Gene 5140 (Tetrahymena)

5140

Species: Tetrahymena
Alias: 86.m00172, 25, TTHERM_00621430, PreTt05140, 5140
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate-E3,

Classification

Group: Other
Family: Ciliate-E3

Sequence

Name Sequence Type Origin Length Description Download
5140.AA Protein None 1034 None Fasta, JSON
5140.kin_dom Protein Kinase Domain None 221 None Fasta, JSON
5140.kin_dom2 Protein Kinase Domain None 198 None Fasta, JSON
5140.NA RNA None 3105 None Fasta, JSON

Protein domain

Protein domains of 5140.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5140.AA Ciliate-E3 79-275 67 1.1e-146 459.97 In-house 1-202 (202) Show / Hide 
Range on Protein: 79-275
Range on HMM: 1-202/202
Sequence Identity: 67% (137 aa)

FTVKRKLGQGSFGLVYKAFDQNNNQDVAIKAILPTKDKN--VGEQFQKTIQEFKNCGKPNSIHVVQVKDALVDLNNKLIFIVQEYCSKGSLTNYIKSLVK
.||...||.|.||.||||||..||||||||||......|  ||||||||.|||.||...|| .||...|...| .||.|||||||||.|.|..|||...|
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQNK

TENILKQIFIQILEGVIAIHEQNIIHSDLKPDNILVDKNN---VVKIADFGEAKQLRLEKGHTHTQGQGWTPLFAAPEVNIQQQISKESDYYSVGAVFCL
|.||...|.|||..|.|||||.||||||.|||||||||||   ..||.||||.||||..|||||||.|||||..||||.|.||||||||||||||||||.
TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQ

LC
||
LC
Kinase 5140.AA Ciliate-A1 79-329 28 8.7e-48 160.76 In-house 1-301 (301) Show / Hide 
Range on Protein: 79-329
Range on HMM: 1-301/301
Sequence Identity: 28% (87 aa)

FTVKRKLGQGSFGLVYKAFDQNNNQ-DVAIKAILPTKDKNVGEQFQKTIQEFKNCGKPNSIHVVQVKDALVDLNN--KLIFIVQEYCSKGSLTNYIKSLV
..|   .. |||| | .|.|  |..  ...| |.  ...   ||..  |||.. |   |.  |. . . | .  |     ||. ||| .| | ||..   
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCK-IIICTNF---EQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQND

--KTENILKQIFIQILEGVIAIHEQNIIHSDLKPDNILVDKNNVVKIADFGEAKQLRLEK----------------GHTHTQGQGWTPLFAAPEV-----
  | | |   |  || ||...||..||.|.||||.|||.   .  ||.|.|  |||   .                 | ||  .| . .. .||      
YMKKEEIY-EICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHY

----NIQQQISKESDYYSVGAVFCLLCD-------------LSFQDLLE------------ISNRKFPKITNHQYKNLLILAFNMMAFEPKKRDSCLKVL
     |   |.| || ||.| ..| ||              .    . .            | .  || . . ... | .|.| ||  ||. | |  ...
RDQMFIENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCI

NLLKNL
  |. .
DCLYIF
Kinase 5140.AA Pkinase 79-326 25 1e-46 166.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 79-326
Range on HMM: 1-293/293
Sequence Identity: 25% (77 aa)

FTVKRKLGQGSFGLVYKAFDQNNNQDVAIKAILPTKDKNVGEQFQKTIQEFKNCGKPNSIHVVQVKDALVDLNNKLIFIVQEYCSKG----SLTNYIK--
....||.|.|||| |||. ...... ||.| |   ..|   .|    ..| .   . |. ..|. .|.  |  .. | .|.||| .|    .|  ||.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

-SLVK--TENILKQIFIQILEGVIAIHEQNIIHSDLKPDNILVDKNNVV----KIADFGEAKQLRLEKGHTHTQGQGWTPLFAAPEVNI-QQQISKESDY
 . .   .|. .| .. |||.|.  .|...||| ||||.|||.|.|...    ||.||| |||.. .   . ...   || ..||||   .| .....| 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSVGAV-FCLLCD-LSFQ--------DLLEISNRKFPKITNHQY------------------------KNLLILAFNMMAFEPKKRDSCLKVLNL--L
.|.| . ...||  . |.        | ... .|. ....  ..                        .... .  .. .. |||| ..  .|.   .
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5140.AA S_TKc 79-326 23 5.2e-45 156.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 79-326
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

FTVKRKLGQGSFGLVYKAFDQNNNQDVAIKAILPTKDKNVGEQFQKTIQEFKNCGKPNSIHVVQVKDALVDLNNKLIFIVQEYCSK--GSLTNYIKSLVK
... ||.|.|.|| |||. . . .. |||| |            .....| . . | .  ..|. .|. .|   . ...| |||.   |.|  |||.  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

-------TENILKQIFIQILEGVIAIHEQNIIHSDLKPDNILVDKNNVVKIADFGEAKQLRLEKGHTHTQGQGWTPLFAAPEVNIQQQISK-ESDYYSVG
       .|   . .. ||....  .|...||| ||||.|||.|.  ..||.||| |.||           .  || . ||||    . .| ..| .|.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

AVFCLLCD----LSFQDLLEISNRKFPKITNHQYKNLLILAFNMMAFEPKKRDSCLKVLN---------LL
 ..  ..      .  .. .. ..          . .. .  ... ..|.|| .. ..|.          .
CILYEMLCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5140.AA ULK 79-271 28 8.6e-43 148.48 In-house 1-242 (324) Show / Hide 
Range on Protein: 79-271
Range on HMM: 1-242/324
Sequence Identity: 28% (71 aa)

FTVKRKLGQGSFG-LVYKAFDQNN---NQDVAIKAILPTKDKNVGEQ------FQKTIQEFKNCGKPN---SIH--VVQVKDALVDLNNKLIFIVQEYCS
. ....||.||||  |||......   ||.||.| |   | ..   .       |. ..| ..  | .   . .  .|. .| . . |.. |.|..||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGSLTNYIKSLVK----------TENILKQIFIQILEGVIAIHEQNIIHSDLKPDNILVDKNN------------VVKIADFGEAKQLRL-EKGHTHTQ-
 | | .|||   |          .|.. .|.|.||..|  ..|..|||| |.||.|||. ...            |.|||||| ||..   ..  . .| 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GQGWTPLFAAPEVNI----QQQIS-KESDYYSVGAVF
        |   |||. ||..      |.. . ...| .|.| .|
CVNEKRIKG---TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 5140.AA ULK 79-271 29 3.3e-41 141.6 In-house 1-246 (329) Show / Hide 
Range on Protein: 79-271
Range on HMM: 1-246/329
Sequence Identity: 29% (72 aa)

FTVKRKLGQGSFGLVYKAFDQNN----NQDVAIKAILPTKDKNVGEQ------FQKTIQEFKNCGKPN----SIH----VVQVKDALVDLNNKLIFIVQE
. ....||.|||| |||......    |..||.| |.  | ..   .       |  ..| |.  | .    ...    .|. .| . . |.. |.|..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCSKGSLTNYIKSLVK-----------TENILKQIFIQILEGVIAIHEQNIIHSDLKPDNILVDKNN------------VVKIADFGEAKQLRLE-----
||  | | .|||   |           .|.. .|.|.|||.|  ..|..|||| |.||.|||.....            |.|||||| ||..  .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KGHTHT-QGQ---GWTPLFAAPEVNI----QQQIS-KESDYYSVGAVF
  .| . . .   | |||. ||..      |.. . ...| .|.| .|
MMMTCVNE-KRLCG-TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 5140.AA Ciliate-E2-Unclassified 79-268 25 9.8e-37 124.96 In-house 1-257 (352) Show / Hide 
Range on Protein: 79-268
Range on HMM: 1-257/352
Sequence Identity: 25% (67 aa)

FTVKRKLGQGSFGLVYKAFDQNNNQDVAIKAILPTKDKNVGEQFQ--------KTIQEFK------NCGK-------PNSIHVVQVKDALVDLNNKLIFI
... ...|||.|| |||. . ...|  |.| .   .....  . .        |.... |      .  .        |. | . ||.  .. . . |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKY--NKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VQEYCSKGSLTNYIKSLVK------------------TENILK-----QIFIQILEGV-IAIHEQNIIHSDLKPDNILVDKNN---VVKIADFGEAK---
| |||  |.| .|||.  |                  ||.  |     ..| |||.|    .|..|||| |.||.|||.|.|.    .||.||| .|   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QLRLEKGHTH-----------TQGQGWTPLFA----APEVNIQQQIS----KESDYYSVG
| . .. ..            .. . .|| .     ||||  .|. .    ...|..|.|
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG
Kinase 5140.AA CAMK 84-268 20 3.3e-36 113.65 In-house 1-321 (425) Show / Hide 
Range on Protein: 84-268
Range on HMM: 1-321/425
Sequence Identity: 20% (65 aa)

KLGQGSFGLVYKAFDQNNN------------QDVAIKAILPTK---------------------------DKNVGEQFQKTIQEFKNCGKPN----SIHV
.||.|||| |..... |..            | |||| |  .|                           . .  ..... |.  |.. . .      ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQVKDALVDLN-----------------NKLIFIVQ---EYCSKG----SLTNYIKSL----------------VKTENILKQIFIQILEGVIAIHEQNI
..  ..  | .                 .| ...|    |||| |     | .||..                   ||   ...| ||...|  .|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHSDLKPDNILVDKN-----------------NVVKIADFGEAKQLRLEK----------------------GHTHTQGQGWTPLFAA-PEVNIQQQ---
.| ||||.|||.|.|                 | .||.||| |....  .                      |.  .   | || ..| |||  ...   
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG-TPEYMAAPEVLNGKGHCN

-----------ISKESDYYSVG
           .....|  |.|
MQNATDEEKPYYGPKCDMWSCG
Kinase 5140.AA Ciliate-E2 79-271 22 6.1e-36 120.86 In-house 1-286 (365) Show / Hide 
Range on Protein: 79-271
Range on HMM: 1-286/365
Sequence Identity: 22% (65 aa)

FTVKRKLGQGSFGLVYKAFDQNNNQDVAIKAILPTK--------------------DKNVGEQFQKTIQEFK-------------NCGKPNSIHVVQVKD
. . .|.|||.|| |||. . ......||| |  .|                     ||  ||. . |....             .. . |. .... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

ALVDLNNKLIFIVQEYCSKGSLTNYIKSL-VK-----------TENILKQIFIQILE---------------GVIAIHEQN-IIHSDLKPDNILVDKNNV
.  . ... |..| |||. |.|  |||.   |           ||.  |.|. |||.               ..  .|..| ||| |.||.|||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKIADFGEAKQ---------------LRLEKGHTHTQGQG---------------WTPLFAAPEVNI---------QQQISKESDYYSVGAVF
.||.||| .|.               . .. .   .  .|               .|| . |||.           |.. ....|..|.| ..
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 5140.AA TKL 85-272 20 5.3e-33 115.95 In-house 1-280 (364) Show / Hide 
Range on Protein: 85-272
Range on HMM: 1-280/364
Sequence Identity: 20% (59 aa)

LGQGSFGLVYKAFDQNNN--------QDVAIKAILPTKDKNVGE-----------------------QFQKTIQEFKNCGKPNSIHVVQVKDALVDLNN-
.|.|.|| |||.  ....        .|||.| .  . |..  .                        ... ..| . . . .  ..|| . .  . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

----------KLIFIVQEYCSKGS-LTNYIKSLVKTENILKQIFIQILEGVIAIHEQN--------IIHSDLKPDNILVDKNNV--------------VK
          . ..|| |||..|| | ...       . . .. ..|  |.   | .|        ||| |||..|||||.|.               .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IADFGEAKQLRLEK-----------------GHTHTQGQGWTPLFAAPEVNIQQ----------------QISKESDYYSVGAVFC
|.||| .. .  ..                 ....|  |. || . ||||  .|                . |. .| || | |..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW
Kinase 5140.AA STE 79-229 25 8.2e-31 106.08 In-house 1-197 (359) Show / Hide 
Range on Protein: 79-229
Range on HMM: 1-197/359
Sequence Identity: 25% (52 aa)

FTVKRKLGQGSFGLVYKAFDQ------NNNQD---------VAIKAI-LPTKDKNVGE-------------QFQKTIQEFKNCGKPN--SIHVVQVKDAL
..  .|.|.|.|| |||| .        ...          .||| . | ...... |             ..|. ..| | . | |  . ..|.  .. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

VDL-----NNKLIFIVQEYCSKGSLTNYIKSLVKT---------------ENILKQIFIQILEG-VIAIHEQNIIHSDLKPDNILVDKNNVVKIADFGEA
..      |.  ..|. ||.. |||.  ||.  ..               |.... |  |||.|    .|...||| |.||.|||.     ||..||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KQL
.||
GQL
Kinase 5140.AA CAMKL 139-252 30 5.3e-27 83.1 In-house 76-204 (297) Show / Hide 
Range on Protein: 139-252
Range on HMM: 76-204/297
Sequence Identity: 30% (39 aa)

HVVQVKDALVDLNN----KLIFIVQEYCSKGS--LTNYIKSL-----VKTENILKQIFIQILEGVIAIHEQNIIHSDLKPDNILVDKNN--VVKIADFGE
....  . . . ..    | |..| |||| |.  | .||..        .|.  ...| ||...|  .|...|.| |.||.|||.|.|.  ..||.||| 
NIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGF

AKQLR---LEKGHTHTQGQGWTPLFAAPEV
. . |     .|.. .   | .| ..|||.
SNMYRPCIFGPGQKLKTFCG-SPPYMAPEI
Kinase 5140.AA CAMKL 79-110 39 2.5e-08 22.54 In-house 1-33 (297) Show / Hide 
Range on Protein: 79-110
Range on HMM: 1-33/297
Sequence Identity: 39% (13 aa)

FTVKRKLGQGSFGLVYKAFD-QNNNQDVAIKAI
... . ||.|||| |  | . ..... |||| |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKII
Kinase 5140.AA Pkinase_Tyr 152-224 39 1.2e-07 26.52 Pfam 80-156 (270) Show / Hide 
Range on Protein: 152-224
Range on HMM: 80-156/270
Sequence Identity: 39% (31 aa)

NKLIFIVQEYCSKGSLTNYIKSL------VKTENILKQIFIQILEGVIAIHEQNIIHSDLKPDNILVDKNNVVKIADFG
|  |.|| ||. .|.| .| ..       ....  | |. .|| .|    ...|.|| ||   |.||..||||||.|||
N-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 5140.AA Pkinase_Tyr 79-116 33 2.4e-05 18.74 Pfam 1-42 (270) Show / Hide 
Range on Protein: 79-116
Range on HMM: 1-42/270
Sequence Identity: 33% (14 aa)

FTVKRKLGQGSFGLVYKAFDQ----NNNQDVAIKAILPTKDK
 |  .|||.|.|| |||.       |....||.| . .. ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMH
Kinase 5140.AA Ciliate-E3 537-733 66 1.8e-145 456.09 In-house 1-202 (202) Show / Hide 
Range on Protein: 537-733
Range on HMM: 1-202/202
Sequence Identity: 66% (134 aa)

FTVQQLLGQGGFGRVYKAFDFNNNQDVAIKAILPSQTQN--VGEQFQKTIQEFQNCGKPNSKHVVQVQKVLVDLDYKLIFIVQEYCSKGSLTNYIQSLVK
.||||.||.|.||||||||||.||||||||||.....||  ||||||||.||||||...||..||.......| ..|.|||||||||.|.|..||....|
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQNK

TENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNN---VVKIGDFGEAKQLRFEKGLTHTKGQGMTPLFAAPEVNLLAQISKESDYYSVGAIFCL
|.||...|.|||..|.|||||.||||||.|||||||||||   ..||.||||.||||..||.|||..||.||..||||.|  .|||||||||||||.||.
TQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQQQISKESDYYSVGAVFCQ

LC
||
LC
Kinase 5140.AA Ciliate-A1 537-787 29 1.3e-47 160.13 In-house 1-301 (301) Show / Hide 
Range on Protein: 537-787
Range on HMM: 1-301/301
Sequence Identity: 29% (90 aa)

FTVQQLLGQGGFGRVYKAFDFNNNQ-DVAIKAILPSQTQNVGEQFQKTIQEFQNCGKPNSKHVVQVQKVLVDLDY--KLIFIVQEYCSKGSLTNYIQSLV
..| ||.. |.|| | .|.|  |..  ...| |  . .    ||..  |||.. |   |.  |. .   | . .      ||. ||| .| | ||.    
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNF----EQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQND

--KTENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNNVVKIGDFGEAKQLRFEK----------------GLTHTKGQGMTPLFAAPEV---NL
  | | |  ||  || || ..||..||.|.||||.|||.   .  || |.|  ||| . .                   ||  .| . .. .||     .
YMKKEEIY-EICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHY

------LAQISKESDYYSVGAIFCLLCD----------------LSFQD------------LKEIQARKIPNVTNHKYKNLLMLAFNMMTYEPKKRASCQ
       . |.| || ||.| |.| ||                 . .|.            .| |     | . . ... |  |.| || |||. | | |
RDQMFIENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKII---FPPMQEPRFEELQNLIFKMMQYEPNNRCSLQ

TVLNLLQNL
 ..  |  .
QCIDCLYIF
Kinase 5140.AA S_TKc 537-784 24 3.2e-46 160.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 537-784
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

FTVQQLLGQGGFGRVYKAFDFNNNQDVAIKAILPSQTQNVGEQFQKTIQEFQNCGKPNSKHVVQVQKVLVDLDYKLIFIVQEYCSK--GSLTNYIQSLVK
... ...|.|.||.|||. . . .. |||| |            .....| | . | . ...|.   | .|   . ...| |||.   |.|  ||..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

-------TENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNNVVKIGDFGEAKQLRFEKGLTHTKGQGMTPLFAAPEVNLLAQISK-ESDYYSVG
       .|   . .. ||...   .|...||| ||||.|||.|.  ..||.||| |.||         . .  || . ||||    . .| ..| .|.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

AIFCLLCD--LSFQDLKEIQARKIPNVTNHKYKNLLMLAFNMMTYEPKKRASCQTVLN---------LL
 |.  ..     |.   .   .||        . .. .  ......|.|| ..  .|.          .
CILYEMLCGYPPFP-QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5140.AA Pkinase 537-784 24 7.8e-40 141.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 537-784
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

FTVQQLLGQGGFGRVYKAFDFNNNQDVAIKAILPSQTQNVGEQFQKTIQ--EFQNCGKPNSKHVVQVQKVLVDLDYKLIFIVQEYCSKG----SLTNYIQ
... . .|.|.||.|||. . .... ||.| |  .   .  .. |  .   | |   . |....|.   .  |   . | .|.||| .|    .|  ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS

---SLVK--TENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNNVV----KIGDFGEAKQLRFEKGLTHTKGQGMTPLFAAPEVNL-LAQISKES
   . .   .|. .| .. |||.|   .|...||| ||||.|||.|.|...    ||.||| |||.. .   . ...   || ..|||| .    .....
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DYYSVGAI-FCLLCD-LSFQDL---------KEIQARKIPNVTNHKY-----------------------KNLLMLAFNMMTYEPKKRASCQTVLNL--L
| .|.| | ...||  . |..          . |. .. | .  . .                       .... .  .. .. |||| ... .|.   .
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5140.AA ULK 537-729 26 1.8e-36 126.91 In-house 1-242 (324) Show / Hide 
Range on Protein: 537-729
Range on HMM: 1-242/324
Sequence Identity: 26% (65 aa)

FTVQQLLGQGGFG-RVYKAFDFNN---NQDVAIKAILPSQTQNVGEQ------FQKTIQEFQNCGKPN---SKH--VVQVQKVLVDLDYKLIFIVQEYCS
. . . ||.| ||  |||... ..   ||.||.| |  .. ..   .       |. ..| |.  | .   ...  .|.  ... . ... |.|..||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGSLTNYIQSLVK----------TENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNN------------VVKIGDFGEAKQLRF-EKGLTHT--
 | | .||.   |          .|.. ...|.||..|  ..|..|||| |.||.|||. ...            |.||.||| ||..   ..  . .  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

-------KGQGMTPLFAAPEVNLLA----QIS-KESDYYSVGAIF
       ||   |||. ||..        . . ...| .|.| ||
CVNEKRIKG---TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 5140.AA ULK 537-729 27 6.9e-36 122.8 In-house 1-246 (329) Show / Hide 
Range on Protein: 537-729
Range on HMM: 1-246/329
Sequence Identity: 27% (68 aa)

FTVQQLLGQGGFGRVYKAFDFNN----NQDVAIKAIL---PSQTQNVGE---QFQKTIQEFQNCGKPN----SKH----VVQVQKVLVDLDYKLIFIVQE
. . . ||.| ||.|||... ..    |..||.| |.    .| .|  |   . |  ..| ..  | .    .|.    .|.  ... . ... |.|..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCSKGSLTNYIQSLVK-----------TENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNN------------VVKIGDFGEAKQLRFE-----
||  | | .||.   |           .|.. ...|.|||.|  ..|..|||| |.||.|||.....            |.||.||| ||..  .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

KGLTHT-----KGQGMTPLFAAPEVNLLA----QIS-KESDYYSVGAIF
  .| .     .|   |||. ||..        . . ...| .|.| ||
MMMTCVNEKRLCG---TPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase 5140.AA Ciliate-E2 537-782 20 2e-33 112.06 In-house 1-361 (365) Show / Hide 
Range on Protein: 537-782
Range on HMM: 1-361/365
Sequence Identity: 20% (75 aa)

FTVQQLLGQGGFGRVYKA------FDF-----------------NNNQDVAIKAILPSQTQNVGE---QF------QKTIQEFQNCGKPNSKHVVQVQKV
. .....|||.|| |||.       .|                 .... .|.| . ..| ...     ..      .| |.| ... . |......   .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LVDLDYKLIFIVQEYCSKGSLTNYIQSL-VK-----------TENILKEIFIQILEGA---------------IAIHEQN-IIHSDLKPDNILVDKNNVV
  . | . |..| |||. |.|  ||..   |           ||.  |.|. |||.|                  .|..| ||| |.||.|||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFGEAKQLRFE---------KGLTHTKGQGM---------------------TPLFAAPEVNLLAQ---------ISKESDYYSVGAI-FCLLCDLS
|| ||| .|..  .          ..    .. .                     || . |||.    .          ....|..|.| | ...|.   
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

-FQDLKEIQARKIP--------------------NVTNHKYKNLLMLAFN--MMTYEPKKRAS-CQTVLN
 |  ...|.  ||                     .    . |.|.   |.  |. ..|.|| .  . .||
PF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK-FGKRMLQKDPEKRITGWEQILN
Kinase 5140.AA Ciliate-E2-Unclassified 537-729 25 5.3e-33 111.81 In-house 1-260 (352) Show / Hide 
Range on Protein: 537-729
Range on HMM: 1-260/352
Sequence Identity: 25% (68 aa)

FTVQQLLGQGGFGRVYKAFDFNNNQDVAIKAILPSQTQNVGEQ-FQKTIQEFQ----NCGK---------------PNSKHVVQVQKVLVDLDYKLIFIV
..... .|||||| |||. . ...|  |.| .  .| ...  . ... .  ..    |. |                |..| . | .. .. |.. |.||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

QEYCSKGSLTNYIQSLVK------------------TENILK-----EIFIQILEGA-IAIHEQNIIHSDLKPDNILVDKNN---VVKIGDFGEAK---Q
 |||  |.| .||..  |                  ||.  |      .| |||.|    .|..|||| |.||.|||.|.|.    .|| ||| .|   |
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

LRFEKGLTH-----------TKGQGMTPLFA----APEVNLLAQIS----KESDYYSVGAIF
 . ..  .            .. .  || .     ||||    . .    ...|..|.| |.
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
Kinase 5140.AA CAMK 542-728 20 8.3e-32 99.22 In-house 1-323 (425) Show / Hide 
Range on Protein: 542-728
Range on HMM: 1-323/425
Sequence Identity: 20% (65 aa)

LLGQGGFGRVYKAFDFNNN------------QDVAIKAILPSQTQN------------------------VGEQFQKTIQEFQNCGK-------PNSKHV
 ||.|.|| |..... |..            | |||| |  .. ..                         ..  ..  .| . . |        . ...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQVQKVLVDLDY-----------------KLIFIVQ---EYCSKG----SLTNYIQSL----------------VKTENILKEIFIQILEGAIAIHEQNI
..   |  | .|                 | ...|    |||| |     | .||..                   ||   . .| ||...   .|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHSDLKPDNILVDKN-----------------NVVKIGDFGEAKQLRFEKGLT----HTKGQGM------------------TPLFAA-PEVNL------
.| ||||.|||.|.|                 | .|| ||| |....  ....    .  |. |                  || ..| ||| .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------LAQISKESDYYSVGAI
           .....|  |.| |
MQNATDEEKPYYGPKCDMWSCGVI
Kinase 5140.AA CAMKL 537-710 27 4.4e-30 93.09 In-house 1-204 (297) Show / Hide 
Range on Protein: 537-710
Range on HMM: 1-204/297
Sequence Identity: 27% (56 aa)

FTVQQLLGQGGFGRVYKAFD-FNNNQDVAIKAILPSQTQNVGEQFQK-----------TIQEFQNCGKPN---SKHVVQVQKVLVDLDY----KLIFIVQ
... . ||.|.|| |  | .  .... |||| |  . ..|     ..             .| |   . |    .....   |. . ..    | |..| 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCSKGS--LTNYIQSL-----VKTENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNN--VVKIGDFGEAKQLR---FEKGLTHTKGQGMTPLF
|||| |.  | .||..        .|.  . .| ||...   .|...|.| |.||.|||.|.|.  ..|| ||| . . |   | .| . .   | .| .
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG-SPPY

AAPEV
.|||.
MAPEI
Kinase 5140.AA STE 537-726 22 2.9e-28 96.95 In-house 1-255 (359) Show / Hide 
Range on Protein: 537-726
Range on HMM: 1-255/359
Sequence Identity: 22% (59 aa)

FTVQQLLGQGGFGRVYKAFDF------NNNQD---------VAIKAI-LPSQTQNVGE-------------QFQKTIQEFQNCGKPN--SKHVVQVQKVL
.. .. .|.|.|| |||| .        ...          .||| . | ...... |             ..|. ..| . . | |  ....|.     
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

VDLDYK-----LIFIVQEYCSKGSLTNYIQSLVKT---------------ENILKEIFIQILEG-AIAIHEQNIIHSDLKPDNILVDKNNVVKIGDFGEA
.. . .      ..|. ||.. |||.  |..  ..               |.... |  |||.|    .|...||| |.||.|||.     ||. ||| .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KQLRF---EKGLTH--------TKGQGM-----TPLFAAPEVNLL------AQISKESDYYSVG
.||     .. .          | .|       || . |||| .        . .  .| .|.|
GQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLG
Kinase 5140.AA TKL 543-730 20 2.5e-26 91.8 In-house 1-280 (364) Show / Hide 
Range on Protein: 543-730
Range on HMM: 1-280/364
Sequence Identity: 20% (58 aa)

LGQGGFGRVYKAFDFNNN--------QDVAIKAILPSQTQNVGE-----------------------QFQKTIQEFQNCGKPNSKHVVQVQKVLVDLDY-
.|.|||| |||.   ...        .|||.| .   . ..  .                        ... ..|   . . .  ..||   .  . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

----------KLIFIVQEYCSKGSLTNYIQSLVKTENILKEIFIQILEGAIAIHEQN--------IIHSDLKPDNILVDKNNV--------------VKI
          . ..|| |||..||| .|..      . .  . ..|  |    | .|        ||| |||..|||||.|.               .||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

GDFGEAKQLRFEK-----------------GLTHTKGQGMTPLFAAPEVNLLA----------------QISKESDYYSVGAIFC
.||| .. .  ..                 . ..|  |. || . ||||   .                . |. .| || | ...
CDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW
Kinase 5140.AA TyrKc 537-784 19 1.3e-12 -18.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 537-784
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

FTVQQLLGQGGFGRVYKAFDFNNNQDVAIKAILPSQTQNVGEQFQKTIQEFQNCGKP--NSKHVVQVQKVLVD-----LDYKLIFIVQEYCSKGSLTNYI
 |  . || | ||.|||.      ..||.| . ..         .  ..| .   |   . ...|.   | ..     .  . ..|| ||...|.| .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QSLVK--TENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNNVVKIGDFGEAKQLRFE------KGLTHTKG--QGM--TPLF-AAPEVNLLAQI
..  .  .   | .. .|| .|   .|..|.|| ||   |.||..|..|||.||| .. .  .      |   ..|.  .|    |.   |||.      
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SKESD------------------YYSVGAIFCLLCDLSFQDLKEIQARKIPNV--------TNHKYKNLLMLAFNMMTYEPKKRASCQTVLNLL
. .||                  |. .     .  .  ....|.   ...|             .  . .|.   .  ..|..| . ...  ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWH--EDPEDRPTFSEIHECF
Kinase 5140.AA Pkinase_Tyr 613-682 38 6.1e-07 24.14 Pfam 82-156 (270) Show / Hide 
Range on Protein: 613-682
Range on HMM: 82-156/270
Sequence Identity: 38% (29 aa)

IFIVQEYCSKGSLTNYIQSL------VKTENILKEIFIQILEGAIAIHEQNIIHSDLKPDNILVDKNNVVKIGDFG
|.|| ||. .|.| .| ..       ....  | .. .|| .|    ...|.|| ||   |.||..||||||.|||
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 5140.AA Pkinase_Tyr 537-571 33 0.000409 14.56 Pfam 1-39 (270) Show / Hide 
Range on Protein: 537-571
Range on HMM: 1-39/270
Sequence Identity: 33% (13 aa)

FTVQQLLGQGGFGRVYKAFDF----NNNQDVAIKAILPS
 |  . ||.| ||.|||.  .    |....||.| . ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase 5140.AA TKL 762-784 34 0.064629 2.7 In-house 342-364 (364) Show / Hide 
Range on Protein: 762-784
Range on HMM: 342-364/364
Sequence Identity: 34% (8 aa)

LAFNMMTYEPKKRASCQTVLNLL
|.   . ..|.|| |.|..|  |
LMQDCWDHDPEKRPSFQEILKRL
Kinase 5140.AA CAMK 765-782 33 0.129542 0.16 In-house 404-421 (425) Show / Hide 
Range on Protein: 765-782
Range on HMM: 404-421/425
Sequence Identity: 33% (6 aa)

NMMTYEPKKRASCQTVLN
.|....|.||.... .||
KMLQVDPEKRMTIEQCLN