Gene 26482 (Tetrahymena)

26482

Species: Tetrahymena
Alias: 3831.m01583, 990, PreTt26482, 48.m00245, 26482, TTHERM_00433390
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDC2

Sequence

Name Sequence Type Origin Length Description Download
26482.NA RNA None 3246 None Fasta, JSON
26482.AA Protein None 1081 None Fasta, JSON
26482.kin_dom Protein Kinase Domain None 295 None Fasta, JSON

Protein domain

Protein domains of 26482.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
F-box 26482.AA F-box 364-412 22 6e-06 23.97 Pfam 1-46 (46) Show / Hide 
Range on Protein: 364-412
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

QSLMTLPFELHFIICSYLSPKDIYLRLANVNQYFRKMCKDTRLWSYIQK
 ..  || ..   | |...||| ..|.. |.  .|. ...  .|  . .
FPWSDLPDDILREIFSHMDPKD-LCRCRCVCKRWRSIVDSP-FWF-FCL
Kinase 26482.AA CDC2 463-762 39 3.8e-153 474.36 In-house 37-301 (301) Show / Hide 
Range on Protein: 463-762
Range on HMM: 37-301/301
Sequence Identity: 39% (122 aa)

QDDG--VPTSILRELSYLQALD-HPNITKIHEVDIKNVIVQIVTKRQEYNLKEYTRRYISQVQDDSKGLTRPQYKIPLIKVKEIAYQILEGLNYLHHQGI
.|.|  ||....||.|.|..|. ||||.|.|.| ..   ...|.......||.|....|...           ...|...||...||||.|....|...|
EDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKN-----------KHMPPQLVKSYMYQILQGVHFCHQRRI

MHRNLKIDNILLDKD-VVKISDFGLSRLVSIPHIPYTPEDPKERERSGREARRLWYRAPELLLRKSIYTFEIDMWSFGCLLAEI---VLNEPLFAGDSEI
|||.||..|||.||. ..||.||||.| ..||. .||.|         .| ..|||||||.||... |....||||.||..||.   | ..|||.|||||
MHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTE---------HEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEI

EQLFKVFKFIGSPDSETLMSMCDNPDYQQTFPKWKMINLSHICEQNQSEEFKQLKTTMIPNRQNGFQKLKNLGTILGMQGMQLLNSLLQLNPYKRISSQE
.||||.|...|.|...|.......|||..|||.||...||.||..||..                    ||. ..| ..|..||...||..|.||||..|
DQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKK--------------------KNQ-SCLDPEGIDLLMQMLQYDPQKRISAKE

ALNHPFF
||.||.|
ALQHPYF
Kinase 26482.AA CDK 464-762 30 4.7e-95 304.57 In-house 48-284 (284) Show / Hide 
Range on Protein: 464-762
Range on HMM: 48-284/284
Sequence Identity: 30% (97 aa)

DDGVPTSILRELSYLQALDHPNITKIHEVDIKN-----------VIVQIVTKRQEYNLKEYTRRYISQVQDDSKGLTRPQYKIPLIKVKEIAYQILEGLN
..|.| . .|| |.|. | |||| |.|.| . .             ...|    .. ||.| .                        .| . .|.|.||.
KEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD------------------------IKCYMWQLLRGLH

YLHHQGIMHRNLKIDNILLDKD-V-----VKISDFGLSRLVSIPHIPYTPEDPKERERSGREARRLWYRAPELLLRKSIYT--FEIDMWSFGCLLAEIVL
|.|...|||| ||  |||.... .     .|| ||||.|. .|||     .. ...     |   ||||||||||  ..|.   .|||||.|| .||...
YCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQ----MS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFT

---NEPLFAGDSEIEQLFKVFKFIGSPDSETLMSMCDNPDYQQTFPKWKMINLSHICEQNQSEEFKQLKTTMIPNRQNGFQKLKNLGTILGMQGMQLLNS
   ..||| |||||.||||.|...|.|. ..  .... |||                                                      .|||.
DVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------------------------------------DLLNK

LLQLNPYKRISSQEALNHPFF
.|...|.||||...||.||.|
MLCYDPKKRISAEQALQHPYF
Kinase 26482.AA CMGC 465-762 22 1.9e-82 270.58 In-house 62-513 (513) Show / Hide 
Range on Protein: 465-762
Range on HMM: 62-513/513
Sequence Identity: 22% (103 aa)

DGVPTSILRELSYLQAL-----------------DHPNITKIHEVDIKNV-----------------IVQIVTKRQEYNLKEYTRRYISQVQD-DSKGLT
||.| ..|||...|. |                 .|.|| |....   .                   . .|.   ...|..| ...    |.   ..|.
DGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLS

RPQ------------YK-IPLIKVKEIAYQILEGLN--YLHHQG--IMHRNLKIDNILLDKD---------------------VVKISDFGLSRLVSIPH
  .             | ...  .. ..||||.||.  |.| ..  |.|| ||  |||....                     ..|| ||||.| .....
E-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHS

IPYTPEDP----------KERERSGREARRLWYRAPELLLRKSIYT---------FEIDMWSFGCLLAEIVLN--------EPLFAGDSE----------
 . . ..|          |...    .   .||||||.||. . ||          .|||||.|| .||....        .||| |.||          
DHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKS

-IEQLFKVFKFIGSPD---------------SETLMSMCDNPDYQQTFPKW---KMINLSHICEQNQSEEFKQLKTTMIPNRQNGFQKLKNLGT------
 |.|||| || .|.|.               .|. ..| ..|.|... .||    |.|   .  .|. . ......   .. .| | ...|...      
HIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAM

----------------------ILGMQGMQLLNSLLQLNPYKRISSQEALNHPFF
                       .  |.  ||. .||..| |||. ..||.||.|
VFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 26482.AA Pkinase 458-762 21 1.8e-47 168.8 Pfam 32-293 (293) Show / Hide 
Range on Protein: 458-762
Range on HMM: 32-293/293
Sequence Identity: 21% (68 aa)

ISNAGQDDGVPTSILR--ELSYLQALDHPNITKIHEVDIKNVIVQIVTKRQEYN-LKEYTRRYISQVQDDSKGLT-RPQYKI--PLIKVKEIAYQILEGL
|.  ....... . .|  |..... |.|||| .....            ....    || .   . |.| .  .. . . ..  .   .| ..||||.||
IKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGL

NYLHHQGIMHRNLKIDNILLD-KDVV----KISDFGLSRLVSIPHIPYTPEDPKERERSGREARR--LWYRAPELLLRKSIYTFEIDMWSFGCLLAEIVL
.|.| .||.|| || .|||.| ....    ||.||||.....            .   |    .   .||.|||...  . |. ..||||.||.|.| ..
EYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC

NEPLFAGD----SEIEQLFKVFKFIGSPDSETLMSMCDNPDYQQTFPKWKMINLSHICEQNQSEEFKQLKTTMIPNRQNGFQKLKNLGTILGMQGMQLLN
 .|.| |.    . ..|......  | | ..     |.....  ... |                                . .. . . .   . ....
GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------F-HWTF-HNWSEECKDFIK

SLLQLNPYKRISSQEALNHPFF
..|...|.||.. ...|.||.|
WCLCKDPKKRPTAEQILQHPWF
S_TKc 26482.AA S_TKc 429-762 21 7.7e-44 152.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 429-762
Range on HMM: 1-231/231
Sequence Identity: 21% (74 aa)

VERRSK------GRLFSAVSRLDHNQFMIRNVNIMISNAGQDDGVPTSILRELSYLQALDHPNITKIHEVDIKNVIVQIVTKRQEY---NLKEYTRRYIS
 |   |      |. . .. . .. .. |  ..              .|.||.. |.  .|||| |...|      . .|.   .    .|..| ... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

QVQDDSKGLTRPQYKIPLIKVKEIAYQILEGLNYLHHQGIMHRNLKIDNILLDKDVVKISDFGLSRLVSIPHIPYTPEDPKERERSGREARRLWYRAPEL
.         ......|   .. ..|||...|.|.| .||.|| || .|||||. ..||.||||.|..                        .||.|||.
H---------GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------------------TTFCGTPWYMAPEV

LLRKSIYTF-EIDMWSFGCLLAEIVLNEPLFAGDSEIEQLFKVFKFIGSPDSETLMSMCDNPDYQQTFPKWKMINLSHICEQNQSEEFKQLKTTMIPNRQ
|     |.. ..|.||.||.|.| .  .|.|       |....|| ||                                                    
L----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------------------------------------------------

NGFQKLKNLGTILGMQGMQLLNSLLQLNPYKRISSQEALN-------HPFF
               .. .... .|| .| ||..  |||.       ||.|
-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26482.AA CDK5 540-700 34 3.8e-37 114.58 In-house 100-255 (287) Show / Hide 
Range on Protein: 540-700
Range on HMM: 100-255/287
Sequence Identity: 34% (57 aa)

VKEIAYQILEGLNYLHHQGIMHRNLKIDNILLDKD-VVKISDFGLSRLVSIPHIPYTPEDPKERERSGREARRLWYRAPELLLRKSIYTFEIDMWSFGCL
.| . || | || . |.. ..|| ||  | |  |    |  |||| |   ||   |.            |   ||||.|  |.    |.  ||||| || 
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYS-----------HEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCI

LAEIV-LNEPLFAGDSEIEQLFKVFKFIGSPDSETLMSMCDNPDYQ---QTFPKWKMIN-LSHICEQ
.||..    ||| | .. .||...|| .|.|  ..  |. . |||.   | .|.. .   .. |. .
FAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK
Kinase 26482.AA GSK 614-762 34 2e-36 108.35 In-house 184-328 (328) Show / Hide 
Range on Protein: 614-762
Range on HMM: 184-328/328
Sequence Identity: 34% (52 aa)

YRAPELLLRKSIYTFEIDMWSFGCLLAEIVLNEPLFAGDSEIEQLFKVFKFIGSPDSETLMSMCDNPDY-QQTFPKWKMINLSHICEQNQSEEFKQLKTT
||||||..  . ||  ||.||.|| .|| ....|||.|||.. ||. ..| .|.|. | . ||  ||.| .. || |. ...  . .|   .      | 
YRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSM--NPSYPEFKFPYWSFQQIKPHPWQKNDTKYEY-QTY

MIPNRQNGFQKLKNLGTILGMQGMQLLNSLLQLNPYKRISSQEALNHPFF
.   ..     .|...|.   . ..|....|. .| ||.|  ||. ||||
YHKKYR-TVYMFKWCHTDMQ-DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 26482.AA CDK10 539-669 42 3.2e-36 123.31 In-house 101-221 (285) Show / Hide 
Range on Protein: 539-669
Range on HMM: 101-221/285
Sequence Identity: 42% (56 aa)

KVKEIAYQILEGLNYLHHQGIMHRNLKIDNILL-DKDVVKISDFGLSRLVSIPHIPYTPEDPKERERSGREARRLWYRAPELLLRKSIYTFEIDMWSFGC
.|| |. |.| || |||.. ..|| ||. |.|. ||  .|. |||| |  ..|  | ||               ||||||||||     |  |||| .||
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTP-----------KMVTLWYRAPELLLGCRTQTTAIDMWAVGC

LLAEIVLNEPLFAGDSEIEQLFKVFKFIGSPD
.|.|.... ||. | ||| |.  . . .|.|.
ILGELLVHKPLMPGNSEIHQIDMIIDLLGTPS
Kinase 26482.AA RCK 613-673 45 2.2e-25 77.23 In-house 178-238 (298) Show / Hide 
Range on Protein: 613-673
Range on HMM: 178-238/298
Sequence Identity: 45% (28 aa)

WYRAPELLLRKSIYTFEIDMWSFGCLLAEIVLNEPLFAGDSEIEQLFKVFKFIGSPDSETL
||||||.|||   |.  .|.|..||  .|.    |||.| ||| |.||  | .|.|. ...
WYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDW
Kinase 26482.AA PITSLRE 612-668 54 4.2e-24 84.74 In-house 170-226 (295) Show / Hide 
Range on Protein: 612-668
Range on HMM: 170-226/295
Sequence Identity: 54% (31 aa)

LWYRAPELLLRKSIYTFEIDMWSFGCLLAEIVLNEPLFAGDSEIEQLFKVFKFIGSP
||||||||||   .|.  .|||| || .||... .||| |.|||.|. ..||  | |
LWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTP
Kinase 26482.AA CDK4 612-668 54 1.5e-19 63.6 In-house 173-228 (290) Show / Hide 
Range on Protein: 612-668
Range on HMM: 173-228/290
Sequence Identity: 54% (31 aa)

LWYRAPELLLRKSIYTFEIDMWSFGCLLAEIVLNEPLFAGDSEIEQLFKVFKFIGSP
||||||| ||  | |   .|||| ||  ||.    ||| | || .|| |.|. .| |
LWYRAPEVLL-QSYYNTPVDMWSVGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLP
Kinase 26482.AA CRK7 612-668 32 4.6e-19 62.2 In-house 178-272 (343) Show / Hide 
Range on Protein: 612-668
Range on HMM: 178-272/343
Sequence Identity: 32% (31 aa)

LWYRAPELLLRKSIY--------------------------------------TFEIDMWSFGCLLAEIVLNEPLFAGDSEIEQLFKVFKFIGSP
||||.|||||    |                                      . |||||| ||.|.|    .|.| |  |..|| |..|  |||
LWYRPPELLLGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSP
Kinase 26482.AA RCK 532-585 37 7.7e-16 46.47 In-house 97-162 (298) Show / Hide 
Range on Protein: 532-585
Range on HMM: 97-162/298
Sequence Identity: 37% (25 aa)

QYKIPLIK--VKEIAYQILEGLNYLHHQGIMHRNLKIDNILLDK----------DVVKISDFGLSR
. ..| ..  .| | |||| ||...| .|..|| ||  ||.. .          |..|| ||||.|
RKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCR
Kinase 26482.AA GSK 534-582 49 1.2e-15 43.68 In-house 112-162 (328) Show / Hide 
Range on Protein: 534-582
Range on HMM: 112-162/328
Sequence Identity: 49% (25 aa)

KIPLIKVKEIAYQILEGLNYLHHQGIMHRNLKIDNILLD--KDVVKISDFG
..|.| .| ..||.. ||.|||. || || .| .|||.|  . |.||.|||
QMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFG
Kinase 26482.AA CRK7 546-586 50 1.1e-12 39.92 In-house 120-161 (343) Show / Hide 
Range on Protein: 546-586
Range on HMM: 120-161/343
Sequence Identity: 50% (21 aa)

QILEGLNYLHHQGIMHRNLKIDNILLD-KDVVKISDFGLSRL
|.|||..|.| ....|| .|. |||.. .  ||| |||| ||
QLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARL
Kinase 26482.AA CDK5 722-762 43 2.8e-12 34.61 In-house 247-287 (287) Show / Hide 
Range on Protein: 722-762
Range on HMM: 247-287/287
Sequence Identity: 43% (18 aa)

QKLKNLGTILGMQGMQLLNSLLQLNPYKRISSQEALNHPFF
| ....   |  .|| ||. .||.|| .||| ..||.||.|
QSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 26482.AA CDK4 540-585 46 9.4e-12 36.39 In-house 112-158 (290) Show / Hide 
Range on Protein: 540-585
Range on HMM: 112-158/290
Sequence Identity: 46% (22 aa)

VKEIAYQILEGLNYLHHQGIMHRNLKIDNILLDKD-VVKISDFGLSR
.|..  |.| |. .||   | || || .|||.  |  ||. ||||.|
IKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLAR
Kinase 26482.AA RCK 734-762 44 1.6e-11 32.57 In-house 270-298 (298) Show / Hide 
Range on Protein: 734-762
Range on HMM: 270-298/298
Sequence Identity: 44% (13 aa)

QGMQLLNSLLQLNPYKRISSQEALNHPFF
....|.. .|| .| |||. |.||.||.|
DCIELMEKMLQWDPQKRITAQQALQHPYF
TyrKc 26482.AA TyrKc 429-694 18 2.6e-11 -39.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 429-694
Range on HMM: 1-280/280
Sequence Identity: 18% (60 aa)

VERRSK------GRLFSAVSRLDHNQFMIRNVNIMISNAGQDDGVPTSILRELSYLQAL--DHPNITKIHEVDIKN-----------VIVQIVTKRQEYN
..   |      |. . .. .        ..| .   ...        ..||.. .  |  .|||| ... | ..            ...  . .    .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG---D

LKEYTRRYISQVQDDSKGLTRPQYKIPLIKVKEIAYQILEGLNYLHHQGIMHRNLKIDNILLDKDV-VKISDFGLSRLVSIP-HIPYTPEDPKERERSGR
||.| |..  .              ... .  ....|| .| .|||.... || |   |.|....  |||||||||| .    .         |..   |
LKDYLRKHRPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------ESKDYYR

E----ARR--LWYR--APELLLRKSIYTFEIDMWSFGCLLAEIV-LNEPLFAG-------DSEIEQLFKVFKFIGSPDS-------------ETLMSMCD
      ..  | .|  ||| . .....|.. | |||| .. ||  . ..   |       ..|. .. |  .    |..              ..|..| 
KKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCW

NPDYQQ--TFPKWKMINL
. |  .  ||       .
HEDPEDRPTFSEI-HECF
Kinase 26482.AA CDK4 717-762 32 1.2e-10 32.56 In-house 245-290 (290) Show / Hide 
Range on Protein: 717-762
Range on HMM: 245-290/290
Sequence Identity: 32% (15 aa)

RQNGFQKLKNLGTILGMQGMQLLNSLLQLNPYKRISSQEALNHPFF
.| . ...| . . .  || .||.  |  |. ||.|  ..|.||.|
PQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 26482.AA Pkinase_Tyr 528-643 30 1.6e-10 36.3 Pfam 98-208 (270) Show / Hide 
Range on Protein: 528-643
Range on HMM: 98-208/270
Sequence Identity: 30% (37 aa)

LTRP---QYKIPLIKVKEIAYQILEGLNYLHHQGIMHRNLKIDNILLD-KDVVKISDFGLSRLVSIPHIPYTPEDPKE-RERSGREARRLWYRAPELLLR
| ..   . ....    ....|| .|..||. ... || |   |.|.. . ||||.||||.|..         .|    | |.|      |. ||| .  
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--------YNDDYYYRKRGGGKLPIKWM-APECINY

KSIYTFEIDMWSFGCLLAEIV
.  .| . | |||| |. ||.
GK-FTTKSDVWSFGVLMWEIF
Kinase 26482.AA CRK7 736-762 40 1.6e-10 32.34 In-house 317-343 (343) Show / Hide 
Range on Protein: 736-762
Range on HMM: 317-343/343
Sequence Identity: 40% (11 aa)

MQLLNSLLQLNPYKRISSQEALNHPFF
..||  .| |.| ||.. .|.|.|..|
LDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 26482.AA PITSLRE 734-762 48 3.1e-10 33.66 In-house 267-295 (295) Show / Hide 
Range on Protein: 734-762
Range on HMM: 267-295/295
Sequence Identity: 48% (14 aa)

QGMQLLNSLLQLNPYKRISSQEALNHPFF
.|  ||| .| .|| .||.  .|| ||.|
TGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 26482.AA PITSLRE 546-585 48 2.6e-07 22.9 In-house 114-154 (295) Show / Hide 
Range on Protein: 546-585
Range on HMM: 114-154/295
Sequence Identity: 48% (20 aa)

QILEGLNYLHHQGIMHRNLKIDNILL-DKDVVKISDFGLSR
| | |  ..|   |||| ||  |.|.  | . || |||| |
QLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAR
Kinase 26482.AA CDK5 464-492 44 2e-06 16.08 In-house 38-66 (287) Show / Hide 
Range on Protein: 464-492
Range on HMM: 38-66/287
Sequence Identity: 44% (13 aa)

DDGVPTSILRELSYLQALDHPNITKIHEV
| ||| . .|| . |. | |.||  .| |
DEGVPSTAIREICLLKELKHKNIVRLHDV
Kinase 26482.AA CDK4 456-492 35 6e-06 16.16 In-house 32-71 (290) Show / Hide 
Range on Protein: 456-492
Range on HMM: 32-71/290
Sequence Identity: 35% (14 aa)

IMISNAGQDDGVPTSILRELS---YLQALDHPNITKIHEV
..|.. .   |.| | .|| |    |....|||| |  .|
VRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDV
Kinase 26482.AA CDK10 717-762 32 1.9e-05 14.6 In-house 240-285 (285) Show / Hide 
Range on Protein: 717-762
Range on HMM: 240-285/285
Sequence Identity: 32% (15 aa)

RQNGFQKLKNLGTILGMQGMQLLNSLLQLNPYKRISSQEALNHPFF
..  .  ||.  ..|.  |..||| |.  || ||  ..|.|.  .|
KKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase 26482.AA CDK10 465-492 50 3.2e-05 13.8 In-house 39-66 (285) Show / Hide 
Range on Protein: 465-492
Range on HMM: 39-66/285
Sequence Identity: 50% (14 aa)

DGVPTSILRELSYLQALDHPNITKIHEV
||.| | |||.  |  . |.|| ..|||
DGLPISGLREIMLLIQCRHENIVELHEV
Kinase 26482.AA RCK 472-492 54 0.002333 6.19 In-house 45-66 (298) Show / Hide 
Range on Protein: 472-492
Range on HMM: 45-66/298
Sequence Identity: 54% (12 aa)

LRELSYLQALD-HPNITKIHEV
|||.  | .|  |||| |..||
LREIKSLRKLNPHPNIIKLKEV
Kinase 26482.AA PITSLRE 465-492 44 0.012908 5.6 In-house 41-69 (295) Show / Hide 
Range on Protein: 465-492
Range on HMM: 41-69/295
Sequence Identity: 44% (13 aa)

DGVPTSILRELS-YLQALDHPNITKIHEV
.| |   ||| .  | || |||| .. |.
EGFPITSLREINMILMALQHPNIVNVKEI
Kinase 26482.AA CRK7 473-492 40 0.018991 4.02 In-house 50-69 (343) Show / Hide 
Range on Protein: 473-492
Range on HMM: 50-69/343
Sequence Identity: 40% (8 aa)

RELSYLQALDHPNITKIHEV
||   |. |.|.|| ...|.
REIKILRQLNHQNIVNLKEI
Cyclin_N 26482.AA Cyclin_N 808-940 34 1.6e-38 139.12 Pfam 1-143 (143) Show / Hide 
Range on Protein: 808-940
Range on HMM: 1-143/143
Sequence Identity: 34% (51 aa)

TIYQTMVKQEKI-ETLIKPDYMKDQA-----LITENMRIILIDWLTDVSVHFEAQDETLHYCISYIDRALGIM-N---IDKQKLQLVGVSCMKIADVFNE
 ||. | ..|.  .....||||..|       |...|| |||||. .|. .|. . |||. ...|||| |  . .   . ..|||||||.|| ||  . |
DIYHYMRHLEEKYQPRPPPDYMMQQPQPDQIDINWKMRAILIDWMVEVHEKFKLMPETLYLAVNYIDRFLSKQPPQNKVPRWKLQLVGVTCMFIACKYEE

RSREYY--KQENAIEYAYIT-AE-EYNAAQLIAMEKKILKVLSFQLN
     .  .  .  ...|||  .  |...|.. ||..|||.| . .|
I----NDAYPPEVKDFCYITKDNQAYTKDQILRMERHILKTLNWDMN
CYCLIN 26482.AA CYCLIN 844-933 26 1.2e-09 39.31 SMART 1-90 (90) Show / Hide 
Range on Protein: 844-933
Range on HMM: 1-90/90
Sequence Identity: 26% (25 aa)

DWLTDVSVHFEAQDETLHYCISYIDRALGIMNIDK-QKLQLVGVSCMKIADVFNERSREYYKQENAIEYAYITAE----EYNAAQLIAMEKKILK
||| ... .|.   |||| .. |.||.|  ... |  ..||....|| ||  . |.        .   ..|..      .|...... .|..||.
DWLRRFCKAFNLDPETLHLAWYYFDRFLMCYKMMKGYHPQLIAAACMYIACKMEEIP-----PWTPTLCHYTGYNWHIYAYTEEEIRRCERHILE
Cyclin_C 26482.AA Cyclin_C 942-1054 17 1.3e-08 33.99 Pfam 1-122 (137) Show / Hide 
Range on Protein: 942-1054
Range on HMM: 1-122/137
Sequence Identity: 17% (23 aa)

PNMMYFLKIM-CTLFDT--DSQVSVIAMFLAD-----LLLMSYE-ALRFKPSLLASCCIFLSFLTNE--RELPTQEKLNEVRSLLDHY--TINEFKEAAE
|. . ||      . .   |.|.   |....      | || |.  |...||..|. ...|.  .    .. |  |  ..    . .|  | ..... ..
PTPYHFLRRFLSKAAQYSPDMQMHHMAKYFMERCELILCLMDYDRFLHYPPSMIAAAAMYLARCMLNHPNSPP--EPWTPTLEHYTGYDITEEQLMPCVK

FVRKFWHYYRSDPN--TLNFQSVYNKYA
   .. .    ...  . ..|.|..||.
MMHELHQ----NAPYHNSKHQAVRKKYS
CYCLIN 26482.AA CYCLIN 946-1032 20 2.9e-08 34.69 SMART 1-90 (90) Show / Hide 
Range on Protein: 946-1032
Range on HMM: 1-90/90
Sequence Identity: 20% (18 aa)

YFLKIMCTLFDTDSQVSVIAMFLADLLLMSYEALR-FKPSLLASCCIFLSFLTNERELPTQEKLNEVRSLL--DHYTINEFKEAAEFVRK
 .|  .|  |. |...   |....|. || |. .. ..|.|.| .|....  . |.. .|..  .  . ..  . ||. |... .  . .
DWLRRFCKAFNLDPETLHLAWYYFDRFLMCYKMMKGYHPQLIAAACMYIACKMEEIPPWTPTLCHYTGYNWHIYAYTEEEIRRCERHILE