Gene 7414 (Tetrahymena)

7414

Species: Tetrahymena
Alias: 207, 87.m00194, PreTt07414, 3814.m00898, TTHERM_00624260, 7414
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
7414.AA Protein None 623 None Fasta, JSON
7414.kin_dom Protein Kinase Domain None 276 None Fasta, JSON
7414.NA RNA None 1872 None Fasta, JSON

Protein domain

Protein domains of 7414.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 7414.AA CDKL 4-279 59 9.80000000001e-203 679.81 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-286/286
Sequence Identity: 59% (172 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETEDDELVRKNIQREVKMLKTLKHKNIVGLVEAFKRKGRIYLVFEYVEKNLLEVLEEKPSGLD----
||.||.||||.||||.||||.||..| |||||||.|||..|.|...||.||||.|||.|||.|.|.|.||....|||||.....|..|||.|.|.|    
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

------LLKALDHCHKHNIIHRDIKPENLLVN-SDGTLKLCDFGFARHMPPKQNEILTDYVATRWYRSPELLLSDPGYSFPVDNWAIACIMGELIDGQPL
      .|||...|||||.|||||||||.|.. ..|..||||||||| |..|..||.||||||||||.||||. |. |. ||| |||.|.|.|.||||||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPL

FPGENEIDQLYLIQKLLGPLTPDQKEMFIKNPRYVGLKFPEIPKPETIERRYLGKLSKKALTFMKGLLKMDPRERMNVQEAMAHPLF
.||...|||||.||| ||||.|...|.|.|||...|.|||||...|..|.||..|..||||.|||..|.|||.|||.....| ||.|
WPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 7414.AA CMGC 4-279 23 7.79999999999e-125 412.46 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-513/513
Sequence Identity: 23% (122 aa)

YEILGVVGEGAYGVVLKCRN--------------RETNEILAIKKFKETEDDELVRK----------NIQREVKMLKTLK-----------------HKN
|||....|||.|||| |||.              .||||| ||||.|. . .|   |           ..||.|.|| |.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVGLVEAFKRKG-----------------RIYLVFEYVEKNLLEVLEEKP---------------------------SGLD--------LLKALD--HCH
||.| . |..|.                  .||||||....|........                             .         .|..|.  .||
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KHN--IIHRDIKPENLLVNSD--------------------GTLKLCDFGFARHMPPKQ--------------------NEILTDYVATRWYRSPELLLS
.|.  |||||.||||.|.|..                    |.||.||||.||.  | .                    |. .|.||.|||||.||.||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

D---------PGYSFPVDNWAIACIMGELIDG--------QPLFPGENE-----------IDQLYLIQKLLGPLT---------------PD--------
.          .|. |.| |...||..|.. |        .|||||..|           ||||..| |.||. |               ..        
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------QKEMFIKNPRYVGLKFPEIPKP--ETIERRYLG-------------------------------KLSKKALTFMKGLLKMDPR
                 ..  | .|..  ...||..|..  . .. ..                                 .....|. ..|..|..|| 
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

ERMNVQEAMAHPLF
.|. ...|..|| |
KRITAEQALQHPYF
Kinase 7414.AA CDK 4-279 34 5.2e-97 310.92 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-284/284
Sequence Identity: 34% (107 aa)

YEILGVVGEGAYGVVLKCRNRETN-----EILAIKKFK-ETE----DDELVRKNIQREVKMLKTLKHKNIVGLVEAFKRK-----------GRIYLVFEY
||.|  .|||.|||| |.|...|.     .| |.||.. |.|    ..| .     ||...|| | |.||| | . .  |            ..|.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VEKNLLEVLEEKPSGLDLLKALDHCHKHNIIHRDIKPENLLVNSDGT-----LKLCDFGFARHMP-PKQ----NEILTDYVATRWYRSPELLLSDPGYS-
..  | .... |   . ||..|..||...|.|||.|| |.|.|..|.     ||. |||.|| .  |.|    |  .|  | |.|||.||||| .  || 
MDHDLKKYMDIKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSG

-FPVDNWAIACIMGELID---GQPLFPGENEIDQLYLIQKLLGPLTPDQKEMFIKNPRYVGLKFPEIPKPETIERRYLGKLSKKALTFMKGLLKMDPRER
  |.| |.. ||..|..    ..|||||..||||| .| ...|  |.|.   . | | |                            .. ..| .||  |
GTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNKMLCYDPKKR

MNVQEAMAHPLF
.. ..|. || |
ISAEQALQHPYF
Kinase 7414.AA S_TKc 4-279 29 2.7e-91 310.53 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-231/231
Sequence Identity: 29% (89 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETEDDELVRKNIQREVKMLKTLKHKNIVGLVEAFKRKGRIYLVFEYVEK---NLLEVLEEKPS----
|||| ..|.||.|.| |||...|..| |||. |         ..|.||...||  .|.||| | ..|   ...|.|.||..    .|.........    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

----------GLDLLKALDHCHKHNIIHRDIKPENLLVNSDGTLKLCDFGFARHMPPKQNEILTDYVATRWYRSPELLLSDPGYSF-PVDNWAIACIMGE
             ...||..||.|.|||||.||||.|...  ..|.||||.||..        | .. |.||..||.|    ||.. ..| |.. ||. |
FPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LIDGQPLFPGENEIDQLYLIQKLLGPLTPDQKEMFIKNPRYVGLKFPEIPKPETIERRYLGKLSKKALTFMKGLLKMDPRERMNVQEAMA-------HPL
.. |.|.||      |.... |..|                                      |. |. |....|..||..|. . ||..       || 
MLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase 7414.AA Pkinase 4-279 28 5.2e-87 300.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETEDDELVRKNIQR--EVKMLKTLKHKNIVGLVEAFKRKGRIYLVFEYVEK-----NLLEVLE---E
|.|....|.|..|.| ||... |..| |.|..|  .... ....  |  |....| |.|.||| | ..| .|..||.|.||.|.      | ....   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KPS----------GLDLLKALDHCHKHNIIHRDIKPENLLVNSDGTL----KLCDFGFARHMPPKQNEILTDYVATRWYRSPELLLSDPGYSFPVDNWAI
..            . .|..|..||...|||||.||||.|....|..    |.||||.|...    |. .|... |.||..||.......|. .|| |..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

ACIMGELIDGQPLFPGE----NEIDQLYLIQKLLGPLTPDQKEMFIKNPRYVGLKFPEIPKPETIERRYLGKLSKKALTFMKGLLKMDPRERMNVQEAMA
 ||. |.. |.|.|||.    | .||...|.. .|| .. . .  . ....  ... . .   . ...   ..|. .. |.|..|..|| .| . .... 
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPLF
|| |
HPWF
Kinase 7414.AA CDC2 4-279 33 4.6e-82 251.9 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-301/301
Sequence Identity: 33% (102 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETEDDEL--VRKNIQREVKMLKTLK-HKNIVGLVEAFKRKGRIYLVFEYVEKNLLEVLE-EKP--SG
|. .  .||| |||| ||....||.| |.||.. . .||   |   . ||   || || |.||| | . ..   ..|.||||.. .| . .. ..|  . 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LD----------LLKALDHCHKHNIIHRDIKPENLLVNSDGTLKLCDFGFARHMPPKQNEILTD-YVATRWYRSPELLLSDPGYSFPVDNWAIACIMGEL
..          .|.....|| . |.|||.|| |.|....|..|. ||| ||  .   ....|.  | |.|||.||.|| .  ||.||| |.| ||. |.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---IDGQPLFPGENEIDQLYLIQKLLGPLTPDQKE-MFIKNPRYVGLKFPEIPKP---ETIERRYLGK----LSKKALTFMKGLLKMDPRERMNVQEAMA
   .   |||.|. |||||. | . ||  ||. .. . ...  .   .||. ..    . ..... .|    | ....   . .|  ||  | ...||..
FMDVTKKPLFHGDSEIDQLFKIFRILG--TPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HPLF
|| |
HPYF
Kinase 7414.AA CDK7 4-210 39 2.6e-78 208.05 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-210
Range on HMM: 1-220/288
Sequence Identity: 39% (89 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFK-----ETEDDELVRKNIQREVKMLKTLKHKNIVGLVEAFKRKGRIYLVFEYVEKNLLEVLEEK----
||..  .||| ...| | .  .|..| |||| |     .  .| . |  | ||.|.|. ..| |..||. .|  |  |.|||.. .  | .| . |    
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAI-REIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIIL

-PSG-----LDLLKALDHCHKHNIIHRDIKPENLLVNSDGTLKLCDFGFARHMP-PKQNEILTDYVATRWYRSPELLLSDPGYSFPVDNWAIACIMGELI
 |.      . .|. | .||.. | |||.|| |||.|..| ||. ||| ||  . |  |.|.|  | |||||.||||     |   || |.. ||. ||.
TPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSP--NRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM

DGQPLFPGENEIDQLYLIQKLLG
   | .||...||||  | . ||
LRVPYLPGDSDIDQLTRIFQTLG
Kinase 7414.AA CDK5 4-279 36 7.8e-72 226.12 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-287/287
Sequence Identity: 36% (105 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETEDDELVRKNIQREVKMLKTLKHKNIVGLVEAFKRKGRIYLVFEYVEKNLLEVLEEKPSGLD----
|| .  .||| ||.| | ||.|| || |.|. .  ..|| |     ||. .|| ||||||| |        .. ||||.. . |   ...   ..|    
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

------LLKALDHCHKHNIIHRDIKPENLLVNSDGTLKLCDFGFARH--MPPKQNEILTDYVATRWYRSPELLLSDPGYSFPVDNWAIACIMGELI-DGQ
      ||| |  ||.|.. ||| || |||.|  |.||| ||| ||    | .     .  | | ||| |  |.    || ..| | . ||. |..  |.
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVR---CYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGR

PLFPGENEIDQLYLIQKLLGPLTPDQKEMFIKNPRYV--GLKFPEIPKPETIERRYLGKLSKKALTFMKGLLKMDPRERMNVQEAMAHPLF
||||| .. ||| .| |..|  . |.     | | |     ..|  |  .. .    . |..| . .....|...| .|.  ..|. || |
PLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 7414.AA ERK7 4-279 32 1.2e-66 226.83 In-house 1-292 (292) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-292/292
Sequence Identity: 32% (96 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETEDDELVRKNIQREVKMLKTLK-HKNIVGLVEAFKRKGR--IYLVFEYVEKNLLEVLE--------
|||.  .| ||||.| |   . | ...|.||      ..       ||. .|. .. | ||. |.. .. .    ||||||. |  |  |          
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

-EKPSGLDLLKALDHCHKHNIIHRDIKPENLLVNSDGTLKLCDFGFARHMPPKQ-----NEILTDYVATRWYRSPELLLSDPGYSFPVDNWAIACIMGEL
  .     ||.|. . |  |.||||.|| |.|..|. ..|.|||| || .  ..     | .||.||||||||.|| ||.   |   || | | ||.||.
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

IDGQPLFPGENEIDQLYLIQKLLGPLTPDQKEMFIKNPRYVGLKFPEIPKPETIERRYLGKLSKKALTFMKGLLKMDPRERMNVQEAMAHPLF
. |.|.|||   ..|. .| ....  |    |    . . . |.  .  |..|..  .  . .. |.  .| || . |..|. ...|..||  
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 7414.AA RCK 100-279 37 1.7e-59 187.29 In-house 114-298 (298) Show / Hide 
Range on Protein: 100-279
Range on HMM: 114-298/298
Sequence Identity: 37% (71 aa)

LLKALDHCHKHNIIHRDIKPENLLVNS---------DGTLKLCDFGFARHMPPKQNEILTDYVATRWYRSPELLLSDPGYSFPVDNWAIACIMGELIDGQ
.|..|.|.|||.. |||.||||.....         ....|..||| .|.   |..   |||| |||||.||.||..  |. |.| ||. ||| ||   .
ILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPP--YTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLR

PLFPGENEIDQLYLIQKLLGPLTPDQKEM--FIKNPRYVGLKFPEIPKPETIERRYLGKLSKKALTFMKGLLKMDPRERMNVQEAMAHPLF
||||| .||||.. | | .|  ||..|.   ..|  . ....||  . .  ..  ..  .|. ..  |. .|. || .| . |.|  || |
PLFPGSSEIDQIFKICKVMG--TPNKKDWPDGYKLASQMNFNFPQCK-GMPLK-QLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 7414.AA MAPK 99-279 33 3.2e-58 199.74 In-house 123-328 (328) Show / Hide 
Range on Protein: 99-279
Range on HMM: 123-328/328
Sequence Identity: 33% (70 aa)

DLLKA--LDHCHKHNIIHRDIKPENLLVNSDGTLKLCDFGFARHMPPKQNEI-------------LTDYVATRWYRSPELLLSD--PGYSFPVDNWAIAC
..|..  | . |  |.||||.||.|.|||....||.|||| ||.  |.....             .|.||||||||.||..|.    .|.  || |.. |
QILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGC

IMGELID-GQPLFPGENEIDQLYLIQKLLGPLTPDQKEM-FIK---NPRYVGLKF--PEIPKPETIERRYLG---KLSKKALTFMKGLLKMDPRERMNVQ
|..|..  ..|||||.. |||. || ..||  ||..  . .|.   ..| .   .  .  ... . |  . .   . . .|. ... .| .|| .| .|.
IFAEMLTDRKPLFPGKDYIDQWNLIMEVLG--TPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVE

EAMAHPLF
||..|| |
EALQHPYF
Kinase 7414.AA ERK 111-210 43 7.3e-46 158.68 In-house 128-234 (307) Show / Hide 
Range on Protein: 111-210
Range on HMM: 128-234/307
Sequence Identity: 43% (47 aa)

NIIHRDIKPENLLVNSDGTLKLCDFGFAR----HMPPK---QNEILTDYVATRWYRSPELLLSDPGYSFPVDNWAIACIMGELIDGQPLFPGENEIDQLY
|.||||.|| |.||||...|| ||||.||    .  .    .....|.||||||||.||..|| . |. ..| |.. ||. |.. ..|||||.. ..|. 
NVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQIN

LIQKLLG
.| ...|
RIFQIIG
Kinase 7414.AA MAPK 4-92 28 1.1e-22 75.16 In-house 1-107 (328) Show / Hide 
Range on Protein: 4-92
Range on HMM: 1-107/328
Sequence Identity: 28% (30 aa)

YEILGVVGEGAYGVVLKCRNRE------TNEILAIKKFKETEDDELVRKNIQREVKMLKTL-KHKNIVGLVEAFKRK-----------GRIYLVFEYVEK
|.||  .|.|||||| ... ..      .... ||||.    ....  | ..||.|.|. . .|.||..| . |. .             ||.|.|. | 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLLEVLE
.|  ...
DLHQIIK
Kinase 7414.AA RCK 4-94 36 3.5e-20 60.49 In-house 1-96 (298) Show / Hide 
Range on Protein: 4-94
Range on HMM: 1-96/298
Sequence Identity: 36% (35 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETEDDELVRKNIQREVKMLKTLK-HKNIVGLVEAFKRKG--RIYLVFEYVEKNLLEVLEE---K
| |.  .|.|.||.|.| .| ||.||.|||| | ..   .   .  ||.| |. |. |.||. | | .. .   . |.||||...|| . ...   .
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKER
Kinase 7414.AA ERK 4-84 33 7.9e-17 59.33 In-house 1-92 (307) Show / Hide 
Range on Protein: 4-84
Range on HMM: 1-92/307
Sequence Identity: 33% (31 aa)

YEILGVVGEGAYGVVLKCRNRE-----TNEILAIKKFKETEDDELVRKNIQREVKMLKTLK-HKNIVGLVEAFKRKGR-----IYLVFEYVE
|.|.  .|.|||||| .... |     |... |||| ..  |...  | . || |.|. .| |.||..|   .. . .     ||.|.|. |
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELME
Kinase 7414.AA TyrKc 4-279 19 1.1e-13 -1.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-279
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETEDDELVRKNIQREVKMLKTL--KHKNIVGLVEAFKRK-------GRIYLVFEYVEK-NLLEVLEE
 . . . ||||.|.| |.. .   .  |.|. ||       |. . || .... |  .|.||| |. .   .       . ...|.||... .|.. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KPS----------GLDLLKALDHCHKHNIIHRDIKPENLLVNSDGTLKLCDFGFARHMPPK------QNEI------LTDY-VATRWYRSPELLLSDPGY
.             ..  .  .. |..|.||||.   | ||....| | .||| .|    .      .  .       ... .  ||. .|| .  .  .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

SFPVDNWAIACIMGELI-DGQPLFPGENE--IDQLYLIQKLLGPLTPDQKEM----FIKNPRYVGLKFPEIPKPETIERRYLGKLSKKALTFMKGLLKMD
..  | |.    | |.  .||.  ||. .  ..   .|...     ..| .                             .    ...  . ||   . |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F-VCCPDEMYQIMKQCWHED

PRERMNVQEAMAHPLF
| .| . .|   | .|
PEDRPTFSEI--HECF
Kinase 7414.AA Pkinase_Tyr 4-105 29 1.7e-12 42.93 Pfam 1-115 (270) Show / Hide 
Range on Protein: 4-105
Range on HMM: 1-115/270
Sequence Identity: 29% (34 aa)

YEILGVVGEGAYGVVLKCRNR----ETNEILAIKKFKETEDDEL-VRKNIQREVKMLKTL-KHKNIVGLVEAFK-RKGR--IYLVFEYVEK-NLLEVLEE
 ... . ||||.|.| |.. .    .|.   |.|. ||. ..|   |.   ||.|..|.| .|.||| |. .   ...   ||.|.||... .||. | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

K---PSGLDLLKALD
.   .  |..   |.
HREDKQPLTMKDLLQ
Kinase 7414.AA CDK7 249-279 29 5.1e-09 19.7 In-house 258-288 (288) Show / Hide 
Range on Protein: 249-279
Range on HMM: 258-288/288
Sequence Identity: 29% (9 aa)

SKKALTFMKGLLKMDPRERMNVQEAMAHPLF
|  .|..|.|.. |.| .|.   ..  .| |
SDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase 7414.AA ERK 259-279 42 0.001639 9.17 In-house 287-307 (307) Show / Hide 
Range on Protein: 259-279
Range on HMM: 287-307/307
Sequence Identity: 42% (9 aa)

LLKMDPRERMNVQEAMAHPLF
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MLVFDPDKRITVEECLEHPYF
Kinase 7414.AA Pkinase_Tyr 108-139 46 0.007154 10.35 Pfam 128-159 (270) Show / Hide 
Range on Protein: 108-139
Range on HMM: 128-159/270
Sequence Identity: 46% (15 aa)

HKHNIIHRDIKPENLLVNSDGTLKLCDFGFAR
. .|.||||.   | ||..... | |||| ||
ESKNCIHRDLAARNCLVTENNVVKICDFGLAR