Gene 9978 (Tetrahymena)

9978

Species: Tetrahymena
Alias: 142, 3828.m01242, TTHERM_00074350, 5.m00329, PreTt09978, 9978
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MAST

Sequence

Name Sequence Type Origin Length Description Download
9978.AA Protein None 1931 None Fasta, JSON
9978.kin_dom Protein Kinase Domain None 313 None Fasta, JSON
9978.NA RNA None 5796 None Fasta, JSON

Protein domain

Protein domains of 9978.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9978.AA MAST 1493-1805 50 2.6e-231 714.96 In-house 1-337 (337) Show / Hide 
Range on Protein: 1493-1805
Range on HMM: 1-337/337
Sequence Identity: 50% (171 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFEVITGDWVVKAFYSFVH--ENYLCFVLEYMMGGDFNKILSLYT-ALD
|||||...|||||.|||||.|.|||.||||||.|....||........|.|.........|||.||||..  ..|||.|.|||.|||....|. |. ...
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

QWIVEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDTTGHLKLADFGLSEVGFKTKLNKHIN-----------KTDEDPSQQGAGELV---GIN----ID
.|....||||.||..|||||..||||||||||||||..||.||.|||||.|||..|...|..           ...|...|. . ...   |||    ..
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

EANKENEFKIEIQVEGMINNEKEQQKRIVGTPDYIAPEIITGESTNNKSLDWWSMGVIMYEFLVGLPPFNADSVEE-IFDNIKN--LRMEWPEIGDINDG
......|.....|...|......|.|...|||||||||.|.|..|..|..||||||.||||||||.||||.|..|| ||.||.|   ..||||.||.||.
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDD

DKISPEAYDLIKRLLNPNYKERLGAKGVKEIKEHAFF
|..||||.||||.||.||.|.||||.|..|||.|.||
DCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase 9978.AA MAST 1493-1805 50 6.1e-210 683.44 In-house 1-334 (334) Show / Hide 
Range on Protein: 1493-1805
Range on HMM: 1-334/334
Sequence Identity: 50% (169 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFEVITGDWVVKAFYSFVHENYLCFVLEYMMGGDFNKILSLYTALDQWI
|||||...|||||.|||||.|.|||.||||||..|....|......|.|.|.........|||.||||...||||.|.|||.|||....|. |...|.|.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

VEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDTTGHLKLADFGLSEVGFKTKLNKHIN-----------KTDEDPSQQGAGELV---GIN----IDEAN
...||||.||..|||||..||||||||||||||..|| ||.|||||.|||...||....           .......||.. ...   |||    .....
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

KENEFKIEIQVEGMINNEKEQQKRIVGTPDYIAPEIITGESTNNKSLDWWSMGVIMYEFLVGLPPFNADSVEEIFDNIKNLR---MEWPEIGDINDGDKI
...|.....|.. |......|.|...|||||||||.|.|..|..|..||||||.|||||||| |||| |..||||.||.| .   .|||| |||||....
QQQEQPQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAM

SPEAYDLIKRLLNPNYKERLGAK-GVKEIKEHAFF
||||.|||..||.|....||||. |..|.|.| ||
SPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 9978.AA AGC 1493-1805 30 5e-159 414.78 In-house 1-395 (395) Show / Hide 
Range on Protein: 1493-1805
Range on HMM: 1-395/395
Sequence Identity: 30% (127 aa)

FEFIKMLGKGAYGGVYLVKKK------NTNDLFAMKVIDCSG---KLDKKYLETLQSE------------KNVFEVITG----------DWVVK-AFYSF
|||.|..|||..| ||||.||       |....||||.. .    ...|. .|  ..|            .|..| . .          ...||  .|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

VHENY--LCFVLEYMM--------GGDFNKILSLYT-----ALDQWIVEIYIAE-------LVLAIEYLHS-MDIVHRD-LKPDNMLIDTTGHLKLADFG
  ...  |.||.|||         ||..   |.|.       .|   . .|.||       .|||.||||| |.|.||| |||.|.|.|  ||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSEVGFK-----------TKLNKHINKTDEDPSQQGAGELVGINIDEANKENEFKIEIQVEGMINN----------EKEQQKRIVG--TPDYIAPEIITG
|. .| .           .|...  ||.    .          | |  . .   | ... . . ||          .... . ..|  ||.|.||||.  
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS---------NMD--T-N---K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--

ESTNNKSLDWWS--MGVIMYEFLVGLPPFNADSVE----------EIFDNIKNLR--MEWPEIG------DINDGDKISPEAYDLIKRLLNPNYKERLGA
    .|. ||||  .|..|||.|.|.|||..|...          |.|..|.| |  ..|..        .. . ...|||| ||||.||... ..|||.
---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGC

K-------GVKEIKEHAFF
.       |..|||.| .|
GGNDFGDKGAEEIKNHPWF
Kinase 9978.AA NDR 1493-1805 35 1.2e-124 386.55 In-house 1-350 (350) Show / Hide 
Range on Protein: 1493-1805
Range on HMM: 1-350/350
Sequence Identity: 35% (126 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFEVIT--GDWVVKAFYSFVHENYLCFVLEYMMGGDFNK---ILSLYTA
||.|| .||||.| |.||.||.|....|||..  | ...|  .  ...|. .. .     .||||..||| ...||..| ||. |||..    .|. .  
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LDQWIVEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDTTGHLKLADFGLSEVGFK-----------------TKLNKHINKTDEDPSQQGAGELVGINI
..  .   ||||.|.|||..|.| ..|||.|||| |||  ||.|| ||||.  |.                  | . . .|      . ... .    |.
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYST-FHWTHNSWYYQNMKEHRPQDFMDNW

DEANKENEF----KIEIQV---EGMINNEKEQQKR------IVGTPDYIAPEIITGESTNNKSLDWWSMGVIMYEFLVGLPPFNADSVEEIFDNIKNLRM
.......      ... |.     ..||....|.|      .||||||.|||.....  .|.. |||| |.||||.||| |||..|...|....|.| . 
NSNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQ

EWPEI-GDINDGDKISPEAYDLIKRLLNPNYKERLGA--KGVKEIKEHAFF
 |...  ..    ..|||| |||.||..|. ..|||.  ||| ||| | ||
TWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 9978.AA S_TKc 1493-1805 25 2.4e-86 294.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 1493-1805
Range on HMM: 1-231/231
Sequence Identity: 25% (83 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFEVITGDWVVKAFYSFVHENYLCFVLEYMMG--GDFNKILSLYTA---
.|... .||||.| ||....|.|. ..|.|.|.          |....| .. .    ...|| ...|.. ..|..|.||. |  ||  ...  .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDQWIVEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDTTGHLKLADFGLSEVGFKTKLNKHINKTDEDPSQQGAGELVGINIDEANKENEFKIEIQ
   ..   .  |......|.||.||. |.||||||.| |.|.  |.|..||||. .                                            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

VEGMINNEKEQQKRIVGTPDYIAPEIITGESTNNK-SLDWWSMGVIMYEFLVGLPPFNADSVEEIFDNIKNLRMEWPEIGDINDGDKISPEAYDLIKRLL
            . ..|||.|.|||..      .| . |||| |.|.||.|.| |||    ....|..|.                  |||| |.|...|
------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCL

NPNYKERLGAKGVKE----IKEHAFF
. . ..|..|  . .    || | .|
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 9978.AA AktR 1493-1805 31 6.3e-79 268.53 In-house 1-268 (268) Show / Hide 
Range on Protein: 1493-1805
Range on HMM: 1-268/268
Sequence Identity: 31% (101 aa)

FEFIKMLGKGAYGGVYLVKKK-NTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFE-VITGDWVVKAFYSFVHENYLCFVLEYMMGGDFNKILSLYTALDQ
|...|.|||||.| ||||.|| ......|||.|. .   ...  . .. |.|. |  .     || .|.|  ...| |..||. ||.   .|.    .. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

WIVEIYIAELVLAIEYLHSM-DIVHRDLKPDNMLIDTTGHLKLADFGLSEVGFKTKLNKHINKTDEDPSQQGAGELVGINIDEANKENEFKIEIQVEGMI
  . .|.|. .||.||||.  .|. |||||.| |.|  ||.|..|||||.                                              ..|.
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK---------------------------------------------LQFMM

-NNEKEQQKRIVGTPDYIAPEIITGESTNNKSLDWWSMGVIMYEFLVGLPPFNADSVEEIFDNIKNLR-MEWPEIGDINDGDKISPEAYDLIK-RLLNPN
 ..||  .. ..||| |.|||.|| .   ||| |||. |.  || ..|.|||.... ...|..||. .  .      ...  ..|... |||. .||. |
HYDEK--AYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNK------FPYPSYFSSQCKDLIQRKLLCKN

YKERLG--AKGVKEIKEHAFF
 ..|||  ..| .|||.| .|
PNKRLGYYCNGWEEIKSHPWF
Kinase 9978.AA RSK 1496-1805 27 1.2e-71 244.37 In-house 1-278 (278) Show / Hide 
Range on Protein: 1496-1805
Range on HMM: 1-278/278
Sequence Identity: 27% (92 aa)

IKMLGKGAYGGVYLVKKK---NTNDLFAMKVIDCSGKLDKKY-LETLQSEKNVFEVIT-GDWVVKAFYSFVHENYLCFVLEYMMGGD-FNKILSLYTA--
.|.||.|.|| |.|..|.   .|. ..||||.. .    ..  ...   | |. | ..    .|. .|.|  | .|  ..||..||. | ...   .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LDQWIVEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDT---TGHLKLADFGLSEVGFKTKLNKHINKTDEDPSQQGAGELVGINIDEANKENEFKIEIQ
..   . .|.||.|||.|.||. .|.||||||.|.| |     ||.|| |||..  .                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

VEGMINNEKEQQKRIVGTPDYIAPEIIT---GESTNNKSLDWWSMGVIMYEFLVGLPPFNA---DSVEEIFDNIKNLR--MEWPEIGDINDGDKISPEAY
     ...... .  ..| .|.|||...   .... .|. |||| ||.||| |.| ||| .   .. .||...|.. .  .. |.       ...|.|| 
----RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNW------QYLSQEAK

DLIKRLLNPNYKERLG--AKGVKEIKEHAFF
|||...|  . . |||   ....|||.|..|
DLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 9978.AA DMPK 1493-1636 42 4.2e-57 139.18 In-house 1-145 (270) Show / Hide 
Range on Protein: 1493-1636
Range on HMM: 1-145/270
Sequence Identity: 42% (61 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFEVITGDWVVKAFYSFVHENYLCFVLEYMMGGDFNKILSLYT-ALDQW
||..|  |.|. | | .|. |.||| .|||..     | .        |...    .  |... .| |  |||| .| ||| |||    .| |   ..  
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

IVEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDTTGHLKLADFG
    |.||.||||  .|.|  |||| ||||||.| .||.||||||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFG
Kinase 9978.AA Akt 1493-1638 40 1.3e-51 163.24 In-house 233-380 (264) Show / Hide 
Range on Protein: 1493-1638
Range on HMM: 233-380/264
Sequence Identity: 40% (60 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLF-AMKVIDCSGKLDKKYLETLQSEKNVFEVITGDWVVKAFYSFVHENYLCFVLEYMMGGDFNKILSLYTALDQW
|.|.|.||||..| |.|||||.|.... ||||.  .  ..|...|  . |.|. . .    .|.  |||  ...|.||..|. ||.    |.     .  
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

IVEIYIAELVLAIEYLHSMDIVHRD-LKPDNMLIDTTGHLKLADFGLS
    |.||..||||.|||..|. || ||| | |.| .||..|.||||.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase 9978.AA SGK 1493-1638 32 9.1e-45 135.89 In-house 1-172 (283) Show / Hide 
Range on Protein: 1493-1638
Range on HMM: 1-172/283
Sequence Identity: 32% (56 aa)

FEFIKMLGKGAYGGVYLVKKKNT------------------NDLFAMKVIDCSGKL-------DKKYLETLQSEK-NVFEVITGDWVVKAFYSFVHENYL
|.|.| .||| .| ||.||.| .                   ...||||.     .        ||     ..|. ..   .     |.  |.|  . .|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVLEYMMGGDFNKILSLYTALDQWIVEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDTTGHLKLADFGLS
 ||..|. ||.    |     .    . .| ||.|.|.||||| ||..|||||.| | |  ||..| ||||.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLC
Kinase 9978.AA RSK-Unclassified 1493-1638 35 3.8e-44 136.26 In-house 1-148 (283) Show / Hide 
Range on Protein: 1493-1638
Range on HMM: 1-148/283
Sequence Identity: 35% (53 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFEVITGDWVVKAFYSFVHENYLCFVLEYMMGGDFNKILS--LYTALDQ
|. ....|.|  | ||||.||.|. ..||||   .  . ..       |.|.  .     .|. ..||  . ||  ..|| ||||| . |       .  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

WIVEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDTTGHLKLADFGLS
  | .|..| ..| ||||  |.. ||||||| . .  || .| ||.||
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLS
Kinase 9978.AA DMPK 1700-1805 40 1.7e-40 97.21 In-house 162-270 (270) Show / Hide 
Range on Protein: 1700-1805
Range on HMM: 162-270/270
Sequence Identity: 40% (46 aa)

VGTPDYIAPEIITGESTN-----NKSLDWWSMGVIMYEFLVGLPPFNADSVEEIFDNIKNL---RMEWPEIGDINDGDKISPEAYDLIKRLLNPNYKERL
|||||||.||. .  ...      .. ||||.||.||| |.|  || |||. | . .| |    ... |.        ..|.|| |||..||  . .|||
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPK----WDVSEEAKDLICQLLC-DREERL

GAKGVKEIKEHAFF
|  |. ..|.| ||
GRNGYEDFKCHPFF
Kinase 9978.AA Pkinase 1493-1640 28 2.7e-40 143.58 Pfam 1-161 (293) Show / Hide 
Range on Protein: 1493-1640
Range on HMM: 1-161/293
Sequence Identity: 28% (46 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQS--EKNVFEVITGDWVVKAFYSFVHENYLCFVLEYMMGG----DFNKILS--L
..... .|.|..| ||. ..|.|....|.|.|. . . ... ..|.    |  .   .  . .|. ...|  ......|.||..||    |   ..|   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

YTAL--DQWIVEIYIAELVLAIEYLHSMDIVHRDLKPDNMLIDTTGHL----KLADFGLSEV
....  . | .  |. ... ..||.||| |.||||||.| ||| .||.    |..||||...
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ
Kinase 9978.AA SGK 1701-1805 38 3.5e-36 108.89 In-house 187-283 (283) Show / Hide 
Range on Protein: 1701-1805
Range on HMM: 187-283/283
Sequence Identity: 38% (41 aa)

GTPDYIAPEIITGESTNNKSLDWWSMGVIMYEFLVGLPPFNADSVEEIFDNIKNLRMEWPEIGDINDGDKISPEAYDLIKRLLNPNYKERLGAK-GVKEI
||| | |||.. .. .  .. |||..| ..||...|||||    ... .||| |  .  |          .|..| |||. ||. . |.|||.| .  ||
GTPEYLAPEVLRKQ-PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPP--------QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEI

KEHAFF
|.| ||
KNHPFF
Kinase 9978.AA Akt 1701-1805 42 8.1e-34 105.43 In-house 164-264 (264) Show / Hide 
Range on Protein: 1701-1805
Range on HMM: 164-264/264
Sequence Identity: 42% (46 aa)

GTPDYIAPEIITGESTNNKSLDWWS-MGVIMYEFLVGLPPFNADSVEEIFDNIKNLRMEWPEIGDINDGDKISPEAYDLIKRLLNPNYKERLG--AKGVK
||| |.||||. |     |. |||.  |..|||.. |.||| .. ... |..|||   . |.    .  |.||||. |||..||| ..|.|||   ....
GTPEYLAPEILNG-NGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPD----K--DWISPECKDLISGLLNKDPKKRLGGGPNDAQ

EIKEHAFF
|||.| .|
EIKRHPWF
Kinase 9978.AA RSK-Unclassified 1700-1805 39 7.5e-32 96.93 In-house 183-283 (283) Show / Hide 
Range on Protein: 1700-1805
Range on HMM: 183-283/283
Sequence Identity: 39% (43 aa)

VGTPDYIAPEIITGESTNNKSLDWWSMGVIMYEFLVGLPPFNADSVEEIFDNIKNLRMEWPEIGDINDGDKISPEAYDLIKRLLNPNYKERLGAK-G-VK
.|| .|.|||.| .     |  ||| .|..||| |.|.||. ..  .|.| ||    .  |.         || .. ||||.||. |   |||.| |   
CGTEEYLAPEMIRR-CGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPH------DSYISNNCRDLIKKLLQRNPAKRLGCKMGDAD

EIKEHAFF
.|| | ||
DIKRHPFF
Kinase 9978.AA Pkinase 1699-1805 26 1.7e-22 80.6 Pfam 171-293 (293) Show / Hide 
Range on Protein: 1699-1805
Range on HMM: 171-293/293
Sequence Identity: 26% (33 aa)

IVGTPDYIAPEIITGESTNNKSLDWWSMGVIMYEFLVGLPPFNAD------SVEEIFDNIKNLRMEWPEIGDINDG-------------DKISPEAYDLI
..|||.|.|||.| | .   .. |.||.|.|.||.| | |||  .      .  .....|.  . ....  ...               ...|.|. |.|
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

KRLLNPNYKERLGAKGVKEIKEHAFF
|..|... |.|..    ..|..| .|
KWCLCKDPKKRPT---AEQILQHPWF
Kinase 9978.AA TyrKc 1493-1805 20 2.5e-10 -55.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 1493-1805
Range on HMM: 1-280/280
Sequence Identity: 20% (70 aa)

FEFIKMLGKGAYGGVYLVKKKNTNDLFAMKVIDCSGKLDKKYLETLQSEKNVFEVI--TGDWVVKAFYSFVHE-------NYLCFVLEYMMGGDFNKILS
 ...|.|| ||.| ||. . |      | |..  .       .| . .| ..   .    . .|. .   ...         |. |.||| .|| .. | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

LYTALDQWIVEIYIAELVL-------AIEYLHSMDIVHRDLKPDNMLIDTTGHLKLADFGLSEVGFKT-KLNKHINKTDEDPSQQGAGELVGINIDEANK
 .         .  ..|.          |||||. ..||||   | |..  .. | .|||||  .    .                              
KHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----------------------------

ENEFKIEIQVEGMINNEKEQQKRI---VGTPD-----YIAPEIITGESTNNKSLDWWSMGVIMYEFL-VGLPPFNA-----DSVEEIFDNIKNL-RMEWP
                | .. .|     |. .       ||| |     . || | || || |.| .  | .|         | .|.. ..|.  ||. |
----------------ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS-DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQP

EIGDINDGDKI-----SPEAYDLIKRLLNPNYKERLGAKGVKEIKEHAFF
. .       .     ..| |...|.  . . ..|   . .     | .|
PNDY----P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase 9978.AA Pkinase_Tyr 1605-1638 44 7e-06 20.63 Pfam 125-158 (270) Show / Hide 
Range on Protein: 1605-1638
Range on HMM: 125-158/270
Sequence Identity: 44% (15 aa)

EYLHSMDIVHRDLKPDNMLIDTTGHLKLADFGLS
|||.|. ..||||   | |.. ... | .||||.
EYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 9978.AA Pkinase_Tyr 1493-1509 52 0.10141 6.45 Pfam 1-17 (270) Show / Hide 
Range on Protein: 1493-1509
Range on HMM: 1-17/270
Sequence Identity: 52% (9 aa)

FEFIKMLGKGAYGGVYL
 .|.|.||.||.| ||.
ITFGKKLGEGAFGEVYK