Gene 23186 (Tetrahymena)

23186

Species: Tetrahymena
Alias: 3737.m00065, 105.m00153, PreTt23186, TTHERM_00689900, 321, 23186
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
23186.AA Protein None 795 None Fasta, JSON
23186.kin_dom Protein Kinase Domain None 301 None Fasta, JSON
23186.NA RNA None 2388 None Fasta, JSON

Protein domain

Protein domains of 23186.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23186.AA ERK 253-553 52 8e-209 700.03 In-house 1-307 (307) Show / Hide 
Range on Protein: 253-553
Range on HMM: 1-307/307
Sequence Identity: 52% (166 aa)

YQLLVPIGIGGYGVVAKAFDQE-----KQDFVAIKKIFKPFLNPLETKRILREIKILKAL-EHDNIISIRDVLSPVPKEKLEDIYIISQLMDTDLHQIIA
||.. .|| |.||||..|.|.|     ....||||||...|..|...||.|||||.|. . .|.|||...|.. |...|...|||....||.||||||| 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SDQILSEDHIQFFIYQLLCGLKYVNQIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTKVNVLV-----LMTEYVATRWYRAPELLLS
|.| ||.||.|.|.||.|||          |||||||.|.||||||.|.||||.|.||||||||||..|....  .      ||||||||||||||..||
SQQELSDDHCQYFMYQILCG----------LKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLS

WNKYTTAIDMWAVGCIFSELYMRKPLLPGESYLNQLILTLNLTGTP-SKEDLENIQSDRAKQFIISLGN--KAPKDLSKLIPNAS--PQAIDLISKMIVF
|.|||.|.|.|..||||.|...||||.||..|..|. ......||| |.|||..|.|..|...|..|.|  ..||......|||.  ||||||..||.||
WQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVF

NPDKRISAEEALKHPFF
.|||||..||.|.||.|
DPDKRITVEECLEHPYF
Kinase 23186.AA MAPK 253-553 50 7.50000000001e-188 630.36 In-house 1-328 (328) Show / Hide 
Range on Protein: 253-553
Range on HMM: 1-328/328
Sequence Identity: 50% (170 aa)

YQLLVPIGIGGYGVVAKAFDQE------KQDFVAIKKIFKPFLNPLETKRILREIKILKAL-EHDNIISIRDVLSP------VPKEKLEDIYIISQLMDT
||.| ||| | ||||..|.|..      ....||||||..|| ||. .||..||||.|. . .|.|||...|.. |       ..|...||||.. ||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHQIIASDQILSEDHIQFFIYQLLCGLKYVNQIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTK-------VNVLVL-----MTEY
|||||| |.|.||.||||.|.||.|.|||        |||||||.| ||||||.|.|||..| ||||||||||..|..       ..  ..     ||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLK--------LKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HCFQKMHMTEY

VATRWYRAPELLLS--WNKYTTAIDMWAVGCIFSELYM-RKPLLPGESYLNQLILTLNLTGTPSKEDLENIQ-SDRAKQFIISL---GNKAPKDLSKLIP
||||||||||..|.  |..||.|.|||.||||| |..  ||||.||..|..|. | ....||||.|....|. |..|...| ||    .. .|...|..|
VATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFP

N----ASPQAIDLISKMIVFNPDKRISAEEALKHPFF
|    |.||||||..|| ||.|||||..|||| ||.|
NANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 23186.AA CMGC 253-553 28 2.7e-136 450.84 In-house 1-513 (513) Show / Hide 
Range on Protein: 253-553
Range on HMM: 1-513/513
Sequence Identity: 28% (149 aa)

YQLLVPIGIGGYGVVAKAFD--------------QEKQDFVAIKKIFKPFLNPLETK----------RILREIKILKALE-----------------HDN
|. . .|| | |||| |..|               | . .||||||..|| .. . |          |.|||||||| |                  | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IISIRDVLSPV---PKEK---------LEDIYIISQLMDTDLHQIIASDQ---------ILSEDH------------IQFFI------YQLLCGLKYVNQ
|....|.. .    ..|.         ....|..  .||.||.|.| . |          ||| |            |..|.      ||.|.|||    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLK----

IYYFLKYIHSAG--VFHRDLKPGNLLVNSDCVL--------------------KICDFGLARTVDTKVNV------------------LVLMTEYVATRW
    |||.||..  ..|||||| |.|.|..| |                    ||||||||| ...  ..                  .  .|.||.|||
----LKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRW

YRAPELLLSW---------NKYTTAIDMWAVGCIFSELYMR--------KPLLP-----------GESYLNQLILTLNLTGTP----------------S
|||||.||.|         ..|||.||||.||||| |.|..        ||| |           |.|...|| .  .. |||                .
YRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHE

KEDLENIQ--------------------SDRAKQFIIS---LGNKAPKDLSKLIPN-----------------------------------ASPQAIDLI
.|. . |.                    |. |...| |   .... ||....|.|.                                   ..||||||.
EEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLL

SKMIVFNPDKRISAEEALKHPFF
.|| ...|||||.||.||.||.|
KKMLQYDPDKRITAEQALQHPYF
Kinase 23186.AA p38 253-553 45 6.8e-131 441.15 In-house 1-289 (289) Show / Hide 
Range on Protein: 253-553
Range on HMM: 1-289/289
Sequence Identity: 45% (138 aa)

YQLLVPIGIGGYGVVAKAFDQEKQDF---VAIKKIFKPFLNPLETKRILREIKILKALEHDNIISIRDVLSP--VPKEKLEDIYIISQLMDTDLHQIIAS
|| | |.| | || |.||.|.. ..    |||||...||  ..  ||. ||.. || ..|.|.|.. ||  |     . ..|.|.....|..||..|. .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

DQILSEDHIQFFIYQLLCGLKYVNQIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTKVNVLVLMTEYVATRWYRAPELLLSWNKYTT
 . ||.||||| .||.| |||          ||||||. ||||||.|. || || |.| ||||||  |..      ||.||||||||||| .|.| .|| 
QR-LSDDHIQFLVYQILRGLK----------YIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDE------MTGYVATRWYRAPEIMLNWMHYTQ

AIDMWAVGCIFSELYMRKPLLPGESYLNQLILTLNLTGTPSKEDLENIQSDRAKQFIISLGNKAPKDLSKLIPNASPQAIDLISKMIVFNPDKRISAEEA
..|.| ||||  ||  ...| ||. ...||   ....|||..| .. |||..|. .| |.     .|.... ..|.||||||. || .  |||||.||||
TVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEA

LKHPFF
..||.|
MQHPYF
Kinase 23186.AA S_TKc 253-553 29 5.9e-87 296.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 253-553
Range on HMM: 1-231/231
Sequence Identity: 29% (93 aa)

YQLLVPIGIGGYGVVAKAFDQEKQDFVAIKKIFKPFLNPLETKRILREIKILKALEHDNIISIRDVLSPVPKEKLEDIYIISQLMDT---DLHQIIASDQ
|..| .|| |..|.| |. . . .  ||||.|          ..|.|||.|||   |.||. . ||         ...|..  ..|.   ||...| . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

I------LSEDHIQFFIYQLLCGLKYVNQIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTKVNVLVLMTEYVATRWYRAPELLLSWN
       ..| |..|..||..|.          |.|.|| |. |||||| |.|...  ..||||||||| .          | .. |.||.|||.|    
RHGLRFPFPE-HARFYMYQICCA----------LEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----

KYTT-AIDMWAVGCIFSELYMRKPLLPGESYLNQLILTLNLTGTPSKEDLENIQSDRAKQFIISLGNKAPKDLSKLIPNASPQAIDLISKMIVFNPDKRI
.|.. ..|.|..|||. |.. ..|. |      |. ..... |                                     ||.|.|.|.|. ...|.||.
GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRP

SAEEALK-------HPFF
.| |||.       ||.|
TA-EALQDEWDIKCHPWF
Kinase 23186.AA ERK7 372-553 44 5.1e-83 282.11 In-house 108-292 (292) Show / Hide 
Range on Protein: 372-553
Range on HMM: 108-292/292
Sequence Identity: 44% (82 aa)

QIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTKV---NVLVLMTEYVATRWYRAPELLLSWNKYTTAIDMWAVGCIFSELYMRKPLL
|.   .||.||. | |||||| |.|..|.|..|.|||||||..  .    .    .||||||||||||| ||.  .|| ..||| .|||  |.   ||. 
QLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMF

PGESYLNQLILTLNLTGTPSKEDLENIQSDRAKQFIISLGNKAPKDLSKLIPNASPQAIDLISKMIVFNPDKRISAEEALKHPFF
|| | .||. . |.... |..||.| |.|. | . . ... . .| |....|.....||||. ...||||.||..||.||.||. 
PGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 23186.AA ERK5 372-553 48 3.1e-78 266.23 In-house 111-295 (295) Show / Hide 
Range on Protein: 372-553
Range on HMM: 111-295/295
Sequence Identity: 48% (89 aa)

QIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDT--KVNVLVLMTEYVATRWYRAPELLLSWNKYTTAIDMWAVGCIFSELYMRKPLLP
||   |||.||| | |||||| |||||  | ||| |||.|| . |    .  . |||||||||||||||..| . || |||.|.||||| |.  |. . |
QILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFP

GESYLNQLILTLNLTGTPSKEDLENIQSDRAKQFIIS-LGNKAPKDLSKLIPNASPQAIDLISKMIVFNPDKRISAEEALKHPFF
|  |..|| | .   |.|.   .. . .|. . .. . . |. |||..|. | | .||.||...|..| | .||.. .||.||| 
GKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 23186.AA ERK1 372-553 51 1.8e-76 260.38 In-house 108-289 (289) Show / Hide 
Range on Protein: 372-553
Range on HMM: 108-289/289
Sequence Identity: 51% (94 aa)

QIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTKVNVLVLMTEYVATRWYRAPELLLSWNKYTTAIDMWAVGCIFSELYMRKPLLPGE
||   ||||||| | |||||| |||.|  | ||||||||||  | .      .|||||||||||||..|    || .||.|.||||  |.   .|. || 
QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK

SYLNQLILTLNLTGTPSKEDLENIQSDRAKQFIISLGNKAPKDLSKLIPNASPQAIDLISKMIVFNPDKRISAEEALKHPFF
 || || . | . | ||..||. |  ..|.....||  |.   . .| |.| ..|.||. ||. |||.|||  |||| ||. 
HYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 23186.AA RCK 377-553 41 8.7e-73 230.21 In-house 118-298 (298) Show / Hide 
Range on Protein: 377-553
Range on HMM: 118-298/298
Sequence Identity: 41% (77 aa)

LKYIHSAGVFHRDLKPGNLLVNS---------DCVLKICDFGLARTVDTKVNVLVLMTEYVATRWYRAPELLLSWNKYTTAIDMWAVGCIFSELYMRKPL
|...|. | ||||||| |.....         . ..||.||||.| .  | .     |.|| ||||||||.||. ..|.. .|.||||||. |||| .||
LAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPP----YTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPL

LPGESYLNQLILTLNLTGTPSKEDLENIQSDRAKQFIISLGNKAPKDLSKLIPNASPQAIDLISKMIVFNPDKRISAEEALKHPFF
 || | . |.   ..  |||.|.|..  .   | |  . .... .  |..||||.|...|.|. ||   .|.|||.|..||.||.|
FPGSSEIDQIFKICKVMGTPNKKDWPDGY-KLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 23186.AA nmo 370-553 46 4.9e-72 220.64 In-house 108-292 (292) Show / Hide 
Range on Protein: 370-553
Range on HMM: 108-292/292
Sequence Identity: 46% (87 aa)

VNQIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTKVNVLVLMTEYVATRWYRAPELLLSWNKYTTAIDMWAVGCIFSELYMRKPLLP
. ||   |||.|||.. |||.|||||||||.||||||||||||. . .      ||. | | .|||||.|.   .|| |.|.|.|||||.||  |. |  
LYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQS--KHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRRILFQ

GESYLNQLILTLNLTGTPSKEDLENIQSDRAKQFIISLGNKAPKDLSKLIPNAS-----PQAIDLISKMIVFNPDKRISAEEALKHPFF
 .| ..|| .  .| |||| ||.     . ||. ..  . |.| .|..|   .|       |..|...|..|.||||||...||.||. 
AQSPIQQLQMITDLLGTPSMEDMK-YACEGAKAHMLRMPHKPP-CLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 23186.AA Pkinase 377-553 31 5.9e-58 203.66 Pfam 121-293 (293) Show / Hide 
Range on Protein: 377-553
Range on HMM: 121-293/293
Sequence Identity: 31% (59 aa)

LKYIHSAGVFHRDLKPGNLLVNSDCVL----KICDFGLARTVDTKVNVLVLMTEYVATRWYRAPELLLSWNKYTTAIDMWAVGCIFSELYMRKPLLPGE-
|.|.|| |. |||||| |.|.......    ||||||||. .|      . || .. |.||.|||.... ..|....|||..|||. |.. ..|. ||. 
LEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC

---SYLNQLILTLNLTGTPSKEDLENIQSDRAKQFIISLGNKAPKDLSKLIPNASPQAIDLISKMIVFNPDKRISAEEALKHPFF
   . ..|. .  .  |.| ..| ..  | .    .     .  . .... .|.|. ..|.|.... ..| ||..||..|.||.|
WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 23186.AA MAPK-Unclassified 424-553 33 2.4e-57 196.83 In-house 405-575 (575) Show / Hide 
Range on Protein: 424-553
Range on HMM: 405-575/575
Sequence Identity: 33% (57 aa)

MTEYVATRWYRAPELLLSWNKYTTAIDMWAVGCIFSELYMR-----------KPLLPGES--------------------YLNQLILTLNLTGTPSKEDL
||.||.||||||||..||   |.|..|.|..|||| |.  .           .||.||..                    .  |. . .   |.| .||.
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

ENIQSDRAKQFIISLGNKAPKDLSKLIPNASP----------QAIDLISKMIVFNPDKRISAEEALKHPFF
  |..|.|...| |.. |.| . . |.. . |          ..||...|| .||| |||.|..||.||.|
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 23186.AA MAPK-Unclassified 253-369 45 5.9e-39 135.75 In-house 1-124 (575) Show / Hide 
Range on Protein: 253-369
Range on HMM: 1-124/575
Sequence Identity: 45% (56 aa)

YQLLVPIGIGGYGVVAKAFDQEK-QDFVAIKKIFKPFLNPLETKRILREIKILKALEHDNIISIRDVLSPVPKEK--LEDIYIISQLMDT---DLHQIIA
| .   || |.||.|..| |       |||||. . | |.  .||.|||| ||  | | ||| |.|.. .   .     ||||   .| |   |||||| 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SDQ-ILSEDHIQFFIYQLLCGLKY
|.|  ... ||| |.||.| ||||
SNQDHWCHQHIQYFFYQILRGLKY
Kinase 23186.AA ERK5 253-370 47 6.5e-39 135.6 In-house 1-119 (295) Show / Hide 
Range on Protein: 253-370
Range on HMM: 1-119/295
Sequence Identity: 47% (57 aa)

YQLLVPIGIGGYGVVAKAFDQEKQDFVAIKKIFKPFLNPLETKRILREIKILKALEHDNIISIRDVLSP-VPKEKLEDIYIISQLMDTDLHQIIASDQIL
|. .  || | ||||. |  .   . ||||||   |    . || .||.|||.   ||||| |||.| | ||   . |.|..  ||. |||||| |.| .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SEDHIQFFIYQLLCGLKYV
. .|| .|.||.| ||||.
TLEHIRYFLYQILRGLKYM
Kinase 23186.AA nmo 254-369 44 5.9e-38 113.88 In-house 2-117 (292) Show / Hide 
Range on Protein: 254-369
Range on HMM: 2-117/292
Sequence Identity: 44% (52 aa)

QLLVPIGIGGYGVVAKAFDQEKQDFVAIKKIFKPFLNPLETKRILREIKILKALEHDNIISIRDVLSPVPKEKLEDIYIISQLMDTDLHQIIASDQILSE
|   ||| | .|||    |      ||.||. . | | . .||. ||.|.|   .|||..| .|.| |  |. ...||..  ||  |||.|| | | || 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHIQFFIYQLLCGLKY
||.. |.||.| ||||
DHVKVFLYQILRGLKY
Kinase 23186.AA ERK1 253-370 46 3.2e-32 113.37 In-house 1-116 (289) Show / Hide 
Range on Protein: 253-370
Range on HMM: 1-116/289
Sequence Identity: 46% (55 aa)

YQLLVPIGIGGYGVVAKAFDQEKQDFVAIKKIFKPFLNPLETKRILREIKILKALEHDNIISIRDVLSPVPKEKLEDIYIISQLMDTDLHQIIASDQILS
|  |  || | ||.|. | |. ... ||||||  ||      .| |||||||.  .|.||| |.|..     |.. |.||. .||.||| ... . | ||
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

EDHIQFFIYQLLCGLKYV
 ||| .|.||.| ||||.
NDHICYFLYQILRGLKYI
Kinase 23186.AA ERK7 253-370 38 7.1e-31 102.59 In-house 1-116 (292) Show / Hide 
Range on Protein: 253-370
Range on HMM: 1-116/292
Sequence Identity: 38% (46 aa)

YQLLVPIGIGGYGVVAKAFDQEKQDFVAIKKIFKPFLNPLETKRILREIKILKALE-HDNIISIRDVLSPVPKEKLEDIYIISQLMDTDLHQIIASDQIL
|...  .| | ||.| ||.|.  .. ||.||||  | |.    |  ||| .|.... |.|||.. .|   .. .   |||..   |.|||| .|   .||
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINV---IRADNDRDIYLVFEFMETDLHAVIRKGNIL

SEDHIQFFIYQLLCGLKYV
 . | |. .||||  .||.
KDIHKQYIMYQLLRAIKYM
Kinase 23186.AA Pkinase 253-369 28 2e-29 105.11 Pfam 1-123 (293) Show / Hide 
Range on Protein: 253-369
Range on HMM: 1-123/293
Sequence Identity: 28% (36 aa)

YQLLVPIGIGGYGVVAKAFDQEKQDFVAIKKIFKPFLNPLETKRILR--EIKILKALEHDNIISIRDVLSPVPKEKLEDIYIISQLMDT-----DLHQII
|... .|| |..|.| |. ..  .. ||.|.| |.  .. . .. .|  ||.|.| | |.||. ..|.          .||..  ...      ||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

A--SDQIL--SEDHIQFFIYQLLCGLKY
   ..  .  ||....|..||.|.||.|
STWRHGCFYFSEWECKFYMYQILRGLEY
Kinase 23186.AA RCK 253-369 34 3.2e-23 70.27 In-house 1-120 (298) Show / Hide 
Range on Protein: 253-369
Range on HMM: 1-120/298
Sequence Identity: 34% (43 aa)

YQLLVPIGIGGYGVVAKAFDQEKQDFVAIKKIFKPFLNPLETKRILREIKILKALE-HDNIISIRDVLSPVPKEKLEDIYIISQLMDTDLHQIIAS----
||..  .| | ||.| || . |....|||||  . | . .|    ||||| |..|  |.||| ...|.   .   |   |..  .||..| | . .    
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYS-WEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQL---YFVFEYMDMNLYQMMKDFKER

DQILSEDH--IQFFIYQLLCGLKY
.. |.|    | . .||.| ||..
RKYLPENQRSIKNIMYQILQGLAH
Kinase 23186.AA MAPK-Unclassified 377-414 63 3e-21 73.23 In-house 122-159 (575) Show / Hide 
Range on Protein: 377-414
Range on HMM: 122-159/575
Sequence Identity: 63% (24 aa)

LKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTV
|||.|||.. |||||| |||.| || ..|||||..| .
LKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI
Kinase 23186.AA TyrKc 253-553 18 6.8e-12 -30.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 253-553
Range on HMM: 1-280/280
Sequence Identity: 18% (60 aa)

YQLLVPIGIGGYGVVAKAFDQEKQDFVAIKKIFKPFLNPLETKRILREIKILKAL--EHDNIISIRDVLSPVPKEKL---EDIYIISQLMDT-DLHQIIA
 .|.  .| | .|.| |.        ||.|.. .        . ..||..|.. |  .|.||. .  | .          | ..|.  .|.  ||.. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SDQI-LSEDHIQFFIYQLLCGLKYVNQIYYFLKYIHSAGVFHRDLKPGNLLVNSDCVLKICDFGLARTVDTK-------VNVLVL---MTEY-VATRWYR
. .  |. ..   | .|  ||  |  .           .. ||||   | ||... . ||.||||.| .. .           .     . . .  ||. 
KHRPKLCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-

APELLLSWNKYTTAIDMWAVGCIFSELYMRKPLLPGE-----SYLNQLILTLNLTGTPSKEDL--ENIQSDRAKQFIISLGNKAPKDLSKLIPNASPQAI
||| .   .|.||. | |. |    |.. .    . .         ..|  .   . . . .   . .                    .   . ...   
APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS-------------------F---VCCPDEMY

DLISKMIVFNPDKRISAEEALKHPFF
.....   ..|..| . .|   | .|
QIMKQCWHEDPEDRPTFSEI--HECF
Kinase 23186.AA Pkinase_Tyr 394-414 61 0.00015 16.03 Pfam 141-161 (270) Show / Hide 
Range on Protein: 394-414
Range on HMM: 141-161/270
Sequence Identity: 61% (13 aa)

NLLVNSDCVLKICDFGLARTV
| ||... | |||||||||..
NCLVTENNVVKICDFGLARDI
Kinase 23186.AA Pkinase_Tyr 279-314 33 0.001498 12.65 Pfam 31-68 (270) Show / Hide 
Range on Protein: 279-314
Range on HMM: 31-68/270
Sequence Identity: 33% (13 aa)

VAIKKIFKPFLNPLE--TKRILREIKILKAL-EHDNIIS
||.|.. |.   . .   .  .||.||.| |  |.||..
VAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVR