Gene 5356 (Tetrahymena)

5356

Species: Tetrahymena
Alias: 5356, TTHERM_00353420, 36.m00320, PreTt05356, 3703.m00179, 480
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
5356.AA Protein None 1178 None Fasta, JSON
5356.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
5356.NA RNA None 3534 None Fasta, JSON

Protein domain

Protein domains of 5356.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5356.AA DYRK2 706-889 59 1.9e-133 436.49 In-house 114-318 (318) Show / Hide 
Range on Protein: 706-889
Range on HMM: 114-318/318
Sequence Identity: 59% (121 aa)

GLLFLTKANIIHCDLKPENILLKQENKSGIKIVDFGSSCFENQ-RVYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAEQFQM
.| || | ||||||||||||||||.|.||||..||||||||.| |.|||||||||||||.|||..||.|||||||||||||||.||||||||||..||..
CLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFAC

FMEILGIPEEEFVEN-----CPRRNVFFE--------------NNKTPKVVKNSRGKIRTPATKHINYYLR-CPDENFIDFVSKCFTWKNHERMSPAEAL
.||.||.|...|...     | ||..||.              ....||..||..||.|.|..|.....|. |.|||||||...||.|...|||.|..||
MMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQAL

VHDWI
 |.||
KHPWI
Kinase 5356.AA DYRK 706-889 51 8e-115 387.76 In-house 115-320 (320) Show / Hide 
Range on Protein: 706-889
Range on HMM: 115-320/320
Sequence Identity: 51% (107 aa)

GLLFLTKA-NIIHCDLKPENILLKQE-NKSGIKIVDFGSSCFENQRVYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAEQFQ
.|.|| |  ||||||||||||.|||. |||.||..||||||||.||.|||||||||||||.|||.||..||||||.|||.|||..|.|||||||| .|..
CLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLA

MFMEILGIPEEEFVEN--CPRRNVFFEN------------NK------TPKVVKNSRGKIRTPATKHINYYLRCPDENFIDFVSKCFTWKNHERMSPAEA
..||.||.| ......  |.|.. ||..            ||      ||| ....||..|.| .........| |..|.||. ||..|  |.|..|..|
CIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQA

LVHDWI
| |.|.
LQHPWF
Kinase 5356.AA CMGC 706-889 20 2.3e-73 240.18 In-house 192-513 (513) Show / Hide 
Range on Protein: 706-889
Range on HMM: 192-513/513
Sequence Identity: 20% (68 aa)

GLL--FLTKAN--IIHCDLKPENILLKQENKS------------------GIKIVDFGSSCFENQR------------------------VYTYIQSRFY
||   .. ...  |||.||||||||. .....                   .|| |||........                         ..|...|.|
GLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWY

RAPEIILGLP----------YGKAIDMWSFGCIMAELYIG--------YPLFPGENE-----------AEQFQMFMEILGIP----------------EE
|||||.|| .          |...|||||.|||.||.| |        .|||||..|            .| .. ...|| |                ||
RAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEE

EFVENCP-----------------------RRNVFFENNKTPKVVKNSRGKIRTPATKHINYYLR--------------------------CPDENFIDF
|. .  .                        || .. ||. |.. ...  ..  .. . .. . .                          | |. .||.
EWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDL

VSKCFTWKNHERMSPAEALVHDWI
..|....  ..|.....|| |...
LKKMLQYDPDKRITAEQALQHPYF
Kinase 5356.AA YAK 710-827 52 3.8e-56 189.07 In-house 122-239 (347) Show / Hide 
Range on Protein: 710-827
Range on HMM: 122-239/347
Sequence Identity: 52% (62 aa)

LTKANIIHCDLKPENILLKQENKSGIKIVDFGSSCFENQRVYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAEQFQMFMEIL
|  ..|||||||||||.|.. ||  |||.|||||| | . ||||||.|.||.||||.. .|  .||||| |||.|||. | |.|||  | .|     ..|
LENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDML

GIPEEEFVENCPRRNVFF
|.|  . ..    .| .|
GYPPSWMIDQGRFKNKYF
Kinase 5356.AA DYRK1 714-845 50 4.4e-54 186.0 In-house 124-256 (321) Show / Hide 
Range on Protein: 714-845
Range on HMM: 124-256/321
Sequence Identity: 50% (67 aa)

NIIHCDLKPENILLKQENKSGIKIVDFGSSCFENQRVYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAEQFQMFMEILGIPE
.|||||||||||||    .| |||.||||||  .||.| ||||||||.||..||..|  |||||| |||. |. .| ||| | || .|..  .|.||.| 
DIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPP

EEFVENCPRRNVFFEN-NKTPKVVKNSRGKIRT
.....  |.   .||  ..   ..| .| | ..
KHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKH
S_TKc 5356.AA S_TKc 630-889 24 4.3e-52 180.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 630-889
Range on HMM: 1-231/231
Sequence Identity: 24% (76 aa)

YELIEALGKGSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQNQTNIVKIKDFVI---------FRSH----------------
||... .|||.||.| |. ..| ... |.|||.      .... |..|||        .  ||||..|.           . ..                
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

-----------------VGLLFLTKANIIHCDLKPENILLKQENKSGIKIVDFGSSCFENQRVYTYIQSRFYRAPEIILGLPYGK-AIDMWSFGCIMAEL
                  .| .. . .|||.||||||||| .     ||| |||....     .|.. ...|.|||..   .||| ..|.||.|||..|.
LRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

YIGYPLFPGENEAEQFQMFMEILGIPEEEFVENCPRRNVFFENNKTPKVVKNSRGKIRTPATKHINYYLRCPDENFIDFVSKCFTWKNHERMSPAEALV-
. |||.||      | || ....|                                                .. ..||..||...   .|..  |||  
LCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------HDWI
      | |.
EWDIKCHPWF
Kinase 5356.AA DYRK2 630-705 51 8e-43 136.88 In-house 1-76 (318) Show / Hide 
Range on Protein: 630-705
Range on HMM: 1-76/318
Sequence Identity: 51% (39 aa)

YELIEALGKGSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQNQTNIVKIKDFVIFRSHV
||. | .||||||||.|..|||.|.. |.|.||||| | ||| .|..||..|. .|..|..|.|...|...|| |.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHH
Kinase 5356.AA Pkinase 714-889 31 2.1e-42 151.04 Pfam 128-293 (293) Show / Hide 
Range on Protein: 714-889
Range on HMM: 128-293/293
Sequence Identity: 31% (59 aa)

NIIHCDLKPENILLKQENKSGI----KIVDFGSSCF---ENQRVYTYIQSRFYRAPEIIL-GLPYGKAIDMWSFGCIMAELYIGYPLFPGE----NEAEQ
.|||.||||||||..  |.  |    || |||....    |.  .|.  ...|.|||.|. | .||...||||.|||..|.. |.|.|||.    | ..|
GIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQ

FQMFMEILG-IPEEEFVENCPRRNVFFENNKTPKVVKNSRGKIRTPATKHINYYLRCPDENFIDFVSKCFTWKNHERMSPAEALVHDWI
 ||. .|.| ...... . |.... |  .  . .         . . |. .|      .|...||...|.... ..| .....| |.|.
MQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------F-HWTF-HN-----WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5356.AA HIPK 715-831 44 7e-39 119.74 In-house 122-241 (329) Show / Hide 
Range on Protein: 715-831
Range on HMM: 122-241/329
Sequence Identity: 44% (53 aa)

IIHCDLKPENILLKQENKSG--IKIVDFGSSCFENQRVY-TYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAEQFQMFMEILGI
.|| |||||||.|  . .    .|..||||     . |  ||.|||.|||||||||||. ...|||| ||..|||. | ||.|| .| .|   . .  . 
LIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHL

PEEEFVENCPRRNVFFENNK
|.|  ..   . . ||.  |
PHEHLLHAACKKHRFFDRDK
Kinase 5356.AA DyrkP 705-793 55 3.2e-38 123.0 In-house 117-205 (323) Show / Hide 
Range on Protein: 705-793
Range on HMM: 117-205/323
Sequence Identity: 55% (49 aa)

VGLLFLTKANIIHCDLKPENILLKQENKSGIKIVDFGSSCFENQRVYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLF
..| ..    .|||||||||||.|   |  .||.|||||||    .  |.||| |||||.|.|  |   ||||| |||.|||. |  ||
IALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase 5356.AA CLK 735-889 30 7.1e-36 104.51 In-house 186-350 (350) Show / Hide 
Range on Protein: 735-889
Range on HMM: 186-350/350
Sequence Identity: 30% (50 aa)

IKIVDFGSSC---FENQRVYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAEQFQMFMEILG--IPEEEFVENC--PRRNVFF
|...||||     |..   .| ...| |||||.||||..    | ||.|||  |||.|. ||.. .. |  .|  .|.|  ||      .        .|
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

ENNKTPKVVKNSRGKIRTPATKHINYYLRCPDEN---FIDFVSKCFTWKNHERMSPAEALVHDWI
 .|..  ...|| |.      |   .|..| |.    ..| ..|..      |.. ..|| | . 
YHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 5356.AA DYRK 630-705 47 2.2e-35 123.86 In-house 1-76 (320) Show / Hide 
Range on Protein: 630-705
Range on HMM: 1-76/320
Sequence Identity: 47% (36 aa)

YELIEALGKGSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQNQTNIVKIKDFVIFRSHV
|| .| .||||||||.|..|||..|. |.|||||.| |..||. |..||.|....||......|...|. ..| |.
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHL
Kinase 5356.AA MAPK 713-819 39 8.8e-35 117.58 In-house 136-261 (328) Show / Hide 
Range on Protein: 713-819
Range on HMM: 136-261/328
Sequence Identity: 39% (51 aa)

ANIIHCDLKPENILLKQENKSGIKIVDFGSSC----FENQRVY-------------TYIQSRFYRAPEIILG---LPYGKAIDMWSFGCIMAELYI-GYP
||.||.||||.|||. ..     || ||| ..    .....                |.  |.||||||.|.     | ||.|||| |||.||..  . |
ANVIHRDLKPSNILVNEN--CDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKP

LFPGENEAEQFQMFMEILGIPEEEFVEN
||||..  .|... ||.|| |.|||...
LFPGKDYIDQWNLIMEVLGTPSEEFIQC
Kinase 5356.AA PRP4 710-810 49 4.3e-32 112.94 In-house 122-222 (320) Show / Hide 
Range on Protein: 710-810
Range on HMM: 122-222/320
Sequence Identity: 49% (50 aa)

LTKANIIHCDLKPENILLKQENKSGIKIVDFGS-SCFENQRVYTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAEQFQMFMEI
| | ||.| |.|| |||   |.|. .|..|||| |  . . .  | .||||||||||.| ||  .||||| || ..||| |  .|||    .   .||..
LKKCNILHADIKPDNILV-NESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDY

LG
 |
KG
Kinase 5356.AA DYRK1 630-709 47 8.6e-28 94.34 In-house 1-80 (321) Show / Hide 
Range on Protein: 630-709
Range on HMM: 1-80/321
Sequence Identity: 47% (38 aa)

YELIEALGKGSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQNQTNIVKIKDFVIFRSHVGLLF
|| . ..||||||||.| .||...|| |.|||.||| ||||| .|. .|  .  .|.... .||..|   .|| |. | |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVF
Kinase 5356.AA CLK 630-709 39 2.2e-24 69.41 In-house 1-86 (350) Show / Hide 
Range on Protein: 630-709
Range on HMM: 1-86/350
Sequence Identity: 39% (34 aa)

YELIEALGKGSFGQVIKVFDHKR-KEYSALKIIRNKKNFYNQAIVELN-ILKYIKDN-DPQNQTN--IVKIKDFVIF-RSHVGLLF
|| .  || | || | .. |||. | | ||||||| . .  .| ||.| |.| |. . ||.|.    ..|. | . .   |. ..|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVF
Kinase 5356.AA CMGC 630-705 22 3.4e-20 62.21 In-house 232-361 (513) Show / Hide 
Range on Protein: 630-705
Range on HMM: 232-361/513
Sequence Identity: 22% (29 aa)

YELIEALGKGSFGQVIKVFD--------------HKRKEYSALKIIRNKKNFYNQAI-------------VELNILKYIK-----------DNDPQNQTN
|| |. .|.|..|.| | .|              |. .|. |.|.|.|.. . .||               |. |||...           | | ..  |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVKIKDFVIFRS-----------------HV
|||..|.. ..                  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHL
Kinase 5356.AA HIPK 630-709 30 1.4e-14 41.82 In-house 1-79 (329) Show / Hide 
Range on Protein: 630-709
Range on HMM: 1-79/329
Sequence Identity: 30% (24 aa)

YELIEALGKGSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQNQTNIVKIKDFVIFRSHVGLLF
|| .| ||.| ||||.|   .  .|  |.||..|   .  |  .|. ||. ... .. .. ..|.  ..   ..|. | |
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENA-DEYHFVRAYECFHHKNHTCLVF
Kinase 5356.AA YAK 630-709 32 3.1e-14 44.39 In-house 1-84 (347) Show / Hide 
Range on Protein: 630-709
Range on HMM: 1-84/347
Sequence Identity: 32% (27 aa)

YELIEALGKGSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQNQTN----IVKIKDFVIFRSHVGLLF
|     ||.| ||||.|      .|  | |.| |.  .  ||. |  ||.   .   .|  |    |... || ... |  | |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVF
Kinase 5356.AA DyrkP 630-704 29 9.6e-11 30.91 In-house 1-75 (323) Show / Hide 
Range on Protein: 630-704
Range on HMM: 1-75/323
Sequence Identity: 29% (22 aa)

YELIEALGKGSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQNQTNIVKIKDFVIFRSH
| ..| ||   | . |.  | .      .||| | | .. |.| |. .|.||  |      |.... |.   . |
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEH
Kinase 5356.AA TyrKc 630-888 16 8.2e-08 -96.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 630-888
Range on HMM: 1-280/280
Sequence Identity: 16% (54 aa)

YELIEALGKGSFGQV----------IKVFDHKRKEYSALKIIRNKKNFYNQAIVELNI---------------------------------------LKY
 .|.. || | ||.|          .|.  .             .. |.. | .  ..                                       ..|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKDNDPQNQTNIVKIKDFVIFRSHV--GLLFLTKANIIHCDLKPENILLKQENKSGIKIVDFGSSCFENQR-------VYTYI----QSR-----FYRAP
.... |.     .. ||.. |   .  |  .| . |.|| ||   |.|.. ..   .|| ||| | .            |       ...        ||
LRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EIILGLPYGKAIDMWSFGCIMAELY-IGYPLFPGENEAEQFQMFMEILGIPEEEFVENCPRR----NVFFENNKTPKVVKNSRGKIRTPATKHINYYLRC
| |    .  . | ||||  | |..  | .  ||. .   .    |..   .. .   .|                                   .  .|
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------F-VCC

PDENFIDFVSKCFTWKNHERMSPAEALVHDW
||| .    ..|   . ..| . .|  ....
PDEMYQ-IMKQCWHEDPEDRPTFSEI-HECF
Kinase 5356.AA PRP4 630-709 28 1.1e-07 24.36 In-house 1-83 (320) Show / Hide 
Range on Protein: 630-709
Range on HMM: 1-83/320
Sequence Identity: 28% (24 aa)

YELIEALGKGSFGQVIKVFDHKRKE-YSALKIIRNKKNFYNQAIVELNILKYIKDN--DPQNQTNIVKIKDFVIFRSHVGLLF
|. .   |.| |. |..  |  |     | |||||.   .     || ||. . |.  |.     .|....   .| |  | |
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVF
Kinase 5356.AA Pkinase 630-699 25 1.3e-07 28.0 Pfam 1-69 (293) Show / Hide 
Range on Protein: 630-699
Range on HMM: 1-69/293
Sequence Identity: 25% (19 aa)

YELIEALGKGSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIV-----ELNILKYIKDNDPQNQTNIVKIKDFV
|.... .|.||||.| |  ...  .  |.|||. ...  .. .      |. |.| ..        |||...|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWF
Kinase 5356.AA MAPK 630-654 24 5e-06 16.45 In-house 184-212 (328) Show / Hide 
Range on Protein: 630-654
Range on HMM: 184-212/328
Sequence Identity: 24% (7 aa)

YELIEALGKGSFGQVIKVFDHK----RKE
|.... .|.|..|.| ...| .    .|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKC
Kinase 5356.AA DyrkP 855-889 42 1.4e-05 13.6 In-house 289-323 (323) Show / Hide 
Range on Protein: 855-889
Range on HMM: 289-323/323
Sequence Identity: 42% (15 aa)

LRCPDENFIDFVSKCFTWKNHERMSPAEALVHDWI
||  |  ||||| .|       | .  ||| | |.
LRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 5356.AA HIPK 861-889 37 4.6e-05 11.36 In-house 301-329 (329) Show / Hide 
Range on Protein: 861-889
Range on HMM: 301-329/329
Sequence Identity: 37% (11 aa)

NFIDFVSKCFTWKNHERMSPAEALVHDWI
.|..   |  ||. |.|..|.||| | ..
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 5356.AA CLK 715-727 61 0.000192 8.44 In-house 135-147 (350) Show / Hide 
Range on Protein: 715-727
Range on HMM: 135-147/350
Sequence Identity: 61% (8 aa)

IIHCDLKPENILL
..| |||||||..
LTHTDLKPENICF
Kinase 5356.AA DYRK1 862-889 25 0.015899 4.11 In-house 294-321 (321) Show / Hide 
Range on Protein: 862-889
Range on HMM: 294-321/321
Sequence Identity: 25% (7 aa)

FIDFVSKCFTWKNHERMSPAEALVHDWI
| | . .   .  ..|..| .|| | ..
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 5356.AA PRP4 864-889 34 0.032516 4.01 In-house 295-320 (320) Show / Hide 
Range on Protein: 864-889
Range on HMM: 295-320/320
Sequence Identity: 34% (9 aa)

DFVSKCFTWKNHERMSPAEALVHDWI
|.  ||.      | .. |||.|  |
DLLDKCLMLDPKKRITCNEALKHPFI