Gene SplA (Slime mold)
SplA
Sequence
Protein domains of SplA.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| SAM_2 | SplA.AA | SAM_2 | 379-402 | 23 | 7.671414 | 2.31 | Pfam | 46-71 (71) | Show / Hide |
Range on Protein: 379-402 Range on HMM: 46-71/71 Sequence Identity: 23% (6 aa) L--KNNQPVSSYRQQQQIQHQIQLQQ | || ..... ....| ..|| . LAMKNRMGITNVGHRKKIWNKIQRMK |
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| SPRY | SplA.AA | SPRY | 826-946 | 28 | 1.1e-33 | 121.01 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 826-946 Range on HMM: 1-141/141 Sequence Identity: 28% (40 aa) SSFTYFELFITNGNG--DKICFGLTTNDH----------PIEVYPGNYQGSYGYSGDGKCYFGTNEG-RVYGPSFSS-GDVVGCGYDSSSK-TLYFTKNG | |.| |... | ....|..|.. | ...||. ||.||.|.|.... ... . |||.. . |||.||..| .. |..|.||| SGRWYWEVEIDQHGGDPTHWWIGWCTKSCHLHFDHRHRKPGHRMPGWDCGSWGYDGWGGQKWHMGWSHEHYGPPWQEQGDVIGCFIDYECGVTISFYKNG VYLG---VAAQKVNLI--GLYPTVGLQNPGESVVINFFGPF .|| .. ... ..||.|.|. ||.....|| ... KHLGCHIYTFRNCTFDDGPFYPAVSLWWPGCKCQFNFGQMH |
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| SPRY | SplA.AA | SPRY | 826-946 | 26 | 3.2e-32 | 114.3 | SMART | 1-145 (145) | Show / Hide |
Range on Protein: 826-946 Range on HMM: 1-145/145 Sequence Identity: 26% (38 aa) SSFTYFELFITNGNG-DKICFGLTTNDH------------PIEVYPGNYQGSYGYSGDGKCYFGTNEG-RVYGPSFSS-GDVVGCGYDSSSK--TLYFTK | |.| |..|.. ....|... . | . .|. .|.||.|.|. . ... . |||.. . |||.||..| .. |..|.| SGRWYWEVEIFDGGWNGHWRVGWCRKSYHFYPFKDRRRRKPYFRLLGWDKHSWGYRGCGGQKWHNSHFNPHYGPPWQQPGDVIGCFLDYECGGSTISFYK NGVYLG----VAAQKVNLI-GLYPTVGLQNP---GESVVINFFGPF || ||| .. ... .|||...|.|. |.....|| . . NGKYLGDCHHYHFFHCTFSEPLYPAFWLWNYDGGGCQCRFNFCQ-P |
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| SPRY | SplA.AA | SPRY | 1026-1151 | 28 | 1.1e-36 | 131.69 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 1026-1151 Range on HMM: 1-141/141 Sequence Identity: 28% (42 aa) EGFCYFEVIIDQLDK--GQLSIGLANLEY----------PTFYHVGWMPRSYGYHNDDGRKFRWREEPGVNEGESYGSSYKK-GDIIGCGLSFTSR-EIF | .|.|| ||| . .. .||... .. | ....||...|.||. ..|.|. ... .| ||.... ||.|||.. . .. .|. SGRWYWEVEIDQHGGDPTHWWIGWCTKSCHLHFDHRHRKPGHRMPGWDCGSWGYDGWGGQKWHMGWS-----HEHYGPPWQEQGDVIGCFIDYECGVTIS FTKNGMYLG---TAFSNVYG---VFYPSVAFNEPGISITGVFGPPF |.|||..|| ..|.|... ||| |... || ... ||... FYKNGKHLGCHIYTFRNCTFDDGPFYPAVSLWWPGCKCQFNFGQMH |
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| SPRY | SplA.AA | SPRY | 1026-1151 | 25 | 1.1e-35 | 125.77 | SMART | 1-145 (145) | Show / Hide |
Range on Protein: 1026-1151 Range on HMM: 1-145/145 Sequence Identity: 25% (38 aa) EGFCYFEVIIDQLD-KGQLSIGLANLEY------------PTFYHVGWMPRSYGYHNDDGRKFRWREEPGVNEGESYGSSYKK-GDIIGCGLSFTSR--E | .|.|| |.. . .|. .|... .| | |...|| ..|.||. ..| |. ... .. ||..... ||.|||.| . .. . SGRWYWEVEIFDGGWNGHWRVGWCRKSYHFYPFKDRRRRKPYFRLLGWDKHSWGYRGCGGQKWHNSHF-----NPHYGPPWQQPGDVIGCFLDYECGGST IFFTKNGMYLG----TAFSNVYG--VFYPSVAFNEP---GISITGVFGPPF |.|.||| ||| ..|..... .||..... . | .. |.. . ISFYKNGKYLGDCHHYHFFHCTFSEPLYPAFWLWNYDGGGCQCRFNFCQ-P |
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| SPRY | SplA.AA | SPRY | 1516-1645 | 26 | 2.4e-35 | 126.92 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 1516-1645 Range on HMM: 1-141/141 Sequence Identity: 26% (39 aa) STICYFEVYLEGHDK-KGSITVGLSHSTY----------PFIKHIGREPKSYGFSSEG-EKYGGSEIGEPYGPFFFFDGDSIASSCVIGCGINTSTR-DI |...|.||. ..| . ......|.. . . |.....| ...|.|... | |. ... .|.|||.. . .||||.|..... | SGRWYWEVEIDQHGGDPTHWWIGWCTKSCHLHFDHRHRKPGHRMPGWDCGSWGYDGWGGQKWHMGWSHEHYGPPWQE------QGDVIGCFIDYECGVTI FFTKNGHYLG---VAFSRVTSD--PLYPSISFRGVVGGLCVATFPGGH .|.|||..|| ..|. .| | |.|| .|... |. |. .|.. | SFYKNGKHLGCHIYTFRNCTFDDGPFYPAVSLWW-PGCKCQFNFGQMH |
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| SPRY | SplA.AA | SPRY | 1516-1645 | 25 | 5e-34 | 120.29 | SMART | 1-145 (145) | Show / Hide |
Range on Protein: 1516-1645 Range on HMM: 1-145/145 Sequence Identity: 25% (39 aa) STICYFEVYLEGHDKKGSITVGLSHSTY------------PFIKHIGREPKSYGFSSEG-EKYGGSEIGEPYGPFFFFDGDSIASSCVIGCGINTSTR-- |...|.||. .... .|...||.. | |.....|....|.|... | |. .|. ...|||.. . .||||....... SGRWYWEVEIFDGGWNGHWRVGWCRKSYHFYPFKDRRRRKPYFRLLGWDKHSWGYRGCGGQKWHNSHFNPHYGPPWQQP------GDVIGCFLDYECGGS DIFFTKNGHYLG----VAFSRVTSD-PLYPSISFRG--VVGGLCVATFPGGH |.|.|||.||| ..|. .| . ||||..... ..| |. .| . . TISFYKNGKYLGDCHHYHFFHCTFSEPLYPAFWLWNYDGGGCQCRFNFCQ-P |
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| SAM_2 | SplA.AA | SAM_2 | 1674-1739 | 40 | 1.1e-23 | 84.07 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 1674-1739 Range on HMM: 1-71/71 Sequence Identity: 40% (29 aa) FKNWAPNDVAIWLESFNY-GQYRKNFRDNNISG-RHL-EGITHAML--KNDLGIEPYGHREDIINRLNRMI ..|...||. ||.| .. .||. |||...|.| .|| ...|| .| ||..||. .||| |.| ..||. VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK |
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| SAM | SplA.AA | SAM | 1674-1741 | 38 | 1.6e-19 | 72.06 | SMART | 1-67 (67) | Show / Hide |
Range on Protein: 1674-1741 Range on HMM: 1-67/67 Sequence Identity: 38% (26 aa) FKNWAPNDVAIWLESFNYGQYRKNFRDNNISGRHLEGITHAMLKNDLGIEPYGHREDIINRLNRMIQI .. | |.||. |||| ...||..|||.|.|.|.|| |. .. ...||...||| |.. .. | . VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ |
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| Sam7 | SplA.AA | sam7 | 1677-1739 | 36 | 1.7e-18 | 63.57 | In-house | 1-70 (70) | Show / Hide |
Range on Protein: 1677-1739 Range on HMM: 1-70/70 Sequence Identity: 36% (26 aa) WAPNDVAIWLESFNY---GQYRKNFRDNNI-----SGRHLEGITHAMLKNDLGIEPYGHREDIINRLNRMI | ..||. |||. . .||..||||..| .|.|| .|. |. .|| ||| | | ...|. WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLME-MGITRPGHRKKIWNHIQQMR |
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| SAM_1 | SplA.AA | SAM_1 | 1675-1739 | 30 | 9.5e-11 | 41.06 | Pfam | 1-66 (66) | Show / Hide |
Range on Protein: 1675-1739 Range on HMM: 1-66/66 Sequence Identity: 30% (20 aa) KNWAPNDVAIWLESFNYGQYRKNF-RDNNISGRHLEGITHAMLKNDLGIEPYGHREDIINRLNRMI .|...||. ||||. ..||...| |.. |....| .| |. ..|. ||| | . . .. DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK |
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| Kinase | SplA.AA | CZAK | 2058-2328 | 64 | 6.2e-235 | 786.77 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 2058-2328 Range on HMM: 1-279/279 Sequence Identity: 64% (179 aa) LEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSS---LVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLL |.||||||.||||||...|||..|||||||.|.||..|.. ..|||.||.|.|||.|||.|||||||...|..|||||.|||||||||..||||.... LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYH EQNPHIRLKLALDIAKGMNYLHG-WTP-PILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKMEQASQMTQSVGCIPYMAPEVFKGDSNS .||||.....|.|||.||||||. |.| ||||||||||||||||...||||||||||||.|||.||||||..|||...|||..||...||||.|||.... KQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENYT EKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRPPIPLTTSSKWK---EILTQCWDSNPDSRPTFKQIIVHL ||.||||.||.|....|.|.|.|.|.|||||||||||.||||.|......|| |....||..|||.||.||||..|| EKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL |
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| Kinase | SplA.AA | TKL | 2064-2328 | 30 | 3.2e-103 | 349.21 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 2064-2328
Range on HMM: 1-364/364
Sequence Identity: 30% (115 aa)
IGKGFFGEVKRGYWRE----------TDVAIKIIYR--DQFKTKSS---------------------LVMFQNEVG-ILSKLRHPNVVQFLGACTAGGED
||.|.|||| .|.|| .|||.|.. . |...||.| . | .|. ..|.|||||.|||.|.|.... .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
-----------HHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNYLHGWT------PPILHRDLSSRNILLDHNIDPKNPVVSSR---Q
..|||.|.. ||||. .|. .| |...|||||.|||||| .. |||.|||| |.|||.| | . . ...
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYM-YNPNA
DIKCKISDFGLSRLKMEQAS-------------------QMTQSVGCIPYMAPEVFKGD----------------SNSEKSDVYSYGMVLFELLTSDEPQ
|..|||.|||||| . . . . .| . .|||||..|. . |||.||||.|.||.|.|| .|
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY
QDMKPMKMA---------HLAAYESYRPPIP------------LTTSSKWKEILTQCWDSNPDSRPTFKQIIVHL
.|...| | .......||||| .. .|.....|||..|..||.|..|. .|
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | SplA.AA | MLK | 2058-2328 | 36 | 1.1e-92 | 314.2 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 2058-2328 Range on HMM: 1-291/291 Sequence Identity: 36% (110 aa) LEFGQTIGKGFFGEVKRGYWRETD-----VAIKIIYRDQFKTKSS----LVMFQNEVGILSKLRHPN----VVQFLGACTAGGEDHHCIVTEWMGGGSLR ..| . ||.| ||.| .|.|| .| ||.|.. . | ||. |. |. .|..|.||| ..||.|.|. . | |||.|.. |||| IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVMEYCEGGSLY QFLTDHFNLLE-----------QNPHIRLKLALDIAKGMNYLHGWTP-PILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKMEQASQ-M .| . . . . .. .. ||..|.||.||| | || |||| |.|||.|. | .. ..||.|||.|| . . . | NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-IC-----H-DMHHGTLKICDFGTSRDWHQMC-TNM TQSVGCIPYMAPEVF---KGDSNSEKSDVYSYGMVLFELLTSDEPQQ-DMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVH . | .|||||. ... .|||.||.|.|.|| |.|| .| . ...|| | .||.. ||||| | . ||. ..|||...| .||.|.||. | MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQH L | L |
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| Kinase | SplA.AA | Pkinase_Tyr | 2058-2328 | 29 | 5.7e-91 | 308.71 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 2058-2328 Range on HMM: 1-270/270 Sequence Identity: 29% (84 aa) LEFGQTIGKGFFGEVKRGYWR------ETDVAIKIIYRDQFKTKSS--LVMFQNEVGILSKL-RHPNVVQFLGACT-AGG-EDHHCIVTEWMGGGSLRQF ..||...|.| ||||..|.|. ...||.|.. .. ... . .| .|. |...| .|||.|...|.|| |. ...||.| | .|.|. . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDY LTDH-FNLLEQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLK--MEQA-SQMTQSVGCIPYMA | .| . ... |. ...|||||.||. . |||| ||.|... . ..||.||||.|. .. . . . |. || LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE-------------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMA PEVFKGDSNSEKSDVYSYGMVLFELLT-SDEP-QQDMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHL ||... ..||||.|.| ...|..| ..| ..|.. . .. . . || |.| .. . ....|||. .|. ||||..|. .| PECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | SplA.AA | TKL-Unique | 2060-2328 | 36 | 1.7e-83 | 283.72 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 2060-2328 Range on HMM: 1-290/290 Sequence Identity: 36% (109 aa) FGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSSLVM-FQNEVGILSKLR-HPNVVQFLGACT--AGGEDHHCIVTEWMGGGSLRQFLTD------ |. .|| | .|.|..| || ..||||.. . . .... | ||| ...||. |||.|.. |.|. . . |||.| . ||||. |.. FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN -HFNLLEQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKMEQASQMTQS----------VGCI | .. |. |.|.|.|||.||.||| |||.|||| |.|.|.| | | .. ||.|||||... . ..|| . .| . NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN--------SNIAEWNIKICDFGLSKFN-SKINKMTNNEHKGTRNQTRCGSF PYMAPEVFKG--DSNSEKSDVYSYGMVLFELLTSDE------PQQDMKPMKMAHLAAY--ESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHL .|||||... . ||||||||.|.|| |..|.. | |.| . . . ...| |.|||||| .....|||...|. ||.| .|| | RWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | SplA.AA | Dicty4 | 2058-2330 | 37 | 1.5e-80 | 268.4 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 2058-2330
Range on HMM: 1-277/277
Sequence Identity: 37% (111 aa)
LEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKT-KSSLVMFQNEVGILSKLRHPNVVQFLGACT----AGGEDHHCIVTEWMGGGSLRQFLTD---
. ..| |||| |||| .| || ..||.|. .. . . | | .|| |..|.||||...|.|||| . |. ||||| | |.| | |
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGK--MCIVTEYMPKGNLYSLLHDKPS
---HFNLLEQNPHIR-LKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSR----LKMEQASQMTQSVGCIPYM
|. .| ...|.|.|.|||.||. .| |.|||| | |.| | | . |..|||||. .. .. |||. .| .|
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKN-------------WRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWM
APEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQ--DMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVH--LKE
|||| ... ||.||||.|.||.|.|| .|| | | .|. . . . . ||||| .. .||. .. ||| .| .||.|..|| | .
APEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
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| Kinase | SplA.AA | HH498 | 2058-2328 | 34 | 2.7e-79 | 250.95 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 2058-2328
Range on HMM: 1-284/284
Sequence Identity: 34% (103 aa)
LEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSS-----LVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFL-----
.|| .|| | ||.| .|.|| ||.| | || || || |...| ||.||||..|| . . |||.. .||| |
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCD-DPSQFAIVTQYCDNGSLFSILNTIPI
-------TDHFNL---LEQNPHIRLKLALDIAKGMNYLHG-WTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKME-QASQMTQSV
.| . . . .. ...|.|.|||||| ..|| |||| | |||.. .| . .. ||| || . . ||
GGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH-------------EDGHAVVADFGESRFVCDMHDDNMTKQP
GCIPYMAPEVFK-GDSNSEKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRPPIPLT----TSSKWKEILTQCWDSNPDSRPTFKQIIVHL
| .||||||. . |.| ||.||.|...|..| | . || | || . ||||| | .| .. .||. .|..||.| ||. |
GNLRWMAPEVFSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
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| Kinase | SplA.AA | LRRK | 2058-2330 | 28 | 5.8e-73 | 248.71 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 2058-2330
Range on HMM: 1-351/351
Sequence Identity: 28% (104 aa)
LEFGQTIGKGFFG-EVKRGYWRE----------------------------TDVAIKIIYRD--------------------------------QFKTKS
|.... ||.| || .| |. || ..||||.. || .....
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR-
SLVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHF-NLL-----EQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSR
.. |..|| |.|.|.|||.|. .| | .. |.|.| . |.| .|| ... . . . .....||.||.|||||.||| .|||.|||| |
AFREFRHEVWIMSHLNHPNIVSLKGFCI----HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSP
NILL-DHNIDP-KNPVVSSRQDIKCKISDFGLSRLKMEQASQMT---QSVGCIPYMAPEVFKGD---SNSEKSDVYSYGMVLFELLTSD-EPQQDMK-P-
|||| .. .. | . ......||.|||.|| | |. .|. .|| . .||||. ... . .||.|.||.||.|.|||| . | .... .
NILLWSSPQNHSPN---YPNAHVCAKIADFGISR--MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFD
----MKMAHLAAYESYRPPIPLT-TSS-----KWKEILTQCWDSNPDSRPTFKQIIVHLKE
| . .. | ||.|| . .. ...||. .|..||.| ||. |..
HMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
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| Kinase | SplA.AA | DRK | 2058-2330 | 33 | 4e-66 | 222.93 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 2058-2330 Range on HMM: 1-258/258 Sequence Identity: 33% (91 aa) LEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQN | ||.| .||| || || | ||.| . | |. |. ....|||||..||.|.|. . ||..| | ||| . | | .| IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPD--ICICMEYMPRGSLYNILHD--ESIEMD PHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSR--LKMEQASQMTQSVGCIPYMAPEVFKGDSNSEKS ......|.||||.|||. .| |.|||| | | | | . . |..||||| |..| .| |||| . || WPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEH-------------WQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKA DVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHLKE ||||.. || |..| | . | .. . |||.| . |. .. ||. .| ||.. ... | DVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA |
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| Kinase | SplA.AA | TyrKc | 2058-2328 | 28 | 5.1e-64 | 219.92 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2058-2328 Range on HMM: 1-280/280 Sequence Identity: 28% (87 aa) LEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTKSSLVMFQNEVGILSKL--RHPNVVQFLGACTAGGE-----DHHCIVTEWMGGGSLRQFLTDH ...|...| |.|||| .| |. ..||.| . | . .| .| |..|| .|||.|...|.|| .|. . ..||.| | .|.|...| .| ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH FNLLEQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKMEQ-------ASQMTQS--VGC--IP . .. |. ...||.||.||| .. |||| ||.|...| .||||||||| . .... | .| RPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP Y--MAPEVFKGDSNSEKSDVYSYGMVLFELLTS-DEPQQD-----MKPMKMAHLAAYESYRPPIPL-------TTSSKWKEILTQCWDSNPDSRPTFKQI . ||||... ..||||.|.| ...|..| ..| . |.. . .. ..|. | . ... .| .|||. .|..||||..| IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI IVHL . . HECF |
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| Kinase | SplA.AA | TK | 2058-2328 | 18 | 1.9e-60 | 201.02 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 2058-2328
Range on HMM: 1-486/486
Sequence Identity: 18% (93 aa)
LEFGQTIGKGFFG---EVKRGYWRE---------------------------TDVAIKII---YRDQFKTKSS-----------LVMFQNEVGILS--KL
...|...|.| || || .| ||. |.||.|.. .. . . .. .| ... ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
RHPNVVQFLGACTAGGE----------DHHCIVTEWMGGGS----LRQFLTDH-----------------------------------------------
.|||.|...|.|| |.. . .||.|.| .|. ||..| ..
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
--------------FNLLE------------QNPHIRLKLALDIAKGMNYLHGWTP----PILHRDLSSRNILLD-HNIDPKNPVVSSRQDIKCKISDFG
|| ..| .| ...||.|| ||| . |||| ||.|.. .|.. . . . |||.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWH-F--DGCGPVCKIADFG
--------LSRLKME------------------------QASQMTQSVGCIP--YMAPEVFKGDSNSEK---------SDVYSYGMVLFELLTSD-EPQQ
|.| . |. . || | .| .||||.... ||. |||.|.| ...|..| ||
LSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYY
DMKPM---------K--MAHLAA------------YESYRPPIPLTTS--------------SKWKEILTQCWDSNPDSRPTFKQIIVHL
. . . | .| . . .|.| | . . ....|||. .|. ||||.|. |
GGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | SplA.AA | Dicty4-Unclassified | 2058-2328 | 35 | 1.2e-59 | 202.99 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 2058-2328 Range on HMM: 1-263/263 Sequence Identity: 35% (98 aa) LEFGQTIGKGFFGEVKRGYWRETDVAIKIIYRDQFKTK-SSLVMFQNEVGILSKLRHPNVVQFLGACTAG--GEDHHCIVTEWMGGGSLRQFLT----DH . | |||| | .| .| |. |||.|.. .|| . | || || . ||| |. |.| . |||.| | | | . IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ FNLLEQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKMEQASQMTQSVGCIPYMAPEVFKGDS . . . .| |.|||.|| .|| | . |||. | |||.| . || |||.|| . || | .||. .. | QQPIKLDDTLIIKYAFDIAQGMQHLH--TRNFIHRDIKSSNILMDKHFN-------------IKIADFGISRV-IDFNFNMTTIAGTPKWESPECLMHES NSEKSDVYSYGMVLFELLTSDEPQQDMK-PMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHL |||||||.|.|.||.| ||| |. .| .| . . || || || || | |||. ||| | YNQKSDVYSYAMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | SplA.AA | Pkinase | 2058-2328 | 25 | 1.2e-58 | 205.98 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 2058-2328 Range on HMM: 1-293/293 Sequence Identity: 25% (80 aa) LEFGQTIGKGFFGEVKRGYWRETD--VAIKIIYRDQFKTKSSLVMFQN--EVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGGG----SLRQFLT- ...|..||.| ||.|...... | ||.||| .. . .. .. . |. |. .|.|||.|....... .|| ..|.|...|| .| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST -DHFNLLEQNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLK-MEQASQMTQSVGCIPYMAPEVF .| ... .. . .. |..|..|.| |.|||| . |||.|.| ... . ||.||||.... | || .| ..|||||| WRHGCFY-FSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDA---------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVI K-GDSNSEKSDVYSYGMVLFELLTSDEPQQDM------KPMKMAHLAAYESYRPPIPLTTS-------------------SKWKEILTQCWDSNPDSRPT . | . |.|..|.| .|.|.|. | .. .|.| . . .. ..| . | . |.... |.. .| .||| RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT FKQIIVH--L ..|| | . AEQILQHPWF |
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| Kinase | SplA.AA | S_TKc | 2058-2328 | 25 | 1.2e-46 | 162.22 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2058-2328
Range on HMM: 1-231/231
Sequence Identity: 25% (74 aa)
LEFGQTIGKGFFGEVKRGYWRE--TDVAIKIIYRDQFKTKSSLVMFQNEVGILSKLRHPNVVQFLGACTAGGEDHHCIVTEWMGG--GSLRQFLTDHFNL
|....|||| ||.|....... |||||| ....|. ||.| .|||.|...... || ..|.| ..| |.|.... ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH
LE---QNPHIRLKLALDIAKGMNYLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKMEQASQMTQSVGCIPYMAPEVFKGDS
.. ... |.....|.| |.|||| |||||. ||.||||.|. | .| ||||||. .
GLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---------------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---G
NSE-KSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIV-------H--L
. |.|..| | .|.|.|. | . ...| .. |. |... .|.. .|. ||| .. | .
YGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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