AA LRR_1 633-655 18 33.204786 1.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 633-655
Range on HMM: 1-26/26
Sequence Identity: 18% (5 aa)

RLKSLNVLG-S-NKIN-ELPSF-LSTL
.|..|.. |    ..  ..|.  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
ROC Roco8.AA ROC 697-731 31 0.009451 5.77 In-house 1-35 (215) Show / Hide 
Range on Protein: 697-731
Range on HMM: 1-35/215
Sequence Identity: 31% (11 aa)

LSHIKLMVLGSEKTGRSSLVKALTKSQTKSLSRQS
....||| .| .. | .||.|.| ... .  | .|
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYS
Miro Roco8.AA Miro 701-721 28 0.018624 10.98 Pfam 1-21 (140) Show / Hide 
Range on Protein: 701-721
Range on HMM: 1-21/140
Sequence Identity: 28% (6 aa)

KLMVLGSEKTGRSSLVKALTK
|..|.|....| ||..... .
KVVVCGDKGCGKSSFIHQYCG
COR Roco8.AA COR 934-1326 13 1.1e-27 86.59 In-house 1-292 (434) Show / Hide 
Range on Protein: 934-1326
Range on HMM: 1-292/434
Sequence Identity: 13% (60 aa)

IIQTLLNQSN----NNNNNNNNNNYNNNKQSNSISTTNWLNERIPSIYITLETNLQEEAK------KRPIVTWDEYQNIAKLSNFT--------TSSYEK
|..|.... .                             . ...|  .  ... |.|..|      . |  .| |...|.. ..            . ..
IRKTAKKIKHKQMFED----------------------YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDE

LVRATNTLNRWGSIIWFE--DSKSSLKDFVILDPQWFSDCFYKLLLAKHSF----INSDGI-LLLSNLKNIWKPN----------IVPEQFHIKLLKLLE
| ...  |...|.||.|.  |  . |||||.||||||.. .|... .|.|     .   || .  . |. ||.|            .|  .|  |..|.|
LHTVAMYLHDLGHIIHFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELME

RYQILYTLKN----NSNLQQLQQQQQQQKSFGNLSKENSLNSMSYSIESRSSSSPLPTVVTLSAEISSSPSLSLSNSSQSVFTNPNNNNNNKSEQQQQQQ
.... | . .    ..                                                                                    
KFELCYPIDPDWTHFW------------------------------------------------------------------------------------

QQQQQPQPISTSPKLLRNSLKNLKSIENNSSSLSNNSILNSNSNSSGNLLQNGSYISF--NRIIIPCLLPNGKPSHLASLWDTWS----GEDEHQIGRYY
                                                        ..   . .||.|||. .| |.. .|. ..     .|. ...| |
--------------------------------------------------------HQETTTYLIPQLLPDDRPQHWE-WWQWPQWETNEHDCRYLRRHY

QF-----RNISAKNCFERVMVRFL-YMMEPIV-----------YWSTGILFRKTQ
..      .  .   . | .||.. . ... .           || .|... ...
HYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKCFYERSCCEWMYWRNGMVLKWEG
ROC Roco8.AA ROC 831-933 22 1e-20 66.51 In-house 80-215 (215) Show / Hide 
Range on Protein: 831-933
Range on HMM: 80-215/215
Sequence Identity: 22% (31 aa)

DVYYHTHQFFLSE-RAFYLVTYDINK-----DLS----HSG--LEFWVESIKKKAPN--------APIYIVATHIDTFNQYGG---DILVPLNEIDQYLT
..|. ||||||.. |..||. .|. .       .    ..   ||.|  .||  .|.        .|. ||.||.|  ...     .  ...  . | | 
EIYHATHQFFLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCC-RMWQKLR

QRSLEV----------TGVIGVSSTTL-RNIDLLKNE
..   .           |.. |...|   .|| |.. 
NKFPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH
Miro Roco8.AA Miro 834-886 16 0.00094 15.61 Pfam 82-140 (140) Show / Hide 
Range on Protein: 834-886
Range on HMM: 82-140/140
Sequence Identity: 16% (10 aa)

YHTHQFF--LSERAFYLVTYDINKDLSHSGL-EF--WVESIKKKAPN-APIYIVATHID
...|..|  . ..  ....||  .. | . . ..  |  ...|.. .  |...|....|
KFEHMHFACMKWADAICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
Kinase Roco8.AA LRRK 1456-1858 32 9.90000000001e-175 586.77 In-house 1-351 (351) Show / Hide 
Range on Protein: 1456-1858
Range on HMM: 1-351/351
Sequence Identity: 32% (148 aa)

LIYQEEIGVGGFS-RVYKGIYKN----------------------------NTVAIKQFNFERMDLIDSTSFNNLNSLTISPSNSSLSISLSSSTSSLSP
|...|.||.|||  .||......                            ..||||..|...| .|| .. .|                          
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPM-TID-ND-CN--------------------------

PIVNNNNNNNNLNNNLNNLNNNNKLYIQQQQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQPKILQRNLSTSSLSSNSSQGEDSMN
    |.|||||||||.                                                                           |.|.|| |.
----NSNNNNNLNNNN---------------------------------------------------------------------------SEQVED-MD

QISSGKLNAINEFRREVWLMSGLSHSNIVLMKGFCFEPYAIVMEYMDIGSLSSFLKKKKEDGQ-----VLDWQMLLKIVTDIASGMAFLHNITPPLVHRD
|.......| .|||.|||.||.| |.||| .||||..|...||||...|.|..||..||.||.     ...|...|||...||.||..||. .||..|||
QNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRD

LKSPNILLASHPTNP------NEISAKVSDFGLSR--SIVQN-FSSKVVDNPTWQSPEVLKGM---EYNEKSDIYSFGMILWECYHLE-LPFDEFD----
|||||||| |.|.|.      ... ||..|||.||  ..... . ...|.||.|..||.....   ||.||.|.|||||||||..... .||||.|    
LKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDH

FKFMSTLEDNILSGLRPSINQN-CNR-----MYSSLITKCWNADPNLRPSFNSILKTLNE
...|...||.|..||||.|.|. |..     ||..||..||..||. ||.|..|.|.| .
MQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Roco8.AA TKL 1462-1856 23 2.4e-105 356.3 In-house 1-364 (364) Show / Hide 
Range on Protein: 1462-1856
Range on HMM: 1-364/364
Sequence Identity: 23% (116 aa)

IGVGGFSRVYKGIYKN----------NTVAIKQFNFERMDLIDSTSFNNLNSLTISPSNSSLSISLSSSTSSLSPPIVNNNNNNNNLNNNLNNLNNNNKL
|| |||. ||||....          ..||.|.|. . .|. ...| .|                             |. || |.              
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQEN-----------------------------ND-NN-NY--------------

YIQQQQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQPKILQRNLSTSSLSSNSSQGEDSMNQISSGKLNAINEFRREVW-LMSGLS
                                                                   |   | | |. . ..  ...|..|.. .|| |.
-------------------------------------------------------------------S---D-M-QLNDPEASWFRFFEEEEIMMMSRLR

HSNIVLMKG---------FCFEP------YAIVMEYMDIGSLSSFLKKKKEDGQVLDWQMLLKIVTDIASGMAFLHNIT------PPLVHRDLKSPNILL
| |||...|         .| .|      ..|||||.. ||| ..|           |. ..... |||.||..||. .      ||..||||||.|||.
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV

ASHPT-------NPNEIS-AKVSDFGLSRSIVQNF---------------------SSKVVDNPTWQSPEVLKGM----------------EYNEKSDIY
 .. |       |||..  .|..||||||.. |..                     ..... .| | .||||.|.                ||.||.|.|
DENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY

SFGMILWECYHLELPFDEFDFKFMS-------TLEDNILSGLRPSIN------------QNCNRMYSSLITKCWNADPNLRPSFNSILKTL
|||..|||..  ..|......  |         .. ... |||| |              .| . ...|...||..||. ||||. |||.|
SFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Roco8.AA TKL-Unique 1638-1856 34 4e-73 249.24 In-house 41-290 (290) Show / Hide 
Range on Protein: 1638-1856
Range on HMM: 41-290/290
Sequence Identity: 34% (86 aa)

EFRREVWLMSGLS-HSNIVLMKGFCF----EPY--AIVMEYMDIGSLSSFLK------KKKEDGQVLDWQMLLKIVTDIASGMAFLHNITPPLVHRDLKS
||..|| .|. |  | |||.  |.|.     |    |||||.. ||| . |          ..   |..|. .|.. |||.|| .||.  ||  ||||||
EFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKS

PNILLASHPTNPNEISAKVSDFGLSRSIVQN---FSS--------KVVDNPTWQSPEVLKG--MEYNEKSDIYSFGMILWECYHLEL------PFDEFDF
.|.|. ..  | .|...|..|||||..  ..   ...         ..... | .||||..    |.||||.||||..|||..  ..      |....|.
SNFLVDNN-SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQ

KFMSTLEDNILSGLRPSINQNCNRMYSSLITKCWNADPNLRPSFNSILKTL
..   ...  . ..|| | ..|.  |. ||..||. ||  ||||..|.. |
EQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Roco8.AA MLK 1638-1856 32 2.9e-60 206.53 In-house 51-291 (291) Show / Hide 
Range on Protein: 1638-1856
Range on HMM: 51-291/291
Sequence Identity: 32% (79 aa)

EFRREVWLMSGLSHSN----IVLMKGFCFEP---YAIVMEYMDIGSLSSFLKKKKEDGQ----------VLDWQMLLKIVTDIASGMAFLHNITP-PLVH
.|..|. . . ||| |    |.  .| | .|   ..|||||.. |||...|. ..  .           | | . .... ...|.||..||.  | |..|
DFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIH

RDLKSPNILLAS--HPTNPNEISAKVSDFGLSRSIVQNFSS---KVVDNPTWQSPEVL---KGMEYNEKSDIYSFGMILWECYHLELPFDEFDFKFMSTL
|||||.|||..   |  . ..  .|..|||.||.. |.  .   .   .. | .|||.   ..  |.||.|..|.|..|||    |.|..  . . |  .
RDLKSHNILIDEICH--DMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK-QHYDPMAIA

EDNILSGLRPSINQNCNRMYSSLITKCWNADPNLRPSFNSILKTL
  ... |||| | ..|..  ..|...|||.||. |||| .|.. |
WWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Roco8.AA TK 1456-1856 13 1.2e-52 174.44 In-house 1-486 (486) Show / Hide 
Range on Protein: 1456-1856
Range on HMM: 1-486/486
Sequence Identity: 13% (83 aa)

LIYQEEIGVGGFS---RVYKGIYKNN---------------------------TVAIKQFN----FERMDLID-------STSFNNLNSLTISPSNSSLS
... ...| | |    .||||....                            .||.|.       . .. .|        .                  
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGG------------------

ISLSSSTSSLSPPIVNNNNNNNNLNNNLNNLNNNNKLYIQQQQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQPKILQRNLSTSSL
                                                                                                    
----------------------------------------------------------------------------------------------------

SSNSSQGEDSMNQISSGKLNAINEFRREVWLMSGLS-----HSNIVLMKGFCF--------------EPYAIVMEYMDIGS----LSSFLKKKKEDGQV-
                     . .| .|.  |. ..     | ||| . | |.              ||. ||||||. |.    | ..|.|.....|  
---------------------E-DFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHE

-----------------------------------------------------------------------LDWQMLLKIVTDIASGMAFLHNITP----
                                                                       |. . || .  .||.||..||        
QDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQ

PLVHRDLKSPNILLASHPTNP-----NEISAKVSDFG--------LSRSIVQNFSSKVVDNPT----------------------------WQSPEVLKG
 .|||||   |.|.... ..      ..  .|..|||        |.| | ..    ......                            | .||.|..
NFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLND

ME---------YNEKSDIYSFGMILWECYHLE-LPFDE-----------FDFKFMSTLED----------NILSGLRPSINQNCN--------------R
 .         . .|||..|||  .||.. .   |. .            .  .|  |..          ..  ..|.   ..|                
RVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPE

MYSSLITKCWNADPNLRPSFNSILKTL
.|  |...||..||. ||.|  ... |
EYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Roco8.AA Pkinase_Tyr 1638-1856 33 1.3e-49 168.63 Pfam 49-270 (270) Show / Hide 
Range on Protein: 1638-1856
Range on HMM: 49-270/270
Sequence Identity: 33% (78 aa)

EFRREVWLMSGL-SHSNIVLMKGFCF---EP--YAIVMEYMDIGSLSSFLKKKKEDGQVLDWQMLLKIVTDIASGMAFLHNITPPLVHRDLKSPNILLAS
.| ||. .|. | .| ||| . | |    ||  . ||||||  |.| ..|.|..||.| |. ..||.. ..||.||..|...   ..||||   |.|...
DFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE

HPTNPNEISAKVSDFGLSRSI-------VQNFSSKVVDNPTWQSPEVLKGMEYNEKSDIYSFGMILWECYHLE-LPFDEFDFKFMSTLE--DNI-LSGLR
      .  .|..||||.| |       ..  ..|      | .||... .....|||..|||  .|| . .   |    ... ||  |  . |  .| |
------NNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQP----TYPGMSNEEVYEYIYEDGYR

PSINQNCNRMYSSLITKCWNADPNLRPSFNSILKTL
  . .||     .|...||..||. ||.|  |.  |
MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Roco8.AA Dicty4-Unclassified 1636-1856 35 1.8e-49 167.58 In-house 42-263 (263) Show / Hide 
Range on Protein: 1636-1856
Range on HMM: 42-263/263
Sequence Identity: 35% (84 aa)

INEFRREVWLMSGLSHSNIVLMKGFCFEP------YAIVMEYMDIGSLSSFLK-KKKEDGQVLDWQM--LLKIVTDIASGMAFLHNITPPLVHRDLKSPN
| .|..|| ..  ..| | | ..| |  |      . |||| |  | |      |  |  | .       .|.  ||| ||..||  |  ..|||.|| |
IQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLH--TRNFIHRDIKSSN

ILLASHPTNPNEISAKVSDFGLSRSIVQNFSSKVVD-NPTWQSPEVLKGMEYNEKSDIYSFGMILWECYHLELPFDEFDFKFMSTLEDNIL---SGLRPS
||.  |        .|. |||.|| |  ||    .   | | |||.|..  || |||.||..|.|.|    . |. |      | ..  ..    .||| 
ILMDKH------FNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEPYQEIQ----SIMNAARSVCDKKLRPK

INQNCNRMYSSLITKCWNADPNLRPSFNSILKTL
|  ||   ...||  ||  ||| ||..| | . |
IPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase Roco8.AA Dicty4 1633-1793 37 3.3e-46 152.21 In-house 39-210 (277) Show / Hide 
Range on Protein: 1633-1793
Range on HMM: 39-210/277
Sequence Identity: 37% (66 aa)

LNAINEFRREVWLMSGLSHSNIVLMKGFCF----EP--YAIVMEYMDIGSLSSFLKK---KKEDGQVLDWQMLLK---IVTDIASGMAFLHNITPPLVHR
.| .||||.|| .|. ..| ||.| .| |     .|    ||.|||  |.| | | .    . .   |||   ..   .  |.| ||. ||. .|  .||
ENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHR

DLKSPNILLASHPTNPNEISAKVSDFGLSR----SIVQNF-SSKVVDNPTWQSPEVLKGMEYNEKSDIYSFGMILWEC
|||| |.|   .        .||.|||||.     . ...  . ..  | | .|||. . .||||.| ||||..|||.
DLKSHNLLVDKN------WRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEI
Kinase Roco8.AA HH498 1639-1856 31 1.8e-44 138.63 In-house 49-284 (284) Show / Hide 
Range on Protein: 1639-1856
Range on HMM: 49-284/284
Sequence Identity: 31% (77 aa)

FRREVWLMSGLSHSNIVLMKGFCFE---PYAIVMEYMDIGSLSSFL--------------KKKKEDGQVLDWQMLLKIVTDIASGMAFLHN-ITPPLVHR
| ||| .|. |.| . |   . | .     ||| .| | ||| | |                 |.   ..| |  . |  |.| || .|||  ..| .||
FCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHR

DLKSPNILLASHPTNPNEISAKVSDFGLSRSIVQNFSSKVVD---NPTWQSPEVLK-GMEYNEKSDIYSFGMILWECYHLELPFDEFDFKFMSTLEDNIL
|| | |||.        .  |.| ||| || . .           |. | .||| . .  | .| |..|..|..|| .  |.||   ..|      .   
DLNSHNILIH------EDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFH--HYKPAAAAAEMAY

SGLRPSINQN----CNRMYSSLITKCWNADPNLRPSFNSILKTL
   || | |       .  |.||  ||.. |. ||.|  |.  |
HHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase Roco8.AA TyrKc 1456-1856 18 3.8e-43 150.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 1456-1856
Range on HMM: 1-280/280
Sequence Identity: 18% (84 aa)

LIYQEEIGVGGFSRVYKGIYKNNTVAIKQFNFERMDLIDSTSFNNLNSLTISPSNSSLSISLSSSTSSLSPPIVNNNNNNNNLNNNLNNLNNNNKLYIQQ
.   ...| | | .||||..|                                                                               
ITLGKKLGEGAFGEVYKGTWK-------------------------------------------------------------------------------

QQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQP---KILQRNLSTSSLSSNSSQGEDSMNQISSGKLNAINEFRREVWLMSGL--S
                                             ..   | |. .                           . .|.||  .|. |  .
---------------------------------------------IQVAVKMLKEDA--------------------------REDFMREARIMCKLGGH

HSNIVLMKGFCF---------EPYAIVMEYMDIGSLSSFLKKKKEDGQVLDWQMLLKIVTDIASGMAFLHNITPPLVHRDLKSPNILLASHPTNPNEISA
| ||| . | |          ||. ||||||. |.| ..|.|....   | .. ||.. ..||.||..||    ...||||   |.|...         .
HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH------TV

KVSDFGLSRSIVQN----FSSKVVD-----NPT------WQSPEVLKGMEYNEKSDIYSFGMILWECYHL-ELPFDE---FDFKFMSTLEDNILSGLRPS
|.||||||| |        |... .     .        | .||...  ....|||..|||  .|| . . . |  .     ..  . .  .. .| |. 
KISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMP

INQN--------C-NRMYSSLITKCWNADPNLRPSFNSILKTL
. .|        |   ||. ....||..||. ||.|. | . .
QPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase Roco8.AA DRK 1633-1793 40 9e-40 132.4 In-house 38-195 (258) Show / Hide 
Range on Protein: 1633-1793
Range on HMM: 38-195/258
Sequence Identity: 40% (67 aa)

LNAINEFRREVWLMSGLSHSNIVLMKGFCFEP--YAIVMEYMDIGSLSSFLKKKKEDGQVLDWQMLLKIVTDIASGMAFLHNITPPLVHRDLKSPNILLA
.| .|||.||. ||. | | ||..  | | .|    |.||||  ||| . |   .     .||  ....  |.| || .||. .|  .|||||| | |  
ENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIE---MDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVD

SHPTNPNEISAKVSDFGLSR----SIVQNFSSKVVDNPTWQSPEVLKGMEYNEKSDIYSFGMILWEC
 |         ||.|||||        . |    .  | | .||||    | || |.|||. .||||
EH------WQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWEC
Kinase Roco8.AA S_TKc 1456-1864 16 2e-37 131.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 1456-1864
Range on HMM: 1-231/231
Sequence Identity: 16% (71 aa)

LIYQEEIGVGGFSRVYKGIYKN--NTVAIKQFNFERMDLIDSTSFNNLNSLTISPSNSSLSISLSSSTSSLSPPIVNNNNNNNNLNNNLNNLNNNNKLYI
    ..|| |.|..|||.. |.    ||||. .                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

QQQQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQPKILQRNLSTSSLSSNSSQGEDSMNQISSGKLNAINEFRREVWLMSGLSHSN
                                                                                   . .|||. ...   | |
-----------------------------------------------------------------------------------EHIRREIQILKK-HHPN

IVLMKGFCF-EPYAIVMEYMDI--GSLSSFLKKKKEDG--QVLDWQMLLKIVTDIASGMAFLHNITPPLVHRDLKSPNILLASHPTNPNEISAKVSDFGL
|| .....  . . .||||.|   |.| ...||..  |  ....  .  ...  |.......|.     .|||||  |||| .          |..||||
IVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--------HIKICDFGL

SRSIVQNFSSKVVDNPTWQSPEVLKGMEYNE-KSDIYSFGMILWECYHLELPFDEFDFKFMSTLEDNILSGLRPSINQNCNRMYSSLITKCWNADPNLRP
.| .     . ..  | . .||||    |.  |.|..|.| ||.|..  . ||.      | .. ..|.            .   ..| ||.. ||. ||
ARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRP

SFNSILK-TLNEIKDSTI
.   .|.  .   ..  .
TA-EALQDEWDIKCHPWF
Kinase Roco8.AA CZAK 1639-1792 40 2.3e-32 113.84 In-house 47-214 (279) Show / Hide 
Range on Protein: 1639-1792
Range on HMM: 47-214/279
Sequence Identity: 40% (69 aa)

FRREVWLMSGLSHSNIVLMKGFCFEPY----AIVMEYMDIGSLSSFLKKKKEDGQVLDWQ---MLLKIVTDIASGMAFLHN-ITP-PLVHRDLKSPNILL
| .||  || | | |.|   | | |       ||||.|  |||  .|     |   .  |   . ...  ||| || .||   .| | .|||| | ||||
FQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLL----TDHYFYHKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL

ASHPT--NP-----NEISAKVSDFGLSRSIVQNFSS--KVVDNPTWQSPEVLKGMEYNEKSDIYSFGMILWE
 .  |  ||      .| .|..||||||      .     .    |. ||. ||  | ||.|.||||||||.
DHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVYSFGMILWC
Kinase Roco8.AA Pkinase 1640-1856 21 2.1e-30 108.6 Pfam 46-293 (293) Show / Hide 
Range on Protein: 1640-1856
Range on HMM: 46-293/293
Sequence Identity: 21% (56 aa)

RR--EVWLMSGLSHSNIVLMKGFC--FEPYAIVMEYMDIG----SLSSFLKKKKEDGQVL--DWQMLLKIVTDIASGMAFLHNITPPLVHRDLKSPNILL
||  |. .|  |.| ||| .....     . .||||.. |    .|.....   ... ..  ... . .... |..|....|.     .|||||. |||.
RRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILI

ASHPTNPNEISAKVSDFGLSR---SIVQNFSSKVVDNPTWQSPEVLK-GMEYNEKSDIYSFGMILWECYHLELPFDEF----DFKFMSTLEDNILSGLRP
 ......   . |..||||..      .   . ..  | . .|||.. | .|  |.|..|.| ||.| .  ..||..     .   .  . ..|...  .
DNNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLH

SINQ--------------------NCNRMYSSLITKCWNADPNLRPSFNSILKT--L
.  .                    | ..   ..|..|.. ||. ||..  ||.   .
FDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Roco8.AA Dicty4 1818-1858 39 1.9e-16 51.5 In-house 235-277 (277) Show / Hide 
Range on Protein: 1818-1858
Range on HMM: 235-277/277
Sequence Identity: 39% (17 aa)

GLRPSINQNCNRMYSSLITKCWNADPNLRPSFNSILKT--LNE
.|||.| ..|   ...||..||. ||. ||||. |..   |..
KLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Roco8.AA DRK 1818-1858 41 7.1e-11 33.11 In-house 218-258 (258) Show / Hide 
Range on Protein: 1818-1858
Range on HMM: 218-258/258
Sequence Identity: 41% (17 aa)

GLRPSINQNCNRMYSSLITKCWNADPNLRPSFNSILKTLNE
|.|| . |.|   |  |.. ||| ||  |||.  .|. |  
GMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Roco8.AA CZAK 1820-1856 42 6e-10 32.46 In-house 240-279 (279) Show / Hide 
Range on Protein: 1820-1856
Range on HMM: 240-279/279
Sequence Identity: 42% (17 aa)

RPSINQNCNRMYS---SLITKCWNADPNLRPSFNSILKTL
|| ..|    |      ||..|||  | .||||  ||  |
RPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase Roco8.AA TKL-Unique 1458-1487 46 2.1e-07 22.38 In-house 94-123 (290) Show / Hide 
Range on Protein: 1458-1487
Range on HMM: 94-123/290
Sequence Identity: 46% (14 aa)

YQEEIGVGGFSRVYKGIYKNNTVAIKQFNF
  . || ||...||||...   ||||||..
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP
Kinase Roco8.AA Dicty4-Unclassified 1456-1486 45 1e-06 18.78 In-house 1-31 (263) Show / Hide 
Range on Protein: 1456-1486
Range on HMM: 1-31/263
Sequence Identity: 45% (14 aa)

LIYQEEIGVGGFSRVYKGIYKNNTVAIKQFN
.    .|| | ||.|.||. |   ||.| ||
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFN
Kinase Roco8.AA HH498 1456-1483 46 1e-06 16.5 In-house 105-132 (284) Show / Hide 
Range on Protein: 1456-1483
Range on HMM: 105-132/284
Sequence Identity: 46% (13 aa)

LIYQEEIGVGGFSRVYKGIYKNNTVAIK
. ..| || | |  |||| . |  ||.|
IEFHEKIGSGSFGKVYKGEWRNKIVAVK
Kinase Roco8.AA MLK 1456-1488 31 2e-06 18.49 In-house 1-38 (291) Show / Hide 
Range on Protein: 1456-1488
Range on HMM: 1-38/291
Sequence Identity: 31% (12 aa)

LIYQEEIGVGGFSRVYKGIYKNNT-----VAIKQFNFE
.  .| ||.|.|  |.|| ..|..     ||.|.....
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRAR
Kinase Roco8.AA Dicty4 1456-1483 39 7e-06 15.72 In-house 1-28 (277) Show / Hide 
Range on Protein: 1456-1483
Range on HMM: 1-28/277
Sequence Identity: 39% (11 aa)

LIYQEEIGVGGFSRVYKGIYKNNTVAIK
.  ...|| |.|. ||||. .   ||.|
INIEQRIGKGSFGEVYKGTWRGKEVAVK
Kinase Roco8.AA Pkinase_Tyr 1456-1483 32 5.1e-05 17.61 Pfam 1-34 (270) Show / Hide 
Range on Protein: 1456-1483
Range on HMM: 1-34/270
Sequence Identity: 32% (11 aa)

LIYQEEIGVGGFSRVYKGIYK------NNTVAIK
..  ...| | | .||||..|      . .||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase Roco8.AA Pkinase 1456-1486 33 6.5e-05 18.46 Pfam 1-33 (293) Show / Hide 
Range on Protein: 1456-1486
Range on HMM: 1-33/293
Sequence Identity: 33% (11 aa)

LIYQEEIGVGGFSRVYKGIYKNNT--VAIKQFN
.   . || |.|..|||.. |..   ||.|...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK
Kinase Roco8.AA CZAK 1456-1483 42 0.001493 8.95 In-house 1-28 (279) Show / Hide 
Range on Protein: 1456-1483
Range on HMM: 1-28/279
Sequence Identity: 42% (12 aa)

LIYQEEIGVGGFSRVYKGIYKNNTVAIK
|    .|| | |  |||.  .   ||||
LKFGQTIGQGFFGEVYKAYWRGKDVAIK