Gene 4868 (Tetrahymena)

4868

Species: Tetrahymena
Alias: 3694.m00115, 574, 4868, TTHERM_00283290, PreTt04868, 25.m00332
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: NDR

Sequence

Name Sequence Type Origin Length Description Download
4868.AA Protein None 936 None Fasta, JSON
4868.kin_dom Protein Kinase Domain None 295 None Fasta, JSON
4868.NA RNA None 2811 None Fasta, JSON

Protein domain

Protein domains of 4868.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 4868.AA NDR 96-390 49 2.6e-216 674.59 In-house 1-350 (350) Show / Hide 
Range on Protein: 96-390
Range on HMM: 1-350/350
Sequence Identity: 49% (172 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIVAVKKMKKSEMVFKNQVGHVRAERDVLASAN--IPWIVELKYSFQDKKYLYLVMEFIEGGDLMT---LLMEKDI
||...||||||||||...|.| ||.|.|.|.|.||||. ||||.|||||||..|.|.   ||.|.|.||||||.|||||||.. |||.||   |||..||
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LSETEAKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHIKLSDFGLCKE---------------------------ADISPKIDFGRRDLREEN-G
..| .|.|||||...|.|.||||.|||||.||||.|. .||||||.|||||..                           ..........|.. . .|  
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

SSSEAVLTNLHQ-------------INKERFNRNRQKLYSTVGTPDYIAPEVFTN-QGYNETVDWWSVGVILYEMLVGYPPFYSDDPKTTCMKILKWRKY
|.... ....|               |... ...|.. |||||||||.|||||.. .|||.|.||||.|.|.||||||||||.||.|..|||||..|...
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

L-----DIPKEVNLSVPAQDLIRRLLT-DANERLGVNG--VQEIKIHPFF
.     ..|.|.|||. |.||||||.. |...|||..|  |.|||.||||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 4868.AA AGC 96-390 31 1.1e-179 469.42 In-house 1-395 (395) Show / Hide 
Range on Protein: 96-390
Range on HMM: 1-395/395
Sequence Identity: 31% (131 aa)

FEPLTIIGKGAFGEVRICRCK------LTGEIVAVKKMKKSE--------MVFKNQVGH-------VRAERDVLASAN----------IPWIVE-LKYSF
|| |..||||.||.|. .| |       ||.. |.|..||..        || .... |       |..||..|. .|           |.||  |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKKY--LYLVMEFIE---------GG-DLMTLLM---EKDILSETEAKFYIAE-------TILAVEAVHK-MNYIHRD-LKPDNILMTADGHIKLSDFG
|||..  ||.|||...         || .|.. |.    . ...| .|.||.||       ..||.|  |. |..|||| |||.|||...||||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEADISP----------------------KIDFGRRDLREENGSSSEAVLTNLHQINKERFNRNR------------QKLYSTVG--TPDYIAPEVFT
||||   ..                      . |       . |           . .|.....||.            .. .. .|  ||.|.|||.. 
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMD-------T-N-----------K-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-

NQGYNETVDWWS--VGVILYEMLVGYPPFYSD----------DPKTTCMKIL------KWRKYL------DIPKEVNLSVPAQDLIRRLLT-DANERLGV
   |. ..||||  .|...||||.||||||.|          .|. .  ||.      .|.  .      ..|.....|. |.|||..||. | ..||| 
---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGC

N-------GVQEIKIHPFF
.       |..||| ||.|
GGNDFGDKGAEEIKNHPWF
Kinase 4868.AA MAST 96-390 37 3.9e-110 356.3 In-house 1-334 (334) Show / Hide 
Range on Protein: 96-390
Range on HMM: 1-334/334
Sequence Identity: 37% (126 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIVAVKKMKKSEMVFKNQVGHVRAERDVLASANIPWIVELKYSFQDKKYLYLVMEFIEGGDLMTLLMEKDILSETE
||   .|.|||.| |   . | |....|.|..|||.|  ||.| .|..||..|| .  |..|.. |||| |.||..|||. ||||. .||     . |  
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

AKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHIKLSDFGLCKE--------ADIS--------------PKIDFGRRDLR-------EENGSSSE
||.|||||.|..|  |..  .||||||||.| ...||||| |||| |          ...              .|.. . . ..       . |  ...
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

AVLTNLHQINKERFNRNRQKLYSTVGTPDYIAPEVFTNQG-YNETVDWWSVGVILYEMLVGYPPFYSDDPKTTCMKILKWRKY-LDIPKE------VNLS
    .. .. ..  . | ..  . .|||||||||| ..|| .. .|||||.|.|.|| |||.|||  |.|  .  .||. .     .| .        .|
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

VPAQDLIRRLLTD-ANERLGVN-GVQEIKIHPFF
..|||||..||.   ..||| | |..|.| ||||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 4868.AA S_TKc 96-390 33 7.2e-106 358.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 96-390
Range on HMM: 1-231/231
Sequence Identity: 33% (105 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIVAVKKMKKSEMVFKNQVGHVRAERDVLASANIPWIVELKYSFQDKKYLYLVMEFIEG--GDLMTLLMEKDI---
.| | .|||||||.|. || | ||.|||.|..|           |.| |...| . . |.|| |...||| ..||.|||...|  |||.... ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSETEAKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHIKLSDFGLCKEADISPKIDFGRRDLREENGSSSEAVLTNLHQINKERFNRNRQKL
   ..| .|.||......|.|  |... |||||||.|||..   |||..||||...                                            
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

YSTVGTPDYIAPEVFTNQGYNE-TVDWWSVGVILYEMLVGYPPFYSDDPKTTCMKILKWRKYLDIPKEVNLSVPAQDLIRRLLT-DANERLGVNGVQE--
.. .|||.|.||||.   ||.   .||||.|.||||||.|||||.  .....  ||.              | .| |.||..|. | ..|...  . .  
TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

--IKIHPFF
  ||.||.|
WDIKCHPWF
Kinase 4868.AA RSK 99-390 36 8e-98 331.29 In-house 1-278 (278) Show / Hide 
Range on Protein: 99-390
Range on HMM: 1-278/278
Sequence Identity: 36% (114 aa)

LTIIGKGAFGEVRICRCK---LTGEIVAVKKMKKSEMVFKNQ-VGHVRAERDVLASAN-IPWIVELKYSFQDKKYLYLVMEFIEGGDLMTLLMEKDI---
|   |.|..|.| .|| .    || | |.|  ||...| ..  . |...||..|.  .  | ||.|.|.||....|||.||...||.| | | .. .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSETEAKFYIAETILAVEAVHKMNYIHRDLKPDNILMTA---DGHIKLSDFGLCKEADISPKIDFGRRDLREENGSSSEAVLTNLHQINKERFNRNR--Q
.||.||.||.|| .||||  |.   |||||||.||| .    .|||||.|||.||..                                     |..  |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------RCDHNQ

KLYSTVGTPDYIAPEVFT----NQGYNETVDWWSVGVILYEMLVGYPPFYS---DDPKTTCMKILKWRKYLDIPKEVNLSVPAQDLIRRLLT-DANERLG
.... ..| .|.|||. .    . |... .|||| ||..||||.|.|||..   ...| .  .|.| .  |..|   .|| .|.||||..|. | . |||
WTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLG

--VNGVQEIKIHPFF
   ....||| ||.|
CGPQDAEEIKQHPWF
Kinase 4868.AA AktR 96-390 36 1e-97 330.92 In-house 1-268 (268) Show / Hide 
Range on Protein: 96-390
Range on HMM: 1-268/268
Sequence Identity: 36% (111 aa)

FEPLTIIGKGAFGEVRICRCK-LTGEIVAVKKMKKSEMVFKNQVGHVRAERDVLA-SANIPWIVELKYSFQDKKYLYLVMEFIEGGDLMTLLMEKDILSE
|. . ..||||||.|  .. |  .....| |  ||.... .||  |.. ||....  .| | || |.|.||.|..|...||...||.| . |  |  .||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

TEAKFYIAETILAVEAVHKM-NYIHRDLKPDNILMTADGHIKLSDFGLCKEADISPKIDFGRRDLREENGSSSEAVLTNLHQINKERFNRNRQKLYSTVG
 .|.||.|. .||.|  |.  | | |||||.|||.  |||.|..|||| |                                   .  . ...| || .|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK----------------------------------LQFMMHYDEKAYSFCG

TPDYIAPEVFTN-QGYNETVDWWSVGVILYEMLVGYPPFYSDDPKTTCMKILKWRKYLDIPKEVNLSVPAQDLIRR--LLTDANERLG--VNGVQEIKIH
|| |.|||. |. .|.| .||||..|. .|||..|.||||... ..   ||.. .  . .|. ...|  ..||| |  |  . |.|||   || .||| |
TPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSH

PFF
|.|
PWF
Kinase 4868.AA DMPK 96-241 47 8.1e-96 237.11 In-house 1-147 (270) Show / Hide 
Range on Protein: 96-241
Range on HMM: 1-147/270
Sequence Identity: 47% (70 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIVAVKKMKKSEMVFKNQVGHVRAERDVLASANIPWIVELKYSFQDKKYLYLVMEFIEGGDLMTLLMEKD-ILSET
|| |..||.|.|||| . | | |... | |.|.| ||. . ..  .. |||... .| .||. | | |||..|||.|||.  |||| ||.   .  ..| 
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

EAKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHIKLSDFGLC
 |.||.|| .||. ..|.| |.||| ||||.|.   ||||| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase 4868.AA Pkinase 96-390 31 1.2e-79 275.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 96-390
Range on HMM: 1-293/293
Sequence Identity: 31% (106 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIVAVKKMKKSEMVFKNQVGHVR-AERDVLASANIPWIVELKYSFQDKKYLYLVMEFIEGG----DLMTLLM--EK
.. . .||.|.||.|..|. | ||.|||||..||..   . .. |.| .|  .... | | ||.|...|.||...|.|||. |||    ||.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DIL--SETEAKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHI----KLSDFGLCKEADISPKIDFGRRDLREENGSSSEAVLTNLHQINKERFNR
  .  || |.|||. ... ..|  |.|. |||||||.|||.  .|||    |..||||.| .|                                   . 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------------------------------Y-

NRQKLYSTVGTPDYIAPEVFT-NQGYNETVDWWSVGVILYEMLVGYPPFYSD------DPKTTCMKILKWRKYLDIPKEVNLS-----------------
| . ... .|||.|.||||   .|.|   ||.||.|.|||||| |.|||...      |..    .|.. .   |.|.. . |                 
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWS

VPAQDLIRRLLT-DANERLGVNGVQEIKIHPFF
 ...|.|...|. | ..|..    ..|. ||.|
EECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 4868.AA MAST 96-242 46 2.4e-69 210.81 In-house 1-150 (337) Show / Hide 
Range on Protein: 96-242
Range on HMM: 1-150/337
Sequence Identity: 46% (69 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIVAVKKMKKSEMVFKNQVGHVRAERDVLASANIPWIVELKYSFQD--KKYLYLVMEFIEGGDLMTLLMEKD-ILS
|| . .|.|||.| |   . | |....| |..... .  |||| .|..||..|. .  |..|.. ||||   ||||..|||. ||||  .||      . 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ETEAKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHIKLSDFGLCK
| .||.|||||.|..|  |..  .||||||||.| ...||||| |||| |
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSK
Kinase 4868.AA Akt 96-243 50 6.3e-67 212.94 In-house 1-150 (264) Show / Hide 
Range on Protein: 96-243
Range on HMM: 1-150/264
Sequence Identity: 50% (75 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIV-AVKKMKKSEMVFKNQVGHVRAERDVLASANIPWIVELKYSFQDKKYLYLVMEFIEGGDLMTLLMEKDILSET
|. | ..|||.|| |  .. | |...  | |  ||.  . |||| |. .|| .|   | | || |.||||....||.||... ||.| ..|  | . || 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

EAKFYIAETILAVEAVHKMNYIHRD-LKPDNILMTADGHIKLSDFGLCKE
.|.||.|| ||| |. |..| | || ||| |||| .||||.| |||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKE
Kinase 4868.AA SGK 96-243 35 8.7e-63 192.54 In-house 1-174 (283) Show / Hide 
Range on Protein: 96-243
Range on HMM: 1-174/283
Sequence Identity: 35% (62 aa)

FEPLTIIGKGAFGEVRICRCKLT------------------GEIVAVKKMKKSEMV-------FKNQVGHVRAER-DVLASANIPWIVELKYSFQDKKYL
|. |..|||| ||.|   . | .                  . . |.|  .|   .        |... |. ||| ..|   . | || |.|.|| |..|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVMEFIEGGDLMTLLMEKDILSETEAKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHIKLSDFGLCKE
|.||....||..   |    ...| .|.|| || ..| |  |. . |.|||||.|||  ..||..| |||||||
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKE
Kinase 4868.AA DMPK 291-390 45 1.8e-60 147.73 In-house 162-270 (270) Show / Hide 
Range on Protein: 291-390
Range on HMM: 162-270/270
Sequence Identity: 45% (50 aa)

VGTPDYIAPEVFTNQGYN------ETVDWWSVGVILYEMLVGYPPFYSDDPKTTCMKILKW-RKYLDIPKEVN--LSVPAQDLIRRLLTDANERLGVNGV
|||||||.||| .... .        .|||||||..||||.|  ||| |    |  ||.   .  |. |...   .|. |.|||..||.|. |||| ||.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

QEIKIHPFF
...| ||||
EDFKCHPFF
Kinase 4868.AA ROCK 96-241 46 1.8e-57 194.21 In-house 1-145 (263) Show / Hide 
Range on Protein: 96-241
Range on HMM: 1-145/263
Sequence Identity: 46% (68 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIVAVKKMKKSEMVFKNQVGHVRAERDVLASANIPWIVELKYSFQDKKYLYLVMEFIEGGDLMTLLMEKDILSETE
|. . .||.||||||.. | | . .. |.| . | ||. .        |||..| || .|||.|.| |||..|||.||... ||||. |. . |. .|  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEKW

AKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHIKLSDFGLC
|.|| .| .||..|.| | .|||| ||||.|.   ||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase 4868.AA MAST 291-390 49 1.5e-46 139.83 In-house 229-337 (337) Show / Hide 
Range on Protein: 291-390
Range on HMM: 229-337/337
Sequence Identity: 49% (54 aa)

VGTPDYIAPEVFTNQG-YNETVDWWSVGVILYEMLVGYPPFYSDDPKT-TCMKILKWRKYLDIPKE--VN----LSVPAQDLIRRLLT-DANERLGVNGV
.|||||||||| . || |. .|||||.|.|.|| |||.|||  | |   .  .|..  . .  |.|   |    .|  |||||..||. .  .||| ||.
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

QEIKIHPFF
.||| ||||
DEIKQHPFF
Kinase 4868.AA ROCK 291-390 52 4.4e-40 134.05 In-house 160-263 (263) Show / Hide 
Range on Protein: 291-390
Range on HMM: 160-263/263
Sequence Identity: 52% (55 aa)

VGTPDYIAPEVFTNQG----YNETVDWWSVGVILYEMLVGYPPFYSDDPKTTCMKILKWRKYLDIPKEVNLSVPAQDLIRRLLTDANERLGVNGVQEIKI
|||||||.|||  .||    |   .||||||| .||||||  ||| |    |  ||.  .  |  |..|..| .|.|||.. |||...||| |||..|| 
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase 4868.AA SGK 292-390 46 1.1e-38 116.72 In-house 187-283 (283) Show / Hide 
Range on Protein: 292-390
Range on HMM: 187-283/283
Sequence Identity: 46% (47 aa)

GTPDYIAPEVFTNQGYNETVDWWSVGVILYEMLVGYPPFYSDDPKTTCMKILKWRKYLDIPKEVNLSVPAQDLIRRLLT-DANERLGVN-GVQEIKIHPF
||| | ||||   |..  |||||. | .||||..| ||||| . ..   .|.  .. | ||. .  |..| |||  ||. |  .||| . .  ||| |||
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNII--NQPLQIPPQM--SNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPF

F
|
F
Kinase 4868.AA Akt 292-390 41 5.4e-36 112.48 In-house 164-264 (264) Show / Hide 
Range on Protein: 292-390
Range on HMM: 164-264/264
Sequence Identity: 41% (43 aa)

GTPDYIAPEVFTNQGYNETVDWWS-VGVILYEMLVGYPPFYSDDPKTTCMKILKWRKYLDIPKEVNLSVPAQDLIRRLLT-DANERLG--VNGVQEIKIH
||| |.|||.  ..|.  .||||. .|...|||. | ||||..| ..   ||.   . . .|.  ..|  ..|||..||. | ..|||   |..|||| |
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKN--QPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRH

PFF
|.|
PWF
Kinase 4868.AA TyrKc 96-384 18 1.8e-12 -21.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 96-384
Range on HMM: 1-280/280
Sequence Identity: 18% (60 aa)

FEPLTIIGKGAFGEVRICRCKLTGEIVAVKKMKKSEMVFKNQVGHVRAERDVLASA--NIPWIVELKYSFQDK-------KYLYLVMEFIEGGDLMTLLM
 . . ..| ||||||. .. |   . ||||..|..       .   . |  .. .   . | || |     ..       . |..|||. ..|||   | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EKDI-LSETEAKFYIAETILAVEAVHKMNYIHRDLKPDNILMTADGHIKLSDFGLCKEADIS-PKIDFGRRDLREENGSSSEAVLTNLHQINKERFNRNR
..   |.  .   .        |  |..|.|||||   |.| ......| |||||... .    .                                  .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--------------------------------ES

QKLYST---VGTPD-----YIAPEVFTNQGYNETVDWWSVGVILYEML-VGYPPFYSD----DPKTTCMKILKWRKYLDIPKEVNLSVP-----AQDLIR
.. |..    |. .       |||..    ...  | || || ..|..  | .| . .     . .  .. .| ......|...    |     . | . 
KDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMY

RLLTDANER----------LGVNGVQEI
.. ..  ..          .    ....
QIMKQCWHEDPEDRPTFSEI----HECF
Kinase 4868.AA Pkinase_Tyr 211-242 43 1.3e-05 19.65 Pfam 128-159 (270) Show / Hide 
Range on Protein: 211-242
Range on HMM: 128-159/270
Sequence Identity: 43% (14 aa)

HKMNYIHRDLKPDNILMTADGHIKLSDFGLCK
. .|.|||||   |.| | ....| .||||..
ESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 4868.AA S_TK_X 391-453 21 2.5e-05 22.42 SMART 1-79 (79) Show / Hide 
Range on Protein: 391-453
Range on HMM: 1-79/79
Sequence Identity: 21% (19 aa)

QGIDWKNIRN----QKSPYIPEIK----GPLGSR-FDKYEEEEPWNYEFNSGQQLQKNRQ-----QDIN----------FIGYTFKK
 ||||....|     . |..|.||    .|   . ||. ..||..         |.   .     .. |          |.|.|.. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 4868.AA Pkinase_Tyr 96-130 35 2.6e-05 18.59 Pfam 1-39 (270) Show / Hide 
Range on Protein: 96-130
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

FEPLTIIGKGAFGEVRICRCK----LTGEIVAVKKMKKS
 . .  .|.||||||. ...|     |.  ||||..| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase 4868.AA Pkinase_Tyr 168-181 50 0.790266 3.43 Pfam 81-94 (270) Show / Hide 
Range on Protein: 168-181
Range on HMM: 81-94/270
Sequence Identity: 50% (7 aa)

YLYLVMEFIEGGDL
..|.|||. ..|||
QIYIVMEYMPHGDL