Gene 22369 (Tetrahymena)

22369

Species: Tetrahymena
Alias: TTHERM_00219410, 3701.m00154, 509, PreTt22369, 18.m00395, 22369
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
22369.AA Protein None 928 None Fasta, JSON
22369.kin_dom Protein Kinase Domain None 920 None Fasta, JSON
22369.NA RNA None 2787 None Fasta, JSON

Protein domain

Protein domains of 22369.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22369.AA CLK 532-923 39 1.1e-236 718.38 In-house 1-350 (350) Show / Hide 
Range on Protein: 532-923
Range on HMM: 1-350/350
Sequence Identity: 39% (162 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETE-IIRKIQAA-DPENKYR--IVKLESTFKH-GANFCMIFEKLGLSLYELLKKN
|..|..|..||||.|.|..|..||.|..|||.||.||.|..||..|.. |..||... ||.|||.  ..|....|.. ....|..||..|||.|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------YIGYKIRLVQSFFKQILESVGFLHSIHLTHTDLKPENILLASPELRLVVENNSQKDSPSTQYQSSDKTNATAGTVSENNQKNEHQNNSTGKRS
|      ||.|.|. ......|..|.|.|||...|||||||||||.......        ........|....|.|                        
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRF--------THFDCTFKYNHKKKIN------------------------

SSSSSSSSSSSSSSGSHAKSSSKNSKKYWVPVSDEIKIIDFGGAT---FEDEHHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGELFFPT
                 .|| ......||......|..||||.||   |..||||.|..||.|||||||||.. |....||||||||..|||.|...|.|
-----------------KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLG-WSQPCDVWSIGCILFELYTGFTLFQT

HEKIEHLAMIEKVCG-PIPQWMAQRSDNSVNSHFKVTEEHFQQNGTYFDWPKNDTSRKSISNVKNLLSFDDILKPEHRILGDLVRKCLIIDPNQRITCAQ
|...|||||.|...| ||||||.||...     |||....|..|....|| .|...|....|.|.|....|. .||||.|.||.||.|..||..||||..
HDNREHLAMMERIMGMPIPQWMIQRTRR-----FKVKQKYFYHNRLDWDW-HNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKD

ALQHEFF
||||.||
ALQHPFF
Kinase 22369.AA CMGC 532-923 18 3.8e-104 343.23 In-house 1-513 (513) Show / Hide 
Range on Protein: 532-923
Range on HMM: 1-513/513
Sequence Identity: 18% (108 aa)

YVVVKHLSDGTFGRVLEVQDRQNG-------------NKLYALKVIRAVERYVDAAQ-------------IETEIIRKIQAA---------DPENKYR--
| ..| .  ||.| | . .|....             |...|.| |. .. | . |.              | .| .... .         ||.|| .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKLESTFKHGA-----------------NFCMIFEKLGLSLYELLKKNN--YIG-YKIRL---------------VQSFF------KQILESVG--FLH
||||   |.|                   .....|| .. .||...|.|.  | | ... |               ...|.      .|||...   ..|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SIH--LTHTDLKPENILLASP-----------ELRLVVENNSQKDSPSTQYQSSDKTNATAGTVSENNQKNEHQNNSTGKRSSSSSSSSSSSSSSSGSHA
|      |.||||||||. .            |                                                                   
SHWGNIIHRDLKPENILINHNCELITRMMWKSE-------------------------------------------------------------------

KSSSKNSKKYWVPVSDEIKIIDFGGATFEDEH------------------------HSDIINTRQYRAPEVILGC---------CKWNEVSDVWSIGCII
  . . ...    .....||.||| |.....|                        ... . || |||||..||.          ....  |.||.|||.
--D-W-NPC---QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIF

MELYSG--------ELFFPTHEK-----------IEHLAMIEKVCGPIPQWMAQRSDNSV-NSHFKVTEEHFQQNGTYFDWP-------------KNDTS
 |.| |        . .||.|             |..|..| ||.|... ||.|... .. | ..| .|| .. .. .   .             ...  
AEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RHFN-FCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFA

RKSISN-----VKNLLSFDDILKP-----------------------------------EHRILGDLVRKCLIIDPNQRITCAQALQHEFF
|. |..      ..  .. .. ..                                   ..  . ||. |.|..||..|||..|||||..|
RNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 22369.AA S_TKc 532-923 18 1.4e-56 195.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 532-923
Range on HMM: 1-231/231
Sequence Identity: 18% (75 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETEIIRKIQAADPENKYRIVKLESTFKHGANFCMIFEKLGL---SLYELLKKNNY
| .....  |.||.|  ....   ....|.|.|.      . .. | .| .|       .   ||||  .| .  ...|..| ..    .|....||...
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

IG----YKIRLVQSFFKQILESVGFLHSIHLTHTDLKPENILLASPELRLVVENNSQKDSPSTQYQSSDKTNATAGTVSENNQKNEHQNNSTGKRSSSSS
 |    .    ......||.. . ..|| .  | ||||||||| .                                                       
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------------------------------------------------

SSSSSSSSSSGSHAKSSSKNSKKYWVPVSDEIKIIDFGGATFEDEHHSDIINTRQYRAPEVILGCCKWNE-VSDVWSIGCIIMELYSGELFFPTHEKIEH
                              .|||.||| |..     . .. |. |.||||.    ...   .|.||.|||. |...|.  ||     ..
------------------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QM

LAMIEKVCGPIPQWMAQRSDNSVNSHFKVTEEHFQQNGTYFDWPKNDTSRKSISNVKNLLSFDDILKPEHRILGDLVRKCLIIDPNQRITCAQALQ----
 .|..|..                                                              . . |..||||  ||..|.|. .|||    
QMMFKKIG-------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HEFF
   |..|
IKCHPWF
Kinase 22369.AA Pkinase 532-923 19 5.2e-54 190.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 532-923
Range on HMM: 1-293/293
Sequence Identity: 19% (79 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQI-----ETEIIRKIQAADPENKYRIVKLESTFKHGANFCMIFEKLGL-----SLYE
|.... .  |.||.| . ... .|  ..|.|.|. ...  .  |.     | .| ....    .|   ||.|  .|  . . .|..| ..      .|..
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPN---IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

LLK---KNNYIGYKIRLVQSFFKQILESVGFLHSIHLTHTDLKPENILLA-SPELRLVVENNSQKDSPSTQYQSSDKTNATAGTVSENNQKNEHQNNSTG
...   .....    . ......|||. . ..||    | ||||||||.   ...                                             
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------------------------------------------

KRSSSSSSSSSSSSSSSGSHAKSSSKNSKKYWVPVSDEIKIIDFGGA----TFEDEHHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGEL
                                      .||.||| |    .  ..  ...  |. |.|||||.|. ..   .|.||.|||. |...|..
-------------------------------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRP

FFPTH----EKIEHLAMIEKVCGPIPQWMAQRSDNSVNSHFKVTEEHFQQNGTYFDWPKNDTSRKSISNVKNLLSFDDILKPEHRILGDLVRKCLIIDPN
 || |    . .....||... ||.. .  . ...  ...|.  . |                       . .  | . . .|   . |....||  ||.
PFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H-----------------------F-HWTF-HNWSEE---CKDFIKWCLCKDPK

QRITCAQALQHEFF
.|.|..|.|||..|
KRPTAEQILQHPWF
Kinase 22369.AA DYRK 532-670 38 9.3e-41 141.72 In-house 1-140 (320) Show / Hide 
Range on Protein: 532-670
Range on HMM: 1-140/320
Sequence Identity: 38% (54 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETEIIRKIQAADPENKYRIVKLESTFKHGANFCMIFEKLGLSLYELLKKNNYIGY
| ... .  |.|| |  ..|. ..|.. |.|.||  .|. . ||||..|....  .||..||..|..   |.|   .|..|| |  .|||.||.|.  |.
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-KIRLVQSFFKQILESVGFLHSI-HLTHTDLKPENILLASP
  ..||..| .|||..  |||.   . | |||||||.| .|
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP
Kinase 22369.AA DYRK2 532-667 35 6.5e-36 114.04 In-house 1-135 (318) Show / Hide 
Range on Protein: 532-667
Range on HMM: 1-135/318
Sequence Identity: 35% (48 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETEIIRKIQAADPENKYRIVKLESTFKHGANFCMIFEKLGLSLYELLKKNNYIGY
| ... .. | || |... |  .. .. |.|.||   |.   |..|..|. .|   |. | . .|..   |     .|. || |...|||..|||.. |.
YEILEVIGKGSFGQVVKCYDHKTKQHV-AIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

KIRLVQSFFKQILESVGFLHSIHLTHTDLKPENILL
  .||  | ..||..  |||   . | |||||||||
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILL
Kinase 22369.AA Ciliate-E2 532-923 14 7e-36 120.65 In-house 1-365 (365) Show / Hide 
Range on Protein: 532-923
Range on HMM: 1-365/365
Sequence Identity: 14% (77 aa)

YVVVKHLSDGTFGRVLEVQDRQNGN----------------------KLYALKVIRAVERYVDAAQIETEIIRKIQAADPENKYR---------------
| ..| .  |.|| | .........                      |.||.|...  .. . .   |  |.|.|.  .    |.               
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMK--KNQIEQIKQEIHIMREINC-F----YKKINEKNILEQLNHPN

IVKLESTFK--HGANFCMIFEKL-GLSLYELLKKNNYIG---------YKIRLVQSFFKQILE---------------SVGFLHSIH-LTHTDLKPENIL
|.|.  .|.     |. ...| . | .|....|.|.            .... .. ..||||.                . .||| .   | |.||||||
IIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENIL

LASPELRLVVENNSQKDSPSTQYQSSDKTNATAGTVSENNQKNEHQNNSTGKRSSSSSSSSSSSSSSSGSHAKSSSKNSKKYWVPVSDEIKIIDFGGATF
.                                                                                        ||||||| ...
F----------------------------------------------------------------------------------------IKIIDFGLSKK

EDEHHSDIIN----------------------------------TRQYRAPEVILGCCK--------WNEVSDVWSIGCIIMELYSGELFFPTHEKIEHL
 |. . ...                                   |  | |||.. |           ... .|.||.|.|. |. .|.. |         
YDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------

AMIEKVCGPIPQWMAQRSDNSVNSHFKVTEEHFQQNGTYFDWPKNDTSRKSISNVKN-LLSFD------DILKPEHRILG------------DLVRK---
                                                   . . |.  ..|.      | .. .  ...            || .|   
---------------------------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-QCKWKSWKKWSQECKDLIKKFGK

-CLIIDPNQRIT-CAQALQHEFF
 .|  ||..|||   |.|.|..|
RMLQKDPEKRITGWEQILNHPWF
Kinase 22369.AA DYRK 755-923 33 4e-34 119.68 In-house 145-320 (320) Show / Hide 
Range on Protein: 755-923
Range on HMM: 145-320/320
Sequence Identity: 33% (59 aa)

EIKIIDFGGATFEDEHHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGELFFPTHEKIEHLAMIEKVCGPIPQWMAQRS-DNSVNSHFKV-
.||.|||| ..||... .  |  | ||||||||| |. ..  |.|| |||. ||. |. .||     . ||.|  | |..|.|| . .    .. .|.  
TIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILG-CPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCF

-TEEHFQQNGTYF------DWPKNDTSRKSISNVKNLLSFDDILKPEHRILGDLVRKCLIIDPNQRITCAQALQHEFF
  .|.. . .. .        ... |.|    ....  ..|. .. . . . |...|||..||..|||..||||| .|
MYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 22369.AA YAK 532-675 37 2.3e-29 96.65 In-house 1-150 (347) Show / Hide 
Range on Protein: 532-675
Range on HMM: 1-150/347
Sequence Identity: 37% (57 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETEIIRKI-QAADPENKY---RIVKLESTFKHGANFCMIFEKLGLSLYELLKKNN
|.|   |  |||| |   |     | | | |||     |   |  |  | |   |  ||.||    .|...   | |   ||..|| | ..|||.|| |.
YIVLDMLGQGTFGQVVKCQ-NCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNK

YIGYKIRLVQSFFKQILESVGFLHSIHLTHTDLKPENILLAS---PELRLV
. |  . |.. . ||||..   | .  . | |||||||.|     ||....
FCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKII
Kinase 22369.AA DYRK1 532-670 32 9.2e-28 94.24 In-house 1-140 (321) Show / Hide 
Range on Protein: 532-670
Range on HMM: 1-140/321
Sequence Identity: 32% (46 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETEIIRKIQAADPENKYRIVKLESTFKHGANFCMIFEKLGLSLYELLKKNNYIGY
| .   .  | || |    |.|.  .. |.|.|.    . . ||||  ..  . ..|.|.||.||.|   |.. .  |..|| |   ||.||.  .. | 
YEIDSLIGKGSFGQVVKAYDHQE-QEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

KIRLVQSFFKQILESVGFLHS--IHLTHTDLKPENILLASP
 . |.. | .|.. .. |. .  ... | |||||||||  |
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP
Kinase 22369.AA CAMK 537-804 15 1e-27 85.83 In-house 267-589 (425) Show / Hide 
Range on Protein: 537-804
Range on HMM: 267-589/425
Sequence Identity: 15% (63 aa)

HLSDGTFGRVLEVQDRQNGN-----------KLYALKVIRAV-----------------------------ERYVDAAQIETEIIRKIQAADP-ENKYRI
 |  |.|| | .........           . .| |.|                                ..  .  . | || .|.|. .   .   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLES---------------TFKH-----GANFCMIF---EKL---GL--SLYELLKKNNY-------------IGYKIRLVQSFFKQILESVGFLHSIH
.||                 | ..       ...|..   |      |   |.. .... .               .. | .. .|.||.. | ..|| .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LTHTDLKPENILLASPE---LRLVVENNSQKDSPSTQYQSSDKTNATAGTVSENNQKNEHQNNSTGKRSSSSSSSSSSSSSSSGSHAKSSSKNSKKYWVP
  | ||||||||| . .    . | | .                                                                        
IVHRDLKPENILLDDNNDDSDP-V-E-HD-----------------------------------------------------------------------

VSDE--------IKIIDFGGATF--------------------------EDEHHSDIINTRQYRA-PEVILG--CCKW-----------NEVSDVWSIGC
   |        ||||||| |..                          |..  ..   |  | | |||..|  .| .           .. .|.||.|.
---EIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV

I
|
I
Kinase 22369.AA DyrkP 755-840 44 2.4e-23 73.17 In-house 146-230 (323) Show / Hide 
Range on Protein: 755-840
Range on HMM: 146-230/323
Sequence Identity: 44% (38 aa)

EIKIIDFGGATFEDEHHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGELFFPTHEKIEHLAMIEKVCGPIPQWMAQ
..|||||| . |  .| |  .  | |||||||.| ||.    |.||.|||. ||. |   |   .    || .  . ||.| || |
QVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIG-CKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMMQ
Kinase 22369.AA PRP4 532-666 31 9.1e-20 69.07 In-house 1-138 (320) Show / Hide 
Range on Protein: 532-666
Range on HMM: 1-138/320
Sequence Identity: 31% (43 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETEIIRKIQAA--DPENKYRIVKLESTFKHGANFCMIFEKLGLSLYELLKKN-NY
| |.     | |. |   .|  .||.  | |.||  |   .    | ||..|.  |  |.. |. .|..  .|.|    |..|| .  .| |.|||    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

IGYKIRLVQSFFKQILESVGFLHSIHLTHTDLKPENIL
.|  .  | |. .|..     |      | |.|| |||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL
Kinase 22369.AA DYRK2 756-827 45 5e-19 58.21 In-house 143-214 (318) Show / Hide 
Range on Protein: 756-827
Range on HMM: 143-214/318
Sequence Identity: 45% (33 aa)

IKIIDFGGATFEDE-HHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGELFFPTHEKIEHLAMI
||.||||  .||.. .    | .| ||||||||| .| .   | || |||. |||.|  .||     . .|..
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILG-GKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACM
Kinase 22369.AA DYRK1 756-842 35 3.7e-12 38.53 In-house 145-230 (321) Show / Hide 
Range on Protein: 756-842
Range on HMM: 145-230/321
Sequence Identity: 35% (31 aa)

IKIIDFGGATFEDEHHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGELFFPTHEKIEHLAMIEKVCGPIPQWMAQRS
||||||| .   ..     |  | ||.|||.||  ...   |.||.|||..|.  ||  |   . .. .  |  | |  |. | ...
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLG-IEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQA
Kinase 22369.AA CAMK 898-923 46 1.5e-11 32.8 In-house 400-425 (425) Show / Hide 
Range on Protein: 898-923
Range on HMM: 400-425/425
Sequence Identity: 46% (12 aa)

DLVRKCLIIDPNQRITCAQALQHEFF
||.||.|  ||..|.|..|.|.|...
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 22369.AA DyrkP 532-669 28 4e-10 28.82 In-house 1-141 (323) Show / Hide 
Range on Protein: 532-669
Range on HMM: 1-141/323
Sequence Identity: 28% (41 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETEIIRKIQAADPENKYRIVKLESTFKHGANFCMIFEKLGLSLYELLKKN----N
| ..  |    | . .  ||.|  |..  .|.|     | | .  |  ..| |          ...    | |     .| | |   |||  | |     
YQIMEYLGSAAFSKAIQCQDKQT-NQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

YIGYKIRLVQSFFKQILESVGFLHSIHLTHTDLKPENILLAS
   . .  .|   .||| .. ..||. | | ||||||||. |
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKS
Kinase 22369.AA PRP4 756-816 40 4e-10 33.35 In-house 146-206 (320) Show / Hide 
Range on Protein: 756-816
Range on HMM: 146-206/320
Sequence Identity: 40% (26 aa)

IKIIDFGGATFEDEHHSDIIN---TRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGELFFP
.|..||| |    |  ..|.     | |||||.|.|    . . |.||.|| . ||| | . ||
LKMCDFGSASHIHE--NEITPYLVSRFYRAPEIIIGHPYDYQI-DMWSVGCTLYELYTGKIMFP
Kinase 22369.AA PRP4 898-923 57 4.6e-10 33.1 In-house 295-320 (320) Show / Hide 
Range on Protein: 898-923
Range on HMM: 295-320/320
Sequence Identity: 57% (15 aa)

DLVRKCLIIDPNQRITCAQALQHEFF
||  |||. ||  |||| .||.| |.
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase 22369.AA YAK 755-811 43 1e-08 25.34 In-house 146-201 (347) Show / Hide 
Range on Protein: 755-811
Range on HMM: 146-201/347
Sequence Identity: 43% (25 aa)

EIKIIDFGGATFEDEHHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSG
|||||||| .  |       |  | ||.||.|..        | || |||. ||. |
EIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMI-YCTSIDMWSLGCIVAELFLG
Kinase 22369.AA DYRK2 884-923 34 1.7e-08 23.43 In-house 278-318 (318) Show / Hide 
Range on Protein: 884-923
Range on HMM: 278-318/318
Sequence Identity: 34% (14 aa)

SFDDILK-PEHRILGDLVRKCLIIDPNQRITCAQALQHEFF
|. ..||  | . . | ...|.  || .|.| .|||.|...
SWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 22369.AA DYRK1 898-923 57 1.9e-07 21.69 In-house 296-321 (321) Show / Hide 
Range on Protein: 898-923
Range on HMM: 296-321/321
Sequence Identity: 57% (15 aa)

DLVRKCLIIDPNQRITCAQALQHEFF
||... |. ||.||||  .||||.||
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase 22369.AA TyrKc 532-923 15 1e-06 -116.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 532-923
Range on HMM: 1-280/280
Sequence Identity: 15% (65 aa)

YVVVKHLSDGTFGRVLEVQDRQNGNKLYALKVIRAVERYVDAAQIETEIIRKI--QAADPENKYRIVKLESTFKHG-------ANFCMIFEKLGL-SLYE
 .  | |  | ||.| . . .       | |....    . .   | .| .|.  .         ||.|     ..          ....|   . .| .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LLKKNNYIGYKIRLVQSFFKQILESVGFLHSIHLTHTDLKPENILLASPELRLVVENNSQKDSPSTQYQSSDKTNATAGTVSENNQKNEHQNNSTGKRSS
 |.|.     . .   ||  || .   .||| .. | ||   |.|....                                                   
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--------------------------------------------------

SSSSSSSSSSSSSGSHAKSSSKNSKKYWVPVSDEIKIIDFGGATFEDEH-----HSDIINTR---QYR--------APEVILGCCKWNEVSDVWSIGCII
                                  .|| ||| . . ...      .| . ..   . .        |||.|   .| .. ||||| |  .
---------------------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCM

MELYS-GELFFPT--------HEKIEHLAMIEKVCGPIP--QWMAQRSDNSVNSHFKVTEEHFQQNGTYFDWPKNDTSRKSISNVKNLLSFDDILKPEHR
 |... |.   |          | ||..   .    |      |.                                             |     |.  
WEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS---------------------------------------------F--VCCPDEM

ILGDLVRKCLIIDPNQRITCAQALQHEFF
    . ..|   ||..| | ..   ||.|
YQ--IMKQCWHEDPEDRPTFSEI--HECF
Kinase 22369.AA DyrkP 889-923 42 1.8e-05 13.22 In-house 289-323 (323) Show / Hide 
Range on Protein: 889-923
Range on HMM: 289-323/323
Sequence Identity: 42% (15 aa)

LKPEHRILGDLVRKCLIIDPNQRITCAQALQHEFF
|. .  .  | ||.|| ||   | |   |||| .|
LRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 22369.AA YAK 898-923 34 0.002392 6.79 In-house 322-347 (347) Show / Hide 
Range on Protein: 898-923
Range on HMM: 322-347/347
Sequence Identity: 34% (9 aa)

DLVRKCLIIDPNQRITCAQALQHEFF
|..   |  .|. | .  || || | 
DFINQLLQLNPRERWKPMQAMQHPFI