Gene 25533 (Tetrahymena)

25533

Species: Tetrahymena
Alias: 3813.m01608, 216, 25533, 131.m00106, PreTt25533, TTHERM_00784290
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
25533.AA Protein None 337 None Fasta, JSON
25533.kin_dom Protein Kinase Domain None 284 None Fasta, JSON
25533.NA RNA None 1014 None Fasta, JSON

Protein domain

Protein domains of 25533.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25533.AA CDC2 29-312 55 6.4e-208 645.78 In-house 1-301 (301) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-301/301
Sequence Identity: 55% (168 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEG--IPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLE----TM
.....||||||||.|||. |.|||..||.||..|.||.||  .|..|.|||..||.| ||.|||||.|||.|   .||..||||.|.|||||..    ..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

KHLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLT--HEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFY
||.... .| .|||.|.|..|||||||.|||.|||||||||.||.||||||||..|..|..|.|  |||.|||||.|||||| |.||...|||||||.|.
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---MEKKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVFKN---------LENDARDLLMQMIALNPLDRISVKQALL
|.   ..|||||. ||||. .||||...||||..|..|....|..|.||||...||. ....|         |.....||||||....| .|||.|.|| 
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HPYF
||||
HPYF
Kinase 25533.AA CDK 29-312 44 4.2e-166 535.58 In-house 1-284 (284) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-284/284
Sequence Identity: 44% (142 aa)

FKCLQKIGEGTYGIVYKGFDTQTN-----TQVAIKKVKLDQ-----EQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIE---------ESKLFLVFE
...|.||||||||.|||. |.||.       ||.||.....     | ||.|..|.|||..||.|  |.|||||.||... .         |.||..|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YVDYDLKKYLETMKHLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGN-----VKIADFGLAKTFQV------PSKTLTHEVETLWYRPPE
|.|.|||||..         || .|.|||.||..||...|.|||.|||||||.. |.     .||||||||. |..      |..|.|||| |||||.||
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

ILLGVKTYS--LAIDMWSIGCVFYELME---KKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVFKNLENDARDLLMQMI
.||| |.||   .|||||.||.|.|..    .||||  ||||. .||||.. |||. ..  |....|..                        |||..| 
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKML

ALNPLDRISVKQALLHPYF
...|  ||| .||| ||||
CYDPKKRISAEQALQHPYF
Kinase 25533.AA CMGC 29-312 27 9.90000000001e-135 445.58 In-house 1-513 (513) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-513/513
Sequence Identity: 27% (140 aa)

FKCLQKIGEGTYGIVYKGFDTQTN--------------TQVAIKKVKLDQ---------EQEGIPQSALREICILKDLS----------------DHQNI
.....||||||||.|||..|..||               .|||||.|...         | .|.|..||||| ||| |.                .| ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLRDVIYQIEES---------------KLFLVFEYVDYDLKKYLETMK---------HLTQHD------------IKLIM------YQLLNGLD--FCH
|||.|..|  ..                .|.|||||.|.||..|.. ..         .|..              || .|      ||.|.||.  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

QRR--IIHRDIKPQNILIDKA--------------------GNVKIADFGLAKTFQVP---------------------SKTLTHEVETLWYRPPEILLG
...  |||||.||.||||..                     |..||.|||||. . ..                     ....||.| |.|||.||||||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

VKTYS---------LAIDMWSIGCVFYELMEK--------KPLFISDSE-----------IEAIFKIFQFHGTPN---------------SETFQGLEDY
 | |.          .|||||.||.|.|.. .        ||||  .||           |. .||||.  |||.               .|.. .  ..
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PYF---------------KST-----------FPRFHAQDPFIVFKNLEN-----------------------------------DARDLLMQMIALNPL
|..               .|            ||... ..   .|... |                                   .|.|||..|  ..| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

DRISVKQALLHPYF
.||...||| ||||
KRITAEQALQHPYF
Kinase 25533.AA CDK5 29-312 47 9.90000000001e-134 425.16 In-house 1-287 (287) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-287/287
Sequence Identity: 47% (137 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLETMK-HLTQ
.. . ||||||||.|||. . .|   ||.|.|.||.| ||.| .|.||||.|| |  |.||| | |||    | || ||||..| |||||.. ..  . .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKEL-KHKNIVRLHDVIHS--EKKLTLVFEFCDQDLKKYMDSCNGEMDM

HDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFYELM-EKK
| || .||||| || |||.... ||| |||| || | |. | ||||||  | .| .. .||| ||||||| .|.| |.||  |||||.||.| |..   .
HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGR

PLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFK---STFPRFHAQD-PFIVFKNLENDARDLLMQMIALNPLDRISVKQALLHPYF
|||   .. .  ..||.  |||. ..  .. . | .|     .| ..|.     . ..|.   .||| .|. .||  ||| |.|| ||||
PLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 25533.AA S_TKc 29-312 29 5.4e-100 339.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDY---DLKKYLETMKH-
.. |.|||.|..| |||. .. |. .||||..|         ....||| |||   .| ||||| ||..    ..|..|.||.|    ||..|.. ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSL-AIDMWSIGCV
     ..  ... .|||....|..||...|||||.||.|||.|.  ..||.|||||. .       |. . |.||..||.|     |.  ..|.||.||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

FYELMEKKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVFKNLENDARDLLMQMIALNPLDRISVKQALL-------HPY
.||..  .|.|    .....||.                                          .|.|.....   .| .|... .||        ||.
LYEMLCGYPPFP---QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase 25533.AA PFTAIRE 29-312 42 1.1e-97 330.88 In-house 1-287 (287) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-287/287
Sequence Identity: 42% (125 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLETMKH-LTQ
.. |.| |||.|  ||||.   ..  || | ..|.|| || |  | ||   ||.|  | ||| | |.|   |   | .|||||. ||..|..     .  
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE-EGTPFTAIREASLLKNLK-HANIVCLHDIIHTKE--TLTFVFEYVHTDLCQYMDKHPGGMHP

HDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFYELMEKKP
. ..| ..||| || .|||||. |||.|||| || ..|  | ||||||    |||.|  ||| ||||||| .|||   ||  .||| .||.| |.|  .|
NNVRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQP

LFISD-SEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPR--FHAQDPF-IVFKNLE--NDARDLLMQMIALNPLDRISVKQALLHPYF
.|       .   |||.  |||. .|. |    | .|    |  |.  ..   ..  ..  ..| ||.|.|  ..| ||.| ..|. ||||
AFPGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase 25533.AA Pkinase 29-312 31 5.5e-96 329.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALR--EICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDY-----DLKKYLE-
.....|||.|..| |||. .  |. .||.|..|.. | .. .|...|  ||.|.| | .| |||.|.|. .   .... .|.||..      ||. |.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-TMKHL--TQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNV----KIADFGLAKTF-QVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDM
   . .  . ...| .|||.| ||..||...|||||.||.|||||. |..    ||.|||||| |   ..  .|. . |.||..||...| . |. ..||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSIGCVFYELMEKKPLFISD----SEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVFKNLENDARDLLMQMIALNPLDRISVKQALL
||.||..||.. ..|.| ..    . .. ...|..  |.|... .. . . .||. ...   .. .  . .|.. ...|..  .....| .|.. .|.| 
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPYF
||.|
HPWF
Kinase 25533.AA PCTAIRE 29-312 42 8.6e-96 324.54 In-house 1-291 (291) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-291/291
Sequence Identity: 42% (125 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLE-TMKHLTQ
.. | | |||||  |||.    |.  || | ..| . .|| |  | ||.  ||||  | ||| | |.|..  .  | ||||| | |||.|..     .  
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRL-EHEEGAPCTAIREVSLLKDLK-HANIVTLHDIIHT--HHQLTLVFEYMDMDLKQYMDDCGNIMNM

HDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFYELMEKKP
|..||...||| ||..||.|.| ||| |||| ||.  |  | ||||||.   ||.||  ||| |||||||..|.|   ||  |||| .||.|||.   .|
HNVKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRP

LFISDS------EIEAIFKIFQFHGTPNSETFQGLEDYPYFKS-TFPRFHAQDPFIVFKNLE---NDARDLLMQMIALNPLDRISVKQALLHPYF
||            .    ||.. |||  .|  | .  . |..  |||. .|    .   |.    .  ||| ..  . .  |.|  .|..||||
LFPGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase 25533.AA CRK7 29-312 34 5.5e-92 311.9 In-house 1-343 (343) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-343/343
Sequence Identity: 34% (119 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQE---QEGIPQSALREICILKDLSDHQNIVKLRDVIYQ------IEESK--LFLVFEYVDYDLKK
.. .. ||||||| |||  ...|. .|| |||..| |   .|| |  | ||| ||. | .|||||.|....          . |   ..||||.| ||  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQL-NHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMG

YLETM--KHLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPS--KTLTHEVETLWYRPPEILLGVKTY-------
 ||    .|  .  .| .| ||| |.| ||.. ..|||||  |||..  |.|||||||||  .   .  . .|  | |||||||| ||| . |       
LLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILK

-------------------------------SLAIDMWSIGCVFYELMEKKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYPYFKSTFPRF----HA
                                 .||||| || . ||. |||.|    |.. . ||..  |.|| .    . . |...   |.       
ELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRL

QDPFI-VFK--NLENDARDLLMQMIALNPLDRISVKQALLHPYF
   |.  .|  ..  .. ||| .| .|.|  |......| |..|
REEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 25533.AA PITSLRE 29-249 45 1.5e-90 307.16 In-house 1-227 (295) Show / Hide 
Range on Protein: 29-249
Range on HMM: 1-227/295
Sequence Identity: 45% (104 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLD--QEQEGIPQSALREIC-ILKDLSDHQNIVKLRDVIYQIEESKLFLVFEYVDYDLKKYLETMK--
|.|| .|.|||||.||.. |..|.  ||.|..|..  .| ||.|  .||||  ||. |  | |||... ..      | ..|.|||. |||  .|.||  
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMAL-QHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRR

--HLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCVFYE
    .   ||  | |||.| .. |   |.||| |  |.|.  .|. ||.|||||  .. | | .|  | ||||| ||.||| |.|| ..||||.||.| |
NQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAE

LMEKKPLFISDSEIEAIFKIFQFHGTPN
.. .||||  .|||. | .||.  |||.
FITMKPLFQGKSEIDQINCIFKEMGTPT
Kinase 25533.AA CDK4 29-312 39 7.1e-89 301.56 In-house 1-290 (290) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-290/290
Sequence Identity: 39% (119 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQE--GIPQSALREICILKDL--SDHQNIVKLRDVIYQIEESK----LFLVFEYVDYDLKKYLE
..|.. |||| ||.||.  |..|   || |.|.   . |  |.|.| .||| ... |  ..| ||||| ||  ...       . .||| .| ||. ||.
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

TMKH--LTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQVPSKTLTHEVETLWYRPPEILLGVKTYSLAIDMWSIGCV
 .    . .  || .| ||| |.|| |  |||||| ||||||.   | ||.||||||...    . ||  | ||||| ||.||   .|   .||||.||.
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

FYELMEKKPLFISDSEIEAIFKIFQFHGTPNSETFQGLEDYP----YFKSTFPRFHAQDPFIVFKNLENDARDLLMQMIALNPLDRISVKQALLHPYF
| |.   .|||   || .   |||   |.|      . .| |       . ||  |.. .  .   ... . ||| .|   |.  |.|  |.| ||||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLP------PEDDWPRDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 25533.AA MAPK 29-312 31 1.6e-87 297.1 In-house 1-328 (328) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-328/328
Sequence Identity: 31% (103 aa)

FKCLQKIGEGTYGIVYKGFDTQ------TNTQVAIKKVK--LDQEQEGIPQSALREICILKDLSDHQNIVKLRDVIYQ-----IEE----SKLFLVFEYV
.. |..||.| ||.| . .|.       ....|||||.    . ..      ..||| .|. . .| ||.||.|...       ..      . .|.|. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK--RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

DYDLKKYLETMKHLTQHDIKLIMYQLLNG--LDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTFQV-PSKT-------------LTHEVETLWYR
. || . ......|. . |. .|||.|.|  | . |  ..||||.|| |||... . .||.||||| ..    ..              .|  | | |||
ETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYR

PPEILLG--VKTYSLAIDMWSIGCVFYELME-KKPLFISDSEIEAIFKIFQFHGTPNSETFQGLE-D---YPYFKS-TFPRFHAQDPF-IVFKN----LE
 |||.|.   . |. |.||||.|| | |..   ||||  .. |. ...|... |||  |  | .. .   . |..|  ... . . |.  .|.|      
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

NDARDLLMQMIALNPLDRISVKQALLHPYF
 .|.||| .| ...| .||.|..|| ||||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 25533.AA Pkinase_Tyr 29-177 32 3e-28 96.3 Pfam 1-160 (270) Show / Hide 
Range on Protein: 29-177
Range on HMM: 1-160/270
Sequence Identity: 32% (54 aa)

FKCLQKIGEGTYGIVYKGFDT----QTNTQVAIKKVKLDQEQEGIPQSA------LREICILKDLSDHQNIVKLRDVIYQIEES-KLFLVFEYVDY-DLK
 . ..|.||| .| ||||  .    .|...||.|..|     ||  ...      .||. |.| | .|.|||.|  |..  .|. ....|.||. . ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYLETM----KHLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKT
.|| .     ..|| .|.  . .|  .|... .....||||.   |.|... . |||.|||||..
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase 25533.AA TyrKc 29-312 23 1.4e-15 29.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 29-312
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

FKCLQKIGEGTYGIVYKGFDTQTNTQVAIKKVKLDQEQEGIPQSALREICILKDL-SDHQNIVKLRDVIYQIEE-----SKLFLVFEYVDY-DLKKYLET
 . ..|.||| .|.||||  .   .|||.|..| |       .  .||. |.. |  .|.|||.|  |. | ..       |..|.||... |||.||  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MKH-LTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNILIDKAGNVKIADFGLAKTF-----------QVPSKT--LTHEVETLWYRPPEILLGVKTYS
 .. |.  |   ...|  .| .. |....||||.   |.|... . |||.||||..                .|.   .. .  .   .|| .   ....
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

LAIDMWSIGCVFYELME--KKPLF------ISDSEIEAIFKIFQFHGTPNS----ETFQGLEDYPYFKSTFPRFHAQDPFIVFKNLENDARDLLMQMIAL
 . | || | . .|..   ..|        .|..|. .  |       | .                               |     .  ..  |  . 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIMKQCWHE

NPLDRISVKQALLHPYF
.| || . ..   | .|
DPEDRPTFSEI--HECF
Kinase 25533.AA PITSLRE 287-312 53 5e-08 25.52 In-house 270-295 (295) Show / Hide 
Range on Protein: 287-312
Range on HMM: 270-295/295
Sequence Identity: 53% (14 aa)

DLLMQMIALNPLDRISVKQALLHPYF
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DLLNQMLTYNPKNRITASDALKHPWF