Gene 20144 (Tetrahymena)

20144

Species: Tetrahymena
Alias: 110.m00117, PreTt20144, 924, TTHERM_00703680, 20144
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate-E2, Secondary Subfamily: Ciliate-E2c,

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2c

Sequence

Name Sequence Type Origin Length Description Download
20144.AA Protein None 1117 None Fasta, JSON
20144.kin_dom Protein Kinase Domain None 267 None Fasta, JSON
20144.kin_dom2 Protein Kinase Domain None 280 None Fasta, JSON
20144.NA RNA None 3354 None Fasta, JSON

Protein domain

Protein domains of 20144.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20144.AA Ciliate-E2c 14-293 51 1.3e-185 622.97 In-house 1-310 (310) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-310/310
Sequence Identity: 51% (161 aa)

IDTTNPLGSGNYGSVYRGSLYSDDRNIIKR-QMNTIYAIKETPLLSN--NAADLSPKKKIAIKEINNLKQLNHPHIIKFIDAKQTDKNIYLVMEYCNGGT
||..|.||||.||.||......|..|.|.. |||...|||.|.|...  ........|...|.|||..|..||||||||.|||||||.|||.||||||||
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEKLIKDK-KPNEKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIHNDMIKLAGFGFSKKVMNDELQFNT----IAVSPMFSAPQILRVQFNEKAQK
||..|..| |||||.|||||||||||||||..|.|..|||.|||||||||.|||.| |||||....|. |...    ....||..|||||..     ...
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEG-----KNY

YTSKAEIWSLGVTLYFMLCYESEKD-----------KHCYPWQANSQVQLNQEIKE--------------TKEIQFPES--KNLSQKVKDLIRKMLQVEE
||.|..|||||||||.||||. ...           .|||||..|....|.|.|.|              |..|.|||.  .|.||.||.||.|||||.|
YTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDE

EDRLNWEELFDHELF
|.|..|.|.|.||..
EKRIDWDEIFNHECI
Kinase 20144.AA Ciliate-E2 14-293 28 3.7e-94 319.13 In-house 1-365 (365) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-365/365
Sequence Identity: 28% (111 aa)

IDTTNPLGSGNYGSVYRGSLYSDDRNI-IKRQMNTI---------YAIKETPLLSNNAADLSPKK--KIAIKEIN----------NLKQLNHPHIIKFID
..  . .|.||.||||... ....... ||... ..         ..||.  . ...  ..  .|  .  ..|||          .|.|||||.|||...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

AKQ--TDKNIYLVMEYCNGGTLEKLIKDK------------KPNEKECLYYFSQIIS---------------AFKYLIQEVNMIHRDVKPENILIHNDMI
. |  .|.|||||||||.||.|...||..            ...|||..|.. ||..               |..|| .. | |||| ||||||.    |
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KLAGFGFSKKVMND-------------------------------ELQFNTIAVSPMFSAPQILRVQF---NEKAQKYTSKAEIWSLGVTLYFMLCYESE
|.. ||.|||. .|                               . .||||. .|.. ||.||. .    ..| . |. |. ||||||.||.||. .  
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

KDKHCYPWQANSQVQLNQEIKETKEIQFP----------------ESKNLSQKVKDLIRK----MLQVEEEDRLN-WEELFDHELF
                 |.... ..|.||                . |..||..||||.|    |||...| |.. ||....|. |
F----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 20144.AA ULK 14-293 33 1.8e-79 270.34 In-house 1-324 (324) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-324/324
Sequence Identity: 33% (115 aa)

IDTTNPLGSGNYG-SVYRGSLYSDDRNIIKRQMNTIYAIKETPLL-SNNAADLSP----KKKIAIKEINNLKQLN---HPH--IIKFIDAKQTD--KNIY
.   . ||.| .|  ||.|      ||...   | ..|.|  ..   |.   ...    .... ..||...|.|.   ||.  |.|..| ..|.  .|||
YCLNHCLGKGSFGVKVYKG------RNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLL-KNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIY

LVMEYCNGGTLEKLIKDKKP----------NEKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIHND-------------MIKLAGFGFSKKVMN--
..|||||||.||..|| .|.          .|.|.. .| ||...||.| .. | |||| ||.||||||.              .|.| |||.|.|.|  
IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKEL-HKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNN

DELQFNTIAV-------SPMFSAPQILRVQFNEKAQKYT-SKAEIWSLGVTLYFMLCYESEKDKHCYP---WQANSQV----QLNQE------IKETKEI
 | | .. .|       .|.. |||||  |   . ..|. .|. |||||. .| ||          ||   | .|.|.    .| .       . ... |
MEQQMCQTCVNEKRIKGTPLYMAPQILQGQG--EQKPYYDYKCDIWSLGCIFYEMLY-------GKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPI

QFP---ESKNLSQKVKDLIRKMLQVEEEDRLNWEELFDHELF
|||   .....|...|||||.|||..|.|| .|||.|.|..|
QFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 20144.AA ULK 72-293 36 2.7e-76 259.78 In-house 58-329 (329) Show / Hide 
Range on Protein: 72-293
Range on HMM: 58-329/329
Sequence Identity: 36% (103 aa)

IKEINNLKQLN--------HPHIIKFIDAKQTD--KNIYLVMEYCNGGTLEKLIKDKKP-----------NEKECLYYFSQIISAFKYLIQEVNMIHRDV
..|| ..|.|.        ||.|.|..| ..|.  .|||..|||||||.||..|| .|.           .|.|.. .| ||...||.| .. | |||| 
KNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKEL-HKHNIIHRDI

KPENILIHND-------------MIKLAGFGFSKKVMND--ELQFNTIAV-------SPMFSAPQILRVQFNEKAQKYT-SKAEIWSLGVTLYFMLCYES
||.||||||.              .|.| |||.|.|.||  | | .. .|       .|.. |||||  |   . ..|. .|. |||||. .| ||    
KPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQG--EQKPYYDYKCDIWSLGCIFYEMLY---

EKDKHCYP---WQANSQV-QLNQEIKE----------TKEIQFP---ESKNLSQKVKDLIRKMLQVEEEDRLNWEELFDHELF
      .|   | .|.|. | .|. ..          .. .|||   .....|...|||||.|||..|.|| .|||||.|..|
----GKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 20144.AA S_TKc 14-293 26 3.1e-63 217.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-231/231
Sequence Identity: 26% (80 aa)

IDTTNPLGSGNYGSVYRGSLYSDDRNIIKRQMNTIYAIKETPLLSNNAADLSPKKKIAIKEINNLKQLNHPHIIKFIDAKQTDKNIYLVMEYCNG--GTL
 .  ...|.| .|.||..   .          . |.|||. .             . ...||. ||. .||.|.|..|. |. ...|.|||||.|  |.|
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

EKLIKDKKP-------NEKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIHNDMIKLAGFGFSKKVMNDELQFNTIAVSPMFSAPQILRVQFNEKAQ
 ..||....       .| .. .|. ||..| .|. .  . ||||.||||||. .  ||.. ||.....       .|. ..| . || .|         
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---------

KYTS-KAEIWSLGVTLYFMLC----YESEKDKHCYPWQANSQVQLNQEIKETKEIQFPESKNLSQKVKDLIRKMLQVEEEDRLNWEELFD-------HEL
.|.  |. .||.|..|| |||    ..                |... .|  .          |. .||.|||.||.. |.|.   |..        |. 
GYGKCKCDWWSCGCILYEMLCGYPPFP----------------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase 20144.AA Pkinase 14-293 25 8e-60 209.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-293/293
Sequence Identity: 25% (83 aa)

IDTTNPLGSGNYGSVYRGSLYSDDRNIIKRQMNTIYAIKETPLLSNNAADLSPKKKIAIK--EINNLKQLNHPHIIKFIDAKQTDKNIYLVMEYCNGG--
. .  ..|||..|.||..   .. .         |.|.|. .. ...    | |......  ||  .| ||||.|....|. .....||.|||||.||  
YHIGRKIGSGSFGCVYKCHHKGTGK---------IVAVKIIKKRHEK----SWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

--TLEKLIK--DKKPN---EKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIH-NDMI----KLAGFGFSKK--VMNDELQFNTIAVSPMFSAPQIL
   |  .|.  ....    |.||  |. ||... .|. .  . ||||.|||||||. |. |    |.. ||..|.    |..  ..|....| . || ..
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVI

RVQFNEKAQKYTSKAEIWSLGVTLYFMLCYESEKDKHCYPWQAN----SQVQLNQEIKETKEIQFPESKNLS---------------------QKVKDLI
|     ..|.|..|. .||.|..|| |||          |..      . .  .| |..... .....   .                     .  ||.|
R-----GGQYYGPKVDMWSCGCILYEMLC-------GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

RKMLQVEEEDRLNWEELFDHELF
...|..  ..|...|... |. |
KWCLCKDPKKRPTAEQILQHPWF
Kinase 20144.AA Ciliate-E2-Unclassified 14-293 26 2.9e-56 193.22 In-house 1-352 (352) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-352/352
Sequence Identity: 26% (97 aa)

IDTTNPLGSGNYGSVYRGSLYSDDRNI------IKRQMNT-IYAIKETPLLSNNAADLSPKK-----KIAIKEINN-LKQLNHPHIIKFIDAKQTDKNIY
      .|.|..|.||.    ...  .      .| |..   .  ..   ..|..  .  ||     |.  |. .. |....||.|.|.....|...|||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKY-NKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LVMEYCNGGTLEKLIKDKKPN------------------EKECL-----YYFSQIISAFKYLIQEVNMIHRDVKPENILIHNDM----IKLAGFGFSKKV
.|||||.||.|.. ||..| .                  |....     .|| ||.....||... | |||| ||||||..|..    ||...||.||| 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

MNDELQ---------------FNTIAVSPMFS----APQILRVQFNE--KAQKYTSKAEIWSLGVTLYFMLCYESEKDKHCYPWQANSQVQ---------
 ... .               ..|.. .|..     || .|. | ..  ||     |. |||||| ||.||       .  || ..|.. |         
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----YKCDIWSLGVILYEMLF-----GY--YPFYDNNCEQHQQLITQWI

------LNQEIKETKEIQFPESKN------LSQKVKDLIR----KMLQVEEEDRLNWEELFDHELF
        ....  |.||||....      .|...||.|.    |||..  . |...|... | .|
NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20144.AA CAMK 19-293 21 5.7e-55 175.22 In-house 1-425 (425) Show / Hide 
Range on Protein: 19-293
Range on HMM: 1-425/425
Sequence Identity: 21% (94 aa)

PLGSGNYGSVYRGSLYSDDRNI----IKRQMNTIYAIKETPL----------------LSNNAADL------SPKKKIAIKEINNLKQ-------LNHPH
 ||.|..| |...   .. ...    |    .. .|||  .                 ...  ..         ..|   .||. .|.       |.||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IIKFIDAKQT-------------------DKNIYLVM---EYCNGG----TLEKLIKDKKP----------------NEKECLYYFSQIISAFKYLIQEV
|||.... ..                   ||..|.||   ||| ||     |   |.....                .|.|. .|| ||.|| .|.  . 
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYC-HSH

NMIHRDVKPENILIHNDM------------------IKLAGFGFSKKVMNDELQ-----------------------FNTIAVSPMFSA-PQILRVQF--
| .||| ||||||. ...                  ||.. |||..|.. .| .                       ..|   .| . | | .|. .   
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------NEKAQKYTSKAEIWSLGVTLYFMLCYESEKDKHCYPWQAN-------------SQVQLNQEIKETK-E-IQFP--------------------E
      .|. . |. |. .||.|| ||.|||        ..|...              .. .| . |.. | . . ..                    .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLC-------GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFH

SKNLSQKVKDLIRKMLQVEEEDRLNWEELFDHELF
. ..|| .||||||||||. |.|.. |.  .|. .
H-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 20144.AA Ciliate-E2b 14-293 28 3.2e-54 163.24 In-house 1-272 (272) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-272/272
Sequence Identity: 28% (85 aa)

IDTTNPLGSGNYGSVYRGSLYSDDRNIIKRQMNTIYAIKETPLLSNNAADLSPKKKIAIKEINNLKQLNHPHIIKFIDAKQTDKNIYLVMEYCNGGTLEK
..    ||.|..|||| .            . . .||.|     .|     .  | . ..|.| |. .||| |.|||.....|...|..||.|||. |. 
MIYIKKLGFGQFGSVYLVWNT--------KNTKQYYAMKC--ISKNQIIQQNMEKHM-LQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFD

LIKDKK---PNEKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIHN-DMIKLAGFGFSKKVMNDELQ----FNTIAVSPMFSAPQILR-VQFNEKAQ
.| . .    .... . |. .|. ...||  . | |.||.|||||....   .||. .| . |.| .. .      ||   | . ||.|.  .|   |  
VIREIGRLLLSTYDSQFYIASICLCLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMGTA-KHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKG-

KYTSKAEIWSLGVTLYFMLCYESEKDKHCYPWQANSQVQLNQEIKET-KEIQFPESKNLSQKVK--DLIRKMLQVEEEDRL--NWEELFDHELF
 || |. |||.|..||...|      .  .   .  . .. ||| .   |||||    .. |..  .|. ..||   |.||   .. |  |..|
-YTYKVDIWSVGICLYEFMC-----GYVPWAEDVQDPYEIYQEIIKKYDEIQFPS--YCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 20144.AA STE 14-293 21 7e-47 162.06 In-house 1-359 (359) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-359/359
Sequence Identity: 21% (78 aa)

IDTTNPLGSGNYGSVYRGSLYSDD---RNIIK---RQMNTIYAIKETPLLSNNAADLS------------PKKKIAIKEINNLKQLN--HPHIIKFIDAK
 .    .|.|..|.||..    ..   ..  .     ...|.|||. .| ..|. | .             ...  .|||. .|..|  ||.|.|.... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

QTD-------KNIYLVMEYCNGGTLEKLIKDK----KPN-----------EKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIHNDMIKLAGFGFSK
  .        .....|||..||.|...|| |    ||.           |..  |.  ||. .. |.. . . ||||.|| |||.    .||. ||...
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

KVMND----------------ELQFNTIAVSPMFSAPQILRV-QFNEKAQKYTSKAEIWSLGVTLYFMLCYESEKDKHCYPWQANSQVQLNQEIKE----
.. ..                  . ||.. .| . || ...  . . . ..|. |. ||||| |.  |.. . .     .| .|  . . |. . .    
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPW-HDMHPMRAMFMIPFNYHMQQQFEQ

-----TKEIQFPE-----------------SKNLSQKVKDLIRKMLQVEEEDRLNWEELFD--HELF
      .  ..|.                 ....|.. || |.| || . ..| . ..|    |. .
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 20144.AA CAMKL 12-293 28 6.4e-46 144.44 In-house 1-297 (297) Show / Hide 
Range on Protein: 12-293
Range on HMM: 1-297/297
Sequence Identity: 28% (93 aa)

YIIDTTNPLGSGNYGSVYRGSLYSDDRNIIK-RQMNTIYAIKETP--LLSNNAADLSP----KKKIAIK----EINNLKQLN---HPHIIKFIDAKQTDK
|.|     || |..| |            .  |  .. .|||      ..|.   ..     |.  . .    ||. .|.||   ||.|||. .  .|..
YRIGK--TLGKGSFGKVK---------LATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPE

N------IYLVMEYCNGGT--LEKLIKDK-----KPNEKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIHNDM---IKLAGFGFSKKVMN----DE
.      |||||||| ||   |   |. .     .  |.|.  || ||.|| .|. .    .||| ||||||. ...   ||.. |||| . ..    ..
HDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPG

LQFNTIAVSPMFSAPQILRVQFNEK-AQKYT-SKAEIWSLGVTLYFMLCYESEKDKHCYPWQANS------QVQLNQEIKETKEIQFP-ESKNLSQKVKD
  ..|   || . || |.     ..  ..|   |. |||.||.||.|.| .       .|. . .        . . . |. .   .|   . .|  ..|
QKLKTFCGSPPYMAPEIF-----QGNNKPYDGPKVDIWSCGVILYAMVCGY-------LPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRD

LIRKMLQVEEEDRLNWEELFDHELF
||||||||  |.| . ...  |. .
LIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 20144.AA RSK 71-293 32 1.8e-38 134.16 In-house 47-278 (278) Show / Hide 
Range on Protein: 71-293
Range on HMM: 47-278/278
Sequence Identity: 32% (80 aa)

AIKEINNLKQLN-HPHIIKFIDAKQTDKNIYLVMEYCNGGTLEKLIKDKKP----NEKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIHN----DM
. .|.| |.  . || |..  .| ||.. .||.||||.|| | . .. .|      |.|. .|...|..| ..| |    |||| |||||| ..      
TMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQG-IIHRDLKPENILYDDESNEGH

IKLAGFGFSKK-VMNDELQFNTIAVSPMFSAPQILRVQFNEKAQK-YTSKAEIWSLGVTLYFMLCYESEKDKHCYPWQA---NSQVQLNQEIKETK-EIQ
|||  |||.|. . ... . .|   .  . || .|..      |. ..  . .||||| .| ||         | | |.   |.. .. . |.. |    
IKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN---QQGGHDKACDWWSLGVLMYEMLT-------GCPPFQGPNDNNRKEIMKRIQKGKFSLT

FPESKNLSQKVKDLIRKMLQVEEEDRLN-----WEELFDHELF
.|. ..|||  ||||||||......||.      ||. .|. |
MPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 20144.AA TyrKc 14-293 19 2.7e-14 8.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-293
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

IDTTNPLGSGNYGSVYRGSLYSDDRNIIKRQMNTIYAIKETPLLSNNAADLSPKKKIAIKEINNLKQL--NHPHIIKFIDAKQTD-------KNIYLVME
|     ||.|..| ||.| ..            .  |.|     .        .. . ..|.. ...|  .||.|.... .  ..       . ...|||
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA--------REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME

YCNGGTLEKLIKDKK--PNEKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIHNDM-IKLAGFGFSKKVMND-------ELQF-----NTIAVSPMF
|. .| | . .....   . |. |..  || .   || .  | ||||    |.|....  .| . || |... .|       .        .. .. |  
YMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

-SAPQILRVQFNEKAQKYTSKAEIWSLGVTLY--FMLCYESEKDKHCYPWQA-----NSQVQLNQEIKETKEIQFPESKN------LSQKVKDLIRKMLQ
  ||  .      .  |.|.|  .|| ||...  | .. .        |.        |  .. . .|. .    |..         .... .....  .
WMAPECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQ--------PYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

VEEEDRLNWEELFDHELF
 . ||| . .|.  ||.|
EDPEDRPTFSEI--HECF
Kinase 20144.AA Pkinase_Tyr 72-177 29 1.4e-08 29.7 Pfam 51-165 (270) Show / Hide 
Range on Protein: 72-177
Range on HMM: 51-165/270
Sequence Identity: 29% (34 aa)

IKEINNLKQL-NHPHIIKFIDAKQ-TDKN--IYLVMEYCNGGTLEKLIKDK-----KPNEKECLYYFSQIISAFKYLIQEVNMIHRDVKPENILIH-NDM
..|.. .||| .||.|.... .    ..   ||.||||. .| | .  ...     ... |. | .  || ..  ||  . |.||||.   |.|.. |  
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENNV

IKLAGFGFSKKVMNDE
.| . || .. ..||.
VKICDFGLARDIYNDD
Kinase 20144.AA ULK 14-31 38 0.004602 6.64 In-house 1-18 (329) Show / Hide 
Range on Protein: 14-31
Range on HMM: 1-18/329
Sequence Identity: 38% (7 aa)

IDTTNPLGSGNYGSVYRG
.   . ||.| .| ||.|
YCLNHCLGKGSFGKVYKG
Kinase 20144.AA Pkinase_Tyr 14-37 36 0.011282 9.68 Pfam 1-25 (270) Show / Hide 
Range on Protein: 14-37
Range on HMM: 1-25/270
Sequence Identity: 36% (9 aa)

IDTTNPLGSGNYGSVYRGSLY-SDD
|     ||.|..|.||.| .. ..|
ITFGKKLGEGAFGEVYKGTWKGDPD
Kinase 20144.AA Ciliate-E2c 570-836 51 9.5e-181 606.77 In-house 1-310 (310) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-310/310
Sequence Identity: 51% (159 aa)

IDTINPLGSGNYGSVYRGSLYSDDRNIING-QMNTIYAIKETPLLSN--NAADLSSKKKIAIKEINNLKQLNHPHIIKFIDAKQTDKNIYLIMEFCNGGT
||. |.||||.||.||......|..|.||. |||...|||.|.|...  ........|...|.|||..|..||||||||.|||||||.||||||.|||||
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEKLIKEK-KPNEKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIHNDMIKLADFGFSKEVMNDEYQFNT----IAGSPMFSAPQILR--------S
||..|..| |||||.||||||||.||||||..|.|..|||.|||||||||.|||.|||||||....|..|...    ..|.||..|||||.        |
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

EIWSLGVTLYFMLCYENEKD-----------KQCYPWQANSQVKLLQEIEK--------------KKEIQFPES--KNLSQKVKDLIRKMLQVDEEDRLN
.|||||||||.||||.....           ..||||..|....| |.|..              ...|.|||.  .|.||.||.||.||||||||.|..
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WEELFGHELF
|.|.|.||..
WDEIFNHECI
Kinase 20144.AA Ciliate-E2 570-836 27 2.2e-91 309.88 In-house 1-365 (365) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-365/365
Sequence Identity: 27% (108 aa)

IDTINPLGSGNYGSVYRGSLYSDDRNI-INGQMNTI---------YAIKETPLLSNNAADLSSKK--KIAIKEIN----------NLKQLNHPHIIKFID
.. |. .|.||.||||... ....... |. .. ..         ..||.  . ...  .. ..|  .  ..|||          .|.|||||.|||...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

AKQ--TDKNIYLIMEFCNGGTLEKLIKEK------------KPNEKECLYYFSQIVS---------------AFKYLIQEANMLHRDVKPENILIHNDMI
. |  .|.||||.||.|.||.|...||..            ...|||..|.. ||..               |..|| .. | .||| ||||||.    |
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KLADFGFSKEVMNDEY-------------------------------QFNTIAGSPMFSAPQILR----------------SEIWSLGVTLYFMLCYENE
|..|||.||.. .|..                               .||||.|.|.. ||.||.                . ||||||.||.||. .  
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

KDKQCYPWQANSQVKLLQEIEKKKEIQFP----------------ESKNLSQKVKDLIRK----MLQVDEEDRLN-WEELFGHELF
                 |.. |...|.||                . |..||..||||.|    |||.|.| |.. ||... |. |
F----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 20144.AA ULK 570-836 33 2e-85 290.08 In-house 1-324 (324) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-324/324
Sequence Identity: 33% (114 aa)

IDTINPLGSGNYG-SVYRGSLYSDDRNIINGQMNTIYAIKETPLL-SNNAADLSS----KKKIAIKEINNLKQLN---HPH--IIKFIDAKQTD--KNIY
.  .. ||.| .|  ||.|      ||....  | ..|.|  ..   |.   ..     .... ..||...|.|.   ||.  |.|..| ..|.  .|||
YCLNHCLGKGSFGVKVYKG------RNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLL-KNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIY

LIMEFCNGGTLEKLIKEKKP----------NEKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIHND-------------MIKLADFGFSKEVMNDE
.|||.||||.||..||..|.          .|.|.. .| ||...||.| .. |  ||| ||.||||||.              .|.|||||.| |.|..
IIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNN

---YQFNTIA------GSPMFSAPQILRSE------------IWSLGVTLYFMLCYENEKDKQCYP---WQANSQV----KLLQE------IEKKKEIQF
    .. |.       |.|.. ||||| ..            |||||. .| ||          ||   | .|.|.    ||..       ..|.. |||
MEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY-------GKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQF

P---ESKNLSQKVKDLIRKMLQVDEEDRLNWEELFGHELF
|   .....|...|||||.|||.||.|| .|||.| |..|
PKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 20144.AA ULK 570-836 33 1.6e-81 277.18 In-house 1-329 (329) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-329/329
Sequence Identity: 33% (116 aa)

IDTINPLGSGNYGSVYRGSLYSDDRNIING-QMNTIYAIKETPLLSNNAADLSSK----KKIAIKEINNLKQLN--------HPHIIKFIDAKQTD--KN
.  .. ||.| .| ||.|      ||.... . | ..|.|  .. . |     .     ..  ..|| ..|.|.        ||.|.|..| ..|.  .|
YCLNHCLGKGSFGKVYKG------RNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNN

IYLIMEFCNGGTLEKLIKEKKP-----------NEKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIHND-------------MIKLADFGFSKEVM
||.|||.||||.||..||..|.           .|.|.. .| ||...||.| .. |  ||| ||.||||||.              .|.|||||.| |.
IYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD

ND---EYQFNTIA------GSPMFSAPQILRSE------------IWSLGVTLYFMLCYENEKDKQCYP---WQANSQV-----KLLQE-------IEKK
||   . .. |        |.|.. ||||| ..            |||||. .| ||          .|   | .|.|.     ||..        | ||
NDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY-------GKPPFYAW-FNDQYLQIIQKLINNPPPWPQQI-KK

KEIQFP---ESKNLSQKVKDLIRKMLQVDEEDRLNWEELFGHELF
. .|||   .....|...|||||.|||.||.|| .||||| |..|
QPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 20144.AA S_TKc 570-836 26 5e-61 209.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-231/231
Sequence Identity: 26% (77 aa)

IDTINPLGSGNYGSVYRGSLYSDDRNIINGQMNTIYAIKETPLLSNNAADLSSKKKIAIKEINNLKQLNHPHIIKFIDAKQTDKNIYLIMEFCNG--GTL
 . ....|.| .|.||..   .          . |.|||. .             . ...||. ||. .||.|.|..|. |. ...|..||.|.|  |.|
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

EKLIKEKKP-------NEKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIHNDMIKLADFGFSKEVMNDEYQFNTIAGSPMFSAPQIL-----RSEI
 ..||....       .| .. .|. ||..| .|. .  . .|||.||||||. .  ||..|||.....       .|. |.| . || .|     .. .
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVLGYGKCKCDW

WSLGVTLYFMLC----YENEKDKQCYPWQANSQVKLLQEIEKKKEIQFPESKNLSQKVKDLIRKMLQVDEEDRLNWEELFG-------HELF
||.|..|| |||    ..              . .... |              |. .||.|||.||.| |.|.   |..        |. |
WSCGCILYEMLCGYPPFP-------------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20144.AA Pkinase 570-836 25 8.9e-60 209.71 Pfam 1-293 (293) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-293/293
Sequence Identity: 25% (80 aa)

IDTINPLGSGNYGSVYRGSLYSDDRNIINGQMNTIYAIKETPLLSNNAADLSSKKKIAIK--EINNLKQLNHPHIIKFIDAKQTDKNIYLIMEFCNGG--
. .. ..|||..|.||..   .. .         |.|.|. .. ...    |.|......  ||  .| ||||.|....|. .....||..||.|.||  
YHIGRKIGSGSFGCVYKCHHKGTGK---------IVAVKIIKKRHEK----SWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

--TLEKLIK--EKKPN---EKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIH-NDMI----KLADFGFSKE--VMNDEYQFNTIAGSPMFSAPQIL
   |  .|.  ....    |.||  |. ||... .|. .  . .|||.|||||||. |. |    |..|||..|     |..  ..|..|.| . || ..
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVI

R--------SEIWSLGVTLYFMLCYENEKDKQCYPWQAN----SQVKLLQEIEKKKEIQFPESKNLS---------------------QKVKDLIRKMLQ
|        . .||.|..|| |||          |..      . .  .| |..... .....   .                     .  ||.|...|.
RGGQYYGPKVDMWSCGCILYEMLC-------GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

VDEEDRLNWEELFGHELF
.| ..|...|... |. |
KDPKKRPTAEQILQHPWF
Kinase 20144.AA CAMKL 568-836 28 3.4e-57 181.0 In-house 1-297 (297) Show / Hide 
Range on Protein: 568-836
Range on HMM: 1-297/297
Sequence Identity: 28% (92 aa)

YIIDTINPLGSGNYGSVYRGSL-YSDDRNIINGQMNTIYAIKETP--LLSNNAADLSS----KKKIAIK----EINNLKQLN---HPHIIKFIDAKQTDK
|.|     || |..| |  .               .. .|||      ..|.   ..     |.  . .    ||. .|.||   ||.|||. .  .|..
YRIGK--TLGKGSFGKVKLATHIRTT---------GEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPE

N------IYLIMEFCNGGT--LEKLIKEK-----KPNEKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIHNDM---IKLADFGFSKEVM---NDEY
.      |||.|| | ||   |   |...     .  |.|.  || ||||| .|. .     ||| ||||||. ...   ||..||||| . .   . . 
HDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPG

Q-FNTIAGSPMFSAPQILRS--E--------IWSLGVTLYFMLCYENEKDKQCYPWQ-------ANSQVKLLQEIEKKKEIQFPESKNLSQKVKDLIRKM
| ..|  ||| . || |. .  .        |||.||.||.|.|         .|.         .. . .| .....   ..|  . .|  ..||||||
QKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVC-------GYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKM

LQVDEEDRLNWEELFGHELF
|||. |.| . ...  |. .
LQVNPEKRPTIHQIMNHPWM
Kinase 20144.AA Ciliate-E2b 570-836 29 3.6e-57 172.33 In-house 1-272 (272) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-272/272
Sequence Identity: 29% (88 aa)

IDTINPLGSGNYGSVYRGSLYSDDRNIINGQMNTIYAIKETPLLSNNAADLSSKKKIAIKEINNLKQLNHPHIIKFIDAKQTDKNIYLIMEFCNGGTLEK
.. |  ||.|..|||| .            . . .||.|     .|     .  | . ..|.| |. .||| |.|||.....|...|..||||||. |. 
MIYIKKLGFGQFGSVYLVWNT--------KNTKQYYAMKC--ISKNQIIQQNMEKHM-LQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFD

LIKEKK---PNEKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIHN-DMIKLADFGFSKEVMNDEYQ----FNTIAGSPMFSAPQILR---------
.| | .    .... . |. .|. ...||  . | ..||.|||||....   .||.|.| .| .| .. .      || | | . ||.|.          
VIREIGRLLLSTYDSQFYIASICLCLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMGTAK-HMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGY

---SEIWSLGVTLYFMLCYENEKDKQCYPW--QANSQVKLLQEIEKK-KEIQFPESKNLSQKVK--DLIRKMLQVDEEDRL--NWEELFGHELF
   . |||.|..||...|          ||   .  .  . ||| ||  |||||    .. |..  .|. ..||   |.||   .. |  |..|
TYKVDIWSVGICLYEFMC-------GYVPWAEDVQDPYEIYQEIIKKYDEIQFPS--YCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 20144.AA Ciliate-E2-Unclassified 570-836 25 7.1e-57 195.26 In-house 1-352 (352) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

IDTINPLGSGNYGSVYRGSLYSDD------RNIINGQMNTIYAIKETPLLSNNAADLSSKK-----KIAIKEINN-LKQLNHPHIIKFIDAKQTDKNIYL
   |  .|.|..|.||.    ...       .. . . .  .  ..   ..|..  . .||     |.  |. .. |....||.|.|.....|...|||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKY-NKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMEFCNGGTLEKLIKEKKPN------------------EKECL-----YYFSQIVSAFKYLIQEANMLHRDVKPENILIHNDM----IKLADFGFSKEVM
.||.|.||.|.. ||..| .                  |....     .|| ||.....||... | .||| ||||||..|..    ||..|||.||.  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

NDEYQ---------------FNTIAGSPMFS----APQILRS-----------EIWSLGVTLYFMLCYENEKDKQCYPWQANSQVK--------------
.....               ..|..|.|..     || .|..            |||||| ||.||        . || ..|.. .              
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF------GY-YPFYDNNCEQHQQLITQWINNAYR

-LLQEIEKKKEIQFPESKN------LSQKVKDLIR----KMLQVDEEDRLNWEELFGHELF
  |... |.|.||||....      .|...||.|.    |||... . |...|... | .|
KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20144.AA CAMK 575-836 21 1.1e-55 177.55 In-house 1-425 (425) Show / Hide 
Range on Protein: 575-836
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

PLGSGNYGSVYRGSLYSDDRNI----INGQMNTIYAIKETPL----------------LSNNAADL------SSKKKIAIKEINNLKQ-------LNHPH
 ||.|..| |...   .. ...    |    .. .|||  .                 ...  ..        ...|   .||. .|.       |.||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IIKFIDAKQT-------------------DKNIYLIM---EFCNGG----TLEKLIKEKKP----------------NEKECLYYFSQIVSAFKYLIQEA
|||.... ..                   ||..|..|   |.| ||     |   |.|...                .|.|. .|| ||.|| .|. .  
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

NMLHRDVKPENILIHNDM------------------IKLADFGFSKEVMNDE-----------------------YQFNTIAGSPMFSA-PQILRS----
   ||| ||||||. ...                  ||..||||..... .|                         ..|  |.| . | | .|..    
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

------------E-----IWSLGVTLYFMLCYENEKDKQCYPWQAN-------------SQVKLLQEIEKKK-E-IQFP--------------------E
                  .||.|| ||.|||        ..|...              .. .|.. | | | . . ..                    .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLC-------GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFH

SKNLSQKVKDLIRKMLQVDEEDRLNWEELFGHELF
. ..|| .||||||||||| |.|.. |.   |. .
H-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 20144.AA STE 570-836 21 2e-50 173.85 In-house 1-359 (359) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-359/359
Sequence Identity: 21% (79 aa)

IDTINPLGSGNYGSVYRG-SLYSDDRNIINGQM------NTIYAIKETPLLSNNAADLS------------SKKKIAIKEINNLKQLN--HPHIIKFIDA
 . |  .|.|..|.||..     .. .  .|.       ..|.|||. .| ..|. | .            ....  .|||. .|..|  ||.|.|....
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

KQTD-------KNIYLIMEFCNGGTLEKLIKEK----KPN-----------EKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIHNDMIKLADFGFS
   .        .....||...||.|...||.|    ||.           |..  |.  ||. .. |.. . .  |||.|| |||.    .||.|||..
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVC

KEVMND----------------EYQFNTIAGSPMFSAPQILR-------------SEIWSLGVTLYFMLCYENEKDKQCYPWQANSQVKLLQEIEKK---
. . ..                  . ||..|.| . || ...             . ||||| |.  |.. .       .||   .  . . .| ..   
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK-------PPWHDMHPMRAMFMIPFNYHM

------------KEIQFPE-----------------SKNLSQKVKDLIRKMLQVDEEDRLNWEELFG--HELF
            .  ..|.                 ....|.. || |.| || | ..| . ..|    |. .
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 20144.AA RSK 622-836 33 3.6e-45 156.4 In-house 33-278 (278) Show / Hide 
Range on Protein: 622-836
Range on HMM: 33-278/278
Sequence Identity: 33% (85 aa)

SKKKIAIK---------EINNLKQLN-HPHIIKFIDAKQTDKNIYLIMEFCNGGTLEKLIKEKKP----NEKECLYYFSQIVSAFKYLIQEANMLHRDVK
.|.||. .         |.| |.  . || |..  .| ||.. .|||||.|.|| | . ....|      |.|. .|...||.| ..| |     ||| |
KKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQG-IIHRDLK

PENILIHN----DMIKLADFGFSKE-VMNDEYQFNTIAGSPMFSAPQILR----SE-------IWSLGVTLYFMLCYENEKDKQCYPWQA---NSQVKLL
||||| ..      ||| ||||.|. . ... . .|  ..  . || .|.     .       .||||| .| ||         | | |.   |.. ...
PENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTG-------CPPFQGPNDNNRKEIM

QEIEKKK-EIQFPESKNLSQKVKDLIRKMLQVDEEDRLN-----WEELFGHELF
. |.|.|    .|. ..|||  ||||||||..|...||.      ||.  |. |
KRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 20144.AA Pkinase_Tyr 570-734 24 3.7e-15 51.97 Pfam 1-166 (270) Show / Hide 
Range on Protein: 570-734
Range on HMM: 1-166/270
Sequence Identity: 24% (44 aa)

IDTINPLGSGNYGSVYRGSLYSDDRNIINGQMNTIYAIKETPLLSNNAADLSS--KKKIAIKEINNLKQL-NHPHIIKFIDAKQ-TDKN--IYLIMEFCN
|  .  ||.|..|.||.| ..        .. ..  |.|  .    . |. .   ...  ..|.. .||| .||.|.... .    ..   ||..||.. 
ITFGKKLGEGAFGEVYKGTWKG-----DPDNTKIPVAVKMLK----EGAMHEQNCREDF-MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP

GGTLEKLIKEK-----KPNEKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIH-NDMIKLADFGFSKEVMNDEY
.| | .  ...     ... |. | .  || ..  ||  . |. |||.   |.|.. |  .| .||| .. ..||.|
HGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
Kinase 20144.AA TyrKc 570-836 18 7.7e-15 17.24 SMART 1-280 (280) Show / Hide 
Range on Protein: 570-836
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

IDTINPLGSGNYGSVYRGSLYSDDRNIINGQMNTIYAIKETPLLSNNAADLSSKKKIAIKEINNLKQL--NHPHIIKFIDAKQTD-------KNIYLIME
|  .  ||.|..| ||.| ..            .  |.|     .        .. . ..|.. ...|  .||.|.... .  ..       . ....||
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA--------REDF-MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME

FCNGGTLEKLIKEKK--PNEKECLYYFSQIVSAFKYLIQEANMLHRDVKPENILIHNDM-IKLADFGFSKEVMND-------EYQF-----NTIAGSPMF
.. .| | . .....   . |. |..  || .   || .  |  |||    |.|....  .| .||| |... .|       .|       .. .  |  
YMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

-SAPQILRSE-------IWSLGVTLY--FMLCYENEKDKQCYPWQA-----NSQVKLLQEIEKKKEIQFPESKN------LSQKVKDLIRKMLQVDEEDR
  ||  ..         .|| ||...  | .. .        |.        |   ... ... .    |..         .... .....  . | |||
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQ--------PYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

LNWEELFGHELF
 . .|.  ||.|
PTFSEI--HECF