Gene 19924 (Tetrahymena)

19924

Species: Tetrahymena
Alias: 19924, 3830.m00577, TTHERM_00532680, 116, 68.m00213, PreTt19924
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
19924.AA Protein None 406 None Fasta, JSON
19924.kin_dom Protein Kinase Domain None 288 None Fasta, JSON
19924.NA RNA None 1221 None Fasta, JSON

Protein domain

Protein domains of 19924.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19924.AA GSK 67-354 54 4e-220 679.87 In-house 1-328 (328) Show / Hide 
Range on Protein: 67-354
Range on HMM: 1-328/328
Sequence Identity: 54% (179 aa)

GDEDKVVGSGTFGVVYQATTK----ETGEV----VAIKKVFQDKRYK-NRELQMMKEIG--NHPNVIKLRNHYYSYGNSTDD--VYLH-LVMDFVPETLY
 .|.||.|.|.|||||||. .    ||.|.    ||||||.|||||| |||||.||..|  .|||...|....|......|.  ||.. |||...|.|||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

KMIKYYSKKHKGNFPNILLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHNLKMCDFGSAKKLVP--GESNISYICSRCYRAPELMFQATQYTHA
..|..|.| .| ..|.|..|.|.|||.|.|||.|...|||||||||||||||... ||.|||||||.|.|  .|.||||||||.||||||.|..|.||..
QVIRHYVK-NKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQ

IDVWSVGCVIAEMVLGQPIFIGESSVDQLIEIIKVLGTPTQQQIFAMNPDHQGTKMP-----NIKPTPWTK-------------------VFQNCRIDP-
|||||.|||.|||..|||.| |.||||||.||||.|||||..|| .|||... .|.|     .|||.||.|                   .|..|. |. 
IDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQ

LAIDLISKILVYNPEKRLKPLEALLHPFF
 .||||||.|||.|.|||.||||..||||
DWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase 19924.AA CMGC 67-354 22 2.2e-125 414.31 In-house 1-513 (513) Show / Hide 
Range on Protein: 67-354
Range on HMM: 1-513/513
Sequence Identity: 22% (118 aa)

GDEDKVVGSGTFGVVYQATT--------------KETGEVVAIKKVFQDKRYKN----------------RELQMMKEIG----------------NHPN
 . .|..|.||.||||...               .||.|.|||||..... |..                ||....|..                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIKLRNHYYSYGNSTD-----------DVYLHLVMDFVPETLYKMIKYYSKKHKG----NFPNIL------------LKYYS------YQMLRSLA--YI
..||....|. .. ..           ...|.||..... .||..|| ......|    ...                ||..      ||.||.|.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HGIN--ICHRDIKPQNILVDPRNHN-------------------LKMCDFGSAKKLVPG----------------------ESNISYICSRCYRAPELMF
|  .  |.|||.||.|||..... .                   || ||||.|... |                       . . .|...| |||||...
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

QATQYT---------HAIDVWSVGCVIAEMVLG--------QPIFIGESS-----------VDQLIEIIKVLGTPT---------------QQQIFAMNP
 ...||          .||.|||||..|||..|        .|.| |.|.           .||| .|.|||||||               ..... |..
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

DHQGTK---------------------------MPNIKPTPWTKVFQNCR---------------------------------IDPLAIDLISKILVYNP
     |                            |...| ||...| . .                                 .||.||||..|.|.|.|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

EKRLKPLEALLHPFF
.||... .|| ||.|
DKRITAEQALQHPYF
Kinase 19924.AA S_TKc 67-354 28 8.8e-90 305.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 67-354
Range on HMM: 1-231/231
Sequence Identity: 28% (87 aa)

GDEDKVVGSGTFGVVYQATTKETGEVVAIKKVFQDKRYKNRELQMMKEIGNHPNVIKLRNHYYSYGNSTDDVYLHLVMDFVPE---TLYKMIKYYSK-KH
 .  ...|.|.||.||... |.||..||||..    .   ||.|..|.  .|||..||  ....        .|..||....    .|...|| . . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

KGNFPNILLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHNLKMCDFGSAKKLVPGESNISYICSRCYRAPELMFQATQYTH-AIDVWSVGCVIA
.  ||    ..| ||... |.|.|  .|.|||.||.|||.|    ..| ||||.|..|       ... .. |.|||..    .|.. ..|.||.||...
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

EMVLGQPIFIGESSVDQLIEIIKVLGTPTQQQIFAMNPDHQGTKMPNIKPTPWTKVFQNCRIDPLAIDLISKILVYNPEKRLKPLEALL-------HPFF
||. |.| |       |. ...|..|                                    .| |.|.|.|.|...||||.   |||        ||.|
EMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19924.AA Pkinase 67-354 27 4.2e-79 273.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 67-354
Range on HMM: 1-293/293
Sequence Identity: 27% (87 aa)

GDEDKVVGSGTFGVVYQATTKETGEVVAIKKVFQDKRYKNR--------ELQMMKEIGNHPNVIKLRNHYYSYGNSTDDVYLHLVMDFVPETLYKMIKYY
    ...|||.||.||... | ||..||.|..  ... ..         |.|.||.. ||||...|.  ...      . ....||.... .||  .  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIYMVMEYCEGGLY-VMDLF

SKKH---KGNF--PNILLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHN---LKMCDFGSAKK--LVPGESNISYICSRCYRAPELMFQATQYT
.  .   .|.|  .   .| | ||.|| |.|.|  .|.|||.||.|||.| ..|.   .| ||||.||.  . ... . .. ... |.|||.   .. |.
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

HAIDVWSVGCVIAEMVLGQPIFIGE----SSVDQLIEIIKVLGTPTQQQIFAMNP-------DHQGTKMPNIKPTPWTKVFQNCRIDPLAIDLISKILVY
...|.||.||...||..|.|.| |.    . .||.  | ...|.|.  ...  ..       . . .        . ...|   .... ..|.|...| .
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H--------F-HWTF--HNWSEECKDFIKWCLCK

NPEKRLKPLEALLHPFF
.|.||. . ..| ||.|
DPKKRPTAEQILQHPWF
Kinase 19924.AA CDK 68-354 30 4.3e-77 246.15 In-house 2-284 (284) Show / Hide 
Range on Protein: 68-354
Range on HMM: 2-284/284
Sequence Identity: 30% (99 aa)

DEDKVVGSGTFGVVYQATTKETG-----EVVAIKKVF--------QDKRYKN---RELQMMKEIGNHPNVIKLRNHYYSY---GNSTDDV---YLHLVMD
.  . .| ||.|||| |  |.||     ..||.||.          .        ||  ..||.  |||..||.  ...     |   |     | .|..
EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

FVPETLYKMIKYYSKKHKGNFPNILLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNH----NLKMCDFGSAKKLV-------PGESNISYICSRC
...  |.| ..               | | .|.|| |.|.|  .| |||.||||||.. . .     ||  ||| |..         |     . .  . 
YMDHDLKKYMD--------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLW

YRAPELMFQATQYT--HAIDVWSVGCVIAEMVL---GQPIFIGESSVDQLIEIIKVLGTPTQQQ--IFAMNPDHQGTKMPNIKPTPWTKVFQNCRIDPLA
|||||| . ...|.   .||.|||||..|||..   ..|.| |.|  |||  |....|||| ..   .   ||.                          
YRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------

IDLISKILVYNPEKRLKPLEALLHPFF
 ||..| |.|.|.||..  .|| ||.|
-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 19924.AA CDC2 71-354 33 1.9e-73 224.94 In-house 5-301 (301) Show / Hide 
Range on Protein: 71-354
Range on HMM: 5-301/301
Sequence Identity: 33% (104 aa)

KVVGSGTFGVVYQATTKETGEVVAIKKVFQDKRYKN--------RELQMMKEIGNHPNVIKLRNHYYSYGNSTDDVYLHLVMDFVPETLYKMIK-YYSKK
. .| ||.||||..  ..|...||.||.  .             ||.  .||. .|||..||.  ...         | .| ...   | |  . . .|.
EKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-------NKLYMVFEYLDMDLKKYMDMSIPKN

HKGNFPNILLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHNLKMCDFGSAKKL-VPGESNI--SYICSRCYRAPELMFQATQYTHAIDVWSVGC
   ..| .|.| | ||.|. ... |   | |||.||||||.| .. |.|  ||| |.   .|         .  . |||||... . .|. ..|.||.||
--KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGC

VIAEM---VLGQPIFIGESSVDQLIEIIKVLGTPTQQQIFAM--NPDHQGTKMPNIKPTPWTKVFQN-------CRIDPLAIDLISKILVYNPEKRLKPL
..|||   |   |.|.|.|  |||  | ..||||. |    .  .|| . |  |. ||.  .|.. |         .|| .|||....|.|.|.||..  
IFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNT-FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAK

EALLHPFF
||| ||.|
EALQHPYF
Kinase 19924.AA MAPK 68-354 34 8.8e-73 248.11 In-house 2-328 (328) Show / Hide 
Range on Protein: 68-354
Range on HMM: 2-328/328
Sequence Identity: 34% (114 aa)

DEDKVVGSGTFGVVYQATTKE------TGEVVAIKKV---FQDKRYKN---RELQMMKEIGNHPNVIKLRNHYYSYG---NST----DDVYLHLVMDFVP
. .| .|.| .|||  |. |.      .|. |||||.   ||.. .     ||. .......|.|.|||.. ..  .   ...    .|.|  .||..  
QILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY--IVMELME

ETLYKMIKYYSKKHKGNFPNILLKYYSYQMLRS--LAYIHGINICHRDIKPQNILVDPRNHNLKMCDFGSAKKLVPGESNI---------------SYIC
  |.. ||           ..  .|  ||.||   | |||  |. |||.|| ||||.  |  ||.|||| | .. | .. .                |. 
TDLHQIIKSQQ-----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVA

SRCYRAPELMFQ--ATQYTHAIDVWSVGCVIAEMVL-GQPIFIGESSVDQLIEIIKVLGTPTQQQIFAMN-PDHQ---GTKM---PNIKPTPWTKVFQNC
 | |||||.|.   .. || |.|.|||||  |||.  ..|.| |....||.  |..|||||... |  .  ..|       .   |. .. ||.|.| | 
TRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNA

R--IDPLAIDLISKILVYNPEKRLKPLEALLHPFF
.   .|.||||..| || .|.||.   ||| ||.|
NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 19924.AA ERK7 68-354 34 3.1e-61 208.07 In-house 2-292 (292) Show / Hide 
Range on Protein: 68-354
Range on HMM: 2-292/292
Sequence Identity: 34% (106 aa)

DEDKVVGSGTFGVVYQATTKETGEVVAIKKVFQ------DKRYKNRELQMMKEIGNHPNVIKLRNHYYSYGNSTDDVYLHLVMDFVPETLYKMIKYYSKK
.  | .| | .|.|  |. | |..|||.||.|       |     ||  ...|...|||.|.| |      .   |.|  || .|    |   |.     
EIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR--DIY--LVFEFMETDLHAVIR-----

HKGN-FPNILLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHNLKMCDFGSAKKLVPGE-------SNISYICSRCYRAPELMFQATQYTHAIDV
 |||   .|  .|  ||.|| . |.|  |. |||.|| |||.|   . .|.|||| |  .   |           |.  | ||||| .  ...|| ..| 
-KGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECM-VKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDM

WSVGCVIAEMVLGQPIFIGESSVDQLIEIIKVLGTPTQQQIFAMNPDHQGT---KMPNIKPTPWTKVFQNCRIDPLAIDLISKILVYNPEKRLKPLEALL
||.||...||. |.|.| | | ..|.  |..... |||. | |....   .   .|.  |. .  .....|  |  ||||. ..||.||.|||   .|| 
WSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDD--AIDLLKRLLVFNPKKRLTAEQALQ

HPFF
||. 
HPYV
Kinase 19924.AA CDKL 170-354 41 2.1e-58 198.31 In-house 99-286 (286) Show / Hide 
Range on Protein: 170-354
Range on HMM: 99-286/286
Sequence Identity: 41% (79 aa)

LLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHNLKMCDFGSAKKLV-PGESNISYICSRCYRAPELMFQATQYTHAIDVWSVGCVIAEMVLGQP
... | .| |..... |  |. |||||| |||. |.|  .|.|||| |. |  |||    |   | ||||||.   |||  ..|.|..|||.|||. |||
VVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQP

IFIGESSVDQLIEIIKVLG--TPTQQQIFAMNPDHQGTKMPNIK-PTPWTKVFQNCRIDPLAIDLISKILVYNPEKRLKPLEALLHPFF
.. |.| .|||  |.|.||  .| .|.|| .||   | |.| |. . |  | ..|    ..|.|.. | |  .| .|.   ... ||.|
LWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSN-KKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 19924.AA ERK 172-354 39 3e-58 199.81 In-house 111-307 (307) Show / Hide 
Range on Protein: 172-354
Range on HMM: 111-307/307
Sequence Identity: 39% (79 aa)

KYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHN--LKMCDFGSAKKLVPGESNI---------SYICSRCYRAPELMFQATQYTHAIDVWSVGCVI
.|  ||.|. | |||  |. |||.|| ||||   | |  || |||| | .. .. ...          |. .| |||||.|  .. || |.|.||.|| .
QYFMYQILCGLKYIHSANVIHRDLKPSNILV---NSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIF

AEMVLGQPIFIGESSVDQLIEIIKVLGTP-TQQQIFAM---NPDHQGTKMPN--IKPTPWTKVFQNCRIDPLAIDLISKILVYNPEKRLKPLEALLHPFF
|||. ..|.| |...|.|. .|....||| .....      |     ...||  ..| || ..| |  . |.||||..| || .|.||.   |.| ||.|
AEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase 19924.AA Ciliate-E2 67-354 22 1.9e-54 185.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 67-354
Range on HMM: 1-365/365
Sequence Identity: 22% (89 aa)

GDEDKVVGSGTFGVVYQATTKETGEVVAIK----------------------KVF--QDKRYKNRELQMMKEIG---------------NHPNVIKLRNH
 .  |. |.|.||.||... ..... .|||                      |..  ........|...|.||                ||||.||.  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YYSYGNSTDDVYLHLVMDFVPE-TLYKMIKYYSKKHKGNFP------NILLKYYSYQMLR---------------SLAYIHGIN-ICHRDIKPQNILVDP
...    .|| .. |||...   .|.. ||  .||.. ...          ||...| |.                | |.|  | |.||||||.|||.  
FQE----KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--

RNHNLKMCDFGSAKKLVPGESNISYICSRC---------------------------------YRAPELMF--------QATQYTHAIDVWSVGCVIAEM
    .| .||| .||. . . |... ...|                                 | |||           . ..|....|.||.|... ||
----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

VLGQPIFIGESSVDQLIEIIKVLGTPTQQQIFAMNPDHQGTKMPNIKPTPWTKVFQNC----RIDPLAIDLISK----ILVYNPEKRLK-PLEALLHPFF
. |.| |                    ||||   . | .  .. .   .    . ..      ... ..|||.|    .|...||||.  . ..| ||.|
LFGKPPF--------------------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19924.AA RCK 63-292 32 4.9e-54 169.7 In-house 1-236 (298) Show / Hide 
Range on Protein: 63-292
Range on HMM: 1-236/298
Sequence Identity: 32% (81 aa)

YTIVGDEDKVVGSGTFGVVYQATTKETGEVVAIKKVFQDKRYKN-------RELQMMKEIGNHPNVIKLRNHYYSYGNSTDDVYLHLVMDFVPETLYKMI
|.|.    | .| ||.|.|  |  |||||.|||||    .....       ||.. .. .  |||.|||.   .      |.  |..|. .. . ||.|.
YQII----KQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR----DNDTYQLYFVFEYMDMNLYQMM

KYYSKKHKGNFPNIL--LKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPR--------NHNLKMCDFGSAKKLVPGESNI---SYICSRCYRAPELMF
| . .  .  .| .   .| . || | .||..|  .. |||.|| ||.. .         . ..| .|||...     .|.     |. .| |||||.  
KDFKE-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREI---RSKPPYTDYVSTRWYRAPECLL

QATQYTHAIDVWSVGCVIAEMVLGQPIFIGESSVDQLIEIIKVLGTPTQQ
 .|.|.  .|.|.|||...|    .| | | | .||. .|.||.|||...
RCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKK
Kinase 19924.AA TyrKc 67-354 22 2.5e-14 8.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 67-354
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

GDEDKVVGSGTFGVVYQATTKETGEVVAIKKVFQDKRYKN--RELQMMKEIG-NHPNVIKLRNHYYSYGNSTDD-------VYLHLVMDFVPE-TLYKMI
   .|. |.| ||.||..| |   . ||.|..  |.  .   ||...|...| .|||...|      ||  |..         | .|| ..|   | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRL------YGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KYYSKKHKGNFPNILLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHNLKMCDFGSAKKLVPG----ESNISYICSR--CYR--------APELM
... .|    ...  | ....|  .  .|.|  |. |||.   |.||. ..   | .||| ....  .    ||   |  .   . .        ||| .
RKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

FQATQYTHAIDVWSVGCVIAEMV-LGQPIFIGE----SSVDQLIEIIKVLGTPTQQQI----FAMNPDHQGTKMPNIKPTPWTKVFQNCRIDPLAIDLIS
 .   .|.. |||| | .. |.  .||.   |.     | ...|| .|  . . | .                            |   .  .   ....
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F--VCCPDEMYQIMK

KILVYNPEKRLKPLEALLHPFF
.   ..||.|    |   | .|
QCWHEDPEDRPTFSEI--HECF
Kinase 19924.AA Pkinase_Tyr 70-124 33 8.9e-10 33.74 Pfam 4-69 (270) Show / Hide 
Range on Protein: 70-124
Range on HMM: 4-69/270
Sequence Identity: 33% (22 aa)

DKVVGSGTFGVVYQATTK----ETGEVVAIKKVFQDKRYKN-------RELQMMKEIGNHPNVIKL
.|. |.| ||.||..| |    .|.  ||.|.. ..   ..       ||...||..|.|||...|
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase 19924.AA RCK 327-354 42 2.2e-09 25.66 In-house 271-298 (298) Show / Hide 
Range on Protein: 327-354
Range on HMM: 271-298/298
Sequence Identity: 42% (12 aa)

AIDLISKILVYNPEKRLKPLEALLHPFF
.|.|. | | ..|.||  . .|| ||.|
CIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 19924.AA ERK 63-140 31 2e-08 27.69 In-house 1-86 (307) Show / Hide 
Range on Protein: 63-140
Range on HMM: 1-86/307
Sequence Identity: 31% (28 aa)

YTIVGDEDKVVGSGTFGVVYQATTKE-----TGEVVAIKKV---FQDKRYKN---RELQMMKEIGNHPNVIKLRNHYYS-YGNSTDDVYL
| |.    | .| |..|||  |. ||     ||. |||||.   | ...| .   ||. ...    |.|.|.|..   . . .. .|.|.
YQII----KQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYC
Kinase 19924.AA CDKL 63-97 48 1.2e-05 15.28 In-house 1-31 (286) Show / Hide 
Range on Protein: 63-97
Range on HMM: 1-31/286
Sequence Identity: 48% (17 aa)

YTIVGDEDKVVGSGTFGVVYQATTKETGEVVAIKK
| . |    .|| |  |||.    ||||..|||||
YEKLG----KVGEGSYGVVMKCRNKETGQIVAIKK
Kinase 19924.AA Pkinase_Tyr 160-215 32 1.457142 2.53 Pfam 99-156 (270) Show / Hide 
Range on Protein: 160-215
Range on HMM: 99-156/270
Sequence Identity: 32% (19 aa)

KKH---KGNFPNILLKYYSYQMLRSLAYIHGINICHRDIKPQNILVDPRNHNLKMCDFG
.||   |....   |  ...|  . ..| . .|. |||.   |.||. .|.  | ||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-ENNVVKICDFG