Gene 17811 (Tetrahymena)

17811

Species: Tetrahymena
Alias: PreTt17811, 305, 17811, TTHERM_00837980, 146.m00112, 3743.m00043
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
17811.AA Protein None 562 None Fasta, JSON
17811.kin_dom Protein Kinase Domain None 273 None Fasta, JSON
17811.NA RNA None 1689 None Fasta, JSON

Protein domain

Protein domains of 17811.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17811.AA CDKL 240-524 43 5.1e-167 561.16 In-house 2-286 (286) Show / Hide 
Range on Protein: 240-524
Range on HMM: 2-286/286
Sequence Identity: 43% (126 aa)

QILSILEEADYFKLYKCLNKETQKIIAIKAYKLNINQVEEKKRIEREVKIKKMLHHKNIVDIIEICQKNNEIYIVEEYVEISLSNYLKQGSQQKGLDQNV
 .|. . |  | ...|| ||||..|.|||..| . .. ..||...||.|..|.|.|.|||..||..........|.||........|..  ...|.|..|
EKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEE--YPNGVDEHV

IPNIMYQVLSSINQCHKYDIIHQNIKPMHIYINPSNYELKLNGFRLARQLPQKGEIVTDYVEARWYKSPEYLLDYRKYGKPEDIWAAACVMAELIDGEPL
....|.|.|..||.|||...||..|||..|.|.|.|...||..|..||.|...|||.||||..|||..||.|.....||||.||||..|||||.|||.||
VRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGQGEIDQFYRIVQVIGPLTNQYENLFKKK--YKDLKFPIIKNFNSIELRYQGKINAEGLDLMKMMLKMNPDERITAEQSLSHPFF
.|||..|||.|.|....|||.......|.|.  ....|||.|......|.||..|.|.. ||.||..|.|.||||.|.||...||.|
WPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 17811.AA CMGC 254-524 21 4.9e-89 292.65 In-house 16-513 (513) Show / Hide 
Range on Protein: 254-524
Range on HMM: 16-513/513
Sequence Identity: 21% (107 aa)

YKCLN--------------KETQKIIAIKAYKLNINQVEEKK----------RIEREVKIKKML-----------------HHKNIVDIIEICQKNN---
||| .              .||..|.|||  |..    |..|          |. ||.|| |.|                 ||.||| ...|.. .|   
YKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDG

--------------EIYIVEEYVEISLSNYLKQGS------QQKGLDQNV------------IPNIM------YQVLSSIN--QCHKYD--IIHQNIKPM
              ..|.| ||.. .| .|.|. .      ....|.. .            | ..|      ||.| ...   ||. .  |||  .|| 
NEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPE

HIYINPSN-------------------YELKLNGFRLARQLPQK---------------------GEIVTDYVEARWYKSPEYLLDY---------RKYG
 | ||. .                   ..||.  | |||.. .                      ..  |.||  |||..|| || .         ..|.
NILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYT

KPEDIWAAACVMAELIDG--------EPLFPGQGE-----------IDQFYRIVQVIGPLT------------NQYENLFKKKYK---------------
.| |.|...|..||.. |        .|||||. |           ||| ..|..|.|. |            ...|. . .. |               
TPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQT

---DLK------------FPIIK--NFNSIELRYQG-------------------------------KINAEGLDLMKMMLKMNPDERITAEQSLSHPFF
   ...            || ..  ...... ...                                ... ...||.| ||...||.|||||| |.||.|
MTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 17811.AA CDK 254-524 28 3e-50 158.88 In-house 16-284 (284) Show / Hide 
Range on Protein: 254-524
Range on HMM: 16-284/284
Sequence Identity: 28% (87 aa)

YKCLNKETQ-----KIIAIKAYKLNIN-QVEEKKRIE----REVKIKKMLHHKNIVDIIEICQKN-----------NEIYIVEEYVEISLSNYLKQGSQQ
||. .|.|.     .|.|.|  ..  . . |||  .     ||... | | |.||| ....|  .           | .|.| ||..  |. |..     
YKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-----

KGLDQNVIPNIMYQVLSSINQCHKYDIIHQNIKPMHIYINPSNY----ELKLNGFRLARQLPQ------KGEIVTDYVEARWYKSPEYLLDYRKYG--KP
       | ..|.| |. .. ||.  |.|  .||  | ||         ||.  | |||          .    |  |  .|| .|| ||  ..|.   |
-------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTP

EDIWAAACVMAELID---GEPLFPGQGEIDQFYRIVQVIG-PLTNQYENLFKKKYKDLKFPIIKNFNSIELRYQGKINAEGLDLMKMMLKMNPDERITAE
 |.|.. |..||..    ..|||||. ||||  .| ...| |  ..  .. |  .                           ||.  || ..|. ||.||
IDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNKMLCYDPKKRISAE

QSLSHPFF
| |.||.|
QALQHPYF
Kinase 17811.AA CDK5 240-524 30 7.5e-50 155.43 In-house 2-287 (287) Show / Hide 
Range on Protein: 240-524
Range on HMM: 2-287/287
Sequence Identity: 30% (89 aa)

QILSILEEADYFKLYKCLNKETQKIIAIKAYKLNINQVEEKKRIEREVKIKKMLHHKNIVDIIEICQKNNEIYIVEEYVEISLSNYLKQGSQQKGLDQNV
. .  . |  |   || .||||. |.|.|  .|. .         ||. . | | ||||| .. .   .. . .| |..   |  |. .     ..|...
EKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG--EMDMHI

IPNIMYQVLSSINQCHKYDIIHQNIKPMHIYINPSNYELKLNGFRLARQLPQKGEIVTDYVEARWYKSPEYLLDYRKYGKPEDIWAAACVMAELI-DGEP
|  .||| |  .  ||.  . |   ||    ||  | ||||  | |||         .  |   ||  |  |.  ..|  . |.| . |..||..  | |
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLIN-KNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LFPGQGEIDQFYRIVQVIG-PLTNQYENLFK-KKYK--DLKFPIIKNFNSIELRYQGKINAEGLDLMKMMLKMNPDERITAEQSLSHPFF
|||| .. ||  || ...| |  ..   . |  .||    ..|.     | .   ..  ...|.||.. ||..||..||.|.. | ||.|
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 17811.AA CDC2 254-524 29 2.9e-47 143.0 In-house 16-301 (301) Show / Hide 
Range on Protein: 254-524
Range on HMM: 16-301/301
Sequence Identity: 29% (84 aa)

YKCLNKETQKIIAIKAYKLNINQVE--EKKRIEREVKIKKMLH-HKNIVDIIEICQKNNEIYIVEEYVEISLSNYLK-QGSQQKGLDQNVIPNIMYQVLS
||| ...|..|.|.|  .|  .. .      . ||  . | |  |.||| . ..  . | .|.| ||..  | .|.. . ...| ...... ..||| |.
YKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQ

SINQCHKYDIIHQNIKPMHIYINPSNYELKLNGFRLARQLPQKGEIVT--DYVEARWYKSPEYLLDYRKYGKPEDIWAAACVMAEL---IDGEPLFPGQG
 .. ||   |.| ..||  | |. .. ..|.  | |||  .      |    |. .|| .|| ||  ..|  | |.|.  |..||.   .  .|||.|. 
GVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDS

EIDQFYRIVQVIG-PLTNQYENLFKKKYKDLKFPIIKNFNSIELRYQ-------GKINAEGLDLMKMMLKMNPDERITAEQSLSHPFF
|||| ..| ...| |  . .... . ..   .||  |  .  .. ..         .. ||.|| . ||  .|  ||.|.. |.||.|
EIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
S_TKc 17811.AA S_TKc 239-524 26 8.7e-45 156.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 239-524
Range on HMM: 1-231/231
Sequence Identity: 26% (80 aa)

SQILSILEEADYFKLYKCLNKETQKIIAIKAYKLNINQVEEKKRIEREVKIKKMLHHKNIVDIIEICQKNNEIYIVEEYVEI---SLSNYLKQGSQQKG-
 .|| .. .  . | ||| .|.|..| |||  |         ..|.||..| |. ||.||| .....|  ...|.| ||..    .|  |.|.   ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDQNVIPNIMYQVLSSINQCHKYDIIHQNIKPMHIYINPSNYELKLNGFRLARQLPQKGEIVTDYVEARWYKSPEYLLDYRKYGK-PEDIWAAACVMA
  ..  ..  .|||... .. ||.  |||  .||  | ..    ..|.  | |||||       | ..  .|| .|| |    .||| . |.|.  |...
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

ELIDGEPLFPGQGEIDQFYRIVQVIGPLTNQYENLFKKKYKDLKFPIIKNFNSIELRYQGKINAEGLDLMKMMLKMNPDERITAEQSLS-------HPFF
|.. |.|.||      | ... ..||                                      |..|... .|...|..|.|| . |        ||.|
EMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17811.AA Pkinase 254-524 28 2.2e-44 158.04 Pfam 16-293 (293) Show / Hide 
Range on Protein: 254-524
Range on HMM: 16-293/293
Sequence Identity: 28% (82 aa)

YKCLNKETQKIIAIKAYKLNINQVEEKKRIER--EVKIKKMLHHKNIVDIIEICQKNNEIYIVEEYVEI-----SLSNYLKQGSQQKGL--DQNVIPNIM
||| .| |.|| |.|  |.  .  .....  |  |..| |.|.|.||| ...... ...||.| ||.|      .|. |..  ......  . ... ..|
YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYM

YQVLSSINQCHKYDIIHQNIKPMHIYINPSNYEL----KLNGFRLARQL-PQKGEIVTDYVEARWYKSPEYLLDYRKYGKPEDIWAAACVMAELIDGEPL
||.|. .. ||.  |||  .||  | |. .|...    |.  | ||.|.   ...  |...  .|| .|| ......||.. |.|.. |...|.. |.|.
YQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP

FPGQ----GEIDQFYRIVQVIGPLTNQYENLFKKKYKDLKFPIIKNFNSIELRYQGKINAEGLDLMKMMLKMNPDERITAEQSLSHPFF
|||.    . .|| ..|... || .   .     .. .  |.. .    . ..   ... |..|..| .|...| .|.|||| | ||.|
FPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 17811.AA ERK7 240-524 29 3.1e-43 145.54 In-house 2-292 (292) Show / Hide 
Range on Protein: 240-524
Range on HMM: 2-292/292
Sequence Identity: 29% (86 aa)

QILSILEEADYFKLYKCLNKETQKIIAIKAYKLNINQVEEKKRIEREVKIKKMLH-HKNIVDIIEICQKNNE--IYIVEEYVEISLSNYLKQGSQQKGLD
.|.. |    |    | . | |....|.|             |  ||. . . .| | ||. .|.. . .|.  ||.| |. |  | .  ..|.  |   
EIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIH

QNVIPNIMYQVLSSINQCHKYDIIHQNIKPMHIYINPSNYELKLNGFRLARQLPQKGE------IVTDYVEARWYKSPEYLLDYRKYGKPEDIWAAACVM
. .   ||||.|  |   |  ..||  .||  | .. |.  .|.  | ||| . |. |      ..|.||  ||| .|| ||  ..| |  | |   |..
KQY---IMYQLLRAIKYMHSGNVIHRDLKPSNILLD-SECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AELIDGEPLFPGQGEIDQFYRIVQVIGPLTNQYENLFKKKYKD--LKFPIIKNFNSIELRYQGKINAEGLDLMKMMLKMNPDERITAEQSLSHPFF
.|.. | |.|||   ..|  .|...|.  |..  .  . .|    |.  . ..  ...  .. .   ...||.| .| .||..|.|||| |.||. 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 17811.AA MAK 259-457 36 3.3e-39 122.18 In-house 51-265 (352) Show / Hide 
Range on Protein: 259-457
Range on HMM: 51-265/352
Sequence Identity: 36% (80 aa)

KETQKIIAIKAYKLNINQVEEKKRIEREVKIKKMLH-HKNIVDIIEICQ--KNNEIYIVEEYVEISLSNYLKQGSQQK-GLDQNVIPNIMYQVLSSINQC
..|. ..|||  |      ||  .. ||||  | |  | ||| . |.     |.. |.| || .  |   .|    ..  .   || |||||.|  .   
IDTGEKVAIKRMKKKFYSWEECMNL-REVKSLKKLNAHPNIVKLKEVIRDSENDHLYFVFEYMKENLYQMMKD--RDRRHFPEPVIRNIMYQILQGLAFM

HKYDIIHQNIKPMHIYINPS----------------NYELKLNGFRLARQLPQKGEIVTDYVEARWYKSPEYLLDYRKYGKPEDIWAAACVMAELIDGEP
||    |  .||  | ....                |. .|.  | ||| .  |    ||||  ||| .|| ||   .|..| |.||  |.||||    |
HKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRSK-PPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRP

LFPGQGEIDQFYRIVQVIG
||||  |||| . |.||.|
LFPGSSEIDQIFKICQVLG
Kinase 17811.AA RCK 258-457 37 8.3e-39 120.56 In-house 20-231 (298) Show / Hide 
Range on Protein: 258-457
Range on HMM: 20-231/298
Sequence Identity: 37% (81 aa)

NKETQKIIAIKAYKLNINQVEEKKRIEREVKIKKMLH-HKNIVDIIEICQKNN--EIYIVEEYVEISLSNYLKQ--GSQQKGLDQNV--IPNIMYQVLSS
||||..|.|||  |   .  || ..  ||.|  . |. |.||. ..|. . |.  . |.| ||..  |. ..|      .| | .|.  | |||||.| .
NKETGEIVAIKKMKQKFYSWEECMNL-REIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKE-RRKYLPENQRSIKNIMYQILQG

INQCHKYDIIHQNIKPMHIYINPS--------NYELKLNGFRLARQLPQKGEIVTDYVEARWYKSPEYLLDYRKYGKPEDIWAAACVMAELIDGEPLFPG
....||  . |  .||  |....|        .. .|.  | |.|    |    ||||  ||| .|| ||   .| .| ||||  |.|.||    |||||
LAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPY-TDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPG

QGEIDQFYRIVQVIG
. |||| . |..|.|
SSEIDQIFKICKVMG
Kinase 17811.AA p38 281-457 33 2.4e-30 100.69 In-house 46-221 (289) Show / Hide 
Range on Protein: 281-457
Range on HMM: 46-221/289
Sequence Identity: 33% (62 aa)

KRIEREVKIKKMLHHKNIVDIIEICQK-------NNEIYIVEEYVEISLSNYLKQGSQQKGLDQNVIPNIMYQVLSSINQCHKYDIIHQNIKPMHIYINP
||. ||..  |...| |.......           ...|.| .  . .|.|..|.      |    |  . ||.|      |  .|||   ||  | .| 
KRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKCQR----LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVN-

SNYELKLNGFRLARQLPQKGEIVTDYVEARWYKSPEYLLDYRKYGKPEDIWAAACVMAELIDGEPLFPGQGEIDQFYRIVQVIG
 . ||.   | |||   .. .  |.||  |||..|| .|   .| .  |||   |.||||| |..||||.  |||  ||..|.|
EDCELRILDFGLAR---HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCG
Kinase 17811.AA MAPK 377-457 33 1.3e-19 64.33 In-house 155-252 (328) Show / Hide 
Range on Protein: 377-457
Range on HMM: 155-252/328
Sequence Identity: 33% (33 aa)

ELKLNGFRLARQLPQ-KGEIV-------------TDYVEARWYKSPEYLLD--YRKYGKPEDIWAAACVMAELID-GEPLFPGQGEIDQFYRIVQVIG
.||.  | |||.. . . ..              |.||  ||| .|| .|   ...| |  |.|.. | .||..  . |||||.  |||. .|..|.|
DLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLG
Kinase 17811.AA RCK 493-524 43 2.9e-15 44.61 In-house 267-298 (298) Show / Hide 
Range on Protein: 493-524
Range on HMM: 267-298/298
Sequence Identity: 43% (14 aa)

INAEGLDLMKMMLKMNPDERITAEQSLSHPFF
.. ....||..||. .|..||||.|.| ||.|
CSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 17811.AA MAPK 494-524 48 7.2e-14 44.13 In-house 298-328 (328) Show / Hide 
Range on Protein: 494-524
Range on HMM: 298-328/328
Sequence Identity: 48% (15 aa)

NAEGLDLMKMMLKMNPDERITAEQSLSHPFF
| . .||.. || ..||.|||.|. |.||.|
NPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 17811.AA MAK 492-524 35 4.7e-11 30.98 In-house 319-352 (352) Show / Hide 
Range on Protein: 492-524
Range on HMM: 319-352/352
Sequence Identity: 35% (12 aa)

KINA-EGLDLMKMMLKMNPDERITAEQSLSHPFF
...  ....||| ||. .|..| ||.|.. .|.|
NCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 17811.AA p38 498-524 51 5.7e-11 33.44 In-house 263-289 (289) Show / Hide 
Range on Protein: 498-524
Range on HMM: 263-289/289
Sequence Identity: 51% (14 aa)

LDLMKMMLKMNPDERITAEQSLSHPFF
.||. .||.. || |||||. ..||.|
IDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 17811.AA MAPK 281-348 31 9.4e-09 26.16 In-house 49-125 (328) Show / Hide 
Range on Protein: 281-348
Range on HMM: 49-125/328
Sequence Identity: 31% (25 aa)

KRIEREVKIKKML-HHKNIVDIIEICQKN-----------NEIYIVEEYVEISLSNYLKQGSQQKGLDQNVIPNIMYQVL
||. ||.|. ... ||.||. ...| .             |.||||.|. |  | . .|..     |.   |  .|||.|
KRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ---PLSDDHIQYFMYQIL
TyrKc 17811.AA TyrKc 239-524 17 6e-06 -126.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 239-524
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)

SQILSILEEADYFKLYKCLNKETQKIIAIKAYKLNINQVEEKKRIEREVKIKKML--HHKNIVDIIEICQKN-------NEIYIVEEYVE-ISLSNYLKQ
 . . .| |  . . ||.  |      |.|  | .      .. . || .| ..|  ||.||| .. .| .          ..|| ||..  .| .||. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

GSQQKGLDQNVIPNIMYQV------LSSINQCHKYDIIHQNIKPMHIYINPSNYELKLNGFRLARQLPQK-------GEIV------TDY-VEARWYKSP
   .  |      ....|.      |.|        .||  .    . ..  .   |   | |.| .  .         ..      ... .  ||. .|
HRPK--LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-AP

EYLLDYRKYGKPEDIWAAACVMAELI-DGEPLFPGQ----GEIDQFYRIVQVIGPLTNQYE----NLFKKKYKDLKFPIIKNFNSIELRYQGKINAEGLD
| . .|.|.    |.|.   .| |.  .|..  ||.     . .. .. |.  . .    .                            .     .|  .
ECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F-VCCPDEMYQ

LMKMMLKMNPDERITAEQSLSHPFF
.||.  . .|..| | ..   | .|
IMKQCWHEDPEDRPTFSEI--HECF