Gene 27757 (Tetrahymena)

27757

Species: Tetrahymena
Alias: 27757, TTHERM_01018400, PreTt27757, 828, 199.m00050
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CAMK-Tt

Sequence

Name Sequence Type Origin Length Description Download
27757.AA Protein None 870 None Fasta, JSON
27757.kin_dom Protein Kinase Domain None 348 None Fasta, JSON
27757.NA RNA None 2613 None Fasta, JSON

Protein domain

Protein domains of 27757.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27757.AA CAMK-Tt 138-445 82 1.1e-245 822.5 In-house 89-396 (396) Show / Hide 
Range on Protein: 138-445
Range on HMM: 89-396/396
Sequence Identity: 82% (253 aa)

ENQLNHPNIVKVYELYIDNLSGKIHSVMELINGKEMFEVIHELGHYSEKNNVGQSANYIKQKKNRQRYKDTLKIQDIFDVKRKRLGQAAQILKEIDKSIQ
...|||||||||||||||...|.|...||||..||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IRELNHPNIVKVYELYIDETKGRIYTIMELIEAKEMFEVIHKLGHYSEKNNVGQSANYIKQKKNRQRYKDTLKIQDIFDVKRKRLGQAAQILKEIDKSIQ

TRLQFYLRLRSFEEKLVQLLNQIGLFYEQTISQNQLVASKIFSQILDAIAYMHQNYCCHRDLKPNNILCNSDGTEVKITDFNVSKFSDHYKNYQGGESII
||||||||||||||||||||||||||||||||||||||||||.||||||.|||.||.|||||||||||||.|||.|||||||||||.||||||.......
TRLQFYLRLRSFEEKLVQLLNQIGLFYEQTISQNQLVASKIFKQILDAIKYMHENYVCHRDLKPNNILCNEDGTCVKITDFNVSKFCDHYKNYKKDNLMN

HQSIKMCTYTGTMAFSAPEVFNEEICYDETIDMWSAGCILFTMLSGREPFQAEYVHDLVKLICQGKYNFDDPVWQDISSEAKDLISKCLTVDSTQRIKPE
||.|||.|||||.||||||.|||..|||||||||||||||.|||.|.|||||||||||.|.|||..|||...|||.||.||||||.||||....|||||.
HQNIKMWTYTGTVAFSAPEIFNEDCCYDETIDMWSAGCILYTMLCGQEPFQAEYVHDLIKKICQADYNFPSHVWQHISEEAKDLIKKCLTINPEQRIKPD

EALKHPFI
..|.||.|
QMLQHPWI
Kinase 27757.AA CAMK 103-445 22 1.3e-95 308.57 In-house 1-425 (425) Show / Hide 
Range on Protein: 103-445
Range on HMM: 1-425/425
Sequence Identity: 22% (110 aa)

ILGEGCVGLVKKAVRKSDG------------QVFAVKTVR-------------------------------------TRDEETIENQ-------LNHPNI
.||.|  | ||....|...            | .|.| .                                       | |  | ..       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKVYELYID-----------NLSG-------KIHSVM---ELINGKEM----FEVIHELGHYSEKNNVGQSANYIKQKKNRQRYKDTLKIQDIFDVKRKR
.| || | |           . |        ... ||   |.. | |.    |. | | |.|.|.. .                                
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ--------------------------------

LGQAAQILKEIDKSIQTRLQFYLRLRSFEEKLVQLLNQIGLFYEQTISQNQLVASKIFSQILDAIAYMHQNYCCHRDLKPNNILCNSDG-----------
                                       ...  ..   .   |...| ||..|..|.|..  .|||||| |||.....           
---------------------------------------FDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEI

-----TEVKITDFNVSKFSDHYKN------YQGGESIIHQ-------SIKMCTYTGTMAFSA-PEVFNE-------------EICYDETIDMWSAGCILF
       .||.||  ... |. .|      |.||| . |.         || |. || .. | |||.|              .  |.. .||||.|.||.
FDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY

TMLSGREPFQAE-------------YVHDLVKLICQGKYNFDDPV------------WQDISSE--------AKDLISKCLTVDSTQRIKPEEALKHPFI
.||.|. ||...               ..| . |..|||.|..|             | ||| |        .||||.|.|.|| ..|.. |..|.||..
IMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 27757.AA CAMK1 275-445 37 7.8e-64 184.41 In-house 110-276 (276) Show / Hide 
Range on Protein: 275-445
Range on HMM: 110-276/276
Sequence Identity: 37% (68 aa)

ASKIFSQILDAIAYMHQNYCCHRDLKPNNILCNSDGTE--VK--ITDFNVSKFSDHYKNYQGGESIIHQSIKMCTYTGTMAFSAPEVFNE--EICYDETI
|..|  |||.|. |||..  .|||||| |.|. .   .  .|  | ||  ||. ||  |            .| |  ||  . ||||..   .  || ..
ARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN------------LMKTACGTPGYVAPEVLECKKDKPYDKAC

DMWSAGCILFTMLSGREPFQAEY-VHDLVKLICQGKYNFDDPVWQDISSE-AKDLISKCLTVDSTQRIKPEEALKHPFI
||||.|.|....| | .||..|   . | ..|  ..|.|. | | .||.. |||.|.. |.|| ..|.  |..|.||.|
DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 27757.AA Ciliate-E2-Unclassified 98-445 19 3.8e-60 206.15 In-house 1-352 (352) Show / Hide 
Range on Protein: 98-445
Range on HMM: 1-352/352
Sequence Identity: 19% (85 aa)

YELKEILGEGCVGLVKKAVRKSDG-----------QVFAVKTVRT-----RDEETIENQ----------------LNHPNIVKVYELYIDNLSGKIHSVM
|.. ...|.|. | |.|...|...           |....| ...     . .....|.                ||||....|...|...   .|  ||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ELINGKEMFEVIHELGHYSEKNNVGQSANYIKQKKNRQRYKDTLKIQDIFDVKRKRLGQAAQILKEIDKSIQTRLQFYLRLRSFEEKLVQLLNQIGLFYE
|...|..... | . .. ..|                                                                          .. ..
EYCEGGDLWQYIKKRKKQKQK-------------------------------------------------------------------------GNDLFH

QTISQNQL---VAS-----KIFSQILDAIAYMHQNY-CCHRDLKPNNILCNSDGT--EVKITDFNVSKFSDHYKNYQGGES----IIHQSIKMCTYTGTM
.. .....    |.     ..| |||... |.|..  ..|||.||.||| ...|   ..||.||  ||...   |.. ...     | .. .|.| .|| 
NMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTP

AFS----APEVFNEEICYDET---IDMWSAGCILFTMLSGREPFQAEYVHD----------------LVKLICQGKYNFDDPVW----QDISSEAKDLIS
 .     ||||. ..  ....   .|.|| |.||. || |. ||...   .                | . |.|....|.   |    ...| ||||.|.
NYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN

----KCLTVDSTQRIKPEEALKHPFI
    |.| ..  .|| .|..|.||..
DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 27757.AA Ciliate-E2a 140-445 24 2.1e-59 173.53 In-house 55-275 (275) Show / Hide 
Range on Protein: 140-445
Range on HMM: 55-275/275
Sequence Identity: 24% (79 aa)

QLNHPNIVKVYELYIDNLSGKIHSVMELINGKEMFEVIHELGHYSEKNNVGQSANYIKQKKNRQRYKDTLKIQDIFDVKRKRLGQAAQILKEIDKSIQTR
||.|||| | || |.|. . ..  |||...|.|... | . . . |.                                                     
QLDHPNIIKLYEVYEDENNYYL--VMEYCEGGELYDKIKQCKRFFEE-----------------------------------------------------

LQFYLRLRSFEEKLVQLLNQIGLFYEQTISQNQLVASKIFSQIL-DAIAYMHQNYCCHRDLKPNNILCN---SDG---TEVKITDFNVSKFS--DHYKNY
                                  ....|  |.| ....||||.   |||||| ||| .   ...   ...|| ||  ..|   |     
--------------------------------IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKD-----

QGGESIIHQSIK--MCTYTGTMAFSAPEVFNEEIC-----YDETIDMWSAGCILFTMLSGREPFQAEYVHDLVKLICQGKYNFDDPV-WQDISSEAKDLI
          .|  | .  ||  . ||||.| .       ||.  ||||.|.|....|.|. ||... . . .... . |..|..|. |...|.|.|||.
----------EKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLM

SKCLTVDSTQRIKPEEALKHPFI
.| | .|  .||....||.||. 
KKMLEKDPKKRITAQQALNHPWF
Kinase 27757.AA CDPK 275-445 37 2.3e-55 168.39 In-house 105-271 (271) Show / Hide 
Range on Protein: 275-445
Range on HMM: 105-271/271
Sequence Identity: 37% (67 aa)

ASKIFSQILDAIAYMHQNYCCHRDLKPNNILCNSDGT------EVKITDFNVSKFSDH-YKNYQGGESIIHQSIKMCTYTGTMAFSAPEVFNEEICYDET
|..|. ||| |..|.|.|  .|||||| ||| .|. .      ..|. |.  ||  |.  |          .. || .  ||    |||| .    |.| 
AAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKI---------EDKKMSQRCGTPYYIAPEVLQKK--YNEK

IDMWSAGCILFTMLSGREPFQAEYVHDLVKLICQGKYNFDDPVWQDISSEAKDLISKCLTVDSTQRIKPEEALKHPFI
 | ||.| ||...|.|. || ..   . .. .  |||.|..| |..||.||||||.|.|..|. .|.. ..||.|| .
CDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 27757.AA S_TKc 98-445 19 8.6e-55 189.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 98-445
Range on HMM: 1-231/231
Sequence Identity: 19% (73 aa)

YELKEILGEGCVGLVKKAVRKSDGQVFAVKTVRTRDEETIENQLNHPNIVKVYELYIDNLSGKIHSVMELINGKEMFEVIHELGHYSEKNNVGQSANYIK
||. ...|.|  | |.|.. |..|...|.| ..                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

QKKNRQRYKDTLKIQDIFDVKRKRLGQAAQILKEIDKSIQTRLQFYLRLRSFEEKLVQLLNQIGLFYEQTIS--------------------QNQLVASK
                             .|..||.   . .  .  .|  . .      . . .. |                         .  .| .
----------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

IFSQILDAIAYMHQNYCCHRDLKPNNILCNSDGTEVKITDFNVSKFSDHYKNYQGGESIIHQSIKMCTYTGTMAFSAPEVFNEEICYDE-TIDMWSAGCI
.. ||..|..|.|..  .|||||| |||...   ..||.|| ....                     |. ||  . ||||.     |.   .|.|| |||
YMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

LFTMLSGREPFQAEYVHDLVKLICQGKYNFDDPVWQDISSEAKDLISKCLTVDSTQRIKPEEALK-------HPFI
|. ||.|. ||.   .. . |.|.              |.||||.|.|||..| ..|.   |||.       ||..
LYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 27757.AA Ciliate-E2 275-445 27 2.3e-51 174.55 In-house 147-365 (365) Show / Hide 
Range on Protein: 275-445
Range on HMM: 147-365/365
Sequence Identity: 27% (64 aa)

ASKIFSQILD---------------AIAYMHQNY-CCHRDLKPNNILCNSDGTEVKITDFNVSKFSD------HYKNYQGGESIIHQSIKMCTYT-----
...|. |||.               |. |.|..  ..|||.||.|||       .||.||  ||. |       . . | .. .  .. .  |..     
IKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQI

----------GTMAFSAPEVFN--------EEICYDETIDMWSAGCILFTMLSGREPFQAEYVHDLVKLICQGKYNFDDP--------------VWQDIS
          ||  . |||..|        ..  ||. .|.||.|.||. ||.|. ||         . |.|.|..|. |               |...|
IQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWS

SEAKDLISK----CLTVDSTQRIK-PEEALKHPFI
 |.||||.|    .| .|  .||  .|..|.||..
QECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 27757.AA Pkinase 274-445 32 1.6e-48 172.29 Pfam 109-293 (293) Show / Hide 
Range on Protein: 274-445
Range on HMM: 109-293/293
Sequence Identity: 32% (65 aa)

VASKIFSQILDAIAYMHQNYCCHRDLKPNNILCNSDGTE---VKITDFNVSKFSDHYKNYQGGESIIHQSIKMCTYTGTMAFSAPEVFNEEICYDETIDM
.. ... ||| ...|.|.. ..|||||| |||....|.    |||.|| ..|. |          . ..|  | |..||  . |||| ..   |.  .||
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSAGCILFTMLSGREPFQAE------YVHDLVKLICQGKYNFDDPVWQDIS-----------------SEAKDLISKCLTVDSTQRIKPEEALKHPFI
||.||||. ||.|| ||. .          ....| .... || | | .||                 .|.||.|..||..| ..|. .|..|.||..
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 27757.AA RSK 275-445 30 7.5e-46 158.65 In-house 106-278 (278) Show / Hide 
Range on Protein: 275-445
Range on HMM: 106-278/278
Sequence Identity: 30% (57 aa)

ASKIFSQILDAIAYMHQNYCCHRDLKPNNILCNS-DGT--EVKITDFNVSKFSDHYKNYQGGESIIHQSIKMCTYTGTMAFSAPEVFN---EEICYDETI
|. ....|  |. ..||    |||||| ||| .. . .  ..|.|||  .| .            .... .. |. .| .. |||. .    .  .|.  
ACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF-----------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKAC

DMWSAGCILFTMLSGREPFQA---EYVHDLVKLICQGKYNFDDPVWQDISSEAKDLISKCLTVDSTQRIK-----PEEALKHPFI
| || |.....||.|. |||.   .  ... | |..||.... | || .| ||||||.|.|..|  .|..      || ..||..
DWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 27757.AA CAMK-Unique 275-445 29 3.5e-45 146.98 In-house 159-363 (363) Show / Hide 
Range on Protein: 275-445
Range on HMM: 159-363/363
Sequence Identity: 29% (64 aa)

ASKIFSQILDAIAYMHQNYCCHRDLKPNNILCNSD---------------GTEVKITDFNVSKFSDHYKNYQGGESIIHQSIKMCTYTGTMAFSAP----
.. |. ..| |.||||..   |||||. ||. ..                 . .|..||  ..    ..|    .....   .||   ||  . ||    
TCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCC----HYNHNKMCHMMQ---TMC---GTPCYMAPEIVF

----------EVFNEEICYDETI----DMWSAGCILFTMLSGREPFQAEYVH--------DLVKLICQGKY-NFDDPVWQD---ISSEAKDLISKCLTVD
          || |.  |||.      | || | |...||.|. || .|            . . ||.|.| ||| ..|..   || ||||.. .|.|||
CKNYQEMTRDEVINMQ-CYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVD

STQRIKPEEALKHPFI
  .|.. .|.|.|..|
PDHRWSAKELLEHQWI
Kinase 27757.AA MSK 275-445 30 1.3e-39 131.6 In-house 103-277 (277) Show / Hide 
Range on Protein: 275-445
Range on HMM: 103-277/277
Sequence Identity: 30% (56 aa)

ASKIFSQILDAIAYMHQNYCCHRDLKPNNILCNSD--GTEVKITDFNVSKFSDHYKNYQGGESIIHQSIKMCTYTGTMAFSAPEVFN----EEICYDETI
.. |. ..  |. .|||    |||||| |||  ..  . .||..||  ..     ....              . .|. . |||. .    ..  ||| .
CRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS-----------PCFTLHYMAPEMLRRGYAQDGGYDEAC

DMWSAGCILFTMLSGREPFQ--AEYVH-------DLVKLICQGKYNFDDPVWQDISSEAKDLISKCLTVDSTQRIKPEEALKHPFI
|.|| | ||.|||.|. |||  .. .        .. | || |. .|.   || .| .|||||...||.|   | . .. ..|  .
DWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase 27757.AA CAMK-Tt 98-137 80 6.8e-26 86.25 In-house 1-40 (396) Show / Hide 
Range on Protein: 98-137
Range on HMM: 1-40/396
Sequence Identity: 80% (32 aa)

YELKEILGEGCVGLVKKAVRKSDGQVFAVKTVRTRDEETI
||..|||||||||||||..|.|||||||.|.|||||||.|
YEEQEILGEGCVGLVKKVKRISDGQVFACKMVRTRDEEEI
Kinase 27757.AA Pkinase 98-186 29 7.4e-17 60.68 Pfam 1-108 (293) Show / Hide 
Range on Protein: 98-186
Range on HMM: 1-108/293
Sequence Identity: 29% (32 aa)

YELKEILGEGCVGLVKKAVRKSDGQVFAVKTVRTRDEETIE-------------NQLNHPNIVKVYELYIDNLSGKIHSVMELINGK----EMFEVIH--
|......|.|  | |.|...|..|...|||... |.|.  .             . |||||||. |. . |  ...|. |||. .|     . |..|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

ELGHY--SEK
. | .  ||.
RHGCFYFSEW
Kinase 27757.AA CDPK 98-186 36 1.3e-15 44.52 In-house 1-103 (271) Show / Hide 
Range on Protein: 98-186
Range on HMM: 1-103/271
Sequence Identity: 36% (38 aa)

YELKEILGEGCVGLVKKAVRK-SDGQVF-AVKTV---RTRDEETIEN---------QLNHPNIVKVYELYIDNLSGKIHSVME--LINGKEMFEVIHELG
| .|..||.|  | |.|.. | ...|.  |.|..   | .|.| ...         || ||||.|.|| | |.    .. |||  .  | | |..| | |
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEK--NYYIVMETEYCTGGELFDYIIEKG

HYSEK
|..||
HFTEK
Kinase 27757.AA MSK 100-186 26 3.1e-15 47.96 In-house 1-101 (277) Show / Hide 
Range on Protein: 100-186
Range on HMM: 1-101/277
Sequence Identity: 26% (27 aa)

LKEI--LGEGCVGLVKKAVRKSDGQVFAVKTVR-------TRDEET-------IENQLNHPNIVKVYELYIDNLSGKIHSVMELINGKEMFEVIHELGHY
||.   .|.| .....| |....|...|.| ..        . .|.        |   .|||||. .. . | .  . . |||..|| |.|. |   .| 
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQC--HTYLVMEYCNGGELFTHIRKREHF

SEK
.|.
DES
Kinase 27757.AA Ciliate-E2 98-198 19 1.1e-14 46.81 In-house 1-153 (365) Show / Hide 
Range on Protein: 98-198
Range on HMM: 1-153/365
Sequence Identity: 19% (30 aa)

YELKEILGEGCVGLVKKAVR-----------------------KSDGQVFAVKTVRTRDEETIEN----------------------QLNHPNIVKVYEL
|.. ...|.|. | |.|. .                       | ... .|.|... .. | |..                      |||||||.| || 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YIDNLSGKIHSVMELINGKEMFEVIHELGHYSEKN-------NVGQSANYIKQ
....   .|  |||...|...|. | .  . . ..       .  . ....||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQ
Kinase 27757.AA CAMK-Unique 98-185 18 3.9e-12 36.17 In-house 1-154 (363) Show / Hide 
Range on Protein: 98-185
Range on HMM: 1-154/363
Sequence Identity: 18% (28 aa)

YELKEILGEGCVGLVKKAVRKSDGQVFAVKTVRT-RDEETIENQ----------------------------LNHPNIVKVYEL----YIDNL-------
|.. .|.|.|  |.|...  .. |  .|.| |.  .... .  |                            ..||||.|.|.     . |         
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

------SGKIHSVMELINGKEMFEVIHE--------------------LGHYSE
        ... |||...|...|..| .                     ||.||
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSE
Kinase 27757.AA RSK 100-186 26 1e-09 32.03 In-house 1-104 (278) Show / Hide 
Range on Protein: 100-186
Range on HMM: 1-104/278
Sequence Identity: 26% (28 aa)

LKEI--LGEGCVGLVKKAVRKSDGQVFAVK-----TVRTR--------DEETIENQLN-HPNIVKVYELYIDNLSGKIHSVMELINGKEMFEVIHELGH-
||.   .| | | |..| ...  ||..|.|     ....|         | .|    . ||.||. .. . ..  ||.. .||...| |.|. . . .| 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTE--GKLYLIMEYCRGGELFTHLQKEKHF

--YSEK
   ||.
GCFSED
Kinase 27757.AA Ciliate-E2a 98-127 36 4.3e-09 22.93 In-house 1-30 (275) Show / Hide 
Range on Protein: 98-127
Range on HMM: 1-30/275
Sequence Identity: 36% (11 aa)

YELKEILGEGCVGLVKKAVRKSDGQVFAVK
|... ..|.|. | |..| .| .|. ||.|
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMK
Kinase 27757.AA TyrKc 98-445 16 4.5e-09 -75.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 98-445
Range on HMM: 1-280/280
Sequence Identity: 16% (61 aa)

YELKEILGEGCVGLVKKAVRKSDGQVFAVKTVRTRDEETIEN---------QL--NHPNIVKVYELYIDN-----LSGKIHSVMELINGKEMFEVIHELG
 .|...||||. | | |.. |   .  |||...      .|          .|  .|||||. |   ..       .. .  |||.  .    . ... .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

HYSEKNNVGQSANYIKQKKNRQRYKDTLKIQDIFDVKRKRLGQAAQILKEIDKSIQTRLQFYLRLRSFEEKLVQLLNQIGLFYEQTISQNQLVASKIFSQ
.                                                                                     ..  .|.  ..  |
PK------------------------------------------------------------------------------------LCMKDLL--SFCWQ

ILDAIAYMHQNYCCHRDLKPNNILCNSDGTEVKITDFNVSKFSDHY-KNYQGGESIIHQSIKMCTYTGTMAFSAPEVFNEEICYDETIDMWSAGCILFTM
| .  .| |.. | ||||   |.| ....  |||.||  |.. ... ..   .. . ... | . .       |||..|. ..  .. | || |  .. .
IACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS-DVWSFGVCMWEI

LS-GREPFQA-----EYVHDLVKLICQGKYNFDDPVWQD--------ISSEAKDLISKCLTVDSTQRIKPEEALKHPFI
.. | .|            ...... ||..    |  ..         ..|  .....|   |  .|   .|   | ..
FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM---PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 27757.AA CAMK1 140-187 43 3.8e-08 19.72 In-house 64-109 (276) Show / Hide 
Range on Protein: 140-187
Range on HMM: 64-109/276
Sequence Identity: 43% (21 aa)

QLNHPNIVKVYELYIDNLSGKIHSVMELINGKEMFEVIHELGHYSEKN
...||||.| || | ..   ... ||||..| | |. | | |.|.||.
KIDHPNIIKFYEWYESDN--HFYLVMELVTGGELFDRIVEKGNYTEKD
Kinase 27757.AA CAMK1 98-127 27 4e-06 13.62 In-house 1-33 (276) Show / Hide 
Range on Protein: 98-127
Range on HMM: 1-33/276
Sequence Identity: 27% (9 aa)

YELKEILGEGCVGLVKKAVRKS---DGQVFAVK
||.....|.|  . |.....|.   .|. .|.|
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIK
Kinase 27757.AA Ciliate-E2a 794-808 40 0.012113 3.63 In-house 41-55 (275) Show / Hide 
Range on Protein: 794-808
Range on HMM: 41-55/275
Sequence Identity: 40% (6 aa)

ENQEALINEINLLRC
...|...||||..|.
KGKEYFMNEINIMRQ