Gene 18725 (Tetrahymena)

18725

Species: Tetrahymena
Alias: 18725, PreTt18725, 55.m00280, TTHERM_00469230, 420, 3710.m00128
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
18725.AA Protein None 394 None Fasta, JSON
18725.kin_dom Protein Kinase Domain None 288 None Fasta, JSON
18725.NA RNA None 1185 None Fasta, JSON

Protein domain

Protein domains of 18725.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18725.AA ERK 62-349 59 6.2e-222 743.57 In-house 1-307 (307) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-307/307
Sequence Identity: 59% (182 aa)

YEYIKQIGYGAYGVVCSAVNKE-----NGSKVAIKKVQNAYDDLIDAKRIVREIKLLKFF-EHDNIISLLDVIKPNAPVGDEDIYMVFDLMETDLHRVIY
|..|||||.|||||||||..||     .| ||||||..||.|..|..||..||||||..| .|.|||.|.|...|| | . .|||.|..|||||||..|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SRQELSDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFE-EPGES-------LTEYVITRWYRAPEVILNASEYNQAVDI
|.|||||.|.|||.||||.||.||||||||||||||||||.|.|||||||||||||.|. .. |.       .||||.||||||||..|....|..|.||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCITAELLGRTPLFPGENYLDQVQRVIAVLGTP-TQEDMAYIGNQDAIKYIKSQPK--RTKQSWQSLYPKAN--PLALDLLSKMLTFNPEKRYTVKE
||.||| ||.|||.|||||..|..|..|.....||| ..||. ||....| ||||..|.  |....|....|.||  |.|.|||.|||.|.|.||.||.|
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

CIEHPYF
|.|||||
CLEHPYF
Kinase 18725.AA MAPK 62-349 52 1.5e-196 659.24 In-house 1-328 (328) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-328/328
Sequence Identity: 52% (172 aa)

YEYIKQIGYGAYGVVCSAVNKE------NGSKVAIKKVQNAYDDLIDAKRIVREIKLLKFF-EHDNIISLLDVIKPN----APVGD--EDIYMVFDLMET
|...|.||.|||||||||. |.      .| ||||||.... ......||. ||||||..| .|.|||.|||...|     ..  .  .|||.|..||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHRVIYSRQELSDEHIQYFVYQILRG--LLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEE-PGES-------------LTEYVITRWYRAP
|||..|.|.|.|||.|||||.||||||  | ||||||||||||||||||.|.|||||||||||||...    .              .|||| |||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILN--ASEYNQAVDIWSVGCITAELLG-RTPLFPGENYLDQVQRVIAVLGTPTQEDMAYIG-NQDAIKYIKSQ---PKRTKQSWQSLYPK----ANPL
|..||  . .|..|||.|||||| ||.|. |.|||||..|.|| .....|||||..|.. .|. .. | .||.|    ||..|..|....|.    |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

ALDLLSKMLTFNPEKRYTVKECIEHPYF
|.|||.|||.|.|.||.||.|...||||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 18725.AA CMGC 62-349 27 3.8e-152 503.88 In-house 1-513 (513) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-513/513
Sequence Identity: 27% (142 aa)

YEYIKQIGYGAYGVVCSAVNKENGSK--------------VAIKKVQNAYDDLIDAK----------RIVREIKLLKFFE-----------------HDN
|| ||.|| |.||||.....|... |              |||||. |.  . ..||          |. ||||.|| .                  | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IISLLDVIKPNAPVGDE------------DIYMVFDLMETDLHRVIYSRQ---------ELSDEH------------IQYFV------YQILRGLL--YI
|..|.|..... . |.|            ..|.||..|..||...|.. |         .||. |            |.||.      |||||||   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VIHRDLKPSNILLNKNCDL--------------------KICDFGLARGFEEP---------------------GESLTEYVITRWYRAPEVIL
||..  .|||||||.|||.|.||.|                    ||||||||| ....                     .. .|.|| ||||||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NASEYN---------QAVDIWSVGCITAELLGR--------TPLFP-----------GENYLDQVQRVIAVLGTP----------------TQEDMAYIG
....|.         ...|.|||||| ||.. .         ||||           |....|| .. . |||||                ..|.. .|.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------NQDAIKYIKS---QPKRTKQSWQSLYPK-----------------------------------ANPLALDLLSKMLTFNP
                    . .| .||.|    |.. ...|..|.|.                                   ..|.|.|||.|||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

EKRYTVKECIEHPYF
.|| |.... .||||
DKRITAEQALQHPYF
Kinase 18725.AA p38 62-349 49 1.1e-144 486.98 In-house 1-289 (289) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-289/289
Sequence Identity: 49% (145 aa)

YEYIKQIGYGAYGVVCSAVNKENGSK---VAIKKVQNAYDDLIDAKRIVREIKLLKFFEHDNIISLLDVIKP-NAPVGD-EDIYMVFDLMETDLHRVIYS
|. .. .| |||| ||.|. .. | |   |||||    . . |.|||. ||..|||  .|.|.|.||||  | .  . | .|.|||  .|..||.... .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

RQELSDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEPGESLTEYVITRWYRAPEVILNASEYNQAVDIWSVGCITAE
 . |||.|||. |||||||| |||||..|||||||||| .| .|.|.| ||||||   .  ...|.|| ||||||||..||  .|.|.||||||||| ||
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAE

LLGRTPLFPGENYLDQVQRVIAVLGTPTQEDMAYIGNQDAIKYIKSQPKRTKQSWQSLYPKANPLALDLLSKMLTFNPEKRYTVKECIEHPYF
|. . .||||....|| ||...|.|||..| .. | .. |  ||.| |.....  ......|||.|.||| |||   |.|| |..| ..||||
LITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 18725.AA ERK5 62-349 50 2.7e-136 459.09 In-house 1-295 (295) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-295/295
Sequence Identity: 50% (150 aa)

YEYIKQIGYGAYGVVCSAVNKENGSKVAIKKVQNAYDDLIDAKRIVREIKLLKFFEHDNIISLLDVIKPNAPVGD-EDIYMVFDLMETDLHRVIYSRQEL
|. | .|| |||||||||... || .|||||. ||.| .  ||| .||.|.|. | ||||| . |...|  | ..  |.|.|||||| ||| .| | | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEE--PGES---LTEYVITRWYRAPEVILNASEYNQAVDIWSVGCITA
. ||| ||.||||||| |.|||.||||||||||.| | ||.||| |||.|||     | .    .|||| ||||||||...   .| ||.|.||||||  
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELLGRTPLFPGENYLDQVQRVIAVLGTPTQEDMAYIGNQDAIKYIKS-QPKRTKQSWQSLYPKANPLALDLLSKMLTFNPEKRYTVKECIEHPYF
|...|  .||| ||..|.| .. |||.|    .  .. .    |...  | |. . |. .|||| . |||||..|| | | .| || . . ||. 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 18725.AA ERK1 62-349 53 2.8e-127 429.15 In-house 1-289 (289) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-289/289
Sequence Identity: 53% (156 aa)

YEYIKQIGYGAYGVVCSAVNKENGSKVAIKKVQNAYDDLIDAKRIVREIKLLKFFEHDNIISLLDVIKPNAPVGDEDIYMVFDLMETDLHRVIYSRQELS
|  .. || ||||.||||. . .. .|||||.   ..     .| .||||.|. |.|.||| . |.|. ..     |.|.| .|||||| ... . |.||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

DEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEPGES----LTEYVITRWYRAPEVILNASEYNQAVDIWSVGCITAEL
 .|| ||.||||||| |||||||.||||||||.|||. ||||||||||||   .|.      ||||| ||||||||..||.  | ...|||||||| ||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM

LGRTPLFPGENYLDQVQRVIAVLGTPTQEDMAYIGNQDAIKYIKSQPKRTKQSWQSLYPKANPLALDLLSKMLTFNPEKRYTVKECIEHPYF
|   |.|||  ||||.  ...||| | |.|.  | |. |  |..| | ..|..|..|.||| . ||||| |||||||.|| || | . ||| 
LSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 18725.AA ERK7 62-349 45 1.5e-121 410.13 In-house 1-292 (292) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-292/292
Sequence Identity: 45% (133 aa)

YEYIKQIGYGAYGVVCSAVNKENGSKVAIKKVQNAYDDLIDAKRIVREIKLLKFFE-HDNIISLLDVIKPNAPVGDEDIYMVFDLMETDLHRVIYSRQEL
|| .|..| ||||.|  |. |  .  ||.||.  |. . .|| |  ||| .|. |. |.|||.|..||. .    | |||.||. |||||| ||   . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADN---DRDIYLVFEFMETDLHAVIRKGNIL

SDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEPGE------SLTEYVITRWYRAPEVILNASEYNQAVDIWSVGCIT
 | | || .||.|| . |.||.||||||||||||||. .| .|.|||||||   .  |       ||||| ||||||||. | . .| ..|| ||.||| 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AELLGRTPLFPGENYLDQVQRVIAVLGTPTQEDMAYIGNQDAIKYIKSQPKRTKQSWQSLYPKANPLALDLLSKMLTFNPEKRYTVKECIEHPYF
.|.|   |.|||   ..|. ... ... |||||.. || . |.. ... ... ... . ..|.. . |.||| ..| |||.|| |......||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 18725.AA nmo 63-349 46 7.1e-113 348.57 In-house 2-292 (292) Show / Hide 
Range on Protein: 63-349
Range on HMM: 2-292/292
Sequence Identity: 46% (135 aa)

EYIKQIGYGAYGVVCSAVNKENGSKVAIKKVQNAYDDLIDAKRIVREIKLLKFFEHDNIISLLDVIKPNAPVGDEDIYMVFDLMETDLHRVIYSRQELSD
.  . |||||.||| |     .| .||.||. | . .|. .||. ||.|.| ||.|||..|.||...|  .   ..||.| .||  |||..| | |.|| 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

EHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEPGES--LTEYVITRWYRAPEVILNASEYNQAVDIWSVGCITAELLGR
.|.. |.||||||| |.||||..|||.|| |.|.| || ||||||||||  .|. .|  .|. |.| .|||||... |  | .|||||||||| ||||||
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLAR-VWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

TPLFPGENYLDQVQRVIAVLGTPTQEDMAYIGNQDAIKYIKSQPKR-TKQSWQSLYP--KANPLALDLLSKMLTFNPEKRYTVKECIEHPYF
  ||  .. ..|.| .. .||||..||| |  .      ..  .|    |    |    .|.  | .||..|| |.|.||  .|. ..||| 
RILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 18725.AA CDK 62-349 34 1.1e-106 342.34 In-house 1-284 (284) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-284/284
Sequence Identity: 34% (113 aa)

YEYIKQIGYGAYGVVCSAVNKENG-----SKVAIKKVQNAY------DDLID--AKRIVREIKLLKFFEHDNIISLLDVIKPNAPVGD------EDIYMV
|| ...|| |.||||  | .|..|       ||.||.          .. .   |   .|||.|||   |.||..|.||.  ...  .        .|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITA---IREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMV

FDLMETDLHRVIYSRQELSDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCD-----LKICDFGLARGFEE------PGESLTEYVITRWYRA
|. |..||  ..          |. . .|.|||| |.|| ...||||||.|||.|.|       ||| |||||| |        |   .|  |.|.||||
FEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRA

PEVILNASEYN--QAVDIWSVGCITAELLG---RTPLFPGENYLDQVQRVIAVLGTPTQED-MAYIGNQDAIKYIKSQPKRTKQSWQSLYPKANPLALDL
||. | ...|.   ..|.|||||| ||..    | |||||.. .||  ... ..|||| ..       .|                            ||
PELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DL

LSKMLTFNPEKRYTVKECIEHPYF
|.|||...|.|| . ... .||||
LNKMLCYDPKKRISAEQALQHPYF
Kinase 18725.AA S_TKc 62-349 32 1.8e-102 347.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-231/231
Sequence Identity: 32% (98 aa)

YEYIKQIGYGAYGVVCSAVNKENGSKVAIKKVQNAYDDLIDAKRIVREIKLLKFFEHDNIISLLDVIKPNAPVGDEDIYMVFDLMET---DLHRVIYSRQ
|| ...|| ||.|.|. ...|. | .||||..          ..| |||..||   |.||. |.||.        ...|||......   ||...| .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

E------LSDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEPGESLTEYVITRWYRAPEVILNASEYNQ-AVDIWSVG
       ..  |.....|||...| |.|| ..|||||||.||||..   .||||||||| .       | .. |.||.||||.     |.  ..|.||.|
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG

CITAELLGRTPLFPGENYLDQVQRVIAVLGTPTQEDMAYIGNQDAIKYIKSQPKRTKQSWQSLYPKANPLALDLLSKMLTFNPEKRYTVKECIE------
|| .|.| . |.||      |.|... ..|                                      | |.|...|.|...||||.|. |. .      
CILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPYF
 ||.|
CHPWF
Kinase 18725.AA Pkinase 62-349 31 1.6e-98 338.43 Pfam 1-293 (293) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-293/293
Sequence Identity: 31% (98 aa)

YEYIKQIGYGAYGVVCSAVNKENGSKVAIKKVQNAYDDLIDAKRIVR--EIKLLKFFEHDNIISLLDVIKPNAPVGDEDIYMVFDLMET-----DLHRVI
|. ...|| |..|.|. ...| .| .||.|..    ..    .. .|  ||...| . |.||. |.|.        . .||||....|      ||...|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

Y--SRQEL--SDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDL----KICDFGLARGF-EEPGESLTEYVITRWYRAPEVILNASEYNQAV
   ..  .  |..... ..||||||| |.|| ..|||||||.|||...|...    ||||||||. | . ... .| .. |.||.|||||. ...| ..|
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVGCITAELLGRTPLFPGE----NYLDQVQRVIAVLGTPTQEDMAYIGNQDAIKYIKSQPKRTKQSWQSLYPKANPLALDLLSKMLTFNPEKRYTVK
|.||.||| .|.| . |.|||.    | .|| |..  ..|.|. .|  .  .    . ..  . .  .  . . ..... ..|.....|...|.||.| .
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

ECIEHPYF
.. .||.|
QILQHPWF
Kinase 18725.AA MAPK-Unclassified 62-215 50 3e-77 262.93 In-house 1-161 (575) Show / Hide 
Range on Protein: 62-215
Range on HMM: 1-161/575
Sequence Identity: 50% (81 aa)

YEYIKQIGYGAYGVVCSAVNKEN-GSKVAIKKVQNAYDDLIDAKRIVREIKLLKFFEHDNIISLLDVIKPNAPVG--DEDIYMVFDLMET---DLHRVIY
|||.| || ||||.|| |. | | . .||||||  .  . .|.||. ||| .|    | ||| . |.. .  . .    ||| | |.|.|   ||| .|.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SRQ-ELSDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEE
|.|  ....||||| ||||||| |.|||..|||||||||.|.| .| ..|||||..|  |.
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIED
Kinase 18725.AA MAPK-Unclassified 220-349 35 1.1e-53 184.72 In-house 405-575 (575) Show / Hide 
Range on Protein: 220-349
Range on HMM: 405-575/575
Sequence Identity: 35% (60 aa)

LTEYVITRWYRAPEVILNASEYNQAVDIWSVGCITAELLGR-----------TPLFPGEN--------------------YLDQVQRVIAVLGTPTQEDM
.|.|| |||||||| .|  .||  .|||||.||| ||.. .            |||||..                    . || .  . .||.| .||.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

AYIGNQDAIKYIKSQPKRTKQSWQSLYPKANP----------LALDLLSKMLTFNPEKRYTVKECIEHPYF
  |..  |.|||.|  . |   . .|.. ..|          ...|...||| ||| ||.|  .  |||||
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 18725.AA Pkinase_Tyr 62-249 28 1.9e-20 69.85 Pfam 1-199 (270) Show / Hide 
Range on Protein: 62-249
Range on HMM: 1-199/270
Sequence Identity: 28% (59 aa)

YEYIKQIGYGAYGVVCSAVNK----ENGSKVAIKKVQNAYDDLID--AKRIVREIKLLKFF-EHDNIISLLDVIK-PNAPVGDEDIYMVFDLMET-DLHR
 . .|..| ||.|.|. .. |    ... .||.|.. . . .  .   .   ||.|..| .  |.||..|. |.     |     ||.|. .|.  ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLD

VIYS----RQELSDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEPGESLTEYVIT------RWYRAPEVILNASEYN
   .    .| |. ...  . .|| .|. | .| | |||||   |.|...|   |||||||||   .. .    .. .      .|. |||.| .   ..
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWM-APECINYGK-FT

QAVDIWS
 . |.||
TKSDVWS
Kinase 18725.AA TyrKc 62-349 20 1.1e-16 46.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 62-349
Range on HMM: 1-280/280
Sequence Identity: 20% (67 aa)

YEYIKQIGYGAYGVVCSAVNKENGSKVAIKKVQNAYDDLIDAKRIVREIKLLKFF--EHDNIISLLDVIKPNAPVGD-------EDIYMVFDLMET-DLH
 . .|..| ||.|.|. .. |    .||.|....        . . ||..... .  .|.||. |. |.     . .       | ...|. .|.  ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVC-----TQQGRNFMYIEPLMIVMEYMPHGDLK

RVIYSRQE-LSDEHIQYFVYQILRGLLYIHSANVIHRDLKPSNILLNKNCDLKICDFGLARGFEEP------GESLT------EY--VITRWYRAPEVIL
  . .... |. ..  .| .|| .|  |.|| |.|||||   |.|...|   ||.||||.|  ..       ..  .      .   .  ||. |||.| 
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-

NASEYNQAVDIWSVGCITAELLGRTPLFPGE-----NYLDQVQRVIAVLGTPTQEDM----AYIGNQDAIKYIKSQPKRTKQSWQSLYPKANPLALDLLS
| .... . |.|| |    |.. .    . .        ..| . .   . . | .     .                       .  . . .   .. .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F--VCCPDEMYQIMK

KMLTFNPEKRYTVKECIEHPYF
.   ..||.| | .|.  | .|
QCWHEDPEDRPTFSEI--HECF