Gene 11773 (Tetrahymena)

11773

Species: Tetrahymena
Alias: PreTt11773, 1.m00821, 11773, 934, TTHERM_00011670
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CRK7

Sequence

Name Sequence Type Origin Length Description Download
11773.AA Protein None 700 None Fasta, JSON
11773.kin_dom Protein Kinase Domain None 335 None Fasta, JSON
11773.NA RNA None 2103 None Fasta, JSON

Protein domain

Protein domains of 11773.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11773.AA CRK7 26-360 58 1.1e-251 842.46 In-house 1-343 (343) Show / Hide 
Range on Protein: 26-360
Range on HMM: 1-343/343
Sequence Identity: 58% (202 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFESKDDKIKEDGFPITAVREILLLKQLDHVNIIKLREIILSK--PSEKNDYRGSTFLVFDYMDHDFAGL
|..|...|.||||.||||....|...|||||......|||..||||||.|||..|.||.|.||..|.||...|  .||.....||...||.|||||..||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

HRNK--HEFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNPNN--PKYTNKVVTLWYRAPELLLGAKEYTEQHILKE
...|  |.||.|..||.|||.|.|..|.|.|...|||.|..|||.||||||||||||||||.|...  ..|||.|.|||||.||||||...|||||||||
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

LIRNIKSIQLSLLISIYLKLTVQSSIFKKSNKQIDMWSVGCIFIELAVGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWKDMKPKRNFERKLR
||||||||||||||||||||||||||||||...|||||.|||..||........|.||..||.|||..|||||..|||||.||..|..|||||...|.||
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

EQVIERKK--NIDPQFLNLLDGIMVLNPKKRFTVQQCLDHEFF
|.....||  ......|.|||....|.||||||...||.|..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase 11773.AA CDK 26-360 35 1.4e-145 468.85 In-house 1-284 (284) Show / Hide 
Range on Protein: 26-360
Range on HMM: 1-284/284
Sequence Identity: 35% (129 aa)

YRLIAEVGSGTYGRVYKAECLRTK-----QYVALKKFESKDD--KIKEDGFPITAVREILLLKQLDHVNIIKLREIILSKPSEKNDYRG----STFLVFD
|  ....| |||| |||| ...|.     |.|||||.    .  .....||||||.||| |||.| | ||.||......| ...|. ..    . ..||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

YMDHDFAGLHRNKHEFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGE-----VKIADFGLARLLNP------NNPKYTNKVVTLWYRAPE
||||| ... .          ||.|.|.| |. |.| ....||||| .|||.||.||     .|||||||||. .       .| .||..||||||||||
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGAKEYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSNKQIDMWSVGCIFIELAV---GENLLRGENEPRQLDKIYELCGSPNTQNWPEVD
||||.|.|..                                    . .||||||||||.|..    .. |. |..|  ||.|| ..||.|. .|||.| 
LLLGSKHYSG------------------------------------GTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVT

KLQLWKDMKPKRNFERKLREQVIERKKNIDPQFLNLLDGIMVLNPKKRFTVQQCLDHEFF
||...                             .||.. ....||||.. .|.|.|..|
KLPDY-----------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 11773.AA CMGC 26-360 24 1e-121 402.0 In-house 1-513 (513) Show / Hide 
Range on Protein: 26-360
Range on HMM: 1-513/513
Sequence Identity: 24% (133 aa)

YRLIAEVGSGTYGRVYKAEC--------------LRTKQYVALKKFE---SKDDKI---KEDGFPITAVREILLLKQL-----------------DHVNI
|  |  .|.|||| |||. .               .|...||.||.     ....    ..|||||.| ||| .||.|                 .| ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IKLREIILSKPSEKNDYR---------GSTFLVFDYMDHDFAGLHRNKH---------EFSLQE------------LKCIM------KQILLGVQ--YLH
.||..|. .| |..|.|.          . .|||.||||| ... .|..         ..|  .             |..|      .||| |.   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

YKK--VIHRDLKIANILYNNQGEV--------------------KIADFGLARLLNPN---------------------NPKYTNKVVTLWYRAPELLLG
 ..  .|||||| .||| |...|.                    ||.|||||| ..|.                     |  ||. |||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

AKEYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSNKQIDMWSVGCIFIELAVG--------ENLLRGENE-----------PRQLDKIYELC
.|.||..    .                         .... ...|||||||||| |.  |        . |  |..|             ||.|| ...
WKHYTNH----N-------------------------YSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVL

GSPN---------------TQNWPEVDKLQLW-----------------------------KDMKPKRNFERKLREQV----------------------
|.|.               ...||.. ||. .                             . ..|.......   .                       
GTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKS

-----IERKKNIDPQFLNLLDGIMVLNPKKRFTVQQCLDHEFF
     .. .|..|||...||.......|.|| |..|.|.|..|
HKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 11773.AA S_TKc 26-360 21 1e-82 282.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-360
Range on HMM: 1-231/231
Sequence Identity: 21% (76 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFESKDDKIKEDGFPITAVREILLLKQLDHVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDH---DFAG
|... ..|.|..|.|||.   .|...||.|.              ... ||| .||. .| ||.|| ... .         .. ..|..|.|.   |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFD

LHRNKHE------FSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNPNNPKYTNKVVTLWYRAPELLLGAKEYTEQHI
. ...        |.  . ...|.||.....|.| ...|||||| .||| ..  ..||.||||||.|       |  ..|.||.|||.|           
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----------

LKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSNK-QIDMWSVGCIFIELAVGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWKDMKPKRNFE
                               . .|  .|.||.|||..|...|. . .      |........|                          
-------------------------------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------

RKLREQVIERKKNIDPQFLNLLDGIMVLNPKKRFTVQQCLD-------HEFF
              .|........... .|.|| |. ..|        |..|
--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11773.AA CDC2 26-212 42 2.2e-75 231.02 In-house 1-184 (301) Show / Hide 
Range on Protein: 26-212
Range on HMM: 1-184/301
Sequence Identity: 42% (82 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFESKDDKIKEDGFPITAVREILLLKQLD-HVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDHDFAGLH
|  |  .| |||| |||.. ..|.|.|||||.  . .   . |.| ||.||| .|| |. | ||.||...| .          . ..||.|.|.|   . 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGD-GVPSTAIREISCLKELKDHPNIVKLHDVIHQ---------NKLYMVFEYLDMDLKKYM

R----NKHEFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNPNNPKYT--NKVVTLWYRAPELLLGAKEYT
.     . ....| .| .|.||| || ..| ....|||||. ||| ...|..|||||||||  . .  .||    ||||||||||.|||.| |.
DMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYS
Kinase 11773.AA PITSLRE 26-212 43 1.8e-67 230.5 In-house 1-185 (295) Show / Hide 
Range on Protein: 26-212
Range on HMM: 1-185/295
Sequence Identity: 43% (84 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFESKDD--KIKEDGFPITAVREIL-LLKQLDHVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDHDFAG
.  .  .. |||| ||.|   ||   ||||..  | .  | || |||||..|||  .|. | | ||....||.. .   |       ..|..|..|| ..
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRL--KMERQKEKE-GFPITSLREINMILMALQHPNIVNVKEIVMGSNMDK------IYMVMEYVEHDLKS

LHRNKH----EFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNPNNPKYTNKVVTLWYRAPELLLGAKEYT
|  | .    .|.. | || | | |.||...| ....||||| .|.||...|  ||.||||||    .  .||  ||||||||||||||.|.|.
LMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYS
Kinase 11773.AA CDK7 26-212 40 5.1e-61 161.04 In-house 1-181 (288) Show / Hide 
Range on Protein: 26-212
Range on HMM: 1-181/288
Sequence Identity: 40% (77 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFE-SKDDKIKEDGFPITAVREILLLKQLDHVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDHDFAGLH
|  |. .| |... ||||  . | | || ||          .||   ||.||| .|. . | |.| |. |.  |         .  ||||.|| |     
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHK--------SNIQLVFDFMDWDLEVVI

RNKH-EFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNPNNPKYTNKVVTLWYRAPELLLGAKEYT
. |   .   . | .|...|.|. |.|   . |||||  | | |  |..|||||||||     |  || .||| |||||||| ||. |.
KDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYG
Kinase 11773.AA CDK9 26-211 43 1.2e-60 207.75 In-house 1-203 (340) Show / Hide 
Range on Protein: 26-211
Range on HMM: 1-203/340
Sequence Identity: 43% (89 aa)

YRLIAEVGSGTYG-----------RVYKAECLRTKQYVALKKFESKDDKIKEDGFPITAVREILLLKQLDHVNIIKLREIILSKPSEKNDYRG--STFLV
|  .| .| ||.|            |.|| . ..|. ||.||      |    |||||| ||| .|..| | |.. | ||   | .  | |..  . .||
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEK---EGFPITALREIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLV

FDYMDHDFAGLHRNKH-EFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLL------NPNNPKYTNKVVTLWYRAPELL
||. .|| |||  |    ||| . | .|.. . |  |.|  |. |||.| ||.|   .|  | |||||||         || | ||| ||||||| ||||
FDFCEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELL

LGAKEY
||  .|
LGDRNY
Kinase 11773.AA Pkinase 26-212 32 1.9e-58 205.28 Pfam 1-190 (293) Show / Hide 
Range on Protein: 26-212
Range on HMM: 1-190/293
Sequence Identity: 32% (67 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFESKDDKIKEDGFPITAVR--EILLLKQLDHVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDH-----
|...  .|||..|.|||.    | . ||.|... ...| ..|   .|..|  || ..| |.| ||..|...  .        ...  .|..|...     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKD---QTHRRLSEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVM

DFA----GLHRNKHEF--SLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEV----KIADFGLARLL-NPNNPKYTNKVVTLWYRAPELLLG
| .    .  ...  |  | .|.|..|.||| |..|.| ...|||||| .|||..|.|..    ||.|||||... . ||. .|  ..|.||.|||...|
DLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

AKEYT
...|.
GQYYG
Kinase 11773.AA CDK8 30-212 39 2.5e-56 174.86 In-house 1-203 (329) Show / Hide 
Range on Protein: 30-212
Range on HMM: 1-203/329
Sequence Identity: 39% (82 aa)

AEVGSGTYGRVYKAECLRT----KQYVALKKFESKD---DKIKEDGFPITAVREILLLKQLDHVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDHDFAG
 ..|.|||| ||||.   .    .. .|||.| ..    ...   |.  .| ||| |.. | | |.|.|... |.. ..|       ...|||  ||  .
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNH-KDKC-----VWMLFDYAEHDLWH

L---HRNKH-EFSLQE------LKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQG-E-----VKIADFGLARLL-NPNNPKYTNK--VVTLWYRAPE
    ||    ... .        | || ||| |. |||   |.||||| |||.    | |     |||||.|.||.  ||  | |..   |||.||||||
IIKFHRHNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPE

LLLGAKEYT
|||||. ||
LLLGARHYT
Kinase 11773.AA CDK10 26-212 45 7.9e-56 191.79 In-house 1-179 (285) Show / Hide 
Range on Protein: 26-212
Range on HMM: 1-179/285
Sequence Identity: 45% (86 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFESKDDKIKEDGFPITAVREILLLKQLDHVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDHDFAGLHR
.  .  || |||| ||.|   |..  |||||     .|   || || ..||| ||.|. | ||..|.|..  .  .      | ||| .| . | | |  
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEK---DGLPISGLREIMLLIQCRHENIVELHEVVVGQHLD------SIFLVMQYCEQDLASLLD

NKHE-FSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLL-NPNNPKYTNKVVTLWYRAPELLLGAKEYT
|  . |.  . |||| |.| |..||| . .||||||..|.|   .| .|.|||||||   .|  |  | |.|||||||||||||... |
NMPQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKP-MTPKMVTLWYRAPELLLGCRTQT
Kinase 11773.AA CDK5 26-212 41 6e-49 152.52 In-house 1-177 (287) Show / Hide 
Range on Protein: 26-212
Range on HMM: 1-177/287
Sequence Identity: 41% (78 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFESKDDKIKEDGFPITAVREILLLKQLDHVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDHDFAG-LH
|  .  .| |||| ||||    |. .||||.    ..     | | ||.||| ||| | | ||. |  .|    |||        ||| ..| |    . 
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSE---DEGVPSTAIREICLLKELKHKNIVRLHDVIH---SEKK-----LTLVFEFCDQDLKKYMD

RNKHEFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNPNNPKYTNKVVTLWYRAPELLLGAKEYT
  . | ...  | .| | | |... | ..| |||||  | | | .|| | |||||||        |.  |||||||.|  |.|.| |.
SCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYS
Kinase 11773.AA CDK5 253-360 31 3.8e-29 88.87 In-house 180-287 (287) Show / Hide 
Range on Protein: 253-360
Range on HMM: 180-287/287
Sequence Identity: 31% (35 aa)

IDMWSVGCIFIELA-VGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWK---DMKPKRNFERKLREQVIERKKNIDPQFLNLLDGIMVLNPKKR
|||||.|||| |.|  |  |  | ..  || .|... |.|.  .|| . ||  .|   .  |... .  . . |    .. | . ..|| .....||..|
IDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIV----PKLDEKGMDLLQKMLQCNPNQR

FTVQQCLDHEFF
 . .. | | .|
ISAKAALHHPYF
Kinase 11773.AA CDC2 253-360 32 1.5e-27 81.33 In-house 187-301 (301) Show / Hide 
Range on Protein: 253-360
Range on HMM: 187-301/301
Sequence Identity: 32% (38 aa)

IDMWSVGCIFIEL---AVGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWKDMKPKRNFERKLREQVIER--KKN----IDPQFLNLLDGIMVL
.||||.||||.|.   .  . |  |. |  || || .  |.|| |.||.|..|. .|   |.  ....  ......  ||     .||. . ||. . ..
VDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPR--WKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQY

NPKKRFTVQQCLDHEFF
.| || .... |.| .|
DPQKRISAKEALQHPYF
Kinase 11773.AA PITSLRE 253-360 34 8.2e-27 94.73 In-house 188-295 (295) Show / Hide 
Range on Protein: 253-360
Range on HMM: 188-295/295
Sequence Identity: 34% (38 aa)

IDMWSVGCIFIELAVGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWKDMK--PKRNFERKLREQVI-ERKKNIDPQFLNLLDGIMVLNPKKRF
.||||||||| |.  .. |. |..|. |...|  . | |. . || . .| .|| |.  |.   .  ||. .  |  . |  . . || .   .|||.|.
VDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAE--NHISDTGFDLLNQMLTYNPKNRI

TVQQCLDHEFF
|  . |.|..|
TASDALKHPWF
Kinase 11773.AA Pkinase_Tyr 26-193 29 2.9e-21 72.65 Pfam 1-171 (270) Show / Hide 
Range on Protein: 26-193
Range on HMM: 1-171/270
Sequence Identity: 29% (54 aa)

YRLIAEVGSGTYGRVYKAECL----RTKQYVALKKFESKDDKIK--EDGFPITAVREILLLKQL-DHVNIIKLREIILSKPSEKNDYRGS--TFLVFDYM
 ... . |.| .|.|||...      ||. || |.   . ..     . |     ||. ..||| .| ||..|  ...       | ...   ..|. ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCT-------DQGEPNQIYIVMEYM

DH----DFAGLHRN---KHEFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNPNNPKY-TNK
 |    |.  |...   |. .....| ..  ||  | .||. |. |||||   |.| .... |||.||||||..  |   | . .
PHGDLLDY--LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKR
Kinase 11773.AA CDK9 252-360 26 7.6e-20 64.92 In-house 206-340 (340) Show / Hide 
Range on Protein: 252-360
Range on HMM: 206-340/340
Sequence Identity: 26% (36 aa)

QIDMWSVGCIFIELAVGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWKDM----------KPKRNFERKLREQVI----------------ER
.||||  |||  |.      . |. | .||  | .|||| . . || .... ||. |            ||    ...  .                 . 
PIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRKVKDRMKNYMKFDAPDSKTDPFGKNVKQH

KKNIDPQFLNLLDGIMVLNPKKRFTVQQCLDHEFF
    |.| . |.|  ... |||| .  . ||| .|
DSATDQQACHLIDKLLNIDPKKRMDSDEALDHDWF
Kinase 11773.AA CDK10 253-360 33 2e-17 56.97 In-house 182-285 (285) Show / Hide 
Range on Protein: 253-360
Range on HMM: 182-285/285
Sequence Identity: 33% (36 aa)

IDMWSVGCIFIELAVGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQLWKDMKPKRNFERKLREQVIERKKNIDPQFLNLLDGIMVLNPKKRFTVQ
|||| ||||  || |.  |. |  |  |.| | .| |.|. . ||   .| . ..   |.     |...     . .    ..||. ... ||||| | .
IDMWAVGCILGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKF----HWLSQSGRRLLNFLFMYNPKKRATAE

QCLDHEFF
.||. ..|
ECLESSYF
Kinase 11773.AA CDK7 253-303 39 1.2e-14 35.0 In-house 184-234 (288) Show / Hide 
Range on Protein: 253-303
Range on HMM: 184-234/288
Sequence Identity: 39% (20 aa)

IDMWSVGCIFIELAVGENLLRGENEPRQLDKIYELCGSPNTQNWPEVDKLQ
.||||||||| ||      | |...  || .|..  | |. ..||.. ...
VDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMM
Kinase 11773.AA Pkinase 253-360 24 1.3e-14 52.77 Pfam 193-293 (293) Show / Hide 
Range on Protein: 253-360
Range on HMM: 193-293/293
Sequence Identity: 24% (27 aa)

IDMWSVGCIFIELAVGENLLRGE----NEPRQLDKIYELCGSPNTQNWPEVDKLQLWKDMKPKRNFERKLREQVIERKKNIDPQFLNLLDGIMVLNPKKR
.||||.|||..|.. |. . .|.    |  .|. .|..  | |.  .||. .   . .  .. .       .   .. .|... .. .....  ..||||
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----F-HWTF-HNWSEECKDFIKWCLCKDPKKR

FTVQQCLDHEFF
 | .|.| |..|
PTAEQILQHPWF
Kinase 11773.AA CDK8 253-360 26 1.4e-14 41.66 In-house 206-329 (329) Show / Hide 
Range on Protein: 253-360
Range on HMM: 206-329/329
Sequence Identity: 26% (33 aa)

IDMWSVGCIFIELAVGENLLRGENE-----------PRQLDKIYELCGSPNTQNWPEVDKLQLWKDMKP--KR--NFERKLREQVIERKK-NIDPQFLNL
|| |..|||| ||   | .  .. |             |||.| .. | |  . || . |.  .. .    .|  ..   .    .|. | . | . . |
IDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDSHAYHL

LDGIMVLNPKKRFTVQQCLDHEFF
|  ..   | || |  | ..| .|
LYKMLTMDPTKRITCEQAMEHPYF
Kinase 11773.AA TyrKc 26-262 19 7.2e-13 -14.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-262
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

YRLIAEVGSGTYGRVYKAECLRTKQYVALKKFESKDDKIKEDGFPITAVREILLLKQL--DHVNIIKLREIILSKPSEKNDYRGSTFLVFDYMDH----D
 .|. . |.| .|.|||..     . || |.  .               ||. ....|  .| ||..|  .....      | .  ..|. ||.|    |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKD

FAGLHRNKHEFSLQELKCIMKQILLGVQYLHYKKVIHRDLKIANILYNNQGEVKIADFGLARLLNPN-----NPKYTNK----VVT--LWYR--APELL-
.  |...........|  .. ||  | .||| |..|||||   |.|..... |||.||||.| .        . .|  |         | .|  ||| . 
Y--LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

----------------------LGAKEY-------TEQHILKELIRNIKSIQLSLL--------ISIYLKLTVQSSIFKKSNKQIDMWSVGCIF
                      .|.. |        .   . |.... .                .  .    ..    . ..   .. .  .|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 11773.AA CDK7 334-360 44 7.8e-09 19.2 In-house 262-288 (288) Show / Hide 
Range on Protein: 334-360
Range on HMM: 262-288/288
Sequence Identity: 44% (12 aa)

LNLLDGIMVLNPKKRFTVQQCLDHEFF
| |. |.  .|| || |  ||| ...|
LDLMCGMWTMNPCKRWTCTQCLKMPYF