Gene Shk4 (Slime mold)

Shk4

Species: Slime mold
Alias: Shk4, shkD, DDB0230122, DdisK204
External Links: DictyBase Link ,
Annotation:

Classification

Group: TKL
Family: Dicty4
Subfamily: Shk

Sequence

Name Sequence Type Origin Length Description Download
Shk4.AA Protein None 744 None Fasta, JSON
Shk4.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of Shk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Shk4.AA Shk 277-535 68 1.1e-225 756.06 In-house 1-269 (269) Show / Hide 
Range on Protein: 277-535
Range on HMM: 1-269/269
Sequence Identity: 68% (183 aa)

IDRTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKIFHPNVVLFLGACT-QSGKMQIVTELC-QTDLEKLLHNDRTKKEFSLF
|.|.|||||||||.||||.|||.|||||...||.......||||.||.|||||||||..||.|||| |.||..|||||. ...||||||....||.|.|.
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQMVKKPFILY

RR-MQMAKDAALGMNWLHG-ITRIVHNDLKTANLLVDINLRVKVTDFGFSQ-IKEGEEFQD--KAAKGTPLWMAPEVMMGNPYNEKADVYSFGIILWEIL
.| |.|..||||||||||| ...|.|.||||||||||.|.||||.|||||| .|..|...|  |.||||||||||||||..|||||||||||||||||||
KRAMRMCRDAALGMNWLHGSNCNIIHRDLKTANLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEIL

TKEAPYS-HHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFR--LNEILI
|...||. ||..||.|..||||.|||||||.|...||.||||.|||||||.||||.||..|  ||.|||
TCQEPYPKHHSEYDKFYEAICNKKERPPIPDDCPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase Shk4.AA Dicty4 277-532 54 2.4e-190 638.62 In-house 1-277 (277) Show / Hide 
Range on Protein: 277-532
Range on HMM: 1-277/277
Sequence Identity: 54% (151 aa)

IDRTDFLGQGSFGSVYKGKCRGQEVAVKIP--RKQKLSLYELTSFRHEVKIMSKIFHPNVVLFLGACT----QSGKMQIVTELC-QTDLEKLLHN-----
|......|.||||.||||..||.|||||..  ..|......|..||.||.||.||.|||..||.||||    ..|||.||||.. ...|..|||.     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-DRTKKEFSLFRR-MQMAKDAALGMNWLHG-ITRIVHNDLKTANLLVDINLRVKVTDFGFSQ-IKEGEEFQD--KAAKGTPLWMAPEVMMGNPYNEKADV
 ...|....|..| |.||.|||.||||||. ...|.|.|||..|||||.|.||||.|||.|| .|..|...|  ..|.|||.||||||||..||||||||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

YSFGIILWEILTKEAPYS-HHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFR--LNE
|||||.||||||...||. ||..|..|..|.||.|.|||||....||..||||.||||.||.||||.||..|  |..
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase Shk4.AA TKL 283-530 30 7.69999999999e-101 341.31 In-house 1-364 (364) Show / Hide 
Range on Protein: 283-530
Range on HMM: 1-364/364
Sequence Identity: 30% (112 aa)

LGQGSFGSVYKGKCRG----------QEVAVKIPRKQKLSLYELTS-----------------------FRHEVKIMSKIF--HPNVVLFLGACTQSGK-
.|.|.|| |||||.||          ..||||. ...  .. ...|                       |. |. ||...   |||.|.|.|.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MQIVTELC-QTDLEKLLHNDRTKKEFSLFRRMQMAKDAALGMNWLHGITR-------IVHNDLKTANLLVDINLR-------------
            . ||.|.|   .|. .||         . .|...|.|.|.|||.||  .        |.| |||..|.||| |..             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-VKVTDFGFSQIKEGEEFQDKA-------------------AKGTPLWMAPEVMMGN----------------PYNEKADVYSFGIILWEILTKEAPYSH
 .|..|||.|. ..... . .                      ||| ||||||..|.                .|.||.|||||||.|||||| . ||..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

HKDY--------DIFFNAICNEKERPPIP------------ADTLPSLRHLIQTCWDHNPQNRPSFSEILFRL
.. .        ...|  .|....|||||             |..||.. |.| ||||.|..||||.||| ||
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Shk4.AA TKL-Unique 279-530 36 1.7e-87 297.0 In-house 1-290 (290) Show / Hide 
Range on Protein: 279-530
Range on HMM: 1-290/290
Sequence Identity: 36% (105 aa)

RTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTS-FRHEVKIMSKIF-HPNVVLFLGACT----QSGKMQIVTELCQTD-LEKLLH-------N
    .|.|..|.||||| || .||.|.  .. .|  |..  |. ||..|.|.  |||.|.. |.|.    . ..| ||.| |.   | ..||       |
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

DRTKKEFSLFRRMQMAKDAALGMNWLHGITR-IVHNDLKTANLLVDIN-----LRVKVTDFGFSQIKEGEEFQDKAAK---------GTPLWMAPEVMMG
 . ...... .|..||.|.|.||. ||     | | |||. |.||| |     ...|. |||.| ..  .    .  .         |...||||||...
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

--NPYNEKADVYSFGIILWEILTKEA------PYSHHKDYDIF-FNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFRL
  . |.||.|||||||.||||.| .       ||..  .. ..   .   |. ||||| .  ...|.||| ||.|.|..||||.||. ||
NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase Shk4.AA DRK 284-532 37 5.7e-75 253.33 In-house 8-258 (258) Show / Hide 
Range on Protein: 284-532
Range on HMM: 8-258/258
Sequence Identity: 37% (98 aa)

GQGSFGSVYKGKCRGQEVAVKIPRKQKLS-LYELTSFRHEVKIMSKIFHPNVVLFLGACTQSGKMQIVTE-LCQTDLEKLLHNDRTKKEFSLFRRMQMAK
| |..| |. |  || .||||         .  |  |. |. .|..  |||...|.|.|. .    |..| .    | . ||..  . . .|  ..||. 
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL--MKQMMF

DAALGMNWLHGITRIV-HNDLKTANLLVDINLRVKVTDFGFSQ----IKEGEEFQDKAAK---GTPLWMAPEVMMGNPYNEKADVYSFGIILWEILTKEA
|.| ||. ||. . |. | |||. ||||| . .||| ||| |     .|     | |.|.   ||| | ||||    .| ||||||||.|.|||..| . 
DCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHK-----QHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQD

PYSHHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFRLNE
||       . | ..  ...|||.|.   |    |.. ||. .|| |||. |.| ||  
PYFGMPTFQVVF-SVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase Shk4.AA MLK 277-530 31 2.6e-73 249.84 In-house 1-291 (291) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-291/291
Sequence Identity: 31% (94 aa)

IDRTDFLGQGSFGSVYKGKCRGQE-----VAVKIPRKQK----LSLYELTSFRHEVKIMSKIFHPN----VVLFLGACTQSGK-MQIVTELCQT-DLEKL
|.   ..| ||||.|.||..|...     ||||. |  .     .  |   |. |... ... |||    .. |.|.|.|...   ||.| |.   |  .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHNDRTKKE-----------FSLFRRMQMAKDAALGMNWLHGITR--IVHNDLKTANLLVDI------NLRVKVTDFGFSQIKEGEEFQDK-----AAKG
||. |.| .            ..   |. |.. | ||. ||   .  |.| |||  |.|.|       .. .|..||| |      .....      ..|
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR-----DWHQMCTNMMSNAG

TPLWMAPEVM---MGNPYNEKADVYSFGIILWEILTKEAPYS-HHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFRL
|. ||||||     ...|.||.||.|.|..|||.||.| ||. |..   |.. .. ....||||| .  ...  |.. ||. .| .||||..|.  |
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVA-YNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase Shk4.AA Pkinase_Tyr 277-530 31 2.3e-65 222.02 Pfam 1-270 (270) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-270/270
Sequence Identity: 31% (87 aa)

IDRTDFLGQGSFGSVYKGKCR------GQEVAVKIPRKQKLSLYE--LTSFRHEVKIMSKI-FHPNVVLFLGACT-QSGK--MQIVTELCQT-DLEKLLH
|     ||.|.||.||||...      ...||||.  |.. .  .  . .| .|.|||...  |||.| ..|.|| |..   . ||.|...  || . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ND-RTKKEFSLFRRMQMAKDAALGMNWLHGITRIVHNDLKTANLLVDINLRVKVTDFGFSQIKEGEEFQ---DKAAKGTPL-WMAPEVMMGNPYNEKADV
.    |. ... .  ||. . | ||..|. .  ..| || . | ||. |. ||..||| .   . ..      . .|  |  |||||... . ...| ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDV

YSFGIILWEILTKE-AP-YSHHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFRL
.|||. .|||.|    | |   .... ....|  . .| |.| .. . . .|.. ||...|..||.||||. .|
WSFGVLMWEIFTYGEQPTYPGMSNEE-VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Shk4.AA LRRK 275-532 27 3e-65 223.08 In-house 1-351 (351) Show / Hide 
Range on Protein: 275-532
Range on HMM: 1-351/351
Sequence Identity: 27% (99 aa)

EEIDRTDFLGQGSFG-SVYKGKCRG----------------------------QEVAVKIPRK--------------------------------QKLSL
 .| .   .|.|.|| .||..|.||                            |.||.|.  .                                   ..
LKIEEQ--IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCC

YELTSFRHEVKIMSKIFHPNVVLFLGACTQSGKMQIVTELCQT-DLEKLLHNDRTKK------EFSLFRRMQMAKDAALGMNWLHGIT-RIVHNDLKTAN
  . .||||| |||.  |||.|  .| | .   . .|.|. .  || ..||| .  .      ..|   . . | . | ||. ||  .  |.| |||. |
RAFREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

LLV-DI-----------NLRVKVTDFGFSQ--IKEGEE-FQDKAAKGTPLWMAPEVMMGN---PYNEKADVYSFGIILWEILTKE-APYSHHKDY-----
 |.  .           .  .|. ||| |.     ... . ..   |.|.|||||.| .|    |.||.|.||||.||||.|| .  |. .|. .     
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV--GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQW

DIFFNAICNEKERPPIPAD-TLP-----SLRHLIQTCWDHNPQNRPSFSEILFRLNE
 ...  . .|. ||.|| .  .|     ..  ||| ||.|.|..||.||.|. || .
MEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase Shk4.AA TK 277-530 17 1.6e-61 204.72 In-house 1-486 (486) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)

IDRTDFLGQGSFG---SVYKGKCRG---------------------------QEVAVKIPRKQKLSLYELTS---------------FRHEVKIMSK-IF
|   . ||.| ||    ||||. ||                           ..||||. ..   .  |                  . .| |.|.  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVVLFLGACTQS------------GKMQIVTELCQ-TD----LEKLLHNDRTKKE------------------------------------------
 |||.| ..|.|||.            . . ||.|...  |    | . |.. | |.                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FSLFRRMQMAKDAALGMNWLHGIT-----RIVHNDLKTANLLVDINLR-----------VKVTDFG---
                               ... ... |. ..| || .||        ..|| || . | ||. |..           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----FSQIKEGEEFQDKAA-KGTPL-------------------------WMAPEVMMGNP---------YNEKADVYSFGIILWEILTKE-APYSHHK
      .   . ..   ..  .||..                         |||||.....          . .| ||.|||. .|||.|   .||    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DY---------DIFFNAICNE-------------KERPPIPADTL--------------PSLRHLIQTCWDHNPQNRPSFSEILFRL
.          . ... ....             . |.| |..                . .  |.| ||...|. ||.||... .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Shk4.AA Dicty5 277-534 35 1.8e-59 203.34 In-house 1-260 (260) Show / Hide 
Range on Protein: 277-534
Range on HMM: 1-260/260
Sequence Identity: 35% (95 aa)

IDRTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKIF--HPNVVLFLGACTQSGKM-QIVTELCQT-DLEKLLHNDRTK---K
.   |.   |. | ||.|  .|  ||.|         ... .|  || ||| .   |||.. ..|| ..  |   .|||.|.   |  .| ||. |   .
VSFHDWIASGASGRVYNGIYKGMDVAIKVYSQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYL-NDQRKTTGQ

EFSLFRRMQMAKDAALGMNWLHGITRIVHNDLKTANLLVDINLRVKVTDFGFSQIKEGEEFQDKAAKGTPLWMAPEVMMGNPYNEKADVYSFGIILWEIL
  . | .. || |.| .| .|| .  |.| |||  | |.  |. .|. ||| |   .    .     ||. |||.|.  |.|| .|.|||||||.|||..
PIAYFQQLHMAIDIAQSMRHLHSMN-IIHRDLKSMNFLITENWKIKIIDFGTSRFVD-NRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMF

TKEAPYSHHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFRLNEIL
|.  ||      .|    .    ||| ||.|   .   ||  ||   |.||||| ||.  .. | 
TRKEPYDNINNWNI--PVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase Shk4.AA S_TKc 277-534 24 1.8e-56 194.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 277-534
Range on HMM: 1-231/231
Sequence Identity: 24% (66 aa)

IDRTDFLGQGSFGSVYKGKCRG--QEVAVKIPRKQKLSLYELTSFRHEVKIMSKIFHPNVVLFLGACTQSGKMQIVTELCQT---DLEKLLHNDRTKKE-
 .  . .|.|.||.|||.. ..  ..||.|| .          ..| |..|..|  |||.| .....   ... .|.|.| .   || ..... ....  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FSLFRRMQMAKDAALGMNWLHGITRIVHNDLKTANLLVDINLRVKVTDFGFSQIKEGEEFQDKAAKGTPLWMAPEVMMGNPYNE-KADVYSFGIILWE
  |.  .   ...  ..... .|   .|.| ||| .|.|.|   ..|..|||.. .        .   ||| .|||||.   .|.  |.|..|.|.||.|
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

ILTKEAPYSHHKDYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEIL-----FRLNEIL
 |. . |..   ...  |. |.             |.....|. |.. .|..||.  |.|      .. . .
MLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Shk4.AA TyrKc 277-530 29 4.2e-55 190.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-280/280
Sequence Identity: 29% (85 aa)

IDRTDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKI--FHPNVVLFLGACTQS-------GKMQIVTELCQT-DLEKLLHNDR
|   . || | || ||||. . ..||||  .. .     .  |..| .||.|.   |||.| ..|.|||.       . . ||.|..   || . |.. |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

TKKEFSLFRRMQMAKDAALGMNWLHGITRIVHNDLKTANLLVDINLRVKVTDFGFSQIKEGE-------EFQDK----AAKG-TPL-WMAPEVMMGNPYN
 |  ...    ... ..| ||. ||   ...| || . | ||. |..||..||| |   . .       .  .|     .|.  |. |||||... . ..
PK--LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EKADVYSFGIILWEILTK-EAPYSH-----HKDYDIFFNAICNEKERPPIPAD--------TLPSLRHLIQTCWDHNPQNRPSFSEILFRL
.| ||.|||. .|||.|  . ||.       ...... .    . .|.|.|..          . .  ....||...| .||.||||  ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK--QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Shk4.AA Pkinase 277-530 23 1.1e-51 182.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 277-530
Range on HMM: 1-293/293
Sequence Identity: 23% (71 aa)

IDRTDFLGQGSFGSVYKGKCRGQE--VAVKIPRKQKLSLYELTSFRH--EVKIMSKIFHPNVVLFLGACTQSGKMQIVTELCQTDLEKLLHND-----RT
. .   .|.||||.|||.. .| .  ||||| .|.. .  .. . |.  |..|| .. |||.| ...... .... .|.|.|. .|. ..        . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

KKEF--SLFRRMQMAKDAALGMNWLHGITRIVHNDLKTANLLVDINLRV----KVTDFGFSQ---IKEGEEFQDKAAKGTPLWMAPEVMM-GNPYNEKAD
.. |  |      ...  . |.. .|   .|.| ||| .|.|.| |  .    |..|||..    .  .. ...    ||| .||||| . |..|  |.|
HGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTT--FCGTPWYMAPEVIRGGQYYGPKVD

VYSFGIILWEILTKEAPYSHH------KDYDIFFNAICNEKERPPIPADTL------------------PSLRHLIQTCWDHNPQNRPSFSEILFR--L
..|.|.||.| |... |...|       .. ....  . . ...    ..                   ......|  |.. .|. ||.. .||    .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Shk4.AA CZAK 376-530 37 4.5e-40 139.44 In-house 107-279 (279) Show / Hide 
Range on Protein: 376-530
Range on HMM: 107-279/279
Sequence Identity: 37% (65 aa)

RMQMAKDAALGMNWLHG-ITR--IVHNDLKTANLLVDINLR-------------VKVTDFGFSQIKEGEEFQDKAAKGTPLWMAPEVMMGNPYNEKADVY
...|| | | ||| ||.  .   |.| || . | | | ..               |. ||| |. .    |.  .. |   |||||.  |  | ||.|||
QWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYTEKVDVY

SFGIILWEILTKEAPYSHHKDYDIFFNAICNEKERPPIPADTLPSLR---HLIQTCWDHNPQNRPSFSEILFRL
|||.|||.|.| . ||   .   . . |   |  |||.|  . |       ||  ||. ||  ||||..||  |
SFGMILWCIITCDQPYQNMQPMKMAHLA-AYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL
Kinase Shk4.AA CZAK 276-352 45 2.2e-17 59.79 In-house 2-82 (279) Show / Hide 
Range on Protein: 276-352
Range on HMM: 2-82/279
Sequence Identity: 45% (38 aa)

EIDRTDFLGQGSFGSVYKGKCRGQEVAVK-IPRKQKLSLYE---LTSFRHEVKIMSKIFHPNVVLFLGACTQSG--KMQIVTE
.. .|   ||| || |||.  ||  ||.| | | |   . |   .  |  || ||||  |||.| |||||.  |     ||.|
KFGQT--IGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVME
SH2 Shk4.AA SH2 641-672 38 6.7e-11 33.82 Pfam 1-34 (81) Show / Hide 
Range on Protein: 641-672
Range on HMM: 1-34/81
Sequence Identity: 38% (13 aa)

WFHGDIVREQATSRLSK--AAEGAFLIRLSSTEP
|.||.| |..|  .| .    .|.||.| |...|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTP
SH2 Shk4.AA SH2 639-725 25 1.3e-10 42.47 SMART 1-87 (87) Show / Hide 
Range on Protein: 639-725
Range on HMM: 1-87/87
Sequence Identity: 25% (23 aa)

KIWFHGDIVREQATSRLSK--AAEGAFLIRLSSTEPKTCPFTLSMKN-NQHRRIQLIDENNFTGFKIQG-KTAVYNSLIELVEKCNDYPLL
  |.||.| ||.| . | .    .|.||.| |..  .   ..||..  .. . ...  ...  .. |..     ..|| |||.     || 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES--NPGDYVLSVRWKGKVKHYRIRRNDD-GKYYIDETWRRKFPSL-ELVNHYQHNPLG