Gene 6784 (Tetrahymena)

6784

Species: Tetrahymena
Alias: TTHERM_00195990, 16.m00440, 6784, PreTt06784, 884
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
6784.AA Protein None 608 None Fasta, JSON
6784.kin_dom Protein Kinase Domain None 289 None Fasta, JSON
6784.NA RNA None 1827 None Fasta, JSON

Protein domain

Protein domains of 6784.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 6784.AA ERK 258-546 59 1.6e-222 745.53 In-house 1-307 (307) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-307/307
Sequence Identity: 59% (183 aa)

YEFHKQIGHGAYGVVCSGVDTK-----CNKKIAIKKITNAFEDLVDAKRIVREIKMLKFFD-HENIIALHDIIVPEQRTDYNDIYIVTELMETDLHRVIY
|...||||||||||||| .|..     ...|.|||||.|||......||..||||.|..|. ||||| |.||..|.....|||||.|.||||||||..|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SRQELTDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEFDEEDG-------KTEYVVTRWYRAPEVILKASKYTKSIDV
|.|||.|||.|||.||.|.|..|||||||.||||||||||||.|||||.||.||||.|... ...        ||||.||||||||..|...||||..|.
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSIGCIFAELLGRTPLFPGKDYLEQIQRIIAILGTP-TPEELSYITNEGALKYLKSLPK--RTKQSWENLYPNAN--LVGLDLLSKMLTFNPNDRYTIEE
||.||||||.|||.||||||||..||.||..|.||| . |.|.||..|.|.||.|.||.  |....|||..||||    ..|||.|||.|.|..|.|.||
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

CLAHPYF
||.||||
CLEHPYF
Kinase 6784.AA MAPK 258-546 52 6.8e-195 653.75 In-house 1-328 (328) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-328/328
Sequence Identity: 52% (173 aa)

YEFHKQIGHGAYGVVCSGVDTK------CNKKIAIKKITNAFEDLVDAKRIVREIKMLKFF-DHENIIALHDIIVP------EQRTDYNDIYIVTELMET
|.  |.||.|||||||| .|..      |.||.||||| ..|......||. ||||.|..| .||||| | ||. |      . . ..||||||.|||||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHRVIYSRQELTDDHIQYFLYQTLRG--MLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEFDEEDGK-------------TEYVVTRWYRAP
|||..|.|.|.|.|||||||.|| |||  . ||||||| ||||||||||||.|||||.|| ||||... .... .             ||||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILK--ASKYTKSIDVWSIGCIFAELLG-RTPLFPGKDYLEQIQRIIAILGTPTPEELSYIT-NEGALKYLKSL---PKRTKQSWENLYPN----ANLV
|..|   . .|||..|.||.||||||.|. |.||||||||..|...|...||||..| ...|. .| | .|..||   ||..|..||...||    ||  
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

GLDLLSKMLTFNPNDRYTIEECLAHPYF
 .|||.|||.|.|..|.|.||.|.||||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 6784.AA CMGC 258-546 27 1.4e-145 481.86 In-house 1-513 (513) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-513/513
Sequence Identity: 27% (141 aa)

YEFHKQIGHGAYGVVCSGVDTKCN--------------KKIAIKKITNAFEDLVDAK----------RIVREIKMLKFF-----------------DHEN
||  |.||.|.||||....|...|              ...||||| |.| .  .||          |. ||||.|| .                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIALHDIIVPEQ--RTDY----------NDIYIVTELMETDLHRVIYSRQ---------ELTDDH------------IQYFL------YQTLRGML--YI
|. |.||.....  ...|          |..|.|.|.|..||...|.. |         .|.. |            |.||.      || |||.   |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAN--VMHRDLKPSNILVNKNCDL--------------------KVCDLGLARGFEFDEEDG--------------------KTEYVVTRWYRAPEVIL
||..  ..||||||.|||.|.||.|                    |.|| |||| ..  ...                      |.|||||||||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

KA---------SKYTKSIDVWSIGCIFAELLGR--------TPLFP-----------GKDYLEQIQRIIAILGTPT---------------PEELSYITN
 .          .||..||.||.||||||.. .         ||||           ||....|...|. .|||||               .||  ....
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

---------------------EGALKYLKS---LPKRTKQSWENLYPN-----------------------------------ANLVGLDLLSKMLTFNP
                     |.| .|..|   .|.. ...|.||.|.                                   ..  ..|||.|||...|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

NDRYTIEECLAHPYF
..| |.|..|.||||
DKRITAEQALQHPYF
Kinase 6784.AA p38 258-546 44 4.1e-133 448.53 In-house 1-289 (289) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-289/289
Sequence Identity: 44% (131 aa)

YEFHKQIGHGAYGVVCSGVDTKCNKK---IAIKKITNAFEDLVDAKRIVREIKMLKFFDHENIIALHDIIVP--EQRTDYNDIYIVTELMETDLHRVIYS
|.. . .| |||| ||. .|.. ..|   .||||.   |.. ..|||. ||.. ||  .|||.| | |.  |  ... | .|.|.||..|..||.... .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

RQELTDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEFDEEDGKTEYVVTRWYRAPEVILKASKYTKSIDVWSIGCIFA
 . |.|||||. .|| |||  |||||.. ||||||||| || .|.|.. | ||||      .|  |.||.||||||||..|   .||. .|.||.||| |
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMA

ELLGRTPLFPGKDYLEQIQRIIAILGTPTPEELSYITNEGALKYLKSLPKRTKQSWENLYPNANLVGLDLLSKMLTFNPNDRYTIEECLAHPYF
||. . .||||.|...|.|||....|||..| .. | .| |  |..|.|.....  ......||   .||| |||   |  | | || ..||||
ELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 6784.AA ERK1 258-546 54 6.4e-131 441.23 In-house 1-289 (289) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-289/289
Sequence Identity: 54% (160 aa)

YEFHKQIGHGAYGVVCSGVDTKCNKKIAIKKITNAFEDLVDAKRIVREIKMLKFFDHENIIALHDIIVPEQRTDYNDIYIVTELMETDLHRVIYSRQELT
|   . ||.||||.||| .||  ....|||||   ||     .| .||||.|. | ||||| ..|||  .      |.||| .|||||| ... . |.| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

DDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLAR--GFEFDEEDGKTEYVVTRWYRAPEVILKASKYTKSIDVWSIGCIFAELL
 ||| ||||| |||. |||||||.||||||||.|.|. ||||.|| ||||    | |     |||| ||||||||..| .  ||||||.||.||| ||.|
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

GRTPLFPGKDYLEQIQRIIAILGTPTPEELSYITNEGALKYLKSLPKRTKQSWENLYPNANLVGLDLLSKMLTFNPNDRYTIEECLAHPYF
   |.|||| ||.|.  |...|| |  ..|  | || |  ||.||| ..|..|. |.|.|    |||| |||||||. | |.|| ||||| 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 6784.AA ERK5 258-546 48 2.3e-126 426.1 In-house 1-295 (295) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-295/295
Sequence Identity: 48% (142 aa)

YEFHKQIGHGAYGVVCSGVDTKCNKKIAIKKITNAFEDLVDAKRIVREIKMLKFFDHENIIALHDIIVPEQ-RTDYNDIYIVTELMETDLHRVIYSRQEL
|.   .|| |||||||| .  |  ...||||| |||. .  ||| .||.|.|. | |.||||..||. |..   .. |.|.| .||| ||| .| | | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEF----DEEDGKTEYVVTRWYRAPEVILKASKYTKSIDVWSIGCIFA
| .|| ||||| |||. |.|||.|.||||||||.||| ||.||. | |.|||       ...   |||| ||||||||...    ||. |||||.|||| 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELLGRTPLFPGKDYLEQIQRIIAILGTPTPEELSYITNEGALKYLKS-LPKRTKQSWENLYPNANLVGLDLLSKMLTFNPNDRYTIEECLAHPYF
|...|  .|||| |..|.| |. .||.| |  .  .  .    |... .| |. . || .|| |   .||||..|| | | .| |. . | ||. 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 6784.AA nmo 259-546 46 3.9e-116 358.77 In-house 2-292 (292) Show / Hide 
Range on Protein: 259-546
Range on HMM: 2-292/292
Sequence Identity: 46% (135 aa)

EFHKQIGHGAYGVVCSGVDTKCNKKIAIKKITNAFEDLVDAKRIVREIKMLKFFDHENIIALHDIIVPEQRTDYNDIYIVTELMETDLHRVIYSRQELTD
.  . ||.||.||| |  | .  |..|.||. | | .|| .||. ||.||| || |.|.... ||. | .   ...||.|||||  |||..| | |.|. 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

DHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEFDEEDGKTEYVVTRWYRAPEVILKASKYTKSIDVWSIGCIFAELLGRT
||.. |||| |||. |.||||..|||.|| |.||| || ||.|| ||||  | |..   |. ||| .|||||... | .||  .|.||.|||||||||| 
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

PLFPGKDYLEQIQRIIAILGTPTPEELSYITNEGALKYLKSLPKRTKQSWENLYP-----NANLVGLDLLSKMLTFNPNDRYTIEECLAHPYF
 ||  .  ..|.| |. .||||. |.. |   |||   .   |.. . . . ||      .|.    .||..|| |.|. |  ... ||||| 
ILFQAQSPIQQLQMITDLLGTPSMEDMKYAC-EGAKAHMLRMPHK-PPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 6784.AA ERK7 258-546 44 2.2e-113 382.99 In-house 1-292 (292) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-292/292
Sequence Identity: 44% (130 aa)

YEFHKQIGHGAYGVVCSGVDTKCNKKIAIKKITNAFEDLVDAKRIVREIKMLKFFD-HENIIALHDIIVPEQRTDYNDIYIVTELMETDLHRVIYSRQEL
|| .|..| ||||.|   .| .  . .|.|||  || . .|| |  ||| .|. |. |.||| | ..|  .      |||.| | |||||| ||   . |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADND---RDIYLVFEFMETDLHAVIRKGNIL

TDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEFDE-----EDGKTEYVVTRWYRAPEVILKASKYTKSIDVWSIGCIF
 | | || .|| || . |.||.||.||||||||||.. .| .|||| ||||     |     .   |||| ||||||||. | . .||| .| |||||| 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCIL

AELLGRTPLFPGKDYLEQIQRIIAILGTPTPEELSYITNEGALKYLKSLPKRTKQSWENLYPNANLVGLDLLSKMLTFNPNDRYTIEECLAHPYF
.|.|   |.|||   ..|| .|. ... || |..  |  . | . |...... ... ....|..   ..||| ..| |||. | |.|..|.||| 
GEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 6784.AA S_TKc 258-546 28 4.3e-100 339.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-231/231
Sequence Identity: 28% (88 aa)

YEFHKQIGHGAYGVVCSGVDTKCNKKIAIKKITNAFEDLVDAKRIVREIKMLKFFDHENIIALHDIIVPEQRTDYNDIYIVTELMET---DLHRVIYSRQ
||....||.||.|.|. ....| ... |||.|          ..| |||..||  .|.||. |.|...       ...|.|.|....   ||...| .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

E------LTDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEFDEEDGKTEYVVTRWYRAPEVILKASKYTK-SIDVWSI
       ..  |.....||..... |.|| ...||||||.|||...   .|.|| |||| .        | ...|.||.||||.    .|.| ..|.||.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCIFAELLGRTPLFPGKDYLEQIQRIIAILGTPTPEELSYITNEGALKYLKSLPKRTKQSWENLYPNANLVGLDLLSKMLTFNPNDRYTIEECLA-----
|||..|.| . |.||      |.|... ..|                                        ..|...|.|...|..|.|. |.|.     
GCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPYF
  ||.|
KCHPWF
Kinase 6784.AA CDK 258-546 34 2.9e-99 318.24 In-house 1-284 (284) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-284/284
Sequence Identity: 34% (111 aa)

YEFHKQIGHGAYGVVCSGVDTKCN-----KKIAIKKITNAF---EDLVDAKRI--VREIKMLKFFDHENIIALHDIIVPEQRTDY------NDIYIVTEL
||  ..|| |.||||  . |.. .     . .|.|||       |.  .   |  .|||..||   |.||. |||... ... ..      | .|.| | 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

METDLHRVIYSRQELTDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCD-----LKVCDLGLARGFEF--D---EEDGKTEYVVTRWYRAPEV
|..||  ..          |. ...| |||. |.|| ..|||||||.|||.|.|       ||. | |||| |    .   .    |  |||.||||||.
MDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPEL

ILKASKYT--KSIDVWSIGCIFAELLG---RTPLFPGKDYLEQIQRIIAILGTPTPEELS-YITNEGALKYLKSLPKRTKQSWENLYPNANLVGLDLLSK
 | ...|.   .||.||.||||||..    | |||||.  ..|. .|. |.||||..         .                            |||.|
LLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLLNK

MLTFNPNDRYTIEECLAHPYF
||...|. | . |..| ||||
MLCYDPKKRISAEQALQHPYF
Kinase 6784.AA Pkinase 258-546 29 5.4e-97 333.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YEFHKQIGHGAYGVVCSGVDTKCNKKIAIKKITNAFEDLVDAKRIVR--EIKMLKFFDHENIIALHDIIVPEQRTDYNDIYIVTELMET-----DLHRVI
|.....|| |..|.|. ... . .|. |.|.|    |.    .. .|  ||...| ..|.||. |.|.         ..||.|.|..|      ||...|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

Y--SRQEL--TDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDL----KVCDLGLARGFEFDEEDGKTEYVVTRWYRAPEVILKASKYTKSI
   ..  .  ...... ..||.|||. |.|| ...||||||.|||...|...    |.|| |||. |.    .. | ...|.||.|||||.....|....
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSIGCIFAELLGRTPLFPGK----DYLEQIQRIIAILGTPTPEELSYITNEGALKYLKSLPKRTKQSWENLYPNANLVGLDLLSKMLTFNPNDRYTIE
|.||.|||..|.| . |.|||.    . ..|.|.|  |.|.|.... ..  ..   . ..  . .  .  . . .|..  ..|.....|...|..|.|.|
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

ECLAHPYF
..| ||.|
QILQHPWF
Kinase 6784.AA MAPK-Unclassified 258-407 47 3.3e-75 256.17 In-house 1-157 (575) Show / Hide 
Range on Protein: 258-407
Range on HMM: 1-157/575
Sequence Identity: 47% (74 aa)

YEFHKQIGHGAYGVVCSGVDTKC-NKKIAIKKITNAFEDLVDAKRIVREIKMLKFFDHENIIALHDIIVPEQRTD--YNDIYIVTELMET---DLHRVIY
||  | || ||||.||  .|.|  |.. ||||.. .|.. .|.||. |||  |    |.|||.. ||. ..      . |||||...|.|   ||| .|.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SRQ-ELTDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLAR
|.|  . . |||||.|| |||. |.|||.. ||||||||.|.| .| ...|| |..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase 6784.AA MAPK-Unclassified 418-546 34 5.5e-50 172.37 In-house 406-575 (575) Show / Hide 
Range on Protein: 418-546
Range on HMM: 406-575/575
Sequence Identity: 34% (59 aa)

TEYVVTRWYRAPEVILKASKYTKSIDVWSIGCIFAELLGR-----------TPLFPGKD--------------------YLEQIQRIIAILGTPTPEELS
|.||||||||||| .|  . |.. .| |||||||||.. .            |||||.|                    .  ||. |.  ||.|  | ..
TQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCN

YITNEGALKYLKSLPKRTKQSWENLYPNANL----------VGLDLLSKMLTFNPNDRYTIEECLAHPYF
 ||.  | ||..|. . |   .  |.. ..             .|...||| |||. |.|... | ||||
FITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 6784.AA Pkinase_Tyr 258-407 30 3.1e-17 58.98 Pfam 1-159 (270) Show / Hide 
Range on Protein: 258-407
Range on HMM: 1-159/270
Sequence Identity: 30% (50 aa)

YEFHKQIGHGAYGVVCSGVDT----KCNKKIAIKKITNAFEDLVD--AKRIVREIKMLKFF-DHENIIALHDIIV-PEQRTDYNDIYIVTELMET-DLHR
 .| |..|.||.|.|. |. .    . . . |.|.. .   .  .   .   ||.|..| . .|.||. |. ...  ..      ||||.|.|.  ||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLD

VIYS----RQELTDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLAR
   .    .| ||  ..  . .|  .|| | .| |  ||||   |.||..|   |.|| ||||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 6784.AA TyrKc 258-546 24 2.4e-16 41.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 258-546
Range on HMM: 1-280/280
Sequence Identity: 24% (77 aa)

YEFHKQIGHGAYGVVCSGVDTKCNKKIAIKKIT-NAFEDLVDAKRIVREIKMLKFF--DHENIIALHDIIVPEQRTDY---NDIYIVTELMET-DLHRVI
 .. |..|.||.|.|. |. .    . |.|..  .|       . . ||..... .  .|.||..|. ... ..|  .     ..||.|.|.  ||.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYL

YSRQE-LTDDHIQYFLYQTLRGMLYIHSANVMHRDLKPSNILVNKNCDLKVCDLGLARGFEFD-------EEDGK-----TEY-VVTRWYRAPEVILKAS
 .... |. ..  .| .|  .|| |.|| |. ||||   |.||..|   |..| ||.|  . |       .   |     . . .  ||. |||.| . .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

KYTKSIDVWSIGCIFAEL--LGRTPLFPG-----KDYLEQIQRIIAILGTPTPEE---LSYITNEGALKYLKSLPKRTKQSWENLYPNANLVGLDLLSKM
|.|   |||| |    |.  .| .|  ||     ..  | |... .    | |..   .|                         .. .     .. .. 
KFTTKSDVWSFGVCMWEIFTYGQQP-YPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQC

LTFNPNDRYTIEECLAHPYF
  ..|.|| | .|.  | .|
WHEDPEDRPTFSEI--HECF