Gene 2238 (Tetrahymena)

2238

Species: Tetrahymena
Alias: 2238, 57.m00177, 3709.m00037, PreTt02238, 427, TTHERM_00474370
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
2238.AA Protein None 327 None Fasta, JSON
2238.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
2238.NA RNA None 984 None Fasta, JSON

Protein domain

Protein domains of 2238.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2238.AA AGC 16-272 29 2.1e-157 410.51 In-house 1-395 (395) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-395/395
Sequence Identity: 29% (116 aa)

YKVLELIGNGTYGDVVLAQDLRG----NGDEQVAIKIIK----NNKERKNQISSIQNE------------RIILEKCKN---------HPFFVQ-SKEFV
...| .|| |..| | |...  |      ... |.|..|      . .||..  ...|            | |||||..         ||| |.  .   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDKSC--SFFIMEYVQ---------GG-ELYDIIQ---NRGHLSEDAARFYASQ-------VLIALDYLHQ-NDIVYRD-LKPENILLDENGYVKLTDFG
.||.    .|.|||..         || ||. ..|   ..|...|..|||||..       .. ||.|||. ..|..|| ||||||||||.|..||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSEVEVVSP---------------------------------------------------TLDKICG--TPEYVSPEMLFESGYGKQVDHWA--LGVLIF
|. . . ..                                                   .   .||  ||||..||.|    |||..| |.  ||.|..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMITGHTPFEAKS----------QEELFEKIK------FSQVTYP----------ACISPQLKSLLEGLFMKNPSKRLGAK-------GIEQIKKHPWF
||.||..|| ...          ..|.|.||.      . .|..|            .||..|.|...|. |.|.||||..       |.|.||.||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 2238.AA AktR 16-272 46 5.6e-157 527.79 In-house 1-268 (268) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-268/268
Sequence Identity: 46% (125 aa)

YKVLELIGNGTYGDVVLAQDLRGNGDEQVAIKIIKN-NKERKNQISSIQNERIILEKCKNHPFFVQSKEFVKDKSCSFFIMEYVQGGELYDIIQNRGHLS
..|....|.|..|.|.|.|..| . ..|.|.|.||. . ...||.. ...|| |.|.|.||||.|. ... ..|...||||||..||||..........|
FHVYKCLGKGAFGKVYLVQKKR-DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFS

EDAARFYASQVLIALDYLHQN-DIVYRDLKPENILLDENGYVKLTDFGLSE---VEVVSPTLDKICGTPEYVSPEMLFE-SGYGKQVDHWALGVLIFEMI
|. ||||..|.|.||.||||. .|.|||||||||||||.|.||.||||||.   ... ... ...||||||..|||...  |..|.||.||.|..|.||.
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMV

TGHTPFEAKSQEELFEKIKFSQ---VTYPACISPQLKSLLE-GLFMKNPSKRLG--AKGIEQIKKHPWF
||..||..|.|...|.|||..|   ..||...|.|.|.|.. .|..||| ||||  ..|.|.||.||||
TGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 2238.AA S_TKc 16-272 36 1.1e-101 344.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-231/231
Sequence Identity: 36% (99 aa)

YKVLELIGNGTYGDVVLAQDLRGNGDEQVAIKIIKNNKERKNQISSIQNERIILEKCKNHPFFVQSKEFVKDKSCSFFIMEYVQG--GELYDIIQNRGH-
|..|..|| |..| | .... .   ...|||||||          .|..|. ||.|  .||. |. ...  | .. ...|||. |  |.|.|.|..||. 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LSEDAARFYASQVLIALDYLHQNDIVYRDLKPENILLDENGYVKLTDFGLSEVEVVSPTLDKICGTPEYVSPEMLFESGYGK-QVDHWALGVLIF
     ..|  ||||. |.. ||.|.|.. |..||||||||||||   .|..||||. .       . .||||.|..||.|   ||||  .| |..|....
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMITGHTPFEAKSQEELFEKIKFSQVTYPACISPQLKSLLEGLFMKNPSKRLGAKGIEQ----IKKHPWF
||..| .||.   ....|.||.          ||..|....... |.|.||..|  . |    ||.||||
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2238.AA Akt 92-272 43 4.1e-96 307.74 In-house 76-264 (264) Show / Hide 
Range on Protein: 92-272
Range on HMM: 76-264/264
Sequence Identity: 43% (83 aa)

FFIMEYVQGGELYDIIQNRGHLSEDAARFYASQVLIALDYLHQNDIVYRD-LKPENILLDENGYVKLTDFGLSEVEVVSP--TLDKICGTPEYVSPEMLF
.|.|.|..||||.  .| ..  ||| ||||....  |...||...|.||| |||||||.|..|...||||||.  ....   . . .|||||| .||.| 
YFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILN

ESGYGKQVDHWA-LGVLIFEMITGHTPFEAKSQEELFEKIKFSQVTYP--ACISPQLKSLLEGLFMKNPSKRLG--AKGIEQIKKHPWF
  |..|.|| |. ||....||..|  || .. ....|.||| ..| .|    |||. |.|..||  |.|.||||   .....|| ||||
GNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 2238.AA PKA 16-272 37 4.2e-96 325.58 In-house 1-263 (263) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-263/263
Sequence Identity: 37% (102 aa)

YKVLELIGNGTYGDVVLAQDLRGNGDEQVAIKIIKNNK-ERKNQISSIQNERIILEKCKNHPFFV-QSKEFVKDKSCSFFIMEYVQGGELYDIIQNRGHL
.. . ..|.|..| | |... ...| . .|.|..| ..  | .|.  . ||. ||  .| ||| | . . . .| .  ...||||.|||. . ....|..
FEIIQTLGTGSFGRVMLCRH-KHSG-NYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIK-HPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRF

SEDAARFYAS-QVLIALDYLHQNDIVYRDLKPENILLDENGYVKLTDFGLS-EVEVVSPTLDKICGTPEYVSPEMLFES-GYGKQVDHWALGVLIFEMIT
|.. |.|||  |.  ||.|||. .|.||||||||||.|.||..|.|||| . .|. .. ||   ||||||  ||..  . |.|| || ||||.||.|| .
SNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTL---CGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLA

GHTPFEAK--SQEELFEKIKFSQVTYPACISPQL---KSLLEGLFMKNPSKRLGAK--GIEQIKKHPWF
|..||...  .. ...|||   .. .|  .....   |.|.. |  ....||.| .  |...||.|.||
GYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 2238.AA RSK 19-272 36 5.8e-94 318.47 In-house 1-278 (278) Show / Hide 
Range on Protein: 19-272
Range on HMM: 1-278/278
Sequence Identity: 36% (102 aa)

LELIGNGTYGDVVLAQDLRGNGDEQV-AIKIIKNNKERKNQ--ISSIQNERIILEKCKNHPFFVQSKEFVKDKSCSFFIMEYVQGGELYDIIQNRGH---
|.. | | || | | .  ..   .|. | |..| .| ...|  .     || ||| |..||| |. ..  ....  . ||||. ||||.. .|...|   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSEDAARFYASQVLIALDYLHQNDIVYRDLKPENILLDE---NGYVKLTDFGLSEVEVVS--PTLDKICGTPEYVSPEMLF----ESGYGKQVDHWALGV
.||| |.||....  |...||| .|..|||||||||.|.   .| .||||||..   . .    ... |.| ||. ||||     ..|..|..| | |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIFEMITGHTPFEA---KSQEELFEKIKFSQ--VTYP--ACISPQLKSLLEGLFMKNPSKRLG--AKGIEQIKKHPWF
|..|| ||..|| .   ....|....|.  .  .| |  . .|.  |.|. ......|.||||   ...|.||.||||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 2238.AA Pkinase 16-272 30 5.2e-89 306.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

YKVLELIGNGTYGDVVLAQDLRGNGDEQVAIKIIKNNKERKNQISSIQN--ERIILEKCKNHPFFVQSKEFVKDKSCSFFIMEYVQGG----ELYDIIQ-
|.... || |..| | ....   .   .||.||||  .|....  .  .  |  |. .. |||. |. .... ||.   ..|||..||    .|.|.|. 
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-NRGHL--SEDAARFYASQVLIALDYLHQNDIVYRDLKPENILLDENGYV----KLTDFGLSEV--EVVSPTLDKICGTPEYVSPEMLF-ESGYGKQVDH
 ..| .  ||. ..||. |.| .|.|.|.. |..|||||||||.|.||..    |..||||...  .  .. .. .||||.|..|| .   ..||. || 
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WALGVLIFEMITGHTPFEAK------SQEELFEKIKF----SQVTYPACIS-----------------PQLKSLLEGLFMKNPSKRLGAKGIEQIKKHPW
|..|....||..|..||  .      .| .....|.     ..  .. .||                 . .|....... |.|.||..   .|||..|||
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPW

F
|
F
Kinase 2238.AA SGK 16-272 35 3.2e-88 272.48 In-house 1-283 (283) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-283/283
Sequence Identity: 35% (100 aa)

YKVLELIGNGTYGDVVLAQDLRG----------------NGDEQVAIKIIKNNKER--------KNQISSIQNER-IILEKCKNHPFFVQSKEFVKDKSC
 . | .|| | .| | ...                      |   |.|... .  .        |..   |. ||  || |. .||| |. .     |  
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVIL-KNMKHPFIVNLHYAFQTKWK

SFFIMEYVQGGELYDIIQNRGHLSEDAARFYASQVLIALDYLHQNDIVYRDLKPENILLDENGYVKLTDFGLSEVEVVSPTLDK-ICGTPEYVSPEMLFE
 .| |.||.|||.   .| ..|..|| |||||...  ||.|||  ||.||||||||||||  |...||||||.  ..   .  . .||||||  ||.|  
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

SGYGKQVDHWALGVLIFEMITGHTPFEAKSQEELFEKIKFSQVTYPACISPQLKSLLEGLFMKNPSKRLGAK-GIEQIKKHPWF
 .... || | || . .||..|  ||. .  ......|  .    |  .|.. ..|..||  |.|.||||.| . ..||.||.|
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 2238.AA CAMK 21-272 22 2.8e-87 281.22 In-house 1-425 (425) Show / Hide 
Range on Protein: 21-272
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

LIGNGTYGDVVLAQDLRGNGD----------EQVAIKIIKNNKERKNQ--------------------------ISSIQNERIILEKCK------NHPFF
 .| |..| | |... . .|.          ..||||||. .| ...|                            ....|  |. |..      .||  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQSKEFVKD-------------------KSCSFFIM---EYVQGGEL----YDIIQNRGH---------------LSEDAARFYASQVLIALDYLHQNDI
..  |.  |                   ... ...|   ||..||||    .| |. .|.               ..|. ||.|  |.. |..|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VYRDLKPENILLDENG----------------Y-VKLTDFGLSEVEVV------------------------SPTLDKICGTPEYVS-PEMLF-------
| |||||||||||.|.                . .|..|||.. .                            . .   ||||||.. ||.|        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------ESGYGKQVDHWALGVLIFEMITGHTPFEAK-------------SQEELFEKIKFSQVTYPAC------------------------ISPQLKS
       . .||...| |..||. . | .|. ||...             ...||||||.  . ..|                          .|.. |.
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLEGLFMKNPSKRLGAKGIEQIKKHPWF
|. ..  ..|.||.    |||...|||.
LIRKMLQVDPEKRM---TIEQCLNHPWM
Kinase 2238.AA CAMKL 16-272 29 4.2e-84 268.28 In-house 1-297 (297) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-297/297
Sequence Identity: 29% (91 aa)

YKVLELIGNGTYGDVVLAQD-LRGNGDEQVAIKIIKNNKERKNQISS-------------IQNERIILEKCK--NHPFFVQSKEFVKDKSC------SFF
|.... .| |..| | ||.. .     |.||||||. .| .......             |. |  |... .   ||  ..  | . ....       . 
YRIGKTLGKGSFGKVKLATHIRTT--GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

IMEYVQGGE--LYDIIQNRGH----LSEDAARFYASQVLIALDYLHQNDIVYRDLKPENILLDENG--YVKLTDFGLSEVEV-V----SPTLDKICGTPE
.|||..|||  |.| |...||    ..|. ||.|  |.. |..|.|...|| ||.|||||||||||   .|..|||.|     .      .|.  ||.|.
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YVSPEMLFE---SGYGKQVDHWALGVLIFEMITGHTPFEAKS-------QEELFEKIKFSQVTYPA---CISPQLKSLLEGLFMKNPSKRLGAKGIEQIK
| .||..     . .|..|| |..||. . |..|. ||.. .          ...... .. .||     .| ....|. .. ..||.||     |.||.
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRP---TIHQIM

KHPWF
.|||.
NHPWM
Kinase 2238.AA Ciliate-E2 16-272 25 9.5e-82 277.89 In-house 1-365 (365) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YKVLELIGNGTYGDVVLAQDLRGNGDEQ---------------------VAIKII-KNNKERKNQISSIQ----------NERIILEKCKNHPFFVQSKE
||....||.|..|.| .... . . ...                     .|.||. ||..| ..|. .|           ||. |||.  |||. .. .|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQL-NHPNIIKMYE

FVK--DKSCSFFIMEYVQGGELYDIIQNR-----------GHLSEDAAR---------------FYASQVLIALDYLHQND-IVYRDLKPENILLDENGY
. .  |... ...|||.|||.|.|.|.|.           . ..|  ..               ||. ... || |||..  |..||.||||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLTDFGLSE----------------------VEVVSPT----------LDKICGTPEYVSPEMLFESG---------YGKQVDHWALGVLIFEMITGHT
.|..|||||                        . ..|.           . |||||.|..||.|   .         |....| |.|||...||..| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFEAKSQEELFEKIKFSQVTYP------------------ACISPQLKSLLEG----LFMKNPSKRLGAKGIEQIKKHPWF
||        ...||  .. .|                    .|.. | |.      .. |.|.||..  |.|||..||||
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 2238.AA Ciliate-E2-Unclassified 16-272 27 1.3e-81 277.4 In-house 1-352 (352) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-352/352
Sequence Identity: 27% (97 aa)

YKVLELIGNGTYGDVVLAQDLRGNGDEQVAIKIIKNNKERK-NQISS---IQNERIILEKCK------------------NHPFFVQSKEFVKDKSCSFF
||... ||.| .|.| ..|.   .  .. |.|..| ....| .|| .   | || ..... |                  .||| |   .  .|| . ..
YKIIKQIGQGGFGKVYKCQHKKQK--QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMEYVQGGELYDIIQNRGH-----------------LSEDAAR-----FYASQVLIALDYLHQND-IVYRDLKPENILLDENG---YVKLTDFGLS-EVE
.|||..||.| ..|..|..                 ..| .|.     ||. |.| .|.|||..  |..||.||||||.|.||   |.|..|||.| . .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

VV---------------SPTLDKICGTPEYV----SPEMLFESGYG----KQVDHWALGVLIFEMITGHTPFEAKSQEE----------------LFEKI
                 .  .. .||||.|     .||.| . .|.    ...| |.|||...||..|  ||.....|.                |...|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KFSQVTYPA--------CISPQLKSLLEGLFMKNPSKRLGAK-GIEQIKKHPWF
|  .. .|          .||. | ... |. |.. |... . ..|||..||||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 2238.AA TyrKc 16-267 20 1.5e-15 28.68 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-267
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YKVLELIGNGTYGDVVLAQDLRGNGDEQVAIKIIKNNKERKNQISSIQNERIILEKC-KNHPFFVQSKEFVKDK-------SCSFFIMEYVQGGELYDII
 . .. .|.| .| |....       .|||.| .|...     .  . .|  |. |  ..||  |.    . ..          . .|||. .| | | .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QNRGH-LSEDAARFYASQVLIALDYLHQNDIVYRDLKPENILLDENGYVKLTDFGLSEVEVVS-------PTLDK---ICGTP----EYVSPEMLFESGY
..... |. .    .. |.    .|||.. .. |||   |.|..||. || .|||||              . .|    .|         .|| .... .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GKQVDHWALGVLIFEMIT-GHTPFEA-----KSQEELFEKIKFSQVTYPACI---------SPQLKSLLEGLFMKNPSKRLGAKGIEQIK
  . | |. ||...|. | | .| .      .| .|..|..|      .            .. . .. .   . .|..|   . | .. 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 2238.AA Pkinase_Tyr 94-163 31 5e-06 21.07 Pfam 85-158 (270) Show / Hide 
Range on Protein: 94-163
Range on HMM: 85-158/270
Sequence Identity: 31% (23 aa)

IMEYVQGGELYDIIQN----RGHLSEDAARFYASQVLIALDYLHQNDIVYRDLKPENILLDENGYVKLTDFGLS
.|||...| |.|  ..    ...|.      .. |.  ...||... .. |||   |.|..||. || .||||.
VMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 2238.AA Akt 16-80 30 6e-06 14.89 In-house 1-64 (264) Show / Hide 
Range on Protein: 16-80
Range on HMM: 1-64/264
Sequence Identity: 30% (21 aa)

YKVLELIGNGTYGDVVLAQDLRGNGDEQV--AIKIIKNNK-ERKNQISSIQNERIILEKCKNHPFFVQ
  .|...| |..| |.|...   . ....  |.|..| .. . |||.  .. || ||..|. ||| |.
FDFLKVLGKGSFGKVFLVKK---KDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVN
Kinase 2238.AA Pkinase_Tyr 183-228 32 0.000519 14.21 Pfam 182-230 (270) Show / Hide 
Range on Protein: 183-228
Range on HMM: 182-230/270
Sequence Identity: 32% (16 aa)

SPEMLFESGYGKQVDHWALGVLIFEMIT-GHTP-FEAKSQEELFEKI-K
.|| .... .  . | |. |||..|..| | .| ..  | ||..|.| .
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE
Kinase 2238.AA Pkinase_Tyr 16-60 18 0.002936 11.66 Pfam 1-49 (270) Show / Hide 
Range on Protein: 16-60
Range on HMM: 1-49/270
Sequence Identity: 18% (9 aa)

YKVLELIGNGTYGDVVLAQDL--RGNGDEQVAIKIIKNNKERKN--QIS
 . .. .| | .|.|...      .|.. .||.|..|..   ..  . .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCRED