Gene 20817 (Tetrahymena)

20817

Species: Tetrahymena
Alias: 12.m00491, 3700.m00211, TTHERM_00151590, 523, PreTt20817, 20817
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: NDR

Sequence

Name Sequence Type Origin Length Description Download
20817.AA Protein None 839 None Fasta, JSON
20817.kin_dom Protein Kinase Domain None 312 None Fasta, JSON
20817.NA RNA None 2520 None Fasta, JSON

Protein domain

Protein domains of 20817.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20817.AA NDR 134-445 48 4.4e-217 677.02 In-house 1-350 (350) Show / Hide 
Range on Protein: 134-445
Range on HMM: 1-350/350
Sequence Identity: 48% (168 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLSSTG--NPWIVELKSSFQDEKYLYLVMEYLAGGDLMN---VLIKKDI
.....|||.||||||...| | |..|.|.|.|.| ||..| |..|.|.|.......   |||.|.|. ||||..||||||||..|||.|    .|.|.||
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LTEEEAKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHIKLSDFGLCKQTVFIQHWNQKFSLIK------IIQQNNQEIKPKIEFGKKE-NIDAAK
.||..|.|| ||.|.||.|||||.|||||.||||.|| |||||||.|||||.......||.|... ..      . ...|............. ..|...
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

LDPKVLLT-----------------KRPANYQRNRQLAFSTVGTPDYIAPEVFGQ-NGYTETVDWWSLGVILFEMLVGYPPFFSDEPPITCQKIMQWKKT
  |.. ..                 ......|..|.||.||||||||.||||| | .||..|.||||||.|..|||||||||.||.|  ||.|||.||.|
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

F-----QIPPEANLSPAAADLIRKLIA-DSSERLGING--VTEIKIHPFF
.     ..|||||||| |.||||.|.. | ..||| .|  | |||.||||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 20817.AA AGC 134-445 31 3.8e-174 454.78 In-house 1-395 (395) Show / Hide 
Range on Protein: 134-445
Range on HMM: 1-395/395
Sequence Identity: 31% (132 aa)

YDPVSIIGRGAFGEVRVCRDK------QTQEIVAIKRMNKLE--------MSNKTQIGH-------IRSEQQVLSSTG----------NPWIVE-LKSSF
.. . .||.|.||.|. .|.|      .|... |.| ..| .        |  .|.. |       ...| ..|.             .|.||  |..||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEKY--LYLVMEYLA---------GG-DLMNVLI---KKDILTEEEAKFYTAE-------LVLAIDSVHK-MNYIHRD-LKPDNILIAKDGHIKLSDFG
||...  ||.||||.          || .|.  |    |. ...||.|.||.||       .|||... |. |..|||| |||.|||. .||||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKQTVFIQHWNQKFSLIKIIQQNNQEIKPKIEFGKKENIDAAKLDPKVLLTKRPANYQRNR------------QLAFSTVG--TPDYIAPEVFGQNGYT
|||. .  ....|. |   .  ..... ..|   . |.     ..| .    ..|.| |||.            ... . .|  ||.|.|||..    |.
LCKEGMNDGEKGQQ-SQ-SN--MKFHW-HNKKY-Q-KS-----NMD-T-NK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YG

ETVDWWS--LGVILFEMLVGYPPFFSDEPP----------ITCQKIM------QWKKTF------QIPPEANLSPAAADLIRKLIA-DSSERLGIN----
 ..||||  ||....|||.|||||..|.|            . ||||      .|| .|      |.|.. ..|| | |||.||.  | ..||| .    
KACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDF

---GVTEIKIHPFF
   |. ||| ||.|
GDKGAEEIKNHPWF
Kinase 20817.AA MAST 134-445 36 8.70000000001e-107 327.33 In-house 1-337 (337) Show / Hide 
Range on Protein: 134-445
Range on HMM: 1-337/337
Sequence Identity: 36% (125 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLSSTGNPWIVELKSSFQD--EKYLYLVMEYLAGGDLMNVLIKKD-ILT
.. . .|..||.| |   . | | ...|.|..|.  .  | |. ....|  .|. ..||..|.. .|||   .|||..||||. |||    |      . 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EEEAKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHIKLSDFGLCKQ------TVFIQH---WN----QKFSLIKIIQQNNQEI-KPKIEFGKKEN
|..||.|.||.||...  |..  .||||||||.|| ..||||| |||| |       |. .      |    ..| ...|.. ..|.   . |.  ...|
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

IDAAKLDPKVLLTK---RPANYQRNRQLAFSTVGTPDYIAPEVFGQNG-YTETVDWWSLGVILFEMLVGYPPFFSDEPP-ITCQKIMQWKKTFQIPPE--
.   .   .   ..   || | ..| |     .||||||||||    | |  .|||||.|.|..| |||.|||. |.|  .. |.| . ..    |.|  
QIQQQQEQPQCQQQNEMRPHNIHQNKQC----CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGD

AN----LSPAAADLIRKLIA-DSSERLGINGVTEIKIHPFF
 |    .|| | |||.|| . . ..||| ||. ||| ||||
PNDDDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase 20817.AA MAST 134-445 35 4.4e-100 323.35 In-house 1-334 (334) Show / Hide 
Range on Protein: 134-445
Range on HMM: 1-334/334
Sequence Identity: 35% (119 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLSSTGNPWIVELKSSFQDEKYLYLVMEYLAGGDLMNVLIKKDILTEEE
.. . .|..||.| |   . | | ...|.|...| .| || .. . ..|  .|. . ||..|.. .||| ..||..||||. |||.   |     . |. 
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHIKLSDFGLCKQ------TVFIQH------WNQKFSLIKIIQQNNQEIK--PKIEFGKKENIDA
||.|.||.||...  |..  .||||||||.|| ..||||| |||| |       .. .         | ...    .||......  . |.  ...|.  
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

AKLDPKVLLTK--RPANYQRNRQLAFSTVGTPDYIAPEVFGQNG-YTETVDWWSLGVILFEMLVGYPPFFSDEPPITCQKIMQWKKT-FQIPPE------
 .   .   ..  || | ..| |.    .||||||||||  . | .  .|||||.|.|..| |||.|||. |.| .. |.| . .     .|..      
QQQEQPQCQQQNMRPHNIHQNKQC----CGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDD

ANLSPAAADLIRKLIAD-SSERLGIN-GVTEIKIHPFF
  .|| | |||.|| .   ..||| | |..|.| ||||
EAMSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 20817.AA S_TKc 134-445 32 5.6e-100 339.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 134-445
Range on HMM: 1-231/231
Sequence Identity: 32% (106 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLSSTGNPWIVELKSSFQDEKYLYLVMEYLAG--GDLMNVLIKKDI---
|. . .||.||||.|. ||.| |..|||||...           |||.| |.|.. . |.|| |. .||| ..||.||||. |  |||. .. |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTEEEAKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHIKLSDFGLCKQTVFIQHWNQKFSLIKIIQQNNQEIKPKIEFGKKENIDAAKLDPK
   ..| .|.||......|..  |... |||||||.|||. .  |||..||||..|                                            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

VLLTKRPANYQRNRQLAFSTVGTPDYIAPEVFGQNGYTE-TVDWWSLGVILFEMLVGYPPFFSDEPPITCQKIMQWKKTFQIPPEANLSPAAADLIRKLI
                  . .|||.|.||||.   ||.   .||||.|.||.|||.|||||   ..  . .||.              || | |.|||. 
-----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCL

A-DSSERLGINGVTE----IKIHPFF
  | ..|...  . .    ||.||.|
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20817.AA DMPK 134-279 47 2e-91 225.99 In-house 1-147 (270) Show / Hide 
Range on Protein: 134-279
Range on HMM: 1-147/270
Sequence Identity: 47% (70 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLSSTGNPWIVELKSSFQDEKYLYLVMEYLAGGDLMNVLIKKD-ILTEE
.. ...||||.|||| | | |||... | | ||| ||  . .    . |  ...    .||. |   ||||.|||.|||| .|||| . . . .  . |.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

EAKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHIKLSDFGLC
 |.||.||.||||.|.|.| |.||| ||||.|. . ||||| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase 20817.AA AktR 134-445 30 6.3e-88 298.42 In-house 1-268 (268) Show / Hide 
Range on Protein: 134-445
Range on HMM: 1-268/268
Sequence Identity: 30% (99 aa)

YDPVSIIGRGAFGEVRVCRDK-QTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLS-STGNPWIVELKSSFQDEKYLYLVMEYLAGGDLMNVLIKKDILTE
..   ..|.||||.|  ...| ..|...|.|   | .. ...|. |.. |....     .| || |. .||....|...||| .||.| ..| ||  ..|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EEAKFYTAELVLAIDSVHKM-NYIHRDLKPDNILIAKDGHIKLSDFGLCKQTVFIQHWNQKFSLIKIIQQNNQEIKPKIEFGKKENIDAAKLDPKVLLTK
|.|.|| |. .||..  |.  | | |||||.|||. .|||.|..|||| |                                                  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

RPANYQR-NRQLAFSTVGTPDYIAPEVFGQ-NGYTETVDWWSLGVILFEMLVGYPPFFSDEPPITCQKIMQWKKTFQIPPEANLSPAAADLIRK--LIAD
     .. ....| | .||| |.|||.  .  |.. .||||..|. ..||..|.|||...   .  |||      ...|. ...|... |||    |  .
--LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKN

SSERLG--INGVTEIKIHPFF
  .|||   || .||| ||.|
PNKRLGYYCNGWEEIKSHPWF
Kinase 20817.AA RSK 137-445 32 6.9e-88 298.29 In-house 1-278 (278) Show / Hide 
Range on Protein: 137-445
Range on HMM: 1-278/278
Sequence Identity: 32% (108 aa)

VSIIGRGAFGEVRVCRDK---QTQEIVAIKRMNKLEMSNKTQ-IGHIRSEQQVLSSTG-NPWIVELKSSFQDEKYLYLVMEYLAGGDLMNVLIKKDI---
..  |.|..|.| .|| .   .|. | | |  .| .. ..   . | . |...|. ..  | ||.|. .||.|..|||.|||. ||.|   | |. .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LTEEEAKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAK---DGHIKLSDFGLCKQTVFIQHWNQKFSLIKIIQQNNQEIKPKIEFGKKENIDAAKLDPK
..|.||.|| ||.|||..  |.   |||||||.||| .    .|||||.|||.|||.                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

VLLTKRPANYQRNR--QLAFSTVGTPDYIAPEVFG----QNGYTETVDWWSLGVILFEMLVGYPPFFS---DEPPITCQKIMQWKKTFQIPPEANLSPAA
           |..  |.. . ..| .|.|||.      |.|... .|||||||...|||.|.||| .   . .  . ..|.. | .. .|  ..||..|
-----------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEA

ADLIRKLIA-DSSERLG--INGVTEIKIHPFF
 |||||.   | . |||   ... ||| ||.|
KDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 20817.AA Akt 134-281 44 8.3e-61 193.07 In-house 1-150 (264) Show / Hide 
Range on Protein: 134-281
Range on HMM: 1-150/264
Sequence Identity: 44% (66 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIV-AIKRMNKLEMSNKTQIGHIRSEQQVLSSTGNPWIVELKSSFQDEKYLYLVMEYLAGGDLMNVLIKKDILTEE
 | . ..|.|.|| |  ...|.||..  |.|   |    .| |. |.  |  .|  . .| || |. |||....||.||.|  ||.| . | .| . .|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

EAKFYTAELVLAIDSVHKMNYIHRD-LKPDNILIAKDGHIKLSDFGLCKQ
.|.|| ||..|||.  |..| | || ||| |||. |||||.| ||||||.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKE
Kinase 20817.AA GEK 134-279 50 5.4e-59 196.53 In-house 1-147 (269) Show / Hide 
Range on Protein: 134-279
Range on HMM: 1-147/269
Sequence Identity: 50% (74 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLSSTGNPWIVELKSSFQDEKYLYLVMEYLAGGDLMNVLIK-KDILTEE
.. . .||||||||| | . |.|... |.| .|| ||  .. .   | |  ||    . || .|   ||||.||||||.| .||||. .| | .| | |.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

EAKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHIKLSDFGLC
 |.|| ||.|.||||||...|.|||.||||.|. . |||.| ||| |
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSC
Kinase 20817.AA ROCK 134-279 45 8.4e-58 195.37 In-house 1-145 (263) Show / Hide 
Range on Protein: 134-279
Range on HMM: 1-145/263
Sequence Identity: 45% (66 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLSSTGNPWIVELKSSFQDEKYLYLVMEYLAGGDLMNVLIKKDILTEEE
.. . .|||||||||.. |.|..... |.|...| ||  ..       | ...     .|||.|.  |||..|||.||.|. ||||.|.. . |.  |  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEKW

AKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHIKLSDFGLC
|.|||.|.|||.|..| | .|||| ||||.|. | ||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase 20817.AA DMPK 346-445 44 3.4e-53 129.3 In-house 162-270 (270) Show / Hide 
Range on Protein: 346-445
Range on HMM: 162-270/270
Sequence Identity: 44% (48 aa)

VGTPDYIAPEV---FGQN---GYTETVDWWSLGVILFEMLVGYPPFFSDEPPITCQKIMQW-KKTFQIPPEAN--LSPAAADLIRKLIADSSERLGINGV
|||||||.|||    ...    |   .||||.||...|||.|  ||  |    |  |||   |  .. |..    .|. | |||..|. |..|||| ||.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

TEIKIHPFF
 ..| ||||
EDFKCHPFF
Kinase 20817.AA Pkinase 134-281 39 2.7e-50 178.19 Pfam 1-161 (293) Show / Hide 
Range on Protein: 134-281
Range on HMM: 1-161/293
Sequence Identity: 39% (63 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIR-SEQQVLSSTGNPWIVELKSSFQDEKYLYLVMEYLAGG----DLMNVLI--KK
|  ...||.|.||.|. |..| |..|||.|...| . . . .. |.| || |.. . . | ||.|. .|.|....|.||||. ||    ||. ..   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DIL--TEEEAKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHI----KLSDFGLCKQ
  .  .|.|.|||  ... ...  |.|. |||||||.|||| ..|||    |..||||.||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ
Kinase 20817.AA ROCK 346-445 47 6.3e-35 116.2 In-house 160-263 (263) Show / Hide 
Range on Protein: 346-445
Range on HMM: 160-263/263
Sequence Identity: 47% (49 aa)

VGTPDYIAPEVF----GQNGYTETVDWWSLGVILFEMLVGYPPFFSDEPPITCQKIMQWKKTFQIPPEANLSPAAADLIRKLIADSSERLGINGVTEIKI
|||||||.|||     ... |   .|||| || ..|||||  ||. |    |  |||. |   . |.....|  | |||.| ..|  .||| ||| .|| 
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase 20817.AA Akt 347-445 40 5.9e-34 105.87 In-house 164-264 (264) Show / Hide 
Range on Protein: 347-445
Range on HMM: 164-264/264
Sequence Identity: 40% (42 aa)

GTPDYIAPEVFGQNGYTETVDWWS-LGVILFEMLVGYPPFFSDEPPITCQKIMQWKKTFQIPPEANLSPAAADLIRKLIA-DSSERLG--INGVTEIKIH
||| |.|||.  .||.| .||||. ||....||. | |||...  .   .||.. .   ..|.  ..||.. |||..|   | ..|||  .|.. ||| |
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQP--VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRH

PFF
|.|
PWF
Kinase 20817.AA GEK 346-445 46 6.7e-32 104.06 In-house 162-269 (269) Show / Hide 
Range on Protein: 346-445
Range on HMM: 162-269/269
Sequence Identity: 46% (50 aa)

VGTPDYIAPEVF-----GQNGYTETVDWWSLGVILFEMLVGYPPFFSDEPPITCQKIMQWKKTFQIPPEAN---LSPAAADLIRKLIADSSERLGINGVT
|||||||.||.      |.  | .  |||||||...||| |  ||...    |  |||..|  ||.|.. .   .|  | ||||.||  . .||| ||. 
VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQ

EIKIHPFF
. | ||||
DFKKHPFF
Kinase 20817.AA Pkinase 346-445 28 2.5e-23 83.59 Pfam 172-293 (293) Show / Hide 
Range on Protein: 346-445
Range on HMM: 172-293/293
Sequence Identity: 28% (36 aa)

VGTPDYIAPEVFG-QNGYTETVDWWSLGVILFEMLVGYPPFFSD------EPPITCQKIMQWKKTFQIPPEANLS-----------------PAAADLIR
.|||.|.||||   ...|.  ||.||.|.||.||| |.||| ..      ..    ..||. .  |..| . . |                 ... |.|.
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

KLIA-DSSERLGINGVTEIKIHPFF
.... | ..|..    ..|. ||.|
WCLCKDPKKRPT---AEQILQHPWF
Kinase 20817.AA TyrKc 134-440 19 2.9e-11 -40.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 134-440
Range on HMM: 1-280/280
Sequence Identity: 19% (66 aa)

YDPVSIIGRGAFGEVRVCRDKQTQEIVAIKRMNKLEMSNKTQIGHIRSEQQVLSST--GNPWIVELKSSFQDE-------KYLYLVMEYLAGGDLMNVLI
     ..|.||||||. .. |   . ||.| ...        .  ...| .....    .| || |     ..       . |..|||| ..||| . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KKDI-LTEEEAKFYTAELVLAIDSVHKMNYIHRDLKPDNILIAKDGHIKLSDFGLCKQTVFI-QHWNQKFSLIKIIQQNNQEIKPKIEFGKKENIDAAKL
|.   |. ..   .        .  |..|.|||||   |.|.......| |||||..      |.                           .    .| 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------------------------ESKDYYRKKE

--DPKVLLTKRPANYQRNRQLAFSTVGTPDYIAPEVFGQNG-YTETVDWWSLGVILFEML-VGYPPFFSD--EPPITCQKIMQWKKTF-QIPPEAN----
  . | .|  |                     |||.. . | .|.  | || || ..|..  | .|   .  . ... | .... |.    |. .|    
HKGGKTMLPIR-------------------WMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPM

----LSPAAADLIRKLIAD-SSERLGINGVTEIK
     ...  .....  .   ..|   . . |. 
SFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 20817.AA S_TK_X 446-506 23 7.1e-08 33.41 SMART 1-79 (79) Show / Hide 
Range on Protein: 446-506
Range on HMM: 1-79/79
Sequence Identity: 23% (20 aa)

VGVDWKRMR----EKTPPYIPEVK----SSEDVSNFD-KFDEEGDPWGNDDKKKKNIKLDRN--------------FFGYEFNR
 |.||.. .    | .||..|..|    | .|.|||| .|.|| .       .  .  | ..              | |. ...
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-----LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 20817.AA Pkinase_Tyr 249-280 40 2.5e-07 25.44 Pfam 128-159 (270) Show / Hide 
Range on Protein: 249-280
Range on HMM: 128-159/270
Sequence Identity: 40% (13 aa)

HKMNYIHRDLKPDNILIAKDGHIKLSDFGLCK
. .|.|||||   |.|.......| .||||..
ESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 20817.AA Pkinase_C 463-508 27 9e-06 23.69 Pfam 1-46 (46) Show / Hide 
Range on Protein: 463-508
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

EVKSSEDVSNFD-KFDEEGDPWGNDDKKKKNIKLDRNFFGYEFNREA
.||| .|.||||  |..| ..   .|.       ...| |. . .. 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase 20817.AA Pkinase_Tyr 140-219 30 0.000163 15.91 Pfam 7-94 (270) Show / Hide 
Range on Protein: 140-219
Range on HMM: 7-94/270
Sequence Identity: 30% (27 aa)

IGRGAFGEVRVCRDK----QTQEIVAIKRMNKLEMSNKTQ--IGHIRSEQQVLSST-GNPWIVELKSSFQ-DEKY--LYLVMEYLAGGDL
.|.||||||. .. |    .|.  ||.| .   | . . |  .    .| .....   .| || |      ...   .|.|||| ..|||
LGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 20817.AA Pkinase_Tyr 353-379 37 2.442795 1.77 Pfam 182-208 (270) Show / Hide 
Range on Protein: 353-379
Range on HMM: 182-208/270
Sequence Identity: 37% (10 aa)

APEVFGQNGYTETVDWWSLGVILFEML
|||..  . .|.  | || || ..|..
APECINYGKFTTKSDVWSFGVLMWEIF