Gene 23891 (Tetrahymena)
23891
Sequence
Protein domains of 23891.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 23891.AA | Akt | 437-690 | 47 | 3.8e-171 | 551.42 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-264/264 Sequence Identity: 47% (126 aa) FDILDIIGSGAFGRVFLAQKKNHQNMFYAIKSLKKNQLLNKNYLKYAQTELNILKKCRNPFIINLYASFQTQNYIYMALEYCSGGDLGLILAQKNGMKEK ||.|...|.|.||.|||..||..|...||.|.|||.....||......|| |||..|..|||.||. |||||...|. ..||.||.| |..|. ..|. FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED TIKFIIAQVILAIEYLHNMNVVYRD-LKPENILLDQDGYIKLADFGLSREN-VKENEICKSFCGSPAYISPEQLLKIGATKKTDIYG-IGCIMYEMYQGN ...| .|..|||||.||..|..||| |||||||.|.||.|.|.||||..|| .|.....|.|||.|.|..||.|...|.||..|..| .||.||||..|. RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR PPFYHQDLSALFENIKSQPVQFN--ENFSPQCKDLLEKMLHKQYDMRP-----TITEVKSHPYF ||||.|| .|..||.|||.|. ...||.||||....|.|....|. .. |.|.||.| PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
|||||||||
| Kinase | 23891.AA | AGC | 437-690 | 28 | 1.9e-158 | 413.25 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-395/395 Sequence Identity: 28% (113 aa) FDILDIIGSGAFGRVFLAQKKNHQ-----NMFYAIKSLKKNQ---LLNKNYLKYAQTE------------LNILKKCR----------NPFIIN-LYASF |..| .|| |.||.|.|..||. . .||.| ||| ...|| .....|| |||.||. .|||.. |. || FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF QTQNY--IYMALEYCS---------GG-DLGLILA---QKNGMKEKTIKFIIAQ-------VILAIEYLHN-MNVVYRD-LKPENILLDQDGYIKLADFG |.... .|. .||.. || .| |.| .. . |....|..|. ..||.||||. |....|| |||||||||.||.|||.||| QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG LSRENVKENEI--------------------------------------------------CKSFCG--SPAYISPEQLLKIGATKKTDIYG--IGCIMY |. |.....|. ...||| .| |..|| | .| |... ||.|| LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY EMYQGNPPFYHQDLS----------ALFENIK------SQPVQFN----------ENFSPQCKDLLEKMLHKQYDMRPT----------ITEVKSHPYF || | ||||... .|..|. ...|.|. ..|||..|||..|.|.| . |.. . |.|.||.| EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
|||||||||
| Kinase | 23891.AA | AktR | 437-690 | 41 | 4.5e-115 | 388.61 | In-house | 1-268 (268) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-268/268 Sequence Identity: 41% (111 aa) FDILDIIGSGAFGRVFLAQKKNHQNMFYAIKSLKKNQLLNKNYLKYAQTELNILK-KCRNPFIINLYASFQTQNYIYMALEYCSGGDLGLILAQKNGMKE |... ..|.||||.|.|.||| . .||.|..|| . ..| ....|| ||.. .|..|||..|. .|||..... ..||| ||.| .| .|. ..| FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE KTIKFIIAQVILAIEYLHNM-NVVYRDLKPENILLDQDGYIKLADFGLSR-ENVK-ENEICKSFCGSPAYISPEQLLK-IGATKKTDIYGIGCIMYEMYQ ....|..||..||.||||. |..||||||||||||.||..|..|||||. .... ..|. .||||.|.|..||...| | .| |.. .|. ||| EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT GNPPFYHQDLSALFENIKSQP---VQFNENFSPQCKDLLE-KMLHKQYDMRPT-----ITEVKSHPYF |.|||||.. .|..||... ......||.|||||.. | | | .|.. ..|.|||| | GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
|||||||||
| Kinase | 23891.AA | SGK | 437-690 | 35 | 2.6e-106 | 329.35 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-283/283 Sequence Identity: 35% (100 aa) FDILDIIGSGAFGRVFLAQKKNH-----------------QNMFYAIKSLKKNQLL-------NKNYLKYAQTEL-NILKKCRNPFIINLYASFQTQNYI ||.| .|| | ||.|.....| . |||.| |.|.. . .|. |. ..| .|||. . |||.|| .|||. . FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL YMALEYCSGGDLGLILAQKNGMKEKTIKFIIAQVILAIEYLHNMNVVYRDLKPENILLDQDGYIKLADFGLSRENVKENEICKSFCGSPAYISPEQLLKI |. ..| ||... | . .| .| |....|.|||| ...|||||||||||| .|...| ||||. |..|.|. ..|||.|.| || |.| YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ GATKKTDIYGIGCIMYEMYQGNPPFYHQDLSALFENIKSQPVQFNENFSPQCKDLLEKMLHKQYDMRPTIT----EVKSHPYF . . | . .||..||| | ||||... . ...|| .|| |. ..|....||.. |.| . | |.|.||.| PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF |
|||||||||
| Kinase | 23891.AA | S_TKc | 437-690 | 35 | 4.4e-101 | 343.04 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 437-690
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)
FDILDIIGSGAFGRVFLAQKKNHQNMFYAIKSLKKNQLLNKNYLKYAQTELNILKKCRNPFIINLYASFQTQNYIYMALEYCSG--GDLGLILAQKNG--
..||..||.||||.|.....|. . .||| .| . .. |..|||| . |.|..|| .||. ...|| .|||.| ||| .. ....
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----MKEKTIKFIIAQVILAIEYLHNMNVVYRDLKPENILLDQDGYIKLADFGLSRENVKENEICKSFCGSPAYISPEQLLKIGATK-KTDIYGIGCIMY
. | ...|...|...|.||.|......|||||||||||. ||..||||.|. ..|||.| |..|| | | .| | |.. .|||.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY
EMYQGNPPFYHQDLSALFENIKSQPVQFNENFSPQCKDLLEKMLHKQYDMRPTITEVKS-------HPYF
||. | |||. .. ..|..|. ||..||...|.|.| . |||. |. ||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 23891.AA | Pkinase | 437-690 | 30 | 2.6e-90 | 311.13 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-293/293 Sequence Identity: 30% (91 aa) FDILDIIGSGAFGRVFLAQKKNHQNMFYAIKSLKKNQLLNKNYLKYAQT--ELNILKKCRNPFIINLYASFQTQNYIYMALEYCSGG----DLGLILA-- . |. .||||.||.|.....|. . .|.| .|| ... .... |. |.|... |.|. || .|.. ..||| .||| || || .. YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW QKNGM--KEKTIKFIIAQVILAIEYLHNMNVVYRDLKPENILLDQDGYI----KLADFGLSREN-VKENEICKSFCGSPAYISPEQLL-KIGATKKTDIY ..... |...||.. |.. ..||.|.|....|||||||||.|..|.| |..||||.. |. ...|||.| |..|| .. . ..| |.. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW GIGCIMYEMYQGNPPFYHQ------DLSALFENIKSQPVQFNENFS---------------------PQCKDLLEKMLHKQYDMRPTITEVKSHPYF ..|||.|||. |.|||... | .....|.. |. |.. . . |||.....|.| |||..... ||.| SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 23891.AA | CAMK | 442-690 | 22 | 2.4e-89 | 287.99 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 442-690
Range on HMM: 1-425/425
Sequence Identity: 22% (98 aa)
IIGSGAFGRVFLAQKKNHQNMF-----------YAIKSLKKNQLLNKN-------------------------YLKYAQTELNILKKCR-------NPFI
..|.|.|| |.|.. || ... .||| ..|..| .|. .| . |..|.||.. | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
INLYASFQ------------TQNY--------IYMAL---EYCSGGDL--------------------GLILAQKNGMKEKTIKFIIAQVILAIEYLHNM
|.|| .. | .. .|| . ||||||.| ..|. .. ..|. .... |.. |..|.|..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH
NVVYRDLKPENILLDQDG----------------Y-IKLADFGLSRENVK-----------------------ENEICKSFCGSPAYIS-PEQLLKIG--
|.| |||||||||||... . ||..|||.... . |.. .| |||.|.|.. || |.. |
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC
------------ATKKTDIYGIGCIMYEMYQGNPPFYHQ-------------DLSALFENIKSQPVQFNEN------------------------FSPQC
..|.|. .|.|.| | | ||||. ... |||.|.. .| . .|..|
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC
KDLLEKMLHKQYDMRPTITEVKSHPYF
|||. ||| . . |.||.....|| .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
|
|||||||||
| Kinase | 23891.AA | RSK | 440-690 | 33 | 1.6e-87 | 297.09 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 440-690 Range on HMM: 1-278/278 Sequence Identity: 33% (94 aa) LDIIGSGAFGRVFLAQKKN--HQNMFYAIKSLKKNQLLNKNY-LKYAQTELNILKKCR-NPFIINLYASFQTQNYIYMALEYCSGGDLGLILAQKNG--- | | |..| ||| .|.. ... || | |||. . ... .... || |||. |. |||..|. .|||. ..|. .|||.||.|. | .. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC MKEKTIKFIIAQVILAIEYLHNMNVVYRDLKPENILLDQ---DGYIKLADFGLSRE-NVKENEICKSFCGSPAYISPEQLL----KIGATKKTDIYGIGC . |.. .|..|...||.|.|| ...|||||||||.|. .| ||| |||.... . ..|. ..||.. .|. || | . | .| |.. |. FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV IMYEMYQGNPPFYH---QDLSALFENIKSQP--VQFN--ENFSPQCKDLLEKMLHKQYDMRPT-----ITEVKSHPYF .|||| |.|||.. .. . ....|.. . . .. |. .|||. ||||. .|.. . |.|.||.| LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
|||||||||
| Kinase | 23891.AA | Ciliate-E2 | 437-690 | 27 | 7.4e-86 | 291.54 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-365/365 Sequence Identity: 27% (103 aa) FDILDIIGSGAFGRVFLAQKKNHQNMF----------------------YAIKSLKKNQLLNKNYLKYAQ----------TELNILKKCRNPFIINLYAS .... .||.|.|| |....... |..| ||.|..||||. ... .. |.|||.. .|.||..| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FQ--TQNYIYMALEYCSGGDLGLILAQK-----------NGMKEKTIK---------------FIIAQVILAIEYLHNMN-VVYRDLKPENILLDQDGYI || ..|.||. .|||.|||| .. .. . ..|| || |.||..|||.||||. | ...||.||||||. | FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KLADFGLSRENVKENE-------------------------------ICKSFCGSPAYISPEQLL---------KIGATKKTDIYGIGCIMYEMYQGNPP |..|||||... ..|. . ...||.| | .|| | . | ..| ||. .|.|.||| |.|| KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FYHQDLSALFENIKSQPVQFN------------------ENFSPQCKDLLEK----MLHKQYDMRPT-ITEVKSHPYF | ...|| ....|. .. |..||||. | || |. . |.| . ... ||.| F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
|||||||||
| Kinase | 23891.AA | Ciliate-E2-Unclassified | 437-690 | 27 | 1.9e-83 | 283.52 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-352/352 Sequence Identity: 27% (98 aa) FDILDIIGSGAFGRVFLAQKKNHQNMFYAIKSLKKNQLLNKNYLKY---------AQTELN-------------ILKKCRNPFIINLYASFQTQNYIYMA . |. .||.|.|| |...|.|... .||.| .||.| .... .. . ... ||. . .|||.... ||....||. YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LEYCSGGDLGLILAQKNG-----------------MKEKTIK-----FIIAQVILAIEYLHNMN-VVYRDLKPENILLDQDG---YIKLADFGLSR---E .||| |||| .. .... |. .| |..||.....|||| | ...||.||||||.|..| |||..|||.|. . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ NVKE------------NEICKSFCGSPAYI----SPEQLLKIGAT----KKTDIYGIGCIMYEMYQGNPPFYHQDLSA----------------LFENIK |... ......|||.| |. .|| | . . .| ||.. |.|.||| |..||| .. |..||| NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK SQPVQFNE--------NFSPQCKDLLE----KMLHKQYDMRPTITEVKSHPYF ...||.. . ||..||... ||| |. . |.|. ... ||.| QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| Kinase | 23891.AA | RSK-Unclassified | 437-690 | 36 | 3.7e-82 | 257.77 | In-house | 1-283 (283) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-283/283 Sequence Identity: 36% (105 aa) FDILDIIGSGAFGRVFLAQKKNHQNMFYAIKSLKKNQLLNKNYLKYAQTELNILKKCRNPFIINLYASFQTQNYIYMALEYCSGGDLGLILA--QKNGMK | || | ||.|.| .||. | . ||.| |.|.... .| ||. || ||. |||. || ||||| | |. .||| |||.. | . . FIKHRLIGQGDFGKVYLVRKKDTQ-QIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFC EKTIKFIIAQVILAIEYLHNMNVVYRDLKPENILLDQDGYIKLADFGLSREN-------VK--------ENEIC------KSFCGSPAYISPEQLLKIGA | ..| .. |..| |||| ..||||||.||.|.|.| ..| ||.|| . .| . || .||||. .|. || . | EDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGH TKKTDIYGIGCIMYEMYQGNPPFYHQDLSALFENIKSQPVQFN--ENFSPQCKDLLEKMLHKQYDMR----PT-ITEVKSHPYF || | . | .|||| | ||.| .|.|| ..|.| . | .|.||. |.| . | ..| ||.| TKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF |
|||||||||
| Kinase | 23891.AA | MAST | 437-583 | 43 | 3.1e-65 | 209.12 | In-house | 1-146 (334) | Show / Hide |
Range on Protein: 437-583 Range on HMM: 1-146/334 Sequence Identity: 43% (64 aa) FDILDIIGSGAFGRVFLAQKKNHQNMFYAIKSLKKNQLLNKNYLKYAQTELNILKKCRNPFIINLYASFQTQNYIYMALEYCSGGDLGLILAQKNGMKEK |.. .|. ||.|.|.| .|.. | ..|.| .||....|||... |.| |||. .|||. ... |||| ||..| .|| .|||.. .| . . | FEFIKPISKGAYGKVYL-VKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEW TIKFIIAQVILAIEYLHNMNVVYRDLKPENILLDQDGYIKLADFGLS . |..||...|..||||.. | |||||.|.|.| .| |||.||||| MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLS |
|||||||||
| Kinase | 23891.AA | MAST | 594-690 | 34 | 2.1e-21 | 65.49 | In-house | 222-334 (334) | Show / Hide |
Range on Protein: 594-690 Range on HMM: 222-334/334 Sequence Identity: 34% (39 aa) KSFCGSPAYISPEQLLKIG-ATKKTDIYGIGCIMYEMYQGNPPFYHQDLSALFENIKSQP---VQFNEN--------FSPQCKDLLEKMLHKQYDMRPTI |. ||.| ||.|| .|. | . | | | |||| | ||| . .|.||.. . ..| .|| .|| || |. . |.. KQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA T----EVKSHPYF . |||.||.| NNGADEVKQHPFF |
|||||||||
| Kinase | 23891.AA | TyrKc | 437-690 | 22 | 5.3e-17 | 52.18 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 437-690 Range on HMM: 1-280/280 Sequence Identity: 22% (67 aa) FDILDIIGSGAFGRVFLAQKKNHQNMFYAIKSLKKNQLLNKNYLKYAQTELNILKKC--RNPFIINLYASFQTQ-------NYIYMALEYCSGGDLGLIL ....|.||||.|.... | . |.|.||.. .. |..|..| ..| |..||. .| ... .||...||| | ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL AQKNG-MKEKTIKFIIAQVILAIEYLHNMNVVYRDLKPENILLDQDGYIKLADFGLSRENVKE-------NEICKSF--CG---SP-AYISPEQLLKIGA . . . |. . |. |||| .|.. ||| |.|.. .. .| .||||||. . . |. .| | .|| . . RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF TKKTDIYGIGCIMYEMY-QGNPPFYH-----QDLSALFENIKSQ--PVQFNEN-------FSPQCKDLLEKMLHKQYDMRPTITEVKSHPYF | |.|.. | |.|.. | .| . . . ..|..|. . | .. .. .. .. | . ..||| .|. | .| TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
|||||||||
| Kinase | 23891.AA | Pkinase_Tyr | 437-584 | 28 | 1.3e-15 | 53.46 | Pfam | 1-159 (270) | Show / Hide |
Range on Protein: 437-584 Range on HMM: 1-159/270 Sequence Identity: 28% (45 aa) FDILDIIGSGAFGRVFLAQKK-NHQNMFY--AIKSLKKNQLLNKN-YLKYAQTELNILKKC-RNPFIINLYASFQ-TQNY--IYMALEYCSGGDLGLILA .. .|.||||.|... | ..| . |.|.| |.. .. ... |..|.|. ..| |..||. . ||. .||. .||| | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR Q----KNGMKEKTIKFIIAQVILAIEYLHNMNVVYRDLKPENILLDQDGYIKLADFGLSR . |. . |.. . .|. . |||...| . ||| |.|.. .. .| .||||.| KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR |
|||||||||