Gene 22423 (Tetrahymena)

22423

Species: Tetrahymena
Alias: TTHERM_00220950, 18.m00449, 3701.m00206, PreTt22423, 22423, 506
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DyrkP

Sequence

Name Sequence Type Origin Length Description Download
22423.AA Protein None 796 None Fasta, JSON
22423.kin_dom Protein Kinase Domain None 323 None Fasta, JSON
22423.NA RNA None 2391 None Fasta, JSON

Protein domain

Protein domains of 22423.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22423.AA DyrkP 466-788 91 1.8e-289 965.25 In-house 1-323 (323) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-323/323
Sequence Identity: 91% (294 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYFDYFYHKEHLFIITELLEENLYEFYKFNRENEQQ
||.|||||||||||||||.|..||..||||||||||||||||||||||||||||||||||||||||.||||||||||||||||..|||||||||||||||
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

RYFTVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKSKPKGEVKVIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDIWSLGCILAELWT
||||||||||||||||.|||.||||||||||||||||||||.||..||.||||||||||||||||||||||||||||||||||||||.||||||||||||
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GNVLFQNDNIQGLLARVIGIIGPFPEWMMKEGRLVQNFFTREKLLYMEVFEEADQSQAIGDQQDGQRQKIKTGKIQILVPKHSNLKARLRTEDHLFIDFV
|||||||||||||||||||||||||||||.|||||||||||..||||.|||||||||.|.||||.|||..|||||||||||||||.|||||.||.|||||
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRKRLLYMDVFEEADQSQNINDQQDMQRQRQKTGKIQILVPKHSNLRARLRTDDHMFIDFV

RQCLQIDFTRRPTAKEALSHPWF
||||||||||||||||||.||||
RQCLQIDFTRRPTAKEALQHPWF
Kinase 22423.AA DYRK 466-788 42 3.8e-169 568.21 In-house 1-320 (320) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-320/320
Sequence Identity: 42% (139 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYFDYFYHKEHLFIITELLEENLYEFYKFNRENEQQ
|...||.|.  |.. ..| |  ||  ...|||.|||....|...|||.|.|.|.... |........|||||..||.|..|||. |||||.|.|....  
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF-

RYFTVGRLQKITQQILVALDFIHSL-RLIHCDLKPENILMKSK-PKGEVKVIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDIWSLGCILAEL
  |.. . .|..||||..|.|.|.. ..||||||||||..|..  | ..||||||||||.|.....|.||| |||||||.||.|.| ||.||||||||||
--FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAEL

WTGNVLFQNDNIQGLLARVIGIIGPFPEWMMKEG--RLVQNFFTREKLLYMEVFEEADQSQAIGDQQDGQRQKIKTGKIQILVPKHSNLKARLRTEDHLF
.||..||...| . .||... ..|..|.||...|  | ...||..   .......|..... |.|.......... . .|...|...|...|....||.|
FTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQF

IDFVRQCLQIDFTRRPTAKEALSHPWF
.||...|||.| ..|.|...|| ||||
KDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 22423.AA CMGC 466-788 20 5.9e-106 349.26 In-house 1-513 (513) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-513/513
Sequence Identity: 20% (107 aa)

YQVMEYLGSAAFSKAIQCLD--------------LVTNRVMCMKIIENNKDYFDQSI-------------DEIKLLRYINYNGDVDE-----------KN
|......|. ....  .| |                ||..  .|.| |.. | .|               .|||.|...|.|.|  .           .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-VLRYFDYFYHKE-----------------HLFIITELLEENLYEFYKFNREN----------------------EQQRYFTVGRLQKITQQILVALD--
 ... .|.||||.                 ||....|... .||.. | |. .                      .. .||..   . ...||| .|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FIHSLR--LIHCDLKPENILMKSK------------------PKGEVKVIDFGSSCFIHDH------------------------LSSYVQSRSYRAPEV
..|| .   ||.||||||||. ..                   .|..|..|||.....|.|                        ...||..| |||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

IIGCK----------YDYRIDIWSLGCILAELWTG--------NVLFQNDNI-----------QGLLARVIGIIGPFPEWMMKEGR-------LVQNFFT
..|.|          |.. ||.||.|||.||..||          ||. ..            .  |.. . ..|... ||.. |.         .....
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

REKLLYMEVFEEAD--QSQAIGDQQDGQRQKIKT--GKIQILVPKHSNLKARLRT--------------------------------EDHLFIDFVRQCL
. ||.. . | ...  | . .... ...|..|.    . ..  .. .||. ....                                .|...||.. ..|
MIKLPWYNKFPKKWNWQ-TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKML

QIDFTRRPTAKEALSHPWF
|.| ..|.||..||.||.|
QYDPDKRITAEQALQHPYF
Kinase 22423.AA DYRK2 466-788 35 5e-87 283.03 In-house 1-318 (318) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-318/318
Sequence Identity: 35% (116 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYFDYFYHKEHLFIITELLEENLYEFYKFNRENEQQ
| . | .|.  |   . |.|  |.   . |.| | | .  |   ||. | .|  .      |. . .||||   |..| .|||  ||||. | |  .   
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQG--

RYFTVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKSKPKGEVKVIDFGSSCFIHD-HLSSYVQSRSYRAPEVIIGCKYDYRIDIWSLGCILAELW
  |..    . ...|| .|.| |  ..||||||||||| |.. .  .|||||||||| |  ..  |.||| |||||||.|.||.  ||.||.|||.||| 
--FSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELY

TGNVLFQNDNIQGLLARVIGIIGPFPEWMMKE-GRLVQNFFTREKLLYMEVFEEADQSQAIGDQQDGQRQKIKTGKIQILVPKHSNLKARLR-TEDHLFI
||  ||  .| .  .|  . ..|  |. ...  . ...   .| |.   .   |. .   ..|... .   .|  . .. .|  ...|. |. .|| .||
TGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHC---FRRKYFFNSHCFEWYC-TFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFI

DFVRQCLQIDFTRRPTAKEALSHPWF
||...|.. | . | |...|| |||.
DFIKRCFEWDPSERMTPSQALKHPWI
Kinase 22423.AA S_TKc 466-788 23 3.2e-78 267.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-231/231
Sequence Identity: 23% (79 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYFDYFYHKEHLFIITELLEE---NLYEFYKFNREN
|.... .|. ||.|  .| .  |.|.. .|||       .. . ||..|.        . .|. ...|.|.. .||....|...    .|... | .. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

EQQRYFTVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKSKPKGEVKVIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDY-RIDIWSLGCILA
  ...|.  . .....||. ||...||.. ||.||||||||. .    ..|..|||.....    .... .. |.||||.   .|.. ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMMKEGRLVQNFFTREKLLYMEVFEEADQSQAIGDQQDGQRQKIKTGKIQILVPKHSNLKARLRTEDHLF
|. .|  .|.    . .. ..||                                                                         .. .
EMLCGYPPFP---QMQMMFKKIG-------------------------------------------------------------------------SPEA

IDFVRQCLQIDFTRRPTAKEALS-------HPWF
.||.|.||| | ..|||| |||        ||||
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22423.AA Pkinase 466-788 22 2.3e-58 205.03 Pfam 1-293 (293) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-293/293
Sequence Identity: 22% (80 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFDQSID-----EIKLLRYINYNGDVDEKNVLRYFDYFYHKEHLFIITELLEENLYEFYKFN-
|.. . .|| .|..  .| .  |... ..|||.  ..  .. .      ||.... .|       .|..|..|.|. | |. ...|..|  ||       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFD

---RENEQQRYF--TVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKSKPKGEV----KVIDFGSSC---FIHDHLSSYVQSRSYRAPEVII-GCK
   .  .... |  .   ....  ||| .|...|| . ||.||||||||..   .|..    |..|||...     ........ .. |.|||||  | .
YIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQY

YDYRIDIWSLGCILAELWTGNVLFQND------NIQGLLARVIGIIGPFPEWMMKEGRLVQNFFTREKLLYMEVFEEADQSQAIGDQQDGQRQKIKTGKI
|....|.||.||||.|. .|. .|...      . . ...|. | . .|...   ....   |.. .                                 
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------------------------

QILVPKHSNLKARLRTEDHLFIDFVRQCLQIDFTRRPTAKEALSHPWF
         .. .    .  ..||.. ||. | ..||||...| ||||
-------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 22423.AA DYRK1 466-788 29 4.5e-58 199.25 In-house 1-321 (321) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-321/321
Sequence Identity: 29% (96 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYFDYFYHKEHLFIITELLEENLYEFYKFNRENEQQ
|..   .|  .| . ..  | ..   . .||| | | ...|   ||.||  .| .   .. ....    | ...|| ...|||  |||.  .    | . 
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLR----NTHF

RYFTVGRLQKITQQILVALDFIHS--LRLIHCDLKPENILMKSKPKGEVKVIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDIWSLGCILAEL
|   .   .|. ||.. || |. .  | .|||||||||||.    .  .|.|||||||   . .  |.||| ||.|||..| .||  ||.||||||| |.
RGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEM

WTGNVLFQNDNIQGLLARVIGIIGPFPEWMMKEGRLVQNFFTREKLLYMEVFEEADQSQAIGDQQDGQRQKIKTGKIQILVPKHSNLKARLRTEDHLFID
 ||  ||   | .  . ... ..|  |. |. ..   . .|....   . .  . |. .   .    . ..|   .      .  .      .. . | |
HTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKD

FVRQCLQIDFTRRPTAKEALSHPWF
 ... || |  .| |  .|| |..|
LIKRMLQYDPKQRITPYYALQHSFF
Kinase 22423.AA YAK 466-706 37 2.1e-56 189.96 In-house 1-241 (347) Show / Hide 
Range on Protein: 466-706
Range on HMM: 1-241/347
Sequence Identity: 37% (92 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKN----VLRYFDYFYHKEHLFIITELLEENLYEFYKFNRE
| |   ||   |   . |  . || ..  |.| |   || |.. ||..||  |   | ..||    .||  |.| || |. .. |.|. ||||. |    
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLK----

NEQQRYFTVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKSKPKGEVKVIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDIWSLGCILA
.   . | .   .  | ||| ..    . ..||||||||||. .   | |.|.|||||||     .  |.|.| ||.||.|..  |   || ||||||.|
QNKFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVA

ELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMMKEGRLVQNFFTR
||  |  .|        . |.| . | .| ||.  ||    .| .
ELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHC
Kinase 22423.AA HIPK 466-674 37 4.1e-50 155.74 In-house 1-207 (329) Show / Hide 
Range on Protein: 466-674
Range on HMM: 1-207/329
Sequence Identity: 37% (80 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYFDYFYHKEHLFIITELLEENLYEFYKFNRENEQQ
| |.|.||   | . . |    || .  .||. |.  |  |   |...|. .  . . || ...| ...| ||.| ... |.|| |||.| | |.     
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLS-QENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNK----F

RYFTVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKSKPKG--EVKVIDFGS-SCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDIWSLGCILAE
    .  .  |.||.| ||  . .| ||| |||||||..  . .    |||||||| | . .   . |.||| |||||.|.| ..   .|.|||||..||
MPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAE

LWTGNVLFQNDN
|  |  |. . .
LFLGWPLYPGAD
Kinase 22423.AA Ciliate-E2 466-788 18 7e-43 145.02 In-house 1-365 (365) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-365/365
Sequence Identity: 18% (80 aa)

YQVMEYLGSAAFSKAIQCLDLVTNR---------------------VMCMKIIENNKDYFDQSIDEIKLLRYINYNG-----------DVDEKNVLRYFD
| . . .|. .|..  .| .  ...                     ..   .  ..|.   |   ||...| ||  .            .. .|......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

YFY--HKEHLFIITELLEE-NLYEFYKFNRENEQQR-----YFTVGRLQKITQQILV---------------ALDFIHSLR-LIHCDLKPENILMKSKPK
.|.   ........|...  .|... | |. ....      |||    ..|..|||                || ..||    || |.||||||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

GEVKVIDFGSSCFIH----------------------------------DHLSSYVQSRSYRAPEVIIGCK---------YDYRIDIWSLGCILAELWTG
  .|.|||| | ...                                  .   ... .  | |||.. | |         ||| .||||||.|| |. .|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

NVLFQNDNIQGLLARVIGIIGPFPEWMMKEGRLVQNFFTREKLLYMEVFEEADQSQAIGDQQDGQRQKIKTGKIQILVP-KHSNLKARLRTEDHLF----
.  |                                                              |.|| .||..  | . .. .  .  .        
KPPF-------------------------------------------------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWK

------IDFVRQ----CLQIDFTRRPT-AKEALSHPWF
      .|. ..    .|| |   |.| ....| ||||
KWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22423.AA STE 466-674 21 8.4e-36 123.93 In-house 1-272 (359) Show / Hide 
Range on Protein: 466-674
Range on HMM: 1-272/359
Sequence Identity: 21% (62 aa)

YQVMEYLGSAAFSKAIQCLDL------VTNRV---------MCMKIIE------------------NNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYF
.. .| .|. || .  ....        |..|         | .|...                   |.. ..| . |||...  |    .  .|. .|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH---M-HPNIVKYY

DYFYHK-------EHLFIITELLE-ENLYEFYK-----FNRENEQQ---RYFTVGRLQKITQQILVA-LDFIHSLRLIHCDLKPENILMKSKPKGEVKVI
......       ..|.|. |...   | ...|     ... | ..    .|    . .|..||| . |...||.. || |.|| |||.       || .
GCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-------VKLC

DFGSSCFIHD-------------------HLSSYVQSRSYRAPEVIIG------CKYDYRIDIWSLGCILAELWTGNVLFQNDN
||| .  . |                   .  . | .  . ||||| .       .||.. ||||||| . |. ||.. . . .
DFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMH
Kinase 22423.AA CLK 466-606 28 1.4e-30 88.3 In-house 1-149 (350) Show / Hide 
Range on Protein: 466-606
Range on HMM: 1-149/350
Sequence Identity: 28% (42 aa)

YQVMEYLGSAAFSKAIQCLDLVT-NRVMCMKIIENNKDYFDQSIDEIK-LLRYINYNGDVDEKNV---LRYFDYFYH-KEHLFIITELLEENLYEFYKFN
| ..  ||. .|.|  .| |    .. .  |||.| . | ...  ||.  .. || ..| . |.    .. .|.| . . |  |..||.  ..|.| | |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

R---ENEQQRYFTVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKS
.    | . . .     .... |.. |. | |...|.| |||||||.  .
NSKMPN-KYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVD
Kinase 22423.AA CLK 611-713 43 8e-29 82.97 In-house 185-294 (350) Show / Hide 
Range on Protein: 611-713
Range on HMM: 185-294/350
Sequence Identity: 43% (48 aa)

EVKVIDFGSSC---FIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDIWSLGCILAELWTGNVLFQ-NDNIQGLLARVIGIIG-PFPEWMMKEGR---LVQN
...||||||     | | | |  |..| ||||||| |. . .. |.|| |||| || ||  ||| .||..  ||    | | |.| || .  |     | 
HICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREH-LAMMERIMGMPIPQWMIQRTRRFKVKQK

FFTREKLLYME
.| . .|.. .
YFYHNRLDWDW
Kinase 22423.AA CLK 757-788 40 4.3e-12 31.81 In-house 319-350 (350) Show / Hide 
Range on Protein: 757-788
Range on HMM: 319-350/350
Sequence Identity: 40% (13 aa)

EDHLFIDFVRQCLQIDFTRRPTAKEALSHPWF
| . ..| .|..| .| ..|.|.|.||.||.|
EHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 22423.AA STE 761-788 46 1.4e-11 37.23 In-house 330-359 (359) Show / Hide 
Range on Protein: 761-788
Range on HMM: 330-359/359
Sequence Identity: 46% (14 aa)

FIDFVRQCLQIDFTRRPTAKEALS--HPWF
|.||...|||.|   ||||.. |.  ||..
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 22423.AA TyrKc 466-788 16 3.1e-09 -73.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 466-788
Range on HMM: 1-280/280
Sequence Identity: 16% (61 aa)

YQVMEYLGSAAFSKAIQCLDLVTNRVMC-MKIIENNKDYFDQSIDEIKLLRYI-NYNGDVDEKNVLRYFDYFYHK-------EHLFIITELLEE-NLYEF
 .  . ||. || .  ..       ...  | . ...      ..|..... .   .     .|..| . .  ..       | |.|..|. .  .| ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHH-----PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

YKFNRENEQQRYFTVGRLQKITQQILVALDFIHSLRLIHCDLKPENILMKSKPKGEVKVIDFGSSCFIHDH------LSSYVQSR--SYR--------AP
 . .|..     ...  | ..  ||    ...|| ..|| ||   |.| ...    ||. ||| | .|.|.       . |...   . .        ||
LRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EVIIGCKYDYRIDIWSLGCILAELWT-GNVLFQN-----DNIQGLLARVIGI-IGPFPEW---MMKEGRLVQNFFTREKLLYMEVFEEADQSQAIGDQQD
|.|  .|.    |.|| |  . |. | |     .      . | ....|      | |.    |                                    
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------------

GQRQKIKTGKIQILVPKHSNLKARLRTEDHLFIDFVRQCLQIDFTRRPTAKEALSHPWF
                  .      .  | ..    .|| . |   ||| .|   |  |
------------------F-----VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 22423.AA YAK 760-788 37 0.00053 9.05 In-house 319-347 (347) Show / Hide 
Range on Protein: 760-788
Range on HMM: 319-347/347
Sequence Identity: 37% (11 aa)

LFIDFVRQCLQIDFTRRPTAKEALSHPWF
.||||. | || .   | ..  |  ||  
CFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 22423.AA HIPK 761-788 32 0.032211 2.23 In-house 302-329 (329) Show / Hide 
Range on Protein: 761-788
Range on HMM: 302-329/329
Sequence Identity: 32% (9 aa)

FIDFVRQCLQIDFTRRPTAKEALSHPWF
|..  .. . .|  .| |  ||| ||. 
FVHVLKKMCTWDAHKRITPCEALNHPFV