Gene 5655 (Tetrahymena)

5655

Species: Tetrahymena
Alias: 50.m00224, PreTt05655, TTHERM_00442550, 3681.m00083, 1008, 5655
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
5655.AA Protein None 868 None Fasta, JSON
5655.NA RNA None 2607 None Fasta, JSON
5655.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of 5655.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5655.AA DYRK2 520-706 56 1.6e-136 446.68 In-house 111-318 (318) Show / Hide 
Range on Protein: 520-706
Range on HMM: 111-318/318
Sequence Identity: 56% (117 aa)

ILNSINFLRKNRIIHCDLKPENILLKQANKSGVKLIDFGSSCFENE-RLYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQEQ
||....||.||.|||||||||||||||.|.||.|.|||||||||.. |.|||||||.|||||||||..|...|||||||||||||..|||.||||.|..|
ILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQ

IGYIWEIIGAPSKDFLQN-----CTRRKYFFN--------------EDYTPKLIPNSKGKIRVPNSKILKAVLQ-TESEDFTDFLTKCFVWEPQKRLKPS
.....|..|.|.|.|...     |.|||||||              ....||...|..||.|.|.|| .|.||. .|.|.|.||...||.|.|..|..||
FACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPS

DALMHPWI
.||.||||
QALKHPWI
Kinase 5655.AA DYRK 520-706 50 7.80000000001e-118 397.76 In-house 112-320 (320) Show / Hide 
Range on Protein: 520-706
Range on HMM: 112-320/320
Sequence Identity: 50% (105 aa)

ILNSINFLRKN-RIIHCDLKPENILLKQA-NKSGVKLIDFGSSCFENERLYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQE
||... || || .|||||||||||.|||. |||..|.|||||||||..|.|||||||.|||||||||.||...|||||.|||.||||.|.|.||||.|..
ILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYD

QIGYIWEIIGAPSKDFLQN--CTRRKYFFNE------------DY------TPKLIPNSKGKIRVPNSKILKAVLQTESEDFTDFLTKCFVWEPQKRLKP
|. .|.|..|.|.|.....  |.|...||..            ..      |||..|...|..|.|... .....|.. ..|.||..||..|.|.||..|
QLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITP

SDALMHPWI
|.||.|||.
SQALQHPWF
Kinase 5655.AA CMGC 520-706 19 9.6e-78 254.84 In-house 189-513 (513) Show / Hide 
Range on Protein: 520-706
Range on HMM: 189-513/513
Sequence Identity: 19% (65 aa)

ILNSIN--FLRKNR--IIHCDLKPENILLKQANKS------------------GVKLIDFGSSCFENER------------------------LYTYIQS
||....  .. ...  |||.||||||||. . ...                   .|..|||........                        ...|...
ILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVT

RYYRAPEVILGLP----------YDTSIDMWSFGCIMAELFIG--------YPIFPGEDE-----------QEQIGYIWEIIGAPSKDFLQN-------C
|.|||||..|| .          |.|.|||||.|||.||.. |        .|.|||..|           ..|.  | ...| |.  ..|.       |
RWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFC

TRRKYFFNEDYTPKLIPNSK-------------------------GKIRVPNSKILKAVLQT--------------------------------ESEDFT
.. . ..|    |  ... |                         .... .. | |.  ...                                ..... 
KHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAI

DFLTKCFVWEPQKRLKPSDALMHPWI
|.| |.....|.||.....|| ||..
DLLKKMLQYDPDKRITAEQALQHPYF
Kinase 5655.AA YAK 520-643 54 1.2e-58 197.78 In-house 115-239 (347) Show / Hide 
Range on Protein: 520-643
Range on HMM: 115-239/347
Sequence Identity: 54% (68 aa)

ILNSINFLRKNRIIHCDLKPENILLKQANKSGVKLIDFGSSCFENERLYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQEQI
|| ..  |   .|||||||||||.|.. ||  .|.||||||| |   .|||||.|.||.||.|.. .| ||||||| |||.|||| | |||||  | .||
ILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQI

GYIWEIIGAPSKDFL-QNCTRRKYF
  | .. | |  . . |   . |||
KRIIDMLGYPPSWMIDQGRFKNKYF
S_TKc 5655.AA S_TKc 444-706 23 3e-57 197.43 SMART 1-231 (231) Show / Hide 
Range on Protein: 444-706
Range on HMM: 1-231/231
Sequence Identity: 23% (74 aa)

YELLECLGKGSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDEATNIVRIKDFVI---------------------FRKHV---
||.|. .|||.||.| |. ..| ..  |.|.|.      .... |..||.           |||...|.                        .|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHG

---------------ILNSINFLRKNRIIHCDLKPENILLKQANKSGVKLIDFGSSCFENERLYTYIQSRYYRAPEVILGLPYDT-SIDMWSFGCIMAEL
               |.. .... ...|||.||||||||| .     .|..|||....     .|.. ...|.||||.   .|.. ..|.||.|||..|.
LRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

FIGYPIFPGEDEQEQIGYIWEIIGAPSKDFLQNCTRRKYFFNEDYTPKLIPNSKGKIRVPNSKILKAVLQTESEDFTDFLTKCFVWEPQKRLKPSDALM-
. ||| ||      |.  ....||                                                |... ||. ||....|.||.   .||  
LCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------HPWI
      |||.
EWDIKCHPWF
Kinase 5655.AA DYRK1 532-647 51 1e-49 171.47 In-house 125-240 (321) Show / Hide 
Range on Protein: 532-647
Range on HMM: 125-240/321
Sequence Identity: 51% (60 aa)

IIHCDLKPENILLKQANKSGVKLIDFGSSCFENERLYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQEQIGYIWEIIGAPSK
|||||||||||||  . .| .|.|||||||  ..|.| |||||.||.|||.||..||..||||| |||. |. .| |.| | .|..|.  | |..| | |
IIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPK

DFLQNCTRRKYFFNED
....   . . .|. |
HMIDQAPKAHKYFEKD
Kinase 5655.AA DYRK2 444-519 56 2.9e-49 158.2 In-house 1-76 (318) Show / Hide 
Range on Protein: 444-519
Range on HMM: 1-76/318
Sequence Identity: 56% (43 aa)

YELLECLGKGSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDEATNIVRIKDFVIFRKHV
||.||..||||||.|||..|||.|...|.|.|||||.|||||..|..||..|..||||...|.|...|...||.|.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHH
Kinase 5655.AA CDK 520-706 29 3.9e-48 152.0 In-house 117-284 (284) Show / Hide 
Range on Protein: 520-706
Range on HMM: 117-284/284
Sequence Identity: 29% (61 aa)

ILNSINFLRKNRIIHCDLKPENILLKQANKSG------VKLIDFGSSCFENE--------RLYT-YIQSRYYRAPEVIL-GLPYD--TSIDMWSFGCIMA
.|. .... .|.|.| |||| |||.   |. |      .|. ||| ..  .         | ||  .  . |||||. |    |.  |.|||||.|||.|
LLRGLHYCHSNWIMHRDLKPQNILI---NNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFA

ELFI---GYPIFPGEDEQEQIGYIWEIIGAPSKDFLQNCTRRKYFFNEDYTPKLIPNSKGKIRVPNSKILKAVLQTESEDFTDFLTKCFVWEPQKRLKPS
|.|    . |.|||. |..|.  | .|.| |. |   ..|   ..                                     |.| |... .|.||.. .
EMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------------------DLLNKMLCYDPKKRISAE

DALMHPWI
.|| ||. 
QALQHPYF
Kinase 5655.AA Pkinase 520-706 30 1.2e-42 151.88 Pfam 117-293 (293) Show / Hide 
Range on Protein: 520-706
Range on HMM: 117-293/293
Sequence Identity: 30% (61 aa)

ILNSINFLRKNRIIHCDLKPENILLKQANKSGV----KLIDFGSSCF---ENERLYTYIQSRYYRAPEVIL-GLPYDTSIDMWSFGCIMAELFIGYPIFP
||  .... ...|||.||||||||..  |.  .    |..|||....    |. ..|.  ...|.|||||. | .|....||||.|||..|.. |.|.||
ILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP

GE----DEQEQIGYIWEIIGAPSKDFLQNCTRRKYFFNEDYTPKLIPNSKGKIRVPNSKILKAVLQTESEDFTDFLTKCFVWEPQKRLKPSDALMHPWI
|.    .  .|.  | .| |.| .   ..  .. |||   . .               . .. .    ||.. ||...|. . |.||. . ..| |||.
GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5655.AA DyrkP 520-627 53 7.3e-42 135.22 In-house 115-222 (323) Show / Hide 
Range on Protein: 520-627
Range on HMM: 115-222/323
Sequence Identity: 53% (58 aa)

ILNSINFLRKNRIIHCDLKPENILLKQANKSGVKLIDFGSSCFENERLYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQEQI
|| .. ..   |.|||||||||||.|   |  ||.||||||||  . |  |.||| |||||||.|  ||  ||||| |||.|||. |  .|  .  |  .
ILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGLL

GYIWEIIG
  .  |||
ARVIGIIG
Kinase 5655.AA HIPK 532-647 49 5.7e-40 123.24 In-house 122-240 (329) Show / Hide 
Range on Protein: 532-647
Range on HMM: 122-240/329
Sequence Identity: 49% (59 aa)

IIHCDLKPENILLKQANKSG--VKLIDFGS-SCFENERLYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQEQIGYIWEIIGA
.|| |||||||.|    .    || ||||| | . .    ||.|||||||||.|||||.  ..|||| ||..|||| | | .|| || .|| || .  . 
LIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHL

PSKDFLQNCTRRKYFFNED
| .  |.  .. . ||..|
PHEHLLHAACKKHRFFDRD
Kinase 5655.AA DYRK 444-519 51 5.7e-38 132.46 In-house 1-76 (320) Show / Hide 
Range on Protein: 444-519
Range on HMM: 1-76/320
Sequence Identity: 51% (39 aa)

YELLECLGKGSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDEATNIVRIKDFVIFRKHV
|| ||..|||||| |||..|||..| .|.|.|||.|.||.||.||..||.|...||.|. ...|...|. ..|.|.
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHL
Kinase 5655.AA CLK 552-706 31 7.4e-37 107.52 In-house 186-350 (350) Show / Hide 
Range on Protein: 552-706
Range on HMM: 186-350/350
Sequence Identity: 31% (53 aa)

VKLIDFGSSC---FENERLYTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQEQIGYIWEIIG-----APSKDFLQNCTRRKYF
...|||||     |..|  .| ...| ||||||||||.. .  | ||.|||  || .|.  |.. |. |    . .| |     ....  ..    .|||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

FNEDYTPKLIPNSKGKIRVPNSKILKAVLQTESED---FTDFLTKCFVWEPQKRLKPSDALMHPWI
 .         ||.|.    | | ||  .. ....   . | . |..  .| ||.. .||| ||. 
YHNRLDWDW-HNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 5655.AA DYRK1 444-521 46 1.9e-24 82.38 In-house 1-78 (321) Show / Hide 
Range on Protein: 444-521
Range on HMM: 1-78/321
Sequence Identity: 46% (36 aa)

YELLECLGKGSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDEATNIVRIKDFVIFRKHVIL
||    .|||||| ||| .||...|. |.|.|.||| | |||.||. .|  . ..||..  .||..|   .|| |. |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCL
Kinase 5655.AA STE 520-608 31 1.5e-22 76.55 In-house 160-266 (359) Show / Hide 
Range on Protein: 520-608
Range on HMM: 160-266/359
Sequence Identity: 31% (36 aa)

ILNS-INFLRKNRIIHCDLKPENILLKQANKSGVKLIDFGSSC-FENE------------------RLYTYIQSRYYRAPEVILG------LPYDTSIDM
||    ..| ...||| |.|| ||||       |||.||| .  ....                  . .| . .  . |||||..       .|||. |.
ILKGLLYYLHSHHIIHRDIKPANILL-------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDI

WSFGCIMAELFIGYP
||.|| . |.  | |
WSLGCTIIEMATGKP
Kinase 5655.AA CLK 444-519 35 4.9e-21 59.16 In-house 1-82 (350) Show / Hide 
Range on Protein: 444-519
Range on HMM: 1-82/350
Sequence Identity: 35% (29 aa)

YELLECLGKGSFGSVVKVFDHKR-KEFLALKVIRNKKKFHNQALIELN-ILSYIKEQ-DKDEATN--IVRIKDFVIF-RKHV
|| .  || | || ||.. |||. | . |||.||| .|.  .| .|.| |.  |.|  |..      .... | . .   |.
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHI
Kinase 5655.AA CMGC 444-519 18 8.1e-20 60.96 In-house 1-130 (513) Show / Hide 
Range on Protein: 444-519
Range on HMM: 1-130/513
Sequence Identity: 18% (25 aa)

YELLECLGKGSFGSVVKVFD--------------HKRKEFLALKVIRNKKKFHNQAL-------------IELNILSYIK-EQDKDE-----------AT
|| .. .|.|..| |.| .|              |. .|. |.| |.|.. ...||.              |. || ... ..|. .             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NIVRIKDFVIFRK-----------------HV
|||...|.. ...                 |.
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHL
Kinase 5655.AA HIPK 444-521 34 1.2e-16 48.45 In-house 1-77 (329) Show / Hide 
Range on Protein: 444-521
Range on HMM: 1-77/329
Sequence Identity: 34% (27 aa)

YELLECLGKGSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDEATNIVRIKDFVIFRKHVIL
|| || ||.| || |||   .  .|  |.|...|   .  |  ||. ||. ..... ||. ..||  ..   ..|. |
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEY-HFVRAYECFHHKNHTCL
Kinase 5655.AA YAK 444-518 35 6.6e-13 39.8 In-house 1-79 (347) Show / Hide 
Range on Protein: 444-518
Range on HMM: 1-79/347
Sequence Identity: 35% (28 aa)

YELLECLGKGSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDEATN----IVRIKDFVIFRKH
|  |  ||.| || |||      .| .| ||| |.  .  ||  |  ||    .|   .  |    |.|. || ... |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNH
Kinase 5655.AA STE 444-496 20 1.5e-12 40.75 In-house 1-86 (359) Show / Hide 
Range on Protein: 444-496
Range on HMM: 1-86/359
Sequence Identity: 20% (18 aa)

YELLECLGKGSFGSVVKVFDHK---------------RKEFLALKVIRNKK------------------KFHNQALIELNILSYIK
.|..|..|||.||.|.|  .||                .|. | |... ..                  . ..| | |..|..  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCN
Kinase 5655.AA CLK 520-544 40 6.1e-11 28.3 In-house 123-147 (350) Show / Hide 
Range on Protein: 520-544
Range on HMM: 123-147/350
Sequence Identity: 40% (10 aa)

ILNSINFLRKNRIIHCDLKPENILL
......|| .....| |||||||..
LCEAVKFLHDMKLTHTDLKPENICF
Kinase 5655.AA STE 676-706 42 3.9e-09 28.52 In-house 327-359 (359) Show / Hide 
Range on Protein: 676-706
Range on HMM: 327-359/359
Sequence Identity: 42% (14 aa)

SEDFTDFLTKCFVWEPQKRLKPSDALM--HPWI
|..| ||. ||.. .|.|| ..|. |   ||.|
SPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 5655.AA Pkinase 444-513 24 8.4e-08 28.67 Pfam 1-69 (293) Show / Hide 
Range on Protein: 444-513
Range on HMM: 1-69/293
Sequence Identity: 24% (18 aa)

YELLECLGKGSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQ---ALI--ELNILSYIKEQDKDEATNIVRIKDFV
|......|.||||.| |  ...  .  |.|.|. ... ...   ..   |. |.  ..        ||||..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWF
Kinase 5655.AA DyrkP 444-519 25 8.7e-08 21.0 In-house 1-76 (323) Show / Hide 
Range on Protein: 444-519
Range on HMM: 1-76/323
Sequence Identity: 25% (19 aa)

YELLECLGKGSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDEATNIVRIKDFVIFRKHV
| ..| ||   |   ..  | .    . .|.| | | .  |.. |. .| ||      .  |..|. |.   . |.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHL
Kinase 5655.AA CDK 444-476 39 1.2e-07 20.37 In-house 1-38 (284) Show / Hide 
Range on Protein: 444-476
Range on HMM: 1-38/284
Sequence Identity: 39% (15 aa)

YELLECLGKGSFGSVVKVFDHKRK-----EFLALKVIR
|| || .| |..| | |  |....     .. ||| ||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR
Kinase 5655.AA DyrkP 657-706 36 4.6e-07 18.58 In-house 274-323 (323) Show / Hide 
Range on Protein: 657-706
Range on HMM: 274-323/323
Sequence Identity: 36% (18 aa)

KGKIRVPNSKILKAVLQTESEDFTDFLTKCFVWEPQKRLKPSDALMHPWI
| .| ||    |.| |.|.   | ||  .|   .  .|    .|| |||.
KIQILVPKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 5655.AA YAK 679-706 39 1e-05 14.95 In-house 320-347 (347) Show / Hide 
Range on Protein: 679-706
Range on HMM: 320-347/347
Sequence Identity: 39% (11 aa)

FTDFLTKCFVWEPQKRLKPSDALMHPWI
|.||..     .| .| ||. |  || |
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 5655.AA TyrKc 444-706 16 1.2e-05 -131.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 444-706
Range on HMM: 1-280/280
Sequence Identity: 16% (54 aa)

YELLECLGKGSFGSVVK-VFDHKRKEFLALKVIRNKKKFHNQALI-ELNILSYI-KEQDKDEATNIVRIKDFVIFR-------KHVILNS--------IN
 .|.. || | || |.| . .    .  | |.... .    .... |..|.. . .     .  ||||.   ..         . . .           .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRKNR--------------------------IIHCDLKPENILLKQANKSGVKLIDFGSSCFENER-------LYTYI----QSR-----YYRAPEVIL
.|||.|                          .|| ||   |.|..  .   ||  ||| | .  .         |       ...        |||.| 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GLPYDTSIDMWSFGCIMAELF-IGYPIFPGE----DEQEQIGYIWEIIGAPSKDFL----QNCTRRKYFFNEDYTPKLIPNSKGKIRVPNSKILKAVLQT
   . |  | ||||  | |.|  | .  ||.     . ...    .  . . .                                              .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------------F-VC

ESEDFTDFLTKCFVWEPQKRLKPSDALMHPWI
 ...  .  ..|   .| .|   |.   |  .
CPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 5655.AA HIPK 678-706 37 3.9e-05 11.57 In-house 301-329 (329) Show / Hide 
Range on Protein: 678-706
Range on HMM: 301-329/329
Sequence Identity: 37% (11 aa)

DFTDFLTKCFVWEPQKRLKPSDALMHPWI
.| . | |  .|...||. |..|| ||..
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 5655.AA DYRK1 679-706 28 0.000156 11.28 In-house 294-321 (321) Show / Hide 
Range on Protein: 679-706
Range on HMM: 294-321/321
Sequence Identity: 28% (8 aa)

FTDFLTKCFVWEPQKRLKPSDALMHPWI
| | . .   ..|..|..| .|| |...
FKDLIKRMLQYDPKQRITPYYALQHSFF