Gene 5439 (Tetrahymena)

5439

Species: Tetrahymena
Alias: 49.m00211, 3708.m00060, TTHERM_00438820, 5439, 436, PreTt05439
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MARK

Sequence

Name Sequence Type Origin Length Description Download
5439.AA Protein None 972 None Fasta, JSON
5439.kin_dom Protein Kinase Domain None 211 None Fasta, JSON
5439.NA RNA None 2919 None Fasta, JSON

Protein domain

Protein domains of 5439.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5439.AA MARK 718-928 47 1.1e-134 442.57 In-house 1-217 (262) Show / Hide 
Range on Protein: 718-928
Range on HMM: 1-217/262
Sequence Identity: 47% (104 aa)

FEIGQVIGQGSYAVVRKAKDVLTDKIVAIKIYDKFRLIDPQKRNNVKREMHILQKLEHKNIIQLLMTVD--TRTT-VNLVMEYVSSLSLRHFLKSKPNHR
......||.||||.|..| ...|.. ||||||.||.| |||...||.||..|..||.|.|||.|.....  |... ..|.|||.|. .|....|..||.|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEETN-EIKLIDFGFSIQAPNDKKLNMFCGTASYMSPELVQQQDYYGKPTDVWALGVLLFVLL
|.|.||..|||||. ||||||.....|||.|.||||| |..|  ||.|||||||. |...|||.|||| .||.||......|.|...|.|.|||.|....
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

QGRFPFK--VVTQLQLF
.|.|||.   ... .|.
CGYFPFDGDTQDYKELY
Kinase 5439.AA CAMKL 718-945 34 4.7e-117 375.13 In-house 1-267 (297) Show / Hide 
Range on Protein: 718-945
Range on HMM: 1-267/297
Sequence Identity: 34% (92 aa)

FEIGQVIGQGSYAVVRKAKD-VLTDKIVAIKIYDKFRLI-DPQKRNN-----------VKREMHILQKLE---HKNIIQLLMTVDTRTT------VNLVM
..||...|.||...|. |..  .| . |||||.||...  ||....|           ..||..|...|    |.|||.|. ...|...      ..|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYVSSLS--LRHFLKSKPNHR--LPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEETN-EIKLIDFGFSIQ-----APNDKKLNMFCGTASYM
||.|. .  | .........|  .||.||. .||||. ||||||.....|||.|.||||..|  |  ||.||||||..      ....||..|||. .||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPELVQQ--QDYYGKPTDVWALGVLLFVLLQGRFPFKVVT-------QLQLFIYQLQSKIYTYPNYNKV
.||..|   ..|.|...|.|..||.|.... |..||.  |          ..  .  .  | .| ...|
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHV
Kinase 5439.AA CAMK 723-936 25 2e-98 317.78 In-house 1-359 (425) Show / Hide 
Range on Protein: 723-936
Range on HMM: 1-359/425
Sequence Identity: 25% (90 aa)

VIGQGSYAVVRKAKDVLTD------------KIVAIKIYDKFRLID-------------------------PQKRNNVKREMHILQK-------LEHKNI
..|.||...|..... .|             . |||||.|| .| |                         |..| ||.||..|..|       | |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLLMTVD------------TRTT--------VNLVM---EYVSSL----SLRHFLKSKPN-------------HRLPESEAKTIFRQILNAVNYCHQND
|.|. . .            | ..        . .||   ||.|       |  .......             .|..|.||...||||. ||.|||...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VIHRDLKLENILISEET----------------NEIKLIDFGFSIQAPN------------------------DKKLNMFCGTASYMS-PELVQQ-----
..|||||.||||...                  | ||.|||||... .                         ..|.. |||| .||. ||....     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------QDYYGKPTDVWALGVLLFVLLQGRFPFKVVTQLQLF--------IYQLQSKI
        ..|||...|.|..||.|...| |..||   .. . .        .|.|  ||
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKI
Kinase 5439.AA Pkinase 718-928 33 1.4e-76 265.49 Pfam 1-227 (293) Show / Hide 
Range on Protein: 718-928
Range on HMM: 1-227/293
Sequence Identity: 33% (77 aa)

FEIGQVIGQGSYAVVRKAKDVLTDKIVAIKIYDKFRLIDPQKRNNVK-REMHILQKLEHKNIIQLLMTVDTRTTVNLVMEYVSSL----SLRHFLK---S
..||..||.||...|.|.... | ||||.|| .| .  . ....... .| .|...| |.||..|. .. ... . .||||.       .| ....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPNHRLPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEETNEI----KLIDFGFSIQ--APNDKKLNMFCGTASYMSPELVQQQDYYGKPTDVW
..   ..| |.| ...||| ...|||.. .||||||.|||||. ....|    |..|||.. |    |.  .. ||||  ||.||... . |||.. |.|
GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGVLLFVLLQGRFPFKVV------TQLQLF
..|..|. .| ||.||.        .|.|..
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMI
Kinase 5439.AA S_TKc 718-965 29 1.5e-72 248.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 718-965
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

FEIGQVIGQGSYAVVRKAKDVLTDKIVAIKIYDKFRLIDPQKRNNVKREMHILQKLEHKNIIQLLMTVDTRTTVNLVMEYVSS--LSLRHFLKSKPNHR-
.||...||.|....|.|.... |..|||||| .          ....||. ||.|  |.||..|. . .. . . .||||..    .|....|... |. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEETNEIKLIDFGFSIQAPNDKKLNMFCGTASYMSPELVQQQDYYGK-PTDVWALGVLLF
   .|| .|. ...||..|..|||.. .|||||| ||||..|   .||..|||.. |       . ||||  ||.||..     ||| . |.|..|..|.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

VLLQGRFPFKVVTQLQLFIYQLQSKIYTYPNYNKVK-------MTTSYSRKYAKMNIK-------QVVM
 .| |. ||    |.|. . ..            .|             |  |    .          .
EMLCGYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5439.AA AMPK 718-919 37 2.4e-66 195.99 In-house 1-200 (254) Show / Hide 
Range on Protein: 718-919
Range on HMM: 1-200/254
Sequence Identity: 37% (77 aa)

FEIGQVIGQGSYAVVRKAKDVLTDKIVAIKIYDKFRLIDPQKRNNVKREMHILQKLEHKNIIQLLMTV-DTRTTVNLVMEYVSSLSLRHFLKSKPNHRLP
. ||. || |..  |  ..  || . ||||| .| ...| .  . ..|| |||... | .||||   . .| |   .||||||   |  .  ..   ||.
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKH--GRLQ

ESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEETNEIKLIDFGFSIQAPNDKKLNMFCGTASYMSPELVQQQDYYGKPTDVWALGVLLFVLLQGR
| ||.  | ||...| |||.. . |||||.||.|.  . ..||. ||| |      ..|   ||   | .||... . | |  .|.|  || |...| |.
EREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLD-HNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGY

FPF
 ||
LPF
Kinase 5439.AA Ciliate-E2-Unclassified 718-943 22 5.7e-66 225.48 In-house 1-316 (352) Show / Hide 
Range on Protein: 718-943
Range on HMM: 1-316/352
Sequence Identity: 22% (71 aa)

FEIGQVIGQGSYAVVRKAKDVLTDKIV-----AIKIYDKFRLIDPQKRNNVKREMHILQKLE-------------------HKNIIQLLMTVDTRTTVNL
..|...||||....|.|...  ..  .     ..|| .. ...  .|  . ..||.......                   | .|. .. .  .. .. .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYVSSLSLRHFLKSKPN---------------HRLPESEAK-----TIFRQILNAVNYCHQND-VIHRDLKLENILISEETN--EIKLIDFGFSIQAP
||||.  ..|. ..|....               ....| .||     ..|.|||.. .|.|..  .||||.|.||||.... .  .||.||||.|..  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

ND----------------KKLNMFCGTASYM----SPELVQQQDYYG---KPTDVWALGVLLFVLLQGRFPFKVVT------------------QLQLFI
..                .... |||| .||    .||. |.| |..   .  |.|.|||.|. .| |..||.  .                  ||.  |
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

YQLQSKIYTYPN----YN
.| . ..  .|.    ..
KQKNIQFPKFPWQQIPKH
Kinase 5439.AA Ciliate-E2 718-945 23 5.1e-65 222.14 In-house 1-329 (365) Show / Hide 
Range on Protein: 718-945
Range on HMM: 1-329/365
Sequence Identity: 23% (80 aa)

FEIGQVIGQGSYAVVRKAKDVLTDKI------------------VAIKIYDKFRL--IDPQKRNNVKREM-------------HILQKLEHKNIIQLLMT
... ..||||....|.|.|. ...|                   |.|||| . ..   . .  ......|              ||..| |.|||..  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VD--TRTTVNLVMEYVSSLSLRHFLK---SKPNHRLP------ESEAKTIFRQILN---------------AVNYCHQND-VIHRDLKLENILISEETNE
    ..... |||||..  .|....|    | || ..      | |.|.|..|||.               |..|.|..  .||||.|.||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

IKLIDFGFSIQAPND-----------KKLNMF----------------------CGTASYMSPELVQQQDY--------YGKPTDVWALGVLLFVLLQGR
||.||||.| .. .|           .... .                      |||. ||.|| .. ..|        |..  |.|.|||.|. .| |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

FPFKVVTQLQLFIYQLQSK-IYTYP----------------NYNKV
.||          .| . .  . .|                ...|.
PPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKW
Kinase 5439.AA ULK 718-940 25 1.2e-58 201.13 In-house 1-281 (324) Show / Hide 
Range on Protein: 718-940
Range on HMM: 1-281/324
Sequence Identity: 25% (73 aa)

FEIGQVIGQGSYA-VVRKAKDVLT---DKIVAIKIYDKFRLIDPQKR-------NNVKREMHILQKLE---HKN--IIQLLMTVDTR--TTVNLVMEYVS
... ...|.||.. .| |.... |   ...||.|. ||. ... ...       .. |.|  |..||    |.|  |..|.    |   . . ..|||  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

SLSLRHFLKSKPNH-------RLPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEET-----------NEIKLIDFGFSIQAPNDKKLNMFC--
   |....| . ..       ||.|.||. .|.||.|.  . |.. .||||.|..||||.. .           . .|. ||||. .  |. .  . |  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

--------GTASYMSPELVQ----QQDYYGKPTDVWALGVLLFVLLQGRFPFKVVTQLQLF--IYQLQSK-------IYTYP
        ||  ||.|...|    |..|| . .|.| ||.... .| |. ||.     ...  |..|. .       |.. |
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQP
Kinase 5439.AA ULK 718-940 26 8.8e-58 198.28 In-house 1-286 (329) Show / Hide 
Range on Protein: 718-940
Range on HMM: 1-286/329
Sequence Identity: 26% (76 aa)

FEIGQVIGQGSYAVVRKAKDVLT----DKIVAIKIYDKFRLIDPQKRNN-------VKREMHILQKLE----HKN----IIQLLMTVDTR--TTVNLVME
... ...|.||...| |.... |    ...||.|. ||. ..  .. ..       .|.|  |..||     |||    |..|.    |   . . ..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YVSSLSLRHFLKSKPNH--------RLPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEET-----------NEIKLIDFGFSIQAPND-----
|     |....| . ..        ||.|.||. .|.||||.  . |.. .||||.|..||||.. .           . .|. ||||. .  ||     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-KKLNM----FCGTASYMSPELVQ----QQDYYGKPTDVWALGVLLFVLLQGRFPFKV-VTQLQ-LFIYQLQSK-------IYTYP
  .       .|||  ||.|...|    |..|| . .|.| ||.... .| |. ||.   .... ..|..|  .       | . |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQP
Kinase 5439.AA QIK 718-927 35 1.3e-57 197.76 In-house 1-226 (272) Show / Hide 
Range on Protein: 718-927
Range on HMM: 1-226/272
Sequence Identity: 35% (80 aa)

FEIGQVIGQGSYAVVRKAKDVLTDKIVAIKIYDKFRLIDPQKRNNVKREMHILQKLEHKNIIQLLMTVDTRTTVNLVMEYVSSLSLRHFLKSKPN-----
..|.. || | .|||. |.   | . ||||| || .| | .  . ..||  |.  |.| .|| |.    |     .|.|| |.  . . | ..       
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQL-DEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

-------------HRLPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEETNEIKLIDFGFSIQAPNDKKLNMFCGTASYMSPELVQQQDYYGKP
               ..|.||. .| ||. || |||.  ..||||| ||||. .. | ||..|||||    ... |. .||.  |  ||. . ..| |  
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMN-IKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPK

TDVWALGVLLFVLLQGRFPFKVVTQLQL
 |.| .||.|.||  | .||  .|  .|
VDIWSMGVVLYVLVCGALPFDGKTLQNL
Kinase 5439.AA STE 718-919 24 5.5e-57 195.63 In-house 1-268 (359) Show / Hide 
Range on Protein: 718-919
Range on HMM: 1-268/359
Sequence Identity: 24% (67 aa)

FEIGQVIGQGSYAVVRKAKDVL---------------TDKIVAIKIYDK--------------FRLIDPQKRNNVKREMHILQKLE--HKNIIQLLMTVD
.|. ..||.|.. .| ||...                | .|.|||. ..               . ...........|. |..|.   |.||.. . .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

T-------RTTVNLVMEYVSSLSLRHFLK---SKPN---------HRLPESEAKTIFRQILNA-VNYCHQNDVIHRDLKLENILISEETNEIKLIDFGFS
        .......|||..  ||. ..|   ....         ||.|||. ..| |||| .  .| |.. .||||.|  |||.      .||.|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

IQAPN-----------------DKKLNMFCGTASYMSPELVQQ-----QDYYGKPTDVWALGVLLFVLLQGRFPF
 |  .                 ..| | |.||  .|.|| .||      . |.   |.| || ..  .. |. |.
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPW
Kinase 5439.AA TyrKc 718-964 21 2.4e-13 -6.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 718-964
Range on HMM: 1-280/280
Sequence Identity: 21% (62 aa)

FEIGQVIGQGSYAVVRKAKDVLTDKIVAIKIYDKFRLIDPQKRNNVKREMHILQKL--EHKNIIQLLMTVDTR-------TTVNLVMEYVSSLSLRHFLK
 . |...| | . .|.|..       ||.|   .        |    ||. |. ||  .|.||..|.  . .          . .||||..  .|...|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SKPNHRLPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEETNEIKLIDFGFSIQAPND------KKLNMF----CGT----ASYMSPELVQQQD
.. .. |. ..   .  || .  .| |.. .|||||   |.|..|.   .|  ||| |    .|      |.  .     .|        |.||   .  
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYG

YYGKPTDVWALGVLLF-VLLQGRFPFKVV----TQLQLFIYQLQSK--IYTYPNYNKVKM----TTSYSRKYAKM-------------NIKQVV
 .   .|||. ||... ..  |  |   .       |  | ....       ||.    |     ..   .  |.             .|..  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 5439.AA Pkinase_Tyr 718-864 25 1.9e-11 39.4 Pfam 1-156 (270) Show / Hide 
Range on Protein: 718-864
Range on HMM: 1-156/270
Sequence Identity: 25% (41 aa)

FEIGQVIGQGSYAVVRKAKDV----LTDKIVAIKIYDKFRLIDPQK--RNNVKREMHILQKL-EHKNIIQLLMTVD-TRTT--VNLVMEYVSSLSLRHFL
 ..|...|.|.. .|.|..       |.  ||.|.       ...   |    ||. |. .|  |.||..|.  .   .    . .||||.   .|...|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KSK--PNHRLPESEAKTIFRQILNAVNYCHQNDVIHRDLKLENILISEETNEIKLIDFG
...  ....|. ..   . .|| .. .| ...  |||||   |.|..| .| .|  |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFG