Gene 16370 (Tetrahymena)

16370

Species: Tetrahymena
Alias: TTHERM_00085220, 3836.m02037, 6.m00444, 16370, PreTt16370, 96
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: MAPK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
16370.AA Protein None 621 None Fasta, JSON
16370.kin_dom Protein Kinase Domain None 558 None Fasta, JSON
16370.NA RNA None 1866 None Fasta, JSON

Protein domain

Protein domains of 16370.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 16370.AA MAPK-Unclassified 19-576 65 0.0 1447.29 In-house 1-575 (575) Show / Hide 
Range on Protein: 19-576
Range on HMM: 1-575/575
Sequence Identity: 65% (378 aa)

YDLIKVVGSGSYGSVAEATDKKS-GKKVAIKRLNGIFEDNVDCKRILREIHLLRILNHPNLIRINEIIEPKDLQN--FDTLYVVTEYCQS---DLKKLFK
|...|..|||.||.|..|.|||. ...||||..|.||....||||.||||..||.|||||.|.|..|...|.|.|  ||..|.|..|.|.   ||....|
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

SPI-HLCMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSVEGNQNLRFSFFTFSLLIGFIIYLTLLRMKMILLLLFLKYHK
|.. |.|....|...|.||.|.||||||...||||||.|.|||.||||.|||||..||.|.|||||||||||||||||||||||||||||||||||||||
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDNQNLRFSFFTFSLLIGFIIYLTLLRMKMILLLLFLKYHK

AMTSRSRCLNKHYSKILLKLKKNLHIEDDLQEFILKTRIKLLNEQSSLFLKKQNKQQKSTQHSSFHDEFSQQIDDNLAILVNQENIIQDQQQIVKAIETK
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|||..
AMTSRSRCLNKHYSKILLKLKKNLHIEDDLQEFILKTRIKLLNEQSSLFLKKQNKQQKSTQHSSFHDEFSQQIDDNLAILVNQENIIQDQQQIRNAIEFF

KERKNKNRYFSKQNSKIKFYEKKTQRNLNNYQQASNQLLQKADRQIDQKFLCIEGAHIYDDRNSNSPQKQQTSSQSPEKPAATSSGRPKLSKEKGINSKT
|.|||..||...||..|.||..|.|.||||||||||||||||||||||||||||||||||..||||.||||...|....||.......|..|.|.||...
KFRKNMHRYHKQQNKQINFYNNKPQQNLNNYQQASNQLLQKADRQIDQKFLCIEGAHIYDFQNSNSYQKQQFIHQCNQFPAYEFCTKNKKQKHKQINDCH

TKRELTGHVVTRWYRAPELILLEKDYTAAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGGFPHSHSDQLNVIFSVLGTPN
.....|..||||||||||..|....|....|||||||||||.|.|.....|||.|..|||||..|||..|||||.|.||||||||.||...||..||.|.
HCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPP

EEDMDFVTDAKAIEYLKSFKQKKRVDFKDLFPAATP----------ECIDFLNKTLVFNPRKRITIDAALNHPLF
|||..|.|...|..|..|||.|..|.|.||.....|          |||||..|.|.|||.||||.|.||.||.|
EEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 16370.AA MAPK 19-576 23 2.6e-160 538.88 In-house 1-328 (328) Show / Hide 
Range on Protein: 19-576
Range on HMM: 1-328/328
Sequence Identity: 23% (139 aa)

YDLIKVVGSGSYGSVAEATDKK------SGKKVAIKRLNGIFEDNVDCKRILREIHLLRIL-NHPNLIRINEIIEP------KDLQNFDTLYVVTEYCQS
|...| .|.|.|| |. |.||.      .|||||||..   |.. ..|||..|||.||| . .|.| |....|. |      ..|..|...|.|.|....
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLKKLFKSPIHLCMIQVQTLTYNILTG--IKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSVEGNQNLRFSFFTFSLLIGFIIYLTLLRMKMILL
|| .. ||. .|. . .| ..| || |  .||.||| |.||||||.|.|.||.| .||||||||||.. ... . ..... .. . .             
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HC-F-Q-------------

LLFLKYHKAMTSRSRCLNKHYSKILLKLKKNLHIEDDLQEFILKTRIKLLNEQSSLFLKKQNKQQKSTQHSSFHDEFSQQIDDNLAILVNQENIIQDQQQ
                                                                                                    
----------------------------------------------------------------------------------------------------

IVKAIETKKERKNKNRYFSKQNSKIKFYEKKTQRNLNNYQQASNQLLQKADRQIDQKFLCIEGAHIYDDRNSNSPQKQQTSSQSPEKPAATSSGRPKLSK
                                                                                                    
----------------------------------------------------------------------------------------------------

EKGINSKTTKRELTGHVVTRWYRAPELILL--EKDYTAAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGGFPHSHSDQLN
         |. .|..|.||||||||..|    ..|| |.|.||.||||||...          || ||||                     ... ||.|
---------KMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLT----------DRKPLFP--------------------GKDYIDQWN

VIFSVLGTPNEEDMDFVT-DAKAIEYLKSF---KQKKRVDFKDLFPA----ATPECIDFLNKTLVFNPRKRITIDAALNHPLF
 |..||||| ||.. ... . .| .|..|.   ...........||     |.|..||.| | |||.| ||||.. ||.|| |
LIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 16370.AA CMGC 19-576 19 6.8e-121 399.27 In-house 1-513 (513) Show / Hide 
Range on Protein: 19-576
Range on HMM: 1-513/513
Sequence Identity: 19% (143 aa)

YDLIKVVGSGSYGSVAEATD--------------KKSGKKVAIKRLNGIFEDNVDCK----------RILREIHLLRILN-----------------HPN
|. ||..|.|.|| | ...|              ......||||..   | .  ..|          |.|||| .|. ||                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LIRINEIIEPKD-------------LQNFDTLYVVTEYCQSDLKKLFKS---------PIHLCMIQ------------VQTLT------YNILTGIK--Y
.... .|. .|.             . .|. || |.||.. ||... |.         |..|   .            .. ..      | ||.|.|  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSAE--VLHRDLKPANVLINEDCSV--------------------KICDFGLARSVEGNQNLRFSFFTFSLLIGFIIYLTLLRMKMILLLLFLKYHKAM
.||.   ..||||||.|.|||..| .                    |||||||||... ... .|. ...|    |                        
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS----F------------------------

TSRSRCLNKHYSKILLKLKKNLHIEDDLQEFILKTRIKLLNEQSSLFLKKQNKQQKSTQHSSFHDEFSQQIDDNLAILVNQENIIQDQQQIVKAIETKKE
      .|                                                                      ||.                   
------KN----------------------------------------------------------------------VNK-------------------

RKNKNRYFSKQNSKIKFYEKKTQRNLNNYQQASNQLLQKADRQIDQKFLCIEGAHIYDDRNSNSPQKQQTSSQSPEKPAATSSGRPKLSKEKGINSKTTK
                                                                                              ..  . 
----------------------------------------------------------------------------------------------DD-KPN

RELTGHVVTRWYRAPELILLEKDYT---------AAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGGFPHSHSDQLNVIF
| .|  ||||||||||..|  |.||          .||.||.||||||... ..   .  ... |||||.|. |.      . . .    || |||. ||
RPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQ---SLIFRGKPLFPGHSEYPN------D-D-K-NGKSHIDQLFKIF

SVLGTPN---------------EEDMDFVTD---------------------AKAIEYLKS---FKQKKRVDFKDLFPA---------------------
 |||||.               ||..  ...                      .|  |..|   |..... ..|.|||                      
KVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEK

--------------ATPECIDFLNKTLVFNPRKRITIDAALNHPLF
              ..|..||.|.| |...| ||||.. ||.|| |
FKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 16370.AA S_TKc 19-576 15 2.7e-68 234.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-576
Range on HMM: 1-231/231
Sequence Identity: 15% (90 aa)

YDLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDCKRILREIHLLRILNHPNLIRINEIIEPKDLQNFDTLYVVTEYCQS---DLKKLFKSPI
|......|.|..|.|  ...||.|..||||...         ..|.||| .|.  .|||.... ....       | ||.|.|||     ||... |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRG

H------LCMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSVEGNQNLRFSFFTFSLLIGFIIYLTLLRMKMILLLLFLKY
.      .   ... ..| |. ...|.||  ..||||||.|.|..|   .||||||||| .                                       
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------------------

HKAMTSRSRCLNKHYSKILLKLKKNLHIEDDLQEFILKTRIKLLNEQSSLFLKKQNKQQKSTQHSSFHDEFSQQIDDNLAILVNQENIIQDQQQIVKAIE
                                                                                                    
----------------------------------------------------------------------------------------------------

TKKERKNKNRYFSKQNSKIKFYEKKTQRNLNNYQQASNQLLQKADRQIDQKFLCIEGAHIYDDRNSNSPQKQQTSSQSPEKPAATSSGRPKLSKEKGINS
                                                                                                    
----------------------------------------------------------------------------------------------------

KTTKRELTGHVVTRWYRAPELILLEKDYTA-AIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGGFPHSHSDQLNVIFSVLG
       |  ..|.||.|||..     |.  ..|.||.|||..|.           | . |.||                          |....| ..|
-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM-----------LCGYPPFP--------------------------QMQMMFKKIG

TPNEEDMDFVTDAKAIEYLKSFKQKKRVDFKDLFPAATPECIDFLNKTLVFNPRKRITIDAALN-------HPLF
                                     .||..||..| |...|.||.|.  ||.       || |
-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 16370.AA ERK 19-182 42 8e-58 198.41 In-house 1-174 (307) Show / Hide 
Range on Protein: 19-182
Range on HMM: 1-174/307
Sequence Identity: 42% (74 aa)

YDLIKVVGSGSYGSVAEATDKK-----SGKKVAIKRLNGIFEDNVDCKRILREIHLLRILN-HPNLIRINEIIEPKDLQNFDTLYVVTEYCQSDLKKLFK
| .|| .| |.|| |. |.||.     .|.|||||    .|.. ..|||.||||.||| .. |.|.| .. |. |.   ... .|.|.|. ..|| .  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SPIHLCMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLAR----SVEGNQNLRFSFFT
|.  |    .| ..| || |.||.||| |.|||||| |.|.|..|  |||||||||    |.. |   . .|.|
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMT
Kinase 16370.AA nmo 20-176 44 5.7e-57 173.44 In-house 2-158 (292) Show / Hide 
Range on Protein: 20-176
Range on HMM: 2-158/292
Sequence Identity: 44% (70 aa)

DLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDCKRILREIHLLRILNHPNLIRINEIIEPKDLQNFDTLYVVTEYCQSDLKKLFKSPIHLCM
.  . .| | .| |   || ..||.||.|..  .| . | |||. ||. .|   .| | .   .|..| ... |. .|||||  |||| |.  || ||  
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

IQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSVEGNQNL
  |.   | || |.||||||..||||.|| |.|.| .| .|||||||||  | .| .
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSK
Kinase 16370.AA p38 19-171 41 1.1e-54 185.28 In-house 1-157 (289) Show / Hide 
Range on Protein: 19-171
Range on HMM: 1-157/289
Sequence Identity: 41% (65 aa)

YDLIKVVGSGSYGSVAEATDKKSGKK---VAIKRLNGIFEDNVDCKRILREIHLLRILNHPNLIRINEIIEP--KDLQNFDTLYVVTEYCQSDLKKLFKS
|  .. ||||.||.|. | |...|.|   ||||.|.  |.. .. ||. ||. ||. ..| | | . ..  |  .....|   |.||.  ..||... |.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

PIHLCMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSVE
   |   ..| | | || | || |||.. |||||| |. .|||| ..| ||||||. .
QR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCD
Kinase 16370.AA ERK 408-576 36 4.8e-50 172.58 In-house 165-307 (307) Show / Hide 
Range on Protein: 408-576
Range on HMM: 165-307/307
Sequence Identity: 36% (63 aa)

NSKTTKRELTGHVVTRWYRAPELILLEKDYTAAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGGFPHSHSDQLNVIFSVL
|.....  .|. |.||||||||..|  ..|| |.||||.||||||...           | ||||                      .. .|.| ||...
NHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLG-----------RKPLFP--------------------GKDYVHQINRIFQII

GTP-NEEDMDFVTDAKAIEYLKSFKQ--KKRVDFKDLFPAAT--PECIDFLNKTLVFNPRKRITIDAALNHPLF
|||  |||.   .. .| .|.|..    .. ......|| |   |..|| | | |||.| ||||.. .| || |
GTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase 16370.AA ERK7 19-170 40 5.9e-48 161.94 In-house 1-150 (292) Show / Hide 
Range on Protein: 19-170
Range on HMM: 1-150/292
Sequence Identity: 40% (62 aa)

YDLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDCKRILREIHLLRILN-HPNLIRINEIIEPKDLQNFDTLYVVTEYCQSDLKKLFKSPIHL
|...| .| | || |  |.||.... ||.|.    | ...|  |  ||| .|. .. |||.||. ..|  .   |   .|.| |.  .||    .    |
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRAD---NDRDIYLVFEFMETDLHAVIRKGNIL

CMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSV
  | .|   | .|  |||.||..|.||||||.|.|.. .| ||.||||||||.
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSI
Kinase 16370.AA CDK 401-576 33 3.3e-45 142.49 In-house 159-284 (284) Show / Hide 
Range on Protein: 401-576
Range on HMM: 159-284/284
Sequence Identity: 33% (60 aa)

LSKEKGINSK-TTK--RELTGHVVTRWYRAPELILLEKDYT--AAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGGFPHS
|....||...   .  |..|  |||.||||||| | .|.|.   .||.||.||||||...         . | |||||.|                    
LARAFGIPHQMS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTD--------VTRKPLFPGDSE-------------------

HSDQLNVIFSVLGTPNEEDMDFVTDAKAIEYLKSFKQKKRVDFKDLFPAATPECIDFLNKTLVFNPRKRITIDAALNHPLF
  |||  || ..|||.|..   ||.                              |.||| |...| |||. ..||.|| |
-IDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 16370.AA ERK5 19-168 41 3.4e-45 156.45 In-house 1-151 (295) Show / Hide 
Range on Protein: 19-168
Range on HMM: 1-151/295
Sequence Identity: 41% (63 aa)

YDLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDCKRILREIHLLRILNHPNLIRINEIIEPKD-LQNFDTLYVVTEYCQSDLKKLFKSPIHL
|. |  .| | || |. |  .| |..||||..   |.     || .||. .||   | |.| | .|. ||  .  .   ||| .   ||| ..  |   .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

CMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLAR
 .  .    | || |.||.|||.|.||||||.|.|.|| | .|| |||.||
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMAR
Kinase 16370.AA CDK 19-168 32 1.1e-44 140.82 In-house 1-161 (284) Show / Hide 
Range on Protein: 19-168
Range on HMM: 1-161/284
Sequence Identity: 32% (56 aa)

YDLIKVVGSGSYGSVAEATDKKSG-----KKVAIKRLNGIF-----E-DNVDCKRILREIHLLRILNHPNLIRINEIIEPKDLQNF------DTLYVVTE
|. .. .| |.|| |  | ||..|     . ||.|..         | . . .   .||| ||. | ||| ... ...  |.. .        .|| | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPIT-AIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YCQSDLKKLFKSPIHLCMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCS-----VKICDFGLAR
|.  ||||. .         ...... .| |. |.||  ..||||||.| |||.. .     .|| ||||||
YMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLAR
Kinase 16370.AA Pkinase 19-174 33 7.5e-44 156.14 Pfam 1-166 (293) Show / Hide 
Range on Protein: 19-174
Range on HMM: 1-166/293
Sequence Identity: 33% (57 aa)

YDLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDCKRILR--EIHLLRILNHPNLIRINEIIEPKDLQNFDTLYVVTEYCQS-----DLKKLF
| .....||||.|.| ....|..||.||.|...   |.   ... .|  ||.... ||||| .|. .. |       | .|.|.|||.      ||. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

K--SPIHL--CMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSV----KICDFGLARSV-EGNQ
.  .   .   . ...   | || |..|.||  ..||||||.|.||.... .    ||||||||. . . |.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NN
Kinase 16370.AA ERK1 19-168 44 3.4e-42 146.52 In-house 1-148 (289) Show / Hide 
Range on Protein: 19-168
Range on HMM: 1-148/289
Sequence Identity: 44% (66 aa)

YDLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDCKRILREIHLLRILNHPNLIRINEIIEPKDLQNFDTLYVVTEYCQSDLKKLFKSPIHLC
|  .. .| | || |. | |.  ...||||..   ||    |.| ||||..|   .| |.| |..||  . ....  .|.| .    || || |.  || 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLS

MIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLAR
   .    | || |.||.||| ||||||||.|.|.|  | .|||||||||
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR
Kinase 16370.AA ERK7 416-576 33 1.4e-33 111.98 In-house 163-292 (292) Show / Hide 
Range on Protein: 416-576
Range on HMM: 163-292/292
Sequence Identity: 33% (54 aa)

LTGHVVTRWYRAPELILLEKDYTAAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGGFPHSHSDQLNVIFSVLGTPNEEDM
||  | ||||||||  |  . || ..| |||||| .|.           |   |.|||.| .                    .|.. |  ... | .||.
LTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM-----------LRGKPMFPGTSTM--------------------NQIEKILETIPKPTQEDI

DFVTDAKAIEYLKSFKQKKRVDFKDLFPAATPECIDFLNKTLVFNPRKRITIDAALNHPLF
  .    |.  |.. .|.||  .....| . .. || | . |||||.||.|.. ||.||  
EAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 16370.AA Pkinase 420-576 22 2.4e-28 101.28 Pfam 172-293 (293) Show / Hide 
Range on Protein: 420-576
Range on HMM: 172-293/293
Sequence Identity: 22% (36 aa)

VVTRWYRAPELILLEKDYTAAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGGFPHSHS------DQLNVIFSVLGTPNEE
..|.||.|||.|.  ..|. ..|.||.|||..|...                                  | .| ...      ||. .|. ..|.|...
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC----------------------------------GRPPFPGHCWHDNHDQMQMICRIMGPPLHF

DMDFVTDAKAIEYLKSFKQKKRVDFKDLFPAATPECIDFLNKTLVFNPRKRITIDAALNHPLF
| .   .    . ..  . .    .. . .....||.||... | ..| ||.|.. .|.|| |
DWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 16370.AA ERK1 498-576 45 1.4e-23 84.62 In-house 211-289 (289) Show / Hide 
Range on Protein: 498-576
Range on HMM: 211-289/289
Sequence Identity: 45% (36 aa)

DQLNVIFSVLGTPNEEDMDFVTDAKAIEYLKSFKQKKRVDFKDLFPAATPECIDFLNKTLVFNPRKRITIDAALNHPLF
|||| | .||| | ..|.. .   || .||.|   |..| .. ||| | .  .|.|.| | ||| ||||.. || ||  
DQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 16370.AA p38 496-576 43 8.7e-23 74.48 In-house 209-289 (289) Show / Hide 
Range on Protein: 496-576
Range on HMM: 209-289/289
Sequence Identity: 43% (35 aa)

HSDQLNVIFSVLGTPNEEDMDFVTDAKAIEYLKSFKQKKRVDFKDLFPAATPECIDFLNKTLVFNPRKRITIDAALNHPLF
| |||. | .|.||| || .  . . .|  |..|  | .| ||...|..|.|  || | | |.  | ||||   |. || |
HIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 16370.AA p38 412-454 58 1.8e-22 73.38 In-house 156-198 (289) Show / Hide 
Range on Protein: 412-454
Range on HMM: 156-198/289
Sequence Identity: 58% (25 aa)

TKRELTGHVVTRWYRAPELILLEKDYTAAIDIWSIGCIFAELM
.  |.||.|.|||||||| .|.  .|| ..||||.||| |||.
CDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI
Kinase 16370.AA Pkinase_Tyr 19-170 30 8.4e-19 64.31 Pfam 1-161 (270) Show / Hide 
Range on Protein: 19-170
Range on HMM: 1-161/270
Sequence Identity: 30% (49 aa)

YDLIKVVGSGSYGSVAEATDK----KSGKKVAIKRLNGIFEDNV-DCKRILREIHLLRIL-NHPNLIRINEIIEPKDLQNFDTLYVVTEYCQS-DLKKLF
  ..|. |.|..|.| ..| |    . . .||.| |.    .     .  .||. ... | .|||..|   .. ... .|   .|.|.||..  ||..  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL

KS----PIHLCMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSV
..    . .|.| .     . |  |  ||.|    ||||   |.|..|.  |||||||||| .
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 16370.AA nmo 407-454 47 1.2e-18 53.35 In-house 151-198 (292) Show / Hide 
Range on Protein: 407-454
Range on HMM: 151-198/292
Sequence Identity: 47% (23 aa)

INSKTTKRELTGHVVTRWYRAPELILLEKDYTAAIDIWSIGCIFAELM
.  . .....|  ||| .|||||...  . ||.|.||||.|||||||.
VWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELL
Kinase 16370.AA ERK5 498-576 31 2.5e-16 56.19 In-house 216-295 (295) Show / Hide 
Range on Protein: 498-576
Range on HMM: 216-295/295
Sequence Identity: 31% (25 aa)

DQLNVIFSVLGTPNEEDMDFVTDAKAIEYLKS-FKQKKRVDFKDLFPAATPECIDFLNKTLVFNPRKRITIDAALNHPLF
.||..|  |||.|    .  |   .   |... | ... .|.. ..| | .  .| | . |.| | .|||. .|| ||  
HQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 16370.AA ERK5 416-454 61 8.6e-16 54.22 In-house 165-203 (295) Show / Hide 
Range on Protein: 416-454
Range on HMM: 165-203/295
Sequence Identity: 61% (24 aa)

LTGHVVTRWYRAPELILLEKDYTAAIDIWSIGCIFAELM
.|  | |||||||||..  .||| |||.||.|||| |..
MTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMI
Kinase 16370.AA ERK1 416-454 64 5e-15 52.77 In-house 160-198 (289) Show / Hide 
Range on Protein: 416-454
Range on HMM: 160-198/289
Sequence Identity: 64% (25 aa)

LTGHVVTRWYRAPELILLEKDYTAAIDIWSIGCIFAELM
||  | ||||||||..|  | || .|||||.||| ||..
LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML
Kinase 16370.AA nmo 498-576 35 1.7e-13 37.26 In-house 211-292 (292) Show / Hide 
Range on Protein: 498-576
Range on HMM: 211-292/292
Sequence Identity: 35% (29 aa)

DQLNVIFSVLGTPNEEDMDFVTD-AKAIEYLKSFKQKKRVDFKDLFP--AATPECIDFLNKTLVFNPRKRITIDAALNHPLF
.||..|  .||||  ||| .  . |||    .. |. .      |     || | .. | . |.|.| ||| .  || ||  
QQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase 16370.AA TyrKc 19-241 21 6.8e-13 -14.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-241
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

YDLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDCKRILREIHLLRIL--NHPNLIRINEIIEPKDLQNF---DTLYVVTEYCQS-DLKKLFK
  |.|. |.| .| | ..| |    .||.| |.         . ..||. ... |  .|||..|.  ..  .  . |   . |..|.||.   |||.  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLR

SPIH-LCMIQVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSVEGN---------------QNLR------------FSFFTFS
.. . ||| .     . |  |  ||||  . ||||   |.|..|.  |||.||||.| ..                 .. .            . . .|.
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

LL---------------IGFIIYLTLLR--MKMILLLLFLKYHKAMTSRSR--------CLNKHYSKILLKLKKN--------LHIEDDL
                  |   |       |. . .. ..|  . |             |  . |. | ..  .           | ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF