Gene 22792 (Tetrahymena)

22792

Species: Tetrahymena
Alias: TTHERM_01213960, 3822.m00702, 276.m00031, 22792, PreTt22792, 188
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
22792.AA Protein None 488 None Fasta, JSON
22792.kin_dom Protein Kinase Domain None 228 None Fasta, JSON
22792.NA RNA None 1467 None Fasta, JSON

Protein domain

Protein domains of 22792.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22792.AA CK1-Unclassified 13-245 67 1.8e-208 621.34 In-house 1-244 (244) Show / Hide 
Range on Protein: 13-245
Range on HMM: 1-244/244
Sequence Identity: 67% (165 aa)

FLIGQKLGSGSFGDIYLATNTETKEIVAVKLEDSKSKHPQLLFEAKIMKALQDRV-------GIPKLYWFGQE--AGCNVMVLDLLGPSLEDLFNLCKRK
. ...|.|.||||.||...|..|.| ||.|||...||||||..|||||..||..        ||||.||.|||   ..|.||.||||||||||||.|.||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

FSLKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIG-LGKKSNTIYVIDYGLGKKFRDS-KTHQHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE
|||||. ||.||||||.| .|.|..|||||||||||.| |||.....| ||.||.|...|. ||..||||||||||||||||||||||||||||||||||
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

AIGYVLVYFLKGYLPWQGIKANNKQEKYNKIMEKKMSTPVEILC
..||||.|||||.||||.||||||.|||.||||.||||||| ||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 22792.AA CK1 13-271 67 4.90000000001e-201 674.17 In-house 1-271 (271) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-271/271
Sequence Identity: 67% (184 aa)

FLIGQKLGSGSFGDIYLATNTETKEI---VAVKLEDSKSKHPQLLFEAKIMKALQD------RVGIPKLYWFGQE--AGCNVMVLDLLGPSLEDLFNLCK
. .|.|.|.||||||||..|. |..    ||.|||..|||||||..||||.| ||.       .|||..||.|||    .|.||.||||||||||||.|.
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

RKFSLKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIGL-GKKSNTIYVIDYGLGKKFRDSKTHQHIPYRENKNLTGTARYASINAHLGIEQSRRDDL
|||||||..||.||||||.| ||.|..|||||||||||.|. ||.....|.||.|| |..||.||||||||||||||||||||||||.|||||||||||.
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM

EAIGYVLVYFLKGYLPWQGIKANNKQEKYNKIMEKKMSTPVEILCKG-LPIEFSTYLNYCRSLRFEDKPDYL
|..||||.|||.| |||||.|||.|..||.|||||||||||| |||| .| || .||||||.|.||.|||| 
ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 22792.AA CK1-D 13-273 66 3.4e-164 551.76 In-house 1-261 (261) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-261/261
Sequence Identity: 66% (174 aa)

FLIGQKLGSGSFGDIYLATNTETKEIVAVKLEDSKSKHPQLLFEAKIMKALQDRVGIPKLYWFGQEAGCNVMVLDLLGPSLEDLFNLCKRKFSLKTTIMI
. || |.|||||||||. || .| | ||.|||  |.||||| .|.|. | .|  .|||.. |.|||   ||||.|||||||||||| |.||||||| .|.
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

CDQMIQRVESVHYKSYIHRDIKPDNFLIGLGKKSNTIYVIDYGLGKKFRDSKTHQHIPYRENKNLTGTARYASINAHLGIEQSRRDDLEAIGYVLVYFLK
 ||||.|.| .| ...|||||||||||.||||. |..|.||.|| |..||..||||||||||||||||||||||| |.|||||||||||..||||.|| .
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GYLPWQGIKANNKQEKYNKIMEKKMSTPVEILCKGLPIEFSTYLNYCRSLRFEDKPDYLYL
| |||||.|| .|..||..|.||||||... ||||.| ||..|.||||.|.|.|||||.||
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 22792.AA CK1-A 13-273 65 4.3e-155 521.54 In-house 1-261 (261) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-261/261
Sequence Identity: 65% (170 aa)

FLIGQKLGSGSFGDIYLATNTETKEIVAVKLEDSKSKHPQLLFEAKIMKALQDRVGIPKLYWFGQEAGCNVMVLDLLGPSLEDLFNLCKRKFSLKTTIMI
. . .|.||||||||||. |..  | ||.|.|  | .||||..|||. . ||  ||||.. |.|.|   ||||.||||||||||||.|||.|..|| .|.
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

CDQMIQRVESVHYKSYIHRDIKPDNFLIGLGKKSNTIYVIDYGLGKKFRDSKTHQHIPYRENKNLTGTARYASINAHLGIEQSRRDDLEAIGYVLVYFLK
 |||| |.| || |..|||||||||||.|.|.  | ...||.|| ||.|||.|.||||||| |||||||||||||||||||||||||.|..|||..|| .
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GYLPWQGIKANNKQEKYNKIMEKKMSTPVEILCKGLPIEFSTYLNYCRSLRFEDKPDYLYL
| |||||.||..|. || || |||||||.| |||| | ||. |.||||.||||..|||.||
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 22792.AA CK1 13-273 37 1.7e-139 469.71 In-house 1-339 (339) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-339/339
Sequence Identity: 37% (129 aa)

FLIGQKLGSGSFG-DIYLA-----TNTETK-----EIVAVKLEDSKSK--HPQLLFEAKIMKALQDR-------------------VGIPKLYWFGQEAG
. ...|.|.|.|| .||..     ......     | .|.|.|  ||.  ||||. |....|.||.                    ...|..||...| .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--CNVMVLDLLGPSLEDLFN---LCKRKFSLKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIGL------GKKSN--------TIYVIDYGLGK-KF
  .|.||..||||.||||..   .|.||||.||..|| .||....| .| . .||||||||||..|.      ||. .        ..|.||.|. . |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

RDS-----------KTHQHIPYRE---NKNLTG-TARYASINAHLGIEQSRRDDLEAIGYVLVYFLKGY--LPWQGIKANNK-------QEKYNKIMEKK
||.           ||.||.|.||   .|...| ||||.|||.|||.||.|||||.. .|.|...|||   ||||..|...|       ..||..|.|||
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

MSTPVEILCKG-----LPIEFSTYLNYCRSLRFEDKPDYLYL
||||.. ||..     .| || ....|.|||...|.||| ..
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 22792.AA CK1-G 13-273 53 1.9e-139 469.6 In-house 1-266 (266) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-266/266
Sequence Identity: 53% (141 aa)

FLIGQKLGSGSFGDIYLATNTETKEIVAVKLEDSKSKHPQLLFEAKIMKALQDRV-GIPKLYWFGQEAGCNVMVLDLLGPSLEDLFNLCKRKFSLKTTIM
. .| | | |.|| ... .|  . | ||.|.|  ||. |||  | .  | |   . |||. |.|||.   |.||.|||||||||||..| ||||.||..|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

ICDQMIQRVESVHYKSYIHRDIKPDNFLIGL--GKKSNTIYVIDYGLGKKFRDSKTHQHIPYRENKNLTGTARYASINAHLGIEQSRRDDLEAIGYVLVY
.  |||.|.| || .. | ||.||||||||    |. ..|..||.|. |...| .| ||||||| | ||||||| ||| ||| |||||||.||.| .  |
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

FLKGYLPWQGIKANNKQEKYNKIMEKKMSTPVEILCKG--LPIEFSTYLNYCRSLRFEDKPDYLYL
|| | ||||| || |  |.|.|| ..| .|..| ||..  .|..| ||| | |.| |...||| ||
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 22792.AA Worm6 13-273 28 1.2e-63 217.75 In-house 1-279 (279) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-279/279
Sequence Identity: 28% (80 aa)

FLIGQKLGSGSFGDIYLATNTETKE--IVAVKLED--SKSKHPQLLFEAKIMKALQDRV--GIPKLYWFGQEAG--CNVMVLDLLGPSLEDLFNLC-KRK
. ...|.|.|.||..|.......|.   .|.|.|    ..|...| .|. ..||.  .   . .|.   |.      | .|. |.|..|.||   . .||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIGL-----GKKSNTIYVIDYGLGK-KFRDSKTHQHIPYR-ENKNLTGTARYASINAHLGIEQSR
||. |.. |  |.....| .|   .||||.|| || ||       ... ||| .|.|. . |. . |  . .. | ..    || |||....| |.||.|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

RDDLEAIGYVLVYFLKGYLPWQGIKANNKQE-KYNKIMEKKMSTPVEILCKGLPI-EFSTYLNYCRSLRFEDKPDYLYL
.||.|   |..| ...| |||...|. . .|  . ... .. ..  . . .. |  ||.  . |  .....|.||| ..
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 22792.AA TTBKL 13-277 26 3.7e-63 212.07 In-house 1-288 (288) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-288/288
Sequence Identity: 26% (79 aa)

FLIGQKLGSGSFGDIYLATNTETKEIVAVKLEDSKS-KHPQ--LLFEAKIMKALQ--DRVGIPKLYWFGQEAGCNVMVLDLLGPSLEDLFNLCKRK--FS
..| ...|.| || .|.. ....|. .|.. | ...  .    . .|......||  .   .||... |.. ..| ||. |.||.| || .  ..|  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIGLGKK----SNTIYVIDYGLGKKFRDS----------KTHQHIPYRE---NKNLTGTARYASINA
  |.  |. | .  .  .| . .||||.|| |. .|. ..    . ..|.||.|. ......          .. .. . |.      . || ||.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLGIEQSRRDDLEAIGYVLVYFLKGYLPWQGIKANNKQEKYNKIMEKKMSTPVEILCKG------LPIEFSTYLNYCRSLRFEDKPDYLYLRKMF
|.. ||.| ||| .  |.......| |||....         .|...|...  | |.|.      .| ||     . ||||. | ||| .... |
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKM------EIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 22792.AA TTBK 15-273 35 1.5e-53 184.23 In-house 3-257 (257) Show / Hide 
Range on Protein: 15-273
Range on HMM: 3-257/257
Sequence Identity: 35% (93 aa)

IGQKLGSGSFGDIYLATNTETK-EIVAVKLEDSKSKHPQLLFEAKIMKALQDRVGIPKLYWFGQEAGCNVMVLDLLGPSLEDL-FNLCKRKFSLKTTIMI
. .| | | || || |..  .. | ||.|.| .. .   |  |  ..| || .  . . .  | .   | ||..|.| .| ||  .  . .||| ||. .
VVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRL

CDQMIQRVESVHYKSYIHRDIKPDNFLIG-LGKKSNTIYVIDYGLGKKFRDSKTHQHIPYRENKNLTGTARYASINAHLGIEQSRRDDLEAIGYVLVYFL
  |..| .||.|   . |||||| || .| . .. . .| .|.||  ..  ..     | ||     ||.||||||||.  |  |.|||  . |.|| |.
GVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPP-REVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFV

KGYLPWQGIKANNKQEKYNKIMEKKMSTPVEILCKGLPIEFSTYLNYCRSLRFEDKPDYLYL
.| |||  ||   | .    . | |      .| | .| ||.....  .|| .||.|||  .
QGQLPWRKIK--DKDQ----VGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 22792.AA Pkinase 13-264 21 2.8e-32 115.19 Pfam 1-258 (293) Show / Hide 
Range on Protein: 13-264
Range on HMM: 1-258/293
Sequence Identity: 21% (60 aa)

FLIGQKLGSGSFGDIYLATNTETKEIVAVKLEDSKSKHP----QLLF--EAKIMKALQDRVGIPKLYWFGQEAGCNVMVLDLLGPSLEDLFNLC------
. ||.|.||||||  |....  | .|||||  . .....    ...   |..||| |.    .  ..||  .  .  ||.....  |. .. |.      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLY-VMDLFDYISTW

-KRKF--SLKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIGLGKKSNT---IYVIDYGLGKKFRDSKTHQHIPYRENKNLTGTARYASINAHL-GIE
 ...|  | .. .... |... .|  | .. ||||.||.|.||   .. ..   . ..| || |.|.      . ... .. ..|| .|..   .. | .
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQY

QSRRDDLEAIGYVLVYFLKGYLPWQGI----KANNKQEKYNKIMEKKMSTPVEILCKGLPIEFSTYLNYCRSLRF
 ... |  ..| .| ..| |..|..|     . .........||... . . . .| . . .  ..   .. ...
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWT
Kinase 22792.AA Dual 81-202 30 2.3e-22 71.9 In-house 86-208 (282) Show / Hide 
Range on Protein: 81-202
Range on HMM: 86-208/282
Sequence Identity: 30% (38 aa)

CNVMVLDLLGPSLEDLFN-LCKRKFSLKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIGLGKKSNTIYVIDYGLGKKFRDSKTHQHIPYRENKNLTG
|. .|  . ||||..         .|  .   .  ||.. .   |   |.||.||| || .||| .  |.|  |.....|. | .. .| . | .    |
CKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYG

TARYASINAHLGIEQSRRDDLEA
..|||..   .  .| | ||||.
CGRYACRACMMQKDQGRKDDLEC
Kinase 22792.AA S_TKc 13-380 17 1.1e-15 53.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-380
Range on HMM: 1-231/231
Sequence Identity: 17% (65 aa)

FLIGQKLGSGSFGDIYLATNTETKEIVAVKLEDSKSKHPQLLFEAKIMKALQDRVGIPKLYWFGQEAGCNVMVLDLLGPSLEDLFNLCKRK--------F
. |..|.|.|.||  |......|..|||.|  .      ... | .|.|   .   | ||| . |. ..  ||..... .| ||| . |..        |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIGLGKKSNTIYVIDYGLGKKFRDSKTHQHIPYRENKNLTGTARYASINAHLGIEQSR-RDDLEAI
.  ..  .. |... .|  | .  ||||.||.| |.       .| ..| || ...              . . ||  | .         .. . |  ..
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GYVLVYFLKGYLPWQGIKANNKQEKYNKIMEKKMSTPVEILCKGLPIEFSTYLNYCRSLRFEDKPDYLYLRKMFKELFYRENYEWDYIYDWCLPIGGEKI
| .|  .| || |..     . |. ..||.                                                                      
GCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------------------------------------------------

TSYSNGKISITINTNPPSAQNPPVTLHINENVMSKGDDKFIKSEYMKDKLEQLQGLDSQ---DKNEAQQDNLRVDNNPIK
                                          |. .|| ....   | .      || || . . . |  
------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22792.AA Pkinase_Tyr 13-64 38 2.5e-07 25.42 Pfam 1-62 (270) Show / Hide 
Range on Protein: 13-64
Range on HMM: 1-62/270
Sequence Identity: 38% (24 aa)

FLIGQKLGSGSFGDIYLATNT----ETKEIVAVKLEDSKSKHPQ-----LLFEAKIMKAL-Q
  .|.|||.|.||..|..| .    .||  ||||    .. |.|     .. |||||| | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH
Kinase 22792.AA TyrKc 13-277 19 1.8e-05 -134.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

FLIGQKLGSGSFGDIYLATNTETKEIVAVKLEDSKSKHPQLLFEAKIMKAL--QDR-------VGIP--------KLYWFGQEAGCNVMVLDLLGPSLED
   |.|||.| || .|..| .   . ||||   . . .  .. ||.||. |  .         | .         . ..   |  ..   .| |  . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LFNLCKRKFSLKTTIMICDQMIQRVESVHYKSYIHRDIKPDNFLIGLGKKSNTIYVIDYGLGKKFRDS----KTHQHIPYRENKNLT--GTARYASINAH
        ...|. . .| |  .  |  | | .||||.   | |.| ..   |. . | || ..  |       .. .  .| |.       |  ..   
--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP---

LGIEQSRRDDLEAI-GY------------VLVY--FLKGYLPWQG-IK--ANNKQEKYNKIMEKKMSTPVEILCKGL-----PIEFSTYLNYCRSLRFED
           |.|  .            |. .  |  |  |. | |.   .|..   .    . |  | ...   .     | |  .    |     ||
-----------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPED

KPDYLYLRKMF
 |    ... |
RPTFSEIHECF