Gene 8635 (Tetrahymena)

8635

Species: Tetrahymena
Alias: PreTt08635, 562, TTHERM_00188850, 15.m00346, 3697.m00058, 8635
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate-D1, Secondary Subfamily: Ciliate-E2-Unclassified,

Classification

Group: Other
Family: PLK
Subfamily: SAK

Sequence

Name Sequence Type Origin Length Description Download
8635.AA Protein None 1609 None Fasta, JSON
8635.kin_dom Protein Kinase Domain None 215 None Fasta, JSON
8635.kin_dom2 Protein Kinase Domain None 257 None Fasta, JSON
8635.NA RNA None 4830 None Fasta, JSON

Protein domain

Protein domains of 8635.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8635.AA Ciliate-E2-Unclassified 216-474 17 1.3e-37 128.06 In-house 1-352 (352) Show / Hide 
Range on Protein: 216-474
Range on HMM: 1-352/352
Sequence Identity: 17% (61 aa)

FEDQSEINEQIKRQSQIVQKKDDLKILNEIEIIGDIQNIE---------------QIN---------------------------KGGFGSIQKGKLAKI
.. .  |...   . . .|.|..   .. .... .||..                ..|                           |  .   .| ..  .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LKYPLYGHFSQTMSLITK-----------------------L-----YIMWQIAQGIQFLTSKN-VAHLDLKPANIVISKGY---LAKIIDFGEAYHPDV
. |  .|. .| ..   |                       .     ....|| ||...| .|| . | |.|| ||.....      |||||| ..... 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

CNGKEFYN---NQQRLIFKSYFLMKGNPNYKPGR-TLPYTPYSNNNDRQASYKNLDIFSFGMVLSEIVFDTYPVDFKRGALHK--------------LEE
.|... .|   ..|..... .  . |.|||.| . | |    ..|.| ... .  ||.|.|..| |..| .|| . .    |.              |..
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMP-QYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

KFSRGDIRGRLVKN----YQRHFGPKHIIN-LLHCLIFRCIDEKENRPTIDWIILI
..  ..|  .  ..    .. ..  |..|| ||....  ..... . . | .  ..
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 8635.AA Ciliate-E2 222-410 20 1.5e-26 88.12 In-house 32-295 (365) Show / Hide 
Range on Protein: 222-410
Range on HMM: 32-295/365
Sequence Identity: 20% (55 aa)

INEQIKRQSQ-----IVQKKDDLKIL--NEIEIIGDIQNIE------------------------QINKGGFGSIQKGKLAKILKYPLYGHFSQTMS---
|. |.. |.|       .|.  .||.  |.||.|  ...|                            .  | .... ..  .. |  .|   . .    
ID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNK

--------------LITKLYIMWQIAQ---------------GIQFLTSKN-VAHLDLKPANIVISKGYLAKIIDFGEAYHPDVCNGKEFYNNQQRLIFK
              .   .|||.||.|               ....| ||| . | |.|| ||..      |||||| .   | .| .... .||. ...
KKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYM

SYFLMK--------------------GNPNYKPGRTLPYTPYSNNNDRQASYKNLDIFSFGMVLSEIVFDTYP
  . ..                    |.|.|..   | . .|.|.....   .  ||.|.|..| | .|  .|
F-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
Kinase 8635.AA CAMK 293-354 24 7.3e-13 37.06 In-house 183-276 (425) Show / Hide 
Range on Protein: 293-354
Range on HMM: 183-276/425
Sequence Identity: 24% (23 aa)

YIMWQIAQGIQFLTSKNVAHLDLKPANIVI-SKG----------------YLAKIIDFGEA--YHPDV-------CNGKEFYNN-------QQRL
....||....... |.|..|.|||| || . ...                .  |||||| |  . |.        ..|.|. .|        | .
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEM-HNQWTTPTEGQKM
Kinase 8635.AA ULK 292-334 32 3.2e-11 35.52 In-house 133-187 (329) Show / Hide 
Range on Protein: 292-334
Range on HMM: 133-187/329
Sequence Identity: 32% (18 aa)

LYIMWQIAQGIQFLTSKNVAHLDLKPANIVISKG------------YLAKIIDFG
. .. ||..| ..| ..|. | |.||.|| |..|            . .|| |||
IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
Kinase 8635.AA ULK 292-334 32 4.8e-11 35.5 In-house 129-183 (324) Show / Hide 
Range on Protein: 292-334
Range on HMM: 129-183/324
Sequence Identity: 32% (18 aa)

LYIMWQIAQGIQFLTSKNVAHLDLKPANIVISKG------------YLAKIIDFG
. .. ||..| ..| ..|. | |.||.|| |..|            . .|| |||
IQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFG
Kinase 8635.AA Pkinase 294-334 42 5.1e-11 40.04 Pfam 113-157 (293) Show / Hide 
Range on Protein: 294-334
Range on HMM: 113-157/293
Sequence Identity: 42% (19 aa)

IMWQIAQGIQFLTSKNVAHLDLKPANIVIS-KGYLA---KIIDFG
.|.||..|.... |... | ||||.|| |. .|...   ||.|||
YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG
Kinase 8635.AA CAMKL 296-334 36 3.7e-08 21.99 In-house 134-174 (297) Show / Hide 
Range on Protein: 296-334
Range on HMM: 134-174/297
Sequence Identity: 36% (15 aa)

WQIAQGIQFLTSKNVAHLDLKPANIVISKGY--LAKIIDFG
.||  ..... |....| |.|| || ...     .||||||
RQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFG
Kinase 8635.AA PLK 293-334 40 5e-08 22.35 In-house 104-145 (258) Show / Hide 
Range on Protein: 293-334
Range on HMM: 104-145/258
Sequence Identity: 40% (17 aa)

YIMWQIAQGIQFLTSKNVAHLDLKPANIVISKGYLAKIIDFG
|.| ||.||.. | .... | |||..|. ... .  || |||
YYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFG
Kinase 8635.AA PLK-Unclassified 293-334 35 3.8e-07 22.96 In-house 110-151 (264) Show / Hide 
Range on Protein: 293-334
Range on HMM: 110-151/264
Sequence Identity: 35% (15 aa)

YIMWQIAQGIQFLTSKNVAHLDLKPANIVISKGYLAKIIDFG
..  ||.|... | .... | |||..|| ..  .  || |||
CYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFG
Kinase 8635.AA AGC 297-334 35 0.000159 6.04 In-house 161-200 (395) Show / Hide 
Range on Protein: 297-334
Range on HMM: 161-200/395
Sequence Identity: 35% (14 aa)

QIAQGIQFLTS-KNVAHLD-LKPANIVISKGYLAKIIDFG
.|. ....| | ... | | ||| ||.. .    |. |||
CIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG
Kinase 8635.AA Aur 293-334 40 0.010874 2.36 In-house 105-147 (257) Show / Hide 
Range on Protein: 293-334
Range on HMM: 105-147/257
Sequence Identity: 40% (18 aa)

YIMWQIAQGIQFLTSKNVAHLDLKPANIVIS--KGYLAKIIDFG
..| ||. .. .. |||. | |.|| || ..  .| . || |||
KYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNI-KICDFG
Kinase 8635.AA Pkinase_Tyr 284-334 39 0.03003 8.24 Pfam 106-156 (270) Show / Hide 
Range on Protein: 284-334
Range on HMM: 106-156/270
Sequence Identity: 39% (20 aa)

QTMSLITKLYIMWQIAQGIQFLTSKNVAHLDLKPANIVISKGYLAKIIDFG
|  .. ..| . ||||.| ..| |||  | ||   |. ....  .|| |||
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 8635.AA CAMK 584-801 23 1.6e-86 278.71 In-house 32-425 (425) Show / Hide 
Range on Protein: 584-801
Range on HMM: 32-425/425
Sequence Identity: 23% (92 aa)

KQKAMKVVDKKRKD-------------------------IQNVMKRLDQEIKIQKE-------LDHPNIIKLFKHFED-------------------DQN
.. |.|..|||. .                          .. .|.. .||.| |        |||||||||. ..||                   |..
QKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKH

HYLIM---ELAQNG----EIKDYLNINKP---------------Y----------QLACGIKYLHDKDIVHRDLKLNNVLL-SN----------------
 |..|   |....|    .. ||.  ...               .          |......|.|...|||||||. |.|| .|                
MYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWN

-GKIKIADFGLATKVND-----------------------ENPECNTMCGTANYLS-PEILNS--------------KGYGKKTDIWSFGCILYALCSGN
 ..|||.|||.|.|...                       |.. ..|.|||  | . ||.||.              ..||.|.|.|| |.|||.. .| 
NNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGY

LPFFSG-------------NPSQTIQNIKEGKWQ-LPQN---------------ISDN--------VKDLLSNTLNWDQNSRFSIEQVLSHKFY
.|| .              |.... ..|..||..  |                 |||.        .|||... |. | . |..|||.|.|...
PPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 8635.AA PLK 587-801 39 4.4e-83 270.41 In-house 28-258 (258) Show / Hide 
Range on Protein: 587-801
Range on HMM: 28-258/258
Sequence Identity: 39% (91 aa)

AMKVVDKKRKDIQNVMKRLDQEIKIQKELDHPNIIKLFKHFEDDQNHYLIMELAQNGEIKDYLNIN-KP----------YQLACGIKYLHDKDIVHRDLK
| |||.|..   ..  ....|||.|...|.|||| |. ..|||..| |. .|...|..  .|..   |.          ||.. |.||||.. |.|||||
AIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEPEVRYYMYQIVQGLKYLHQHRIIHRDLK

LNNVLL-SNGKIKIADFGLATKVNDENPECNTMCGTANYLSPEIL--NSKGYGKKTDIWSFGCILYALCSGNLPFFSGNPSQTIQNIKEGKWQLPQN--I
| |..| .|  .||.||||||... .  . .||||| || .||.|  | .|.. . |.||.|||.|.|  |  || . .  .| ..||. .  .| .  |
LGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKPPFETKDVKETYKRIKHNHYSFPEHCPI

SDNVKDLLSNTLNWDQNSRFSIEQVLSHKFY
||. |||. . |||.. .|..|.|.|.| |.
SDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 8635.AA AGC 587-801 21 5.6e-83 213.59 In-house 34-395 (395) Show / Hide 
Range on Protein: 587-801
Range on HMM: 34-395/395
Sequence Identity: 21% (77 aa)

AMKVVDKKR-KDIQN--VMKRLDQE------------IKIQKELD----------HPNIIK-LFKHFEDDQN--HYLIMELAQ---------NG-EIKDY
||||..||.   | .   ...   |             .| ....          ||.|.| |.  |.|...   |..||...          | |   .
AMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLH

LN-I-NKP-----------YQ-------LACGIKYLHD-KDIVHRD-LKLNNVLLSN-GKIKIADFGLATKVNDEN------------------------
|    ..             .       ..... |||. ..|.||| ||. |.|| . | ||..||||........                        
LQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNM

--------------------------PECNTMCG--TANYLSPEILNSKGYGKKTDIWS--FGCILYALCSGNLPFFSGNPS----------QTIQNIK-
                            ..|.||  |..|..||||    |||  |.||  .||..| . .|  ||.. ||           .. |.|. 
DTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMN

-----EGKWQLP----------QNISDNVKDLLSNTLNWDQNSRFS----------IEQVLSHKFY
     . | ..|          ...|.. |||..  |. | . |            .|.. .|.. 
GRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 8635.AA Ciliate-E2 584-801 28 5.7e-81 275.3 In-house 48-365 (365) Show / Hide 
Range on Protein: 584-801
Range on HMM: 48-365/365
Sequence Identity: 28% (93 aa)

KQKAMKVVDKK----RKDIQNVMKRLD------QEIKIQKELDHPNIIKLFKHFE--DDQNHYLIMELAQNGEIKDYLNINK------------------
|..|||.. |.     | ....|....      .| .|...|.||||||.. .|.  ||.| ||.||..| |. .||...||                  
KIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI

---PYQLAC---------------GIKYLHDKD-IVHRDLKLNNVLLSNGKIKIADFGLATKVNDENPEC------------------------------
    .|..                ...||| |  |.|||.|..|.|.    |||.||||..|..|.| ..                              
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNM

-NTMCGTANYLSPEILNSKG---------YGKKTDIWSFGCILYALCSGNLPFFSGNPSQTIQNIKEGKWQLP------------------QNISDNVKD
 || |||..|..|||||.|.         |..| ||||.|.||| ...|..||        .|.||..|...|                  ...|...||
FNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKD

LLSN----TLNWDQNSRFS-IEQVLSHKFY
|...     |. |.. |.. .||.| |.. 
LIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 8635.AA CAMKL 587-801 28 7e-73 231.87 In-house 29-297 (297) Show / Hide 
Range on Protein: 587-801
Range on HMM: 29-297/297
Sequence Identity: 28% (78 aa)

AMKVVDKKRKD-IQNVMKR-----------LDQEIKIQKELD---HPNIIKLFKHFEDDQN------HYLIMELAQNGE--IKDYLNINKPY--------
|.|..|||..  .....|.           . .||.|.| |.   |||||||. ..|....       ||.||....||    ||. .....        
AIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYI-VKHGHRRGRMPEH

-------QLACGIKYLHDKDIVHRDLKLNNVLLS-NG--KIKIADFGLATKVND----ENPECNTMCGTANYLSPEILNS--K-GYGKKTDIWSFGCILY
       |. ....|.|...|||||.|. |.||. ||  .|||.|||....  .    ..  ..| ||. .| .|||...  |  .|.|.|||| | |||
EARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILY

ALCSGNLPFFSGNPS---------QTIQNIKEGKWQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLSHKFY
|.  |.|||   . .           ....  ...  .  .|  ..||..  |. . . |..|.|...|...
AMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
S_TKc 8635.AA S_TKc 545-801 29 7.6e-73 249.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 545-801
Range on HMM: 1-231/231
Sequence Identity: 29% (84 aa)

YDI-----KGANGFVCKIEDFKSKECYNSNEAKKYYVYLLLTYTKQKAMKVVDKKRKDIQNVMKRLDQEIKIQKELDHPNIIKLFKHFEDDQNHYLIMEL
|.|     ||| | |.|  . |                      .. |.|...          ... .||.| |. .||||.||. .|.| .. |..||.
YEILRKIGKGAFGKVYKCRHKK--------------------TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEY

AQN--GEIKDYLNINKP---------------YQLACGIKYLHDKDIVHRDLKLNNVLLSNGKIKIADFGLATKVNDENPECNTMCGTANYLSPEILNSK
. .  |. .||.  ...               ||..|...|.|.. |.|||||  |.||..  |||.|||||...       .|.||| .|..||.|   
CDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---

GYGK-KTDIWSFGCILYALCSGNLPFFSGNPSQTIQNIKEGKWQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLS-------HKFY
|||| | |.||.||||| ...|  ||   .. .....|.          |. .||.... |..| . | .. ..|        | . 
GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 8635.AA Ciliate-E2-Unclassified 582-801 25 1.2e-72 247.62 In-house 27-352 (352) Show / Hide 
Range on Protein: 582-801
Range on HMM: 27-352/352
Sequence Identity: 25% (83 aa)

YTKQKAMKVVDKKRKDIQNV---MKRLDQEIKIQ---------------KELDHPNIIKLFKHFEDDQNHYLIMELAQNGEIKDYLNINKP---------
| .. ..|. ..|.| |.|.   |  .... ...               . ..||.|.|.| .|.|.|| |..||....|. ..|....|          
YAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLF

-----------------------YQLACGIKYLHDKD-IVHRDLKLNNVLLSNG----KIKIADFGLATKVNDE---------------NPECNTMCGTA
                       .|. .|..||| |  |.|||.|..|.|..|.    .|||.|||.. | ..                . ...|.||| 
HNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTP

NYL----SPEILNSKGYG----KKTDIWSFGCILYALCSGNLPFFSGNPSQ----------------TIQNIKEGKWQLP--------QNISDNVKDLLS
||.    .||.| ...|.    .| ||||.|.|||... |..||.. |  |                 .||||....| |        ...|...||...
NYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN

----NTLNWDQNSRFSIEQVLSHKFY
      |....|.| ..||.| | . 
DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 8635.AA Pkinase 587-801 29 1.9e-72 251.78 Pfam 28-293 (293) Show / Hide 
Range on Protein: 587-801
Range on HMM: 28-293/293
Sequence Identity: 29% (78 aa)

AMKVVDKKRKDIQNVMKRLD-QEIKIQKELDHPNIIKLFKHFEDDQNHYLIMELAQNG----EIKDYLN--INKPY------------QLACGIKYLHDK
|.|...|.... .  . ..  .||.| |.|.||||..|.  |||... |..||....|    . .||.    ....            |...|..|.|..
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM

DIVHRDLKLNNVLLS-NGKI----KIADFGLATKV-NDENPECNTMCGTANYLSPEILN-SKGYGKKTDIWSFGCILYALCSGNLPFFSG------NPSQ
 |.|||||. |.|.. || |    ||.||||| .. .  |. ..| ||| .|..||... ...||.| |.||.||||| ...|..|| .       .. |
GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQ

TIQNIKEGKWQLPQNIS---------------------DNVKDLLSNTLNWDQNSRFSIEQVLSHKFY
 |..|.....  .   .                     .. ||.... |..| ..| ..||.| |.. 
MICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 8635.AA ULK 589-801 30 7e-72 245.11 In-house 34-324 (324) Show / Hide 
Range on Protein: 589-801
Range on HMM: 34-324/324
Sequence Identity: 30% (90 aa)

KVVDKKRKDIQNVM-------KRLDQEIKIQKELD---HPN--IIKLFKHFEDD--QNHYLIMELAQNGEIKDYLNINKP-------------------Y
|..|||   ... .       . |..||.|.|.|.   |||  |.||.. ||..   |.|.|||. . |  ..|.. ||.                   .
KMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFK

QLACGIKYLHDKDIVHRDLKLNNVLLSNGK-------------IKIADFGLATKVNDEN---PECNTMC------GTANYLSPEILNSKG----YG-KKT
|.. | |.||.. |.|||.|. | |..||.             .||||||.| .|...|     | |..      ||  | .|.||...|    |. .|.
QICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKC

DIWSFGCILYALCSGNLPFFSGNPSQTI-------QN-------IKEGKWQLP-----QNISDNVKDLLSNTLNWDQNSRFSIEQVLSHKFY
||||.|||.| .  |  ||||  .....       .|       ||  . | |     ..||...|||..  |  |.. |.|.|....|.. 
DIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 8635.AA ULK 584-801 28 4.5e-71 242.44 In-house 29-329 (329) Show / Hide 
Range on Protein: 584-801
Range on HMM: 29-329/329
Sequence Identity: 28% (87 aa)

KQKAMKVVDKKRKDIQNV-------MKRLDQEIKIQKELD--------HPNIIKLFKHFEDD--QNHYLIMELAQNGEIKDYLNINKP------------
.. | |..||. ....|        .. |..||||.|.|.        ||||.||.. ||..   |.|.|||. . |  ..|.. ||.            
EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLS

--------YQLACGIKYLHDKDIVHRDLKLNNVLLSNGK-------------IKIADFGLATKVNDE---NPECNTMC------GTANYLSPEILNSKG-
        .|.. | |.||.. |.|||.|. |.|..||.             .||||||.| .|...   .    |.       ||  | .|.||...| 
EQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGE

---YG-KKTDIWSFGCILYALCSGNLPFFSGNPSQTI-----QN----------IKEGKWQLP-----QNISDNVKDLLSNTLNWDQNSRFSIEQVLSHK
   |. .|.||||.|||.| .  |  ||..  .....     ..          ||  . | |     ..||...|||..  |  |.. |.|.|....|.
QKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHP

FY
. 
WF
Kinase 8635.AA Aur 655-801 38 1.7e-62 163.42 In-house 108-257 (257) Show / Hide 
Range on Protein: 655-801
Range on HMM: 108-257/257
Sequence Identity: 38% (58 aa)

YQLACGIKYLHDKDIVHRDLKLNNVLLS--NGKIKIADFGLATKVNDENPECNTMCGTANYLSPEILNSKGYGKKTDIWSFGCILYALCSGNLPFFS-GN
||.. ...|.| |.|.|||.|  |.||.  ||.|||.||| ..  .. |   .|.|||  |..||. .......| |||..| ..| ||.|  || |  |
YQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPN-NNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESNEN

PSQTIQNIK-EGKWQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLSHKFY
 ..|...|| ... | | .||. .||| |. |  | ..| ...|...|.. 
HDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 8635.AA PLK-Unclassified 655-801 46 3e-58 199.85 In-house 113-264 (264) Show / Hide 
Range on Protein: 655-801
Range on HMM: 113-264/264
Sequence Identity: 46% (70 aa)

YQLACGIKYLHDKDIVHRDLKLNNVLL-SNGKIKIADFGLATKVNDENPECNTMCGTANYLSPEILNSKG--YGKKTDIWSFGCILYALCSGNLPFFSGN
||.. ..||||.. | |||||| |..| .| ..||.|||||||.. .  . .| ||| || .||||. |   .. . |.||||||||.|  |  ||    
YQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYTLLIGKPPFETKD

PSQTIQNIK--EGKWQLPQNISDNVKDLLSNTLNWDQNSRFSIEQVLSHKFY
  || ..||  . .   | .|||| |||. . |||.. .|..| | ..| ||
VKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 8635.AA Aur 587-645 45 1.7e-23 58.42 In-house 28-86 (257) Show / Hide 
Range on Protein: 587-645
Range on HMM: 28-86/257
Sequence Identity: 45% (27 aa)

AMKVVDKKRKDIQNVMKRLDQEIKIQKELDHPNIIKLFKHFEDDQNHYLIMELAQNGEI
|.||..|.    ... . | .|||||..|.||||.|.. .|.|||. |||.| |..||.
ALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGEL
TyrKc 8635.AA TyrKc 580-800 22 3.4e-17 55.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 580-800
Range on HMM: 1-280/280
Sequence Identity: 22% (63 aa)

LTYTKQ--------------KAMKVVDKKRKDIQNVMKRLDQEIKIQKEL--DHPNIIKLFKHFEDD-------QNHYLIMELAQNGEIKDYLNINKP--
.|  |.              | ..|  |. |.    .. . .|..| ..|  .||||..|.    ..       . ....||.. .|  ||||  ..|  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

---------YQLACGIKYLHDKDIVHRDLKLNNVLLSNGK-IKIADFGLATKVNDE-----NPECNTM----CGT----ANYLSPEILNSKGYGKKTDIW
         .| |||  |||.| ..||||   |.|..... .||.||||. .. |.     . .  ..    .|        ..|| .| . .  |.|.|
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

SFGCILYALCSGNLPFFSG------NPSQTIQNIKEG-KWQLPQN--------ISDNVKDLLSNTLNWDQNSRFSIEQVLSHKF
|||  .. ...   .  .|      .... |...|.|     |.|         .| . .. .   . | ..| . ...  ..|
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 8635.AA Pkinase_Tyr 655-762 30 3.6e-16 55.38 Pfam 118-232 (270) Show / Hide 
Range on Protein: 655-762
Range on HMM: 118-232/270
Sequence Identity: 30% (35 aa)

YQLACGIKYLHDKDIVHRDLKLNNVLLS-NGKIKIADFGLATKV-NDE---NPECNTMCGTANYLSPEILNSKGYGKKTDIWSFGCILYALCS-GNLP-F
.| |.|  ||..| ..||||   |.|.. |...||.|||||  . ||.       ...      ..|| .| . .  |.|.||||  .. ... |  | .
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY

FSGNPSQTIQNI-KEG
    ... .. | ..|
PGMSNEEVYEYIYEDG
Kinase 8635.AA PLK-Unclassified 584-649 36 3.6e-14 49.12 In-house 25-90 (264) Show / Hide 
Range on Protein: 584-649
Range on HMM: 25-90/264
Sequence Identity: 36% (24 aa)

KQKAMKVVDKKRKDIQNVMKRLDQEIKIQKELDHPNIIKLFKHFEDDQNHYLIMELAQNGEIKDYL
|. | |...|     .   ..| .||||.| |.|.|| |  . |||..| |. .|.  || . .|.
KIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYI
Kinase 8635.AA Pkinase_Tyr 607-649 36 0.000247 15.3 Pfam 52-98 (270) Show / Hide 
Range on Protein: 607-649
Range on HMM: 52-98/270
Sequence Identity: 36% (17 aa)

QEIKIQKEL-DHPNIIKLFKHFE-DDQN--HYLIMELAQNGEIKDYL
.|.|| |.| .||||..|      ...   .|..||....|  .|||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL