Gene 11543 (Tetrahymena)

11543

Species: Tetrahymena
Alias: 11543, PreTt11543, TTHERM_00001360, 943, 1.m00591
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: AMPK

Sequence

Name Sequence Type Origin Length Description Download
11543.AA Protein None 1114 None Fasta, JSON
11543.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
11543.NA RNA None 3345 None Fasta, JSON

Protein domain

Protein domains of 11543.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11543.AA AMPK 50-302 62 2.1e-212 636.8 In-house 1-254 (254) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-254/254
Sequence Identity: 62% (160 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLIDSADKKRLQREISILRKIRHPNIIQLYEII-ETPRQLYLFMEYAPNGELFDYIVKRTRLSER
. ||.|||.|||||||.|.|..|.||||.|.|.|.|..|.....|.||||.||...|||.||||||.| |||......|||...|||||||||..||.||
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

QASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNIKIVDFGLSNTYKDNEKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSSGVILYAMLCGYLPF
.|..|.||||.|.||......|||||||||||||||.|||||||||||..||.|.|||||||||||||||..||.|.|...||||.||||||||||||||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

EDQNTSVLYKKIMNQDPVLPSFLSSNSKGILSGILTKDPEKRYNIQDIRLHPFC
.|.||..|||||.|... .|.|||...|......|..||.||..|.||| ||..
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase 11543.AA CAMKL 50-302 44 2.1e-155 499.51 In-house 1-297 (297) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-297/297
Sequence Identity: 44% (134 aa)

FEIGQTIGRGTFGKVKLGIH-KITNEKVAVKVLDKDKLID-------------SADKKRLQREISILRKIR---HPNIIQLYEIIETPRQ------LYLF
..||.|.|.|.||||||..| ..|.||||.|..||.|. .             ..|. |..|||.|.....   |||||.|||.||||.       .||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MEYAPNGE--LFDYIVKR----TRLSERQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNY--NIKIVDFGLSNTYKD-----NEKLKTACGSPCY
|||...||  |||||||.     |..|..| .. .||. ...|. . |.||||.||||.|||.|   ||||.|||.|| |..     ..|||| ||||.|
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

AAPEMVAG--KPYNGLQTDIWSSGVILYAMLCGYLPFEDQ--------NTSVLYKKIMNQDPVLP--SFLSSNSKGILSGILTKDPEKRYNIQDIRLHPF
.|||...|  |||.| ..|||| |||||||.||||||.|.        |.  ||.||| .    |  ...|   . .....|...||||..|..|. ||.
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

C
.
M
Kinase 11543.AA CAMK 55-302 29 7e-135 437.37 In-house 1-425 (425) Show / Hide 
Range on Protein: 55-302
Range on HMM: 1-425/425
Sequence Identity: 29% (127 aa)

TIGRGTFGKVKLGIHKITN------------EKVAVKVLDKDKLID-------------------------SADKKRLQREISILRK-------IRHPNI
|.|||.||||||.||| |.            .|||.|..||.|| |                           |.|...|||.|..|       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLYEIIE------------TPRQ--------LYLFM---EYAPNGEL----FDYIVKR---------------TRLSERQASKFLQQIINGIEYMSKIG
|.|||..|            | ..        .|..|   ||...|||    |||||..                |..||.|... .||. ...|. . .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VVHRDLKPENLLLDHN-----------------YNIKIVDFGLSNTYKD------------------------NEKLKTACGSPCYAA-PEMVAG-----
.|||||||||.|||.|                 .||||.|||..| ...                        ..|.|| ||.|.|.| ||.. |     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KPYNGLQTDIWSSGVILYAMLCGYLPFEDQ-------------NTSVLYKKIMNQDPV-LPSFLSS-----------------------NSK
        ||| | ..|.|| |||||.|||||.||..              | . |..|||. .    |...|                          |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

GILSGILTKDPEKRYNIQDIRLHPFC
  ....|..|||||..|...  ||. 
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 11543.AA MARK 50-302 44 2.5e-118 388.3 In-house 1-262 (262) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-262/262
Sequence Identity: 44% (116 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLIDSADKKRLQREISILRKIRHPNIIQLYEIIE--TPRQ-LYLFMEYAPNGELFDYIVKR--TR
.....||| |...||||..|| |..|||.|...| || |   .| ..|||.|..|. |||||.|...||  |... .|| ||||..|||.|||...   |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LSERQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNY--NIKIVDFGLSNTYKDNEKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSSGVILYAML
|.|. | .. .||. ...|. ....||||.||||.|.|.|   |||| |||.|.  . ..||.| ||.| |.|||.. .|||.|  .|||| ||.||.|.
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

CGYLPFEDQN--TSVLYKKIMNQDPVLPSFLSSNSKGILSGILTKDPEKRYNIQDIRLHPFC
|||.||....     ||||| . ..  |...|   . ... .|| .||.|  |..|  ||. 
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 11543.AA AGC 50-302 24 4.6e-112 290.53 In-house 1-395 (395) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-395/395
Sequence Identity: 24% (98 aa)

FEIGQTIGRGTFGKVKLGIHK------ITNEKVAVKVLDKDK---LIDSADKKRLQRE------------ISILRKIR----------HPNIIQ-LYEII
||.  .||.|.|||| |  .|       |..  |.|||.|..   ...  . .. ..|              || |..          ||.|.. |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETPRQ--LYLFMEYAP---------NG-ELFDYIV---KRTRLSERQASKFLQQ-------IINGIEYMSK-IGVVHRD-LKPENLLLDHNYNIKIVDFG
....   ||. |||.|          | ||| ..    |. |..| .|  .. .       |. ..||. .  |..||| |||||.|||.. .||..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSNTYKDNE---------------------------------------------------KLKTACG--SPCYAAPEMVAGKPYNGLQTDIWS--SGVIL
|.   ....                                                   . .| ||  .| | |||..      | . |.||   |...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YAMLCGYLPFEDQNTS----------VLYKKIM------NQDPVLP----------SFLSSNSKGILSGILTKDPEKRYN----------IQDIRLHPFC
| ||.|| || ..|.            ...|||      |... .|          ...|.. | .... |.||||||            ...|. ||. 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 11543.AA NuaK 50-302 43 8.8e-111 292.53 In-house 1-252 (252) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-252/252
Sequence Identity: 43% (109 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLIDSADKKRLQREISILRKIRHPNIIQLYEIIETPRQLYLFMEYAPNGELFDYIVKRTRLSERQ
.|. .| |.||.|||||.. . |  .||.|   |.|  | .|  .  ||| |.  . ||.||. ||. |    . . ||||  |||.||| .. .|.|| 
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNIKIVDFGLSNTYKDNEKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSSGVILYAMLCGYLPFE
| .|  ||.  . |  | ...||||| || ||| | |.|| |||||| |.|.. |.| |||| || || | |.||.|   | || ||.||.|  | .||.
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

DQNTSVLYKKIMNQDPVLPSFLSSNSKGILSGILTKDPEKRYNIQDIRLHPFC
 ..   | | | . .   |   |  .. |   .|. .|..|  | ||  |.  
GHDFKHLVKQISQGAYYEPCKPSDACMLIRW-MLMVNPRRRATIYDICHHWWV
Kinase 11543.AA CAMK1 50-302 40 1.8e-110 322.38 In-house 1-276 (276) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-276/276
Sequence Identity: 40% (112 aa)

FEIGQTIGRGTFGKVKLGIHKIT---NEKVAVKVLD-KDKLIDSAD--KKRLQREISILRK---IRHPNIIQLYEIIETPRQLYLFMEYAPNGELFDYIV
.|.| .||||.|..|.|..|| |   ....|.|..| |. .  . .  ...|..||.|..|   | |||||..||. |... .|| ||.  .||||| ||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KRTRLSERQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYN---IK--IVDFGLSNTYKDNE-KLKTACGSPCYAAPEMVAG---KPYNGLQTDI
...  .|..|..  .||.  .||| . |.|||||||||||.  ...   ||  | |||||  ....| ..|||||.| | |||....   ||| .   |.
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPY-DKACDM

WSSGVILYAMLCGYLPFEDQN-TSVLYKKIMNQDPVLPSF--LS-SNS--KGILSGILTKDPEKRYNIQDIRLHPFC
|| |||.| .|||| || | |  . |..||.. .   ||.   . |..  |  ... |..||.|||.....  ||. 
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 11543.AA S_TKc 50-302 38 1.5e-105 357.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-231/231
Sequence Identity: 38% (103 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLIDSADKKRLQREISILRKIRHPNIIQLYEIIETPRQLYLFMEYAPN--GELFDYIVKRTR---
.||...||.|.||||....|| |...||.|...          ....|||.||.| .||||..||.....   ||..|||...  |.|||||.|| |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSERQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNIKIVDFGLSNTYKDNEKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSSGVILYAM
   ..| .| ....||....||. . |..||||||||.|||.  .||| ||||.  .      .| ||.| | |||..   .|..   |.|| |.||| |
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LCGYLPFEDQNTSVLYKKIMNQDPVLPSFLSSNSKGILSGILTKDPEKRYNIQDIRL-------HPFC
|||| ||.  .  ...|||.          |.  | .....|.||||||. . ..         ||. 
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11543.AA QIK 50-302 41 2.3e-104 353.01 In-house 1-272 (272) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-272/272
Sequence Identity: 41% (112 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLIDSADKKRLQREISILRKIRHPNIIQLYEIIETPRQLYLFMEYAPNGELFDYIVKRTR-----
..|..|||.| |. |||. |.|| .|||.|..|| .| |. . ... ||. |.  ..||.|| ||...|| . .|. .||..|||.|||..|  |     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQL-DEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

---------------LSERQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNIKIVDFGLSNTYKDNEKLKTACGSPCYAAPEMVAGKPYNGLQT
               ..|..| .  .||. ...|  | ..|||||| ||.||| | ||||.|||.|| .|  . |.| |||| ||||||  || |.| . 
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKV

DIWSSGVILYAMLCGYLPFEDQNTSVLYKKIMNQDPVLPSFLSSNSKGILSGILTKDPEKRYNIQDIRLHPFC
|||| ||.||.. || |||  ..   | ....     .| |.|.    .    |. |||.||.|. |. |.  
DIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase 11543.AA Pkinase 50-302 34 2.2e-97 334.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-293/293
Sequence Identity: 34% (101 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLIDSADKKRLQ-REISILRKIRHPNIIQLYEIIETPRQLYLFMEYAPNG----ELFDYIV--KR
..||..||.|.||.|....|| |...||||...|..  .. |. ..  .||.|.....||||..||.. |... .|. |||...|    .|||||   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRL--SERQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNI----KIVDFGLSNT--YKDNEKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSS
...  ||... ... ||. |.||. . |..||||||||.|.|.|..|    || ||||.    |  |. ..| ||.| |.||| . | .| |   |.|| 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYAMLCGYLPFEDQ------NTSVLYKKIMNQDPVLPSFLS---------------------SNSKGILSGILTKDPEKRYNIQDIRLHPFC
|.||| ||||..|| ..      .  .....||  ..  ... .                     .. | .....|.|||.||.....|  ||. 
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 11543.AA BRSK 50-302 42 1.9e-93 316.77 In-house 1-254 (254) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-254/254
Sequence Identity: 42% (109 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLI--DSADKKRLQREISILRKIRHPNIIQLYEIIETPRQLYLFMEYAPNGELFDYIVKRTRLSE
. .. | |.|. |.||||.|..| .|||.|.  | ||.  .|  .|   ||| |.. | ||.....|.. |. . ||| .|.   |||||| ||. ||  
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMK-VEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTP

RQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNIKIVDFGLSNTYKDNEKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSSGVILYAMLCGYLP
. | || .||| ....     . ||||||||||||   |||| |||.     .   | | |||| || || . |  | | . |.|| ||||||.| | ||
KEARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALP

FEDQNTSVLYKKIMNQDPVLPSFLSSNSKGILSGILTKDPEKRYNIQDIRLHPFC
| | |   |  |. .    .| |        | | .. ||.||. ...|. ||  
FDDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase 11543.AA MELK 50-302 44 7.8e-92 311.39 In-house 1-254 (254) Show / Hide 
Range on Protein: 50-302
Range on HMM: 1-254/254
Sequence Identity: 44% (114 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLIDSADKKRLQREISILRKIRHPNIIQLYEIIETPRQLYLFMEYAPNGELFDYIVKRTRLSERQ
.|. ..|| | |.||||  | .||..||.|..||..|    |  |.. |.  |...|| .| ||| .|||  .... ||| | ||.||||... ||.| .
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQL--GHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEE

ASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNIKIVDFGLSNTYK---DNEKLKTACGSPCYAAPEMVAGKPYNGLQTDIWSSGVILYAMLCGYL
. .|..||.  | |.   |  ||||||||||.| ....|..||||    |   |  .|.| |||| |||||.. || | |   |.|| |..||...||.|
TRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFL

PFEDQNTSVLYKKIMNQDPVLPSFLSSNSKGILSGILTKDPEKRYNIQDIRLHPFC
||.| | ...|||||      | .|| .|| .|  .|  ||.||  ....  ||. 
PFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase 11543.AA Pkinase_Tyr 50-195 33 4.9e-33 112.5 Pfam 1-158 (270) Show / Hide 
Range on Protein: 50-195
Range on HMM: 1-158/270
Sequence Identity: 33% (53 aa)

FEIGQTIGRGTFGKVKLGIHK----ITNEKVAVKVLDKDKLIDSAD--KKRLQREISILRKI-RHPNIIQLYEIIE-TPRQ--LYLFMEYAPNGELFDYI
 ..|...|.| ||.|..|. |     |. .||||.| |.   .. .  .. . ||..|.... .||||..|| ..    ..  .|. |||.|.| | || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

VK----RTRLSERQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNIKIVDFGLS
 |    . .|.  .  .. .|| .| || . .. .||||   | |...|  .|| ||||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 11543.AA TyrKc 50-301 25 4e-23 84.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-301
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

FEIGQTIGRGTFGKVKLGIHKITNEKVAVKVLDKDKLIDSADKKRLQREISILRKI--RHPNIIQLYEIIETP-------RQLYLFMEYAPNGELFDYIV
 . |...|.| ||.| .|. |   ..||||.| .|.      .. . ||..|..|.  .||||..|| .. ..        .|.. |||.|.| | ||. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRTR-LSERQASKFLQQIINGIEYMSKIGVVHRDLKPENLLLDHNYNIKIVDFGLSNTYKDN------EKLKTA----CG---SPC-YAAPEMVAGKPYN
|. . |. ..  .|  || .| || .. ...||||   | |...|. .|| |||||   .|       .. ...    .|    |    |||    . ..
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

GLQTDIWSSGVILYAML-CGYLPFED-----QNTSVLYKKIMNQDPVLPSFL---------SSNSKGILSGILTKDPEKRYNIQDIRLHPF
  ..|.|| || .. ..  |  | ..      . . ....... .   .            ..    | .     |||.| . ..|  . |
-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
UBA_CAMKL 11543.AA UBA_CAMKL 322-359 31 6.9e-09 30.15 In-house 1-41 (41) Show / Hide 
Range on Protein: 322-359
Range on HMM: 1-41/41
Sequence Identity: 31% (13 aa)

DQNILKQLEKY--QINVEQAEDMVKRNKH-NNITSVYNLLL
|..|.....|.   .. |. .. .. ||. | ||  | |||
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL