Gene 19624 (Tetrahymena)

19624

Species: Tetrahymena
Alias: TTHERM_00486930, 3680.m00119, PreTt19624, 662, 19624, 59.m00262
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
19624.AA Protein None 1446 None Fasta, JSON
19624.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
19624.NA RNA None 4341 None Fasta, JSON

Protein domain

Protein domains of 19624.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 19624.AA Ank 320-353 41 1.8e-08 34.78 Pfam 1-33 (33) Show / Hide 
Range on Protein: 320-353
Range on HMM: 1-33/33
Sequence Identity: 41% (14 aa)

SGQTPLMLACMKGNYDVARFLVSHKSVDINSQDL
 |.|||.|||..|...|...|.. .  |.| || 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 19624.AA Ank 354-377 41 0.000514 18.74 Pfam 1-24 (33) Show / Hide 
Range on Protein: 354-377
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

AGNSSLHYACMYGQRKIVEMLLGQ
 |.. ||.||..|. ..|.|||..
DGFTPLHLACRCGHTEVVKMLLQH
Kinase 19624.AA AGC 1134-1390 30 3.5e-168 438.99 In-house 1-395 (395) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-395/395
Sequence Identity: 30% (121 aa)

YSVYAHLGSGNYGDVYLVEHN------KNKKKYAMKLLDKEK---LIQKNMMKYAIAE------------RNVMQKCN----------SPFIVK-MYHSF
. .. ..| | .| ||||...       ..| |||| |.|..   ...|||......|            ||...|||          .||||| ...||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTDTH--LIITMDYCP---------GG-DLYTYLL---QKKRFEEELAVKYLSE-------ILLAVEELHY-HDVIYRD-MKPENIVLGSDGHVKLIDFG
|...|  | . |.|.|         || .|...|    ...||.|| |  |..|       |.||.| ||  ...|.|| .|||||.| .|||.|| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSRENMGEG---------------------------------------------------VAQSFCG--SAVYLAPEIISKKGHNKSVDWYQ--FGVLAY
|. |.|..|                                                    ...|||  .. |.||||.    ..|..||.   .|.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELMVGQPPFNQLN----------RKELYFNIQ------NKKVEYP----------PYLSFKAKSLISALLNKNPEERLGSGRAD-----AQQIKDHPFF
|...|.|||.  |          ..|.. .|.      |.||..|          ...|  ||.||. ||.|.||.|||.|. |     |..||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 19624.AA AktR 1134-1390 49 2.5e-163 548.89 In-house 1-268 (268) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-268/268
Sequence Identity: 49% (132 aa)

YSVYAHLGSGNYGDVYLVEHN-KNKKKYAMKLLDKEKLIQKNMMKYAIAERNVMQ-KCNSPFIVKMYHSFQTDTHLIITMDYCPGGDLYTYLLQKKRFEE
. ||..||.|..|.||||... .|.|.||||...|.|.|..|.|...| |||.|. .|| |||||....|||...|.. |.|||||.|...| .||.|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ELAVKYLSEILLAVEELHYH-DVIYRDMKPENIVLGSDGHVKLIDFGLSR-ENM--GEGVAQSFCGSAVYLAPEIISK-KGHNKSVDWYQFGVLAYELMV
| | .| ..||||.| ||.| ..||||.|||||.|..|||||..|||||. ..|   . .|.||||. .|.|||.| | |||||||||..||.. ||...
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQPPFNQLNRKELYFNIQNKK---VEYPPYLSFKAKSLIS-ALLNKNPEERLGSGRADAQQIKDHPFF
|.|||.. |.......|..|    ..||.|.|...|.||   ||.|||..|||........||.||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 19624.AA Akt 1140-1390 47 1e-124 400.6 In-house 7-264 (264) Show / Hide 
Range on Protein: 1140-1390
Range on HMM: 7-264/264
Sequence Identity: 47% (122 aa)

LGSGNYGDVYLVEHNKNKKKY-AMKLLDKEKLIQKNMMKYAIAERNVMQKCNSPFIVKMYHSFQTDTHLIITMDYCPGGDLYTYLLQKKRFEEELAVKYL
||.| .| |.||. ....| | ||| | |...||||  .....|||. |.||.||||....|||| ..| . ||||.||.|...| .|.|| |. |  | 
LGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYC

SEILLAVEELHYHDVIYRD-MKPENIVLGSDGHVKLIDFGLSREN-MGE-GVAQSFCGSAVYLAPEIISKKGHNKSVDWYQ-FGVLAYELMVGQPPFNQL
.|| || | || ...|||| .|||||.. .|||..| ||||..|| . .  ....|||.. ||||||....|| |.|||.  .|.. ||.| |.|||   
AEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQ

NRKELYFNIQNKKVEYP--PYLSFKAKSLISALLNKNPEERLGSGRADAQQIKDHPFF
...... .|.|..|..|  ...| ..|.||| ||||.|..|||.|  |||.||.||.|
DHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 19624.AA RSK-Unclassified 1134-1390 41 3.2e-119 376.28 In-house 1-283 (283) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-283/283
Sequence Identity: 41% (117 aa)

YSVYAHLGSGNYGDVYLVEHNKNKKKYAMKLLDKEKLIQKNMMKYAIAERNVMQKCNSPFIVKMYHSFQTDTHLIITMDYCPGGDLYTYLL--QKKRFEE
. .   .| |  | ||||.  . .. |||| | |.|.|..|  ||.. |.|.|   | ||||..||||||   |   |.||.|||..  |    .|.| |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

ELAVKYLSEILLAVEELHYHDVIYRDMKPENIVLGSDGHVKLIDFGLSREN---------------------MGEGV-AQSFCGSAVYLAPEIISKKGHN
...  |.||. .| | ||  |.||||.||.||||  .|||.| ||.|| .                      . .|  ..||||.  |||||.|   || 
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KSVDWYQFGVLAYELMVGQPPFNQLNRKELYFNIQNKKVEYP--PYLSFKAKSLISALLNKNPEERLGSGRADAQQIKDHPFF
| |||.  |.. ||...| ||.   |. |.. ||  ..|  |   |.| ....|| .||..||  |||... ||. || ||||
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 19624.AA RSK 1137-1390 39 1.6e-112 380.1 In-house 1-278 (278) Show / Hide 
Range on Protein: 1137-1390
Range on HMM: 1-278/278
Sequence Identity: 39% (111 aa)

YAHLGSGNYGDVYLVEHN---KNKKKYAMKLLDKEKLIQKNM-MKYAIAERNVMQKCN-SPFIVKMYHSFQTDTHLIITMDYCPGGDLYTYLLQKKR---
   || | || |.|.      .... |||| |.| |..|..   ... .|||... |. .||||. ...|||...| . |.||.||.|.| |...|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEELAVKYLSEILLAVEELHYHDVIYRDMKPENIVLGS---DGHVKLIDFGLSRE-NMG-EGVAQSFCGSAVYLAPEIIS----KKGHNKSVDWYQFGV
| |. |  |..|| |||| || ...|.|| |||||.. .   .||.||.|||.... .   .. ...||... |.|||..     ..||.|..||. .||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LAYELMVGQPPFNQ---LNRKELYFNIQNKK--VEYP--PYLSFKAKSLISALLNKNPEERLGSGRADAQQIKDHPFF
| ||. .|.||| .    ||||.  .||..|  .. |  .|||  ||.||...| ..|. |||.|. ||..||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 19624.AA SGK 1134-1390 38 1.3e-111 346.03 In-house 1-283 (283) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-283/283
Sequence Identity: 38% (110 aa)

YSVYAHLGSGNYGDVYLVEHNKN------------------KKKYAMKLLDKEKLI-------QKNMMKYAIAER-NVMQKCNSPFIVKMYHSFQTDTHL
      .| |..| ||.|.| .                   .|.||||.| |.  |       .|.  |.  ||| ..... ..||||.   .|||.. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

IITMDYCPGGDLYTYLLQKKRFEEELAVKYLSEILLAVEELHYHDVIYRDMKPENIVLGSDGHVKLIDFGLSRENM-GEGVAQSFCGSAVYLAPEIISKK
   |||  ||..  .|   |.| |  |  | .|| .| |.||  |.|||| |||||.|...||..| ||||. |..  .    .|||.  |||||.. |.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHNKSVDWYQFGVLAYELMVGQPPFNQLNRKELYFNIQNKKVEYPPYLSFKAKSLISALLNKNPEERLGSGRADAQQIKDHPFF
.| ..|||.  | . ||.|.| |||   |....| || |..   ||. | .|..||  ||.|.|..|||. ..|. .||.||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGT-KRDFMEIKNHPFF
Kinase 19624.AA S_TKc 1134-1390 33 8.5e-94 318.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-231/231
Sequence Identity: 33% (89 aa)

YSVYAHLGSGNYGDVYLVEHNKNKKKYAMKLLDKEKLIQKNMMKYAIAERNVMQKCNSPFIVKMYHSFQTDTHLIITMDYCPG--GDLYTYLLQKKR---
| .  ..|.| .| ||.. |.| ....|.| ..          . .. |.....| . |.|||.| .||. .|| . |.||.|  |||..|. ...|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FEEELAVKYLSEILLAVEELHYHDVIYRDMKPENIVLGSDGHVKLIDFGLSRENMGEGVAQSFCGSAVYLAPEIISKKGHNK-SVDWYQFGVLAYEL
   | |  | .|. .|..|.| .| | .|.|| ||||| | .  |.|..||||.|.        .|||.  |.|||..   |..| ..||. .|.. ||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

MVGQPPFNQLNRKELYFNIQNKKVEYPPYLSFKAKSLISALLNKNPEERLGSGRADA--QQIKDHPFF
..|.|||   . .... .|           |  ||..|. .|.|.||.|..   | .  . || ||.|
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19624.AA RSK 1134-1390 34 3.3e-91 309.32 In-house 1-271 (271) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-271/271
Sequence Identity: 34% (95 aa)

YSVYAHLGSGNYGDVYLV---EHNKNKKKYAMKLLDKEKLIQKNMMKYAIAERNVMQKCNSPFIVKMYHSFQTDTHLIITMDYCPGGDLYTYLLQKKRFE
| .   .| | ...||..   .|  ....|||| ..| ..  |    .. .||...   ..||||| . .||. ... . || . |||| . || .| | 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EELAVKYLSEILLAVEELHYHDVIYRDMKPENIVLGSD----GHVKLIDFGLSRENMGE-GVAQSFCGSAVYLAPEIISKKGHNKSVDWYQFGVLAYELM
|. .  |..||.||.| || .....|| |||||.. ..    ||.|. |||.. .  .| | . .||..| |.|||.....|| ...||. |||| ||  
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

VGQPPFNQLNRKELYFNIQNKKVEY-------PPYLSFKAKSLISALLNKNPEERLGSGRADAQQIKDHPFF
 | .||   .|...  .||. |.         . ..|  ||.|....|  .|. |||.|. ...||| ||.|
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 19624.AA PKA 1134-1390 38 3.8e-89 302.48 In-house 1-263 (263) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-263/263
Sequence Identity: 38% (101 aa)

YSVYAHLGSGNYGDVYLVEHNKNKKKYAMKLLDKEKLIQKNMMKYAIAERNVMQKCNSPFIV-KMYHSFQTDTHLIITMDYCPGGDLYTYLLQKKRFEEE
.  .. ||.| .| |.|. | .... |||| |.|.. .. .     . |.|..| ...|||| ||| .||.|..|   |.|.|||.. .||  ..|| . 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

LAVKYLS-EILLAVEELHYHDVIYRDMKPENIVLGSDGHVKLIDFGLSRENMGEGVAQSFCGSAVYLAPEIISKK-GHNKSVDWYQFGVLAYELMVGQPP
 |  |   .| || | || .. |||| ||||| . ..||.|. ||| . .  .  . .. ||   |||||||. | ||.|||||  .|.| ||...| ||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FNQL--NRKELYFNIQNKKVEYPPYLSFKA---KSLISALLNKNPEERLGSGRADAQQIKDHPFF
|.    .  ..|  |.| |...|.... .|   |.||. ||......|.|. ......||.|..|
FYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 19624.AA Ciliate-E2 1134-1390 24 4.6e-85 288.91 In-house 1-365 (365) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-365/365
Sequence Identity: 24% (92 aa)

YSVYAHLGSGNYGDVYLVEHNKNKKK-----------------------YAMKLLDKEKLIQKNMMKYAI----------AERNVMQKCNSPFIVKMYHS
| .   .|.||.|.||.... |..|.                       |||| . | ...|...... .           |.|.... |.|.|.||| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TDTHLIITMDYCPGGDLYTYLLQK-----------KRFEEELAVKYLSEILL---------------AVEELHYHD-VIYRDMKPENIVLGSDGHV
||  .|... . |.|| ||||. |. ..           |.| |. . ..  .||                |.|.||    .|.|| |||||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLIDFGLSRENMGE--------------------------------GVAQSFCGSAVYLAPEIISKKG---------HNKSVDWYQFGVLAYELMVGQPP
|.||||||...  .                                 .....||.. |.||||...|.         .....|.. .||. ||.. |.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNQLNRKELYFNIQNKKVEYPPY------------------LSFKAKSLISA----LLNKNPEERLGSGRADAQQIKDHPFF
|        . .|...|...|..                  .| ..| ||.     .|.|.||.|..    ...||..||.|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase 19624.AA p70 1134-1390 36 2.9e-84 286.24 In-house 1-299 (299) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-299/299
Sequence Identity: 36% (109 aa)

YSVYAHLGSGNYGDVYLVEHNK---NKKKYAMKLLDKEKLI--QKNMMKYA------------------------IAERNVMQKCNSPFIVKMYHSFQTD
.     || | || |..|   .   . | |||| | | | .  ||                               ||||.    ..|||..   .|||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

THLIITMDYCPGGDLYTYLLQKKRFEEELAVKYLSEILLAVEELHYHDVIYRDMKPENIVLGSDGHVKLIDFGLSRENMGEGVA-----------QSFCG
  |    .| .|| |.. |  .  . |. |  ||||| .| | || |..|||| ||||. | . |||.| ||||. | . .|              .|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

SAVYLAPEIISKKGHNKSVDWYQFGVLAYELMVGQPPFNQLNRKELYFNIQNKK--VEYPPYLSFKAKSLISALLNKNPEERLGSGRADAQQIKDHPFF
   | ||||....|||. |||.  |.| |  ..|.|||   |||.    |.  |  .. ||||.  .. || .|| ..| .|.|.|  ||..|. ||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 19624.AA Pkinase 1134-1390 26 2.8e-83 287.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1134-1390
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

YSVYAHLGSGNYGDVYLVEHNKNKKKYAMKLLDKEKLIQKNMMKYAIA--ERNVMQKCNSPFIVKMYHSFQTDTHLIITMDYCPGG----DLYTYLL--Q
| .   .|||..| ||.  | .. |..|.| ..|.  . ... ....   |  .|...|.|.||..|..|....|. . |.||.||    ||..|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KKRF--EEELAVKYLSEILLAVEELHYHDVIYRDMKPENIVLGSDGHV----KLIDFGLSRE--NMGEGVAQSFCGSAVYLAPEIIS-KKGHNKSVDWYQ
...|  .|. . .|. .|| ..| .| . .|.||.||||| . ..||.    |..||||..   .   . ...|||.  |.|||.|   ... ..||.. 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGVLAYELMVGQPPFNQL------NRKELYFNIQNKKVEYPPYLS---------------------FKAKSLISALLNKNPEERLGSGRADAQQIKDHPF
.|.. ||.. |.||| .       . ......|  ...... . .                       .|..|. .|.|.|..|..     |.||. ||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase 19624.AA TyrKc 1134-1384 21 1e-11 -33.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 1134-1384
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

YSVYAHLGSGNYGDVYLVEHNKNKKKYAMKLLDKEKLIQKNMMKYAIAERNVMQKC--NSPFIVKMYHSFQTD-------THLIITMDYCPGGDLYTYLL
 .    ||.|..| ||. . .    . | | | ...  .. .|.    | ..| |   . | ||..|    ..         | | | |.|.|||  || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMR----EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QKKR-FEEELAVKYLSEILLAVEELHYHDVIYRDMKPENIVLGSDGHVKLIDFGLSRENMGE------GVAQSF----CGSAV----YLAPEIISKKGHN
 ... .  .  ...   |    | || . .| ||    |. .|....||  ||||||.   .      .   .     .| ..     .||| | ..  .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSVDWYQFGVLAYELM-VGQPPFNQ-----LNRKELYFNIQNKKVEYPPYL---------SFKAKSLISALLNKNPEERLGSGRADAQQI
   | . |||. .|..  ||.|        .. .|.. .... .   .|           . .  ....   . .||.|        ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 19624.AA Pkinase_Tyr 1134-1228 26 0.001658 12.5 Pfam 1-106 (270) Show / Hide 
Range on Protein: 1134-1228
Range on HMM: 1-106/270
Sequence Identity: 26% (28 aa)

YSVYAHLGSGNYGDVYLVEHN----KNKKKYAMKLLDKEKLIQKN-MMKYAIAERNVMQKC-NSPFIVKMYHSFQ-TDTH--LIITMDYCPGGDLYTYLL
 .    ||.|..|.||. . .    ..| . | | | ||.  ... ...  ..| ..| .  . | ||..|      . .  ..| | |.|.|||..|| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QK---KR
..   |.
KHREDKQ
Kinase 19624.AA Pkinase_Tyr 1262-1280 42 0.243765 5.16 Pfam 141-159 (270) Show / Hide 
Range on Protein: 1262-1280
Range on HMM: 141-159/270
Sequence Identity: 42% (8 aa)

NIVLGSDGHVKLIDFGLSR
|. ......||  ||||.|
NCLVTENNVVKICDFGLAR