Gene 13065 (Tetrahymena)

13065

Species: Tetrahymena
Alias: PreTt13065, 13065, 453, 4.m00464, TTHERM_00058800, 3707.m00109
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: RCK

Sequence

Name Sequence Type Origin Length Description Download
13065.AA Protein None 567 None Fasta, JSON
13065.kin_dom Protein Kinase Domain None 317 None Fasta, JSON
13065.NA RNA None 1704 None Fasta, JSON

Protein domain

Protein domains of 13065.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13065.AA RCK 4-320 45 2.8e-203 651.24 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-320
Range on HMM: 1-298/298
Sequence Identity: 45% (149 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIKCMKNHFNSIEQVQRLKEIQALRKVSPHPHIIKLIEVLYDEPTGRLALVFELMDQNLYEAIRG---KKQYL
|......|.||...|.|||....|..||||.||..|.|.|....|.||..|||..|||.||||.||..|..|..|..|||.||.|||. ...   ...||
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

NQQKLNKHIKGEKRPAYYLSQRINNQKFDIFKVTIPISVKFYMYQLLKAIDHMHKKGIFHRDIKPENILLLG----------DHVKLADFGSCKGIYSEH
.....                                |.|..|||.|....||||.|.||||.|||||.. |          ||.|.||||.|. |.|..
PENQR--------------------------------SIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKP

PYTEYISTRWYRAPECLLTDGYYSSKMDLWGVGCVMFEVMSLFPLFPGNDELDQAHKIHNVLGTPNPKILEQFQKHATHMELNFPPKKGTGIEKLAPHIP
|||.|.||||||||||||...||.|.||.|.|||.|.|...|.|||||..|.|| .||..|.||||.|......|.|..|..|||..||.....| |...
PYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCS

KDCVDLIYKLLCYDPEERINAEQALQHPYF
.||..|..|.|..||..||.|.||||||||
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 13065.AA CMGC 4-320 22 5.9e-116 382.74 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-320
Range on HMM: 1-513/513
Sequence Identity: 22% (122 aa)

YKLLSKKGEGTFSEVLKAQS--------------LKEGKFVAIKCMKNHFNSIEQVQ-----------RLKEIQALRKVS----------------PHPH
|. ..| ||||...| |..                . ...|||| .|| |   || .            | ||. |....                 |..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIKLIEVLYDEPTG---------------RLALVFELMDQNLYEAIRGKK--------QYLNQQKLNKHIKGEKRPAYYLSQRINNQKFDIFKVTIPI--
|.||....|.. .                 | ||||.||..||. |. ..        ..|.. . |||   .                        .  
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKH---P------------------------HRR

---SVKFYM------YQLLKAID--HMHKKG--IFHRDIKPENILLLGD---------------------HVKLADFGSCK--GIYSEH-----------
   ..|..|      ||.|....  ..|...  |.|||.||||||.  .                     ..|..|||...  ...|.|           
PPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKN

---------PYTEYISTRWYRAPECLLTDGYYS---------SKMDLWGVGCVMFEVMS--------LFPLFPGNDE-----------LDQAHKIHNVLG
         |||.|..|||||||| || ...|.         ...| |.|||...| .         . |||||..|           .|| .|| .|||
VNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLG

TPN---------------PK-------------------------ILEQFQKHATHMELNFPPKKGTGIEKLAPH-------------------------
||.               ..                         ..  |.... .. ..||....  ...| |                          
TPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSH

----------IPKDCVDLIYKLLCYDPEERINAEQALQHPYF
          ......||. |.|.|||..|| ||||||||||
KFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 13065.AA MOK 139-320 62 3.1e-115 362.75 In-house 102-283 (283) Show / Hide 
Range on Protein: 139-320
Range on HMM: 102-283/283
Sequence Identity: 62% (114 aa)

VKFYMYQLLKAIDHMHKKGIFHRDIKPENILLLGDHVKLADFGSCKGIYSEHPYTEYISTRWYRAPECLLTDGYYSSKMDLWGVGCVMFEVMSLFPLFPG
.. |||||.|..||||. ||||||.||||||.  ||.||||||||. .||  |||||||||||||||||||||||. .||.| |||| .|..|| |||||
IMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLFPG

NDELDQAHKIHNVLGTPNPKILEQFQKHATHMELNFPPKKGTGIEKLAPHIPKDCVDLIYKLLCYDPEERINAEQALQHPYF
  |.||  ||| |.|||  |||..|....  |. .|| ||| ||||| | . | |.... |.  |||.||| |.|..|||||
VNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase 13065.AA CDK 4-320 29 2.6e-87 279.39 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-320
Range on HMM: 1-284/284
Sequence Identity: 29% (105 aa)

YKLLSKKGEGTFSEVLKAQSLKEG-----KFVAIKCMKNHFN--SIE--QVQR--LKEIQALRKVSPHPHIIKLIEVLYDEPTG---------RLALVFE
|. | | ||||. .| ||.... |     ..||.|. .   .  ..|   .    . ||  |..   ||.|.||..| ... .          .| .|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

LMDQNLYEAIRGKKQYLNQQKLNKHIKGEKRPAYYLSQRINNQKFDIFKVTIPISVKFYMYQLLKAIDHMHKKGIFHRDIKPENILLLGDH------VKL
 ||. |.. ..                                            .| ||.|||......|...| |||.|| |||.  .       .|.
YMDHDLKKYMD--------------------------------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKI

ADFGSCKGIYS-------EHPYTEYISTRWYRAPECLLTDGYYS--SKMDLWGVGCVMFEVMS---LFPLFPGNDELDQAHKIHNVLGTPNPKILEQFQK
||||  .   .         .||  . |.|||||| || .  ||     |.|.|||.. | .      |||||. |.|| .|| ...|||....   . |
ADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTK

HATHMELNFPPKKGTGIEKLAPHIPKDCVDLIYKLLCYDPEERINAEQALQHPYF
   .                         ||. |.|||||. ||.||||||||||
LPDY-------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 13065.AA Pkinase 4-320 26 2.9e-85 294.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-320
Range on HMM: 1-293/293
Sequence Identity: 26% (91 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIKCMKNHFNSIEQVQRLK---EIQALRKVSPHPHIIKLIEVLYDEPTGRLALVFELMDQ-----NLYEAIRG
|....| |.|.|..| |..  ..|| ||.|..| . .. .. |..    ||| ....  ||.|..|... .|   ... .|.|...       |.. |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

KKQYLNQQKLNKHIKGEKRPAYYLSQRINNQKFDIFKVTI---PISVKFYMYQLLKAIDHMHKKGIFHRDIKPENILLL-GDHV----KLADFGSCKG--
                                    . ..   .  .||||||.|......|..|| |||.||||||.   .|.    |..|||..|   
----------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD

IYSEHPYTEYISTRWYRAPECLLTDGYYSSKMDLWGVGCVMFEVMSLFPLFPGN----DELDQAHKIHNVLGTPNPKILEQFQKHATHMELNFPPKKGTG
. . . .| .  |.||.||| .... ||..| | |..||...|...  |.|||     . .|| ..| ...|.|..   ..     . . ... . . . 
Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-

IEKLAPHIPKDCVDLIYKLLCYDPEERINAEQALQHPYF
 ... . ....| |.|...||.||..|..|||.||||.|
HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 13065.AA S_TKc 4-320 28 6.1e-77 262.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-320
Range on HMM: 1-231/231
Sequence Identity: 28% (92 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIKCMKNHFNSIEQVQRLKEIQALRKVSPHPHIIKLIEVLYDEPTGRLALVFELMDQ---NLYEAIRGKKQYL
|..| | |.|.|..| |..  | |. ||||..|         . ..||| |.|   ||.|.||..| .|   ..| .|.|..|.   .|.. |. ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

NQQKLNKHIKGEKRPAYYLSQRINNQKFDIFKVTIPISVKFYMYQLLKAIDHMHKKGIFHRDIKPENILLLGDHVKLADFGSCKGIYSEHPYTEYISTRW
......                             .  ..|||||...|....|..|| |||.|||||||   |.|..|||... .      | .. |.|
LRFPFP-----------------------------E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPW

YRAPECLLTDGYYSS-KMDLWGVGCVMFEVMSLFPLFPGNDELDQAHKIHNVLGTPNPKILEQFQKHATHMELNFPPKKGTGIEKLAPHIPKDCVDLIYK
|.||| |     |.  | | | .||...| ..  |.||      | ... ...|                                    .... |.| |
YMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRK

LLCYDPEERINAEQALQ-------HPYF
.|..|||.|. | .|||       ||.|
CLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13065.AA MAK 143-320 38 1.4e-75 239.97 In-house 137-352 (352) Show / Hide 
Range on Protein: 143-320
Range on HMM: 137-352/352
Sequence Identity: 38% (83 aa)

MYQLLKAIDHMHKKGIFHRDIKPENILLLG------------------DHVKLADFGSCKGIYSEHPYTEYISTRWYRAPECLLTDGYYSSKMDLWGVGC
||| | .. .||| | ||||.|||||.. |                  . .|.||||    | |  ||| |.||||||||| ||  .|||| .|.| |||
MYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGC

VMFEVMSLFPLFPGNDELDQAHKIHNVLGTPNPKI----------------LEQFQKHATHMELNFPPKKG---TGIEKLAPHIPK-DCVDLIYKLLCYD
.| |. .. |||||  | ||  ||  |||||. .                      . |  | . ||   .   . ...| | . . | ..|. ..| .|
IMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWD

PEERINAEQALQHPYF
|..| .|.|....|||
PNKRPTAQQCCKYPYF
Kinase 13065.AA CDC2 4-320 31 3.3e-75 230.46 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-320
Range on HMM: 1-301/301
Sequence Identity: 31% (106 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIKCMKNHFNSIEQ---VQRLKEIQALRKVSPHPHIIKLIEVLYDEPTGRLALVFELMDQNLYEAIRGKKQYL
|. . | ||||. .| |.. .. .. ||.|  .   .. .       ..||  | .  .|| |.|| .|..     .| .||| .|..|       |.|.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDL-------KKYM

N-QQKLNKHIKGEKRPAYYLSQRINNQKFDIFKVTIPISVKFYMYQLLKAIDHMHKKGIFHRDIKPENILLLGD-HVKLADFGSCKGI-YSEHPYT--EY
  ... |                         |.  |. || ||||.|..... | ..|.|||.|| |||.  .  .|.||||  . . .   .||    
DMSIPKN-------------------------KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHE

ISTRWYRAPECLLTDGYYSSKMDLWGVGCVMFEV---MSLFPLFPGNDELDQAHKIHNVLGTPNPKILEQFQKHATHMELNFPPKKGTGIEKLAPH----
. |.|||||| || . .||   |.| .||.. |    ..  |||.|  | ||  ||  .||||| ....   .  ..    ||  | ....|. |     
VVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQ-LPDYKNTFPRWKPQDLSKICPNNQKK

-----IPKDCVDLIYKLLCYDPEERINAEQALQHPYF
     ......||. ..|.|||. ||.|..|||||||
KNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 13065.AA Ciliate-E2 4-320 20 4.6e-57 194.41 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-320
Range on HMM: 1-365/365
Sequence Identity: 20% (88 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIK--------------CMKNHFNSIEQ-----VQRLKEIQALRKVSP---------------HPHIIKLIEV
||.. | |.|.|. | |..  |..| .|||              . .. ..   .      | ..||. .|.. .               ||.|||..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LYDEPTGRLALVFELMDQ-NLYEAIR------------------GKKQYLNQQKLN-----KHIKGEKRPAYYLSQRINNQKFDIFKVTIPISVKFYMYQ
 ... .  . ||.|. .. .|.. |.                   . .|. .| |.     .                                .||. .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA--------------------------------EFYIAC

LLKAIDHMHKKG-IFHRDIKPENILLLGDHVKLADFGSCK---------------GIYSEHP------------------YTEYISTRWYRAPECLLTDG
...|. ..|.|. |.||||||||||.    .|..||| .|               ..| .                    .  .. |  | ||| |   .
IILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK

Y--------YSSKMDLWGVGCVMFEVMSLFPLFPGNDELDQAHKIHNVLGTPNPKILEQFQKHATHMELNFPPKKGTGIEKLAP------HIPKDCVDLI
|        |. | |.| .|....| ..  | |                       ..| ..       ... |. | .. . .      .....| |||
YDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------------------QQQIKQCKIDFPCPEWQKD-TQCI-Q-CKWKSWKKWSQECKDLI

YK----LLCYDPEERIN-AEQALQHPYF
 |    .|..|||.||. .||.|.||.|
KKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 13065.AA CDKL 139-320 42 1.7e-56 191.63 In-house 100-286 (286) Show / Hide 
Range on Protein: 139-320
Range on HMM: 100-286/286
Sequence Identity: 42% (79 aa)

VKFYMYQLLKAIDHMHKKGIFHRDIKPENILLL--GDHVKLADFGSCKGIYSEHP--YTEYISTRWYRAPECLLTDGYYSSKMDLWGVGCVMFEVMSLFP
|. ||.|.||||.. ||  . ||||||||||.    . ||| |||  . . ..    ||.|  |||||||| |. |  |..  |.| .|||| | ..  |
VRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQP

LFPGNDELDQAHKIHNVLGTPNPKILEQFQKHATHMELNFP-PKKGTGIEKLAPHIP-KDCVDLIYKLLCYDPEERINAEQALQHPYF
|.||  ..|| ..|  .||.  |.  | | |.     . || ...   .||  | .  |   |.. |.|  || ||...||...||||
LWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 13065.AA MAPK 139-320 35 3.9e-53 182.06 In-house 117-328 (328) Show / Hide 
Range on Protein: 139-320
Range on HMM: 117-328/328
Sequence Identity: 35% (75 aa)

VKFYMYQLLKA--IDHMHKKGIFHRDIKPENILLLGD-HVKLADFGSCKGIYSE--HPY-------------TEYISTRWYRAPECLLTD--GYYSSKMD
... |||.|..  . ..|  .. |||.||.|||.  .  .|..|||   .| .|  |..             |||..|||||||| .|      |. ..|
IQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVD

LWGVGCVMFEVMS-LFPLFPGNDELDQAHKIHNVLGTPNPKILEQFQ--KHATHMELNF---PPKKGTGIEKLAP----HIPKDCVDLIYKLLCYDPEER
 | ||| . | ..   |||||.| .||  .| .||||| .  ... .  .|| ..  ..   |....   ||. |    .   ...||. |.|  ||..|
MWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKR

INAEQALQHPYF
|..|.|||||||
ITVEEALQHPYF
Kinase 13065.AA ERK7 137-320 38 1.9e-50 170.61 In-house 100-292 (292) Show / Hide 
Range on Protein: 137-320
Range on HMM: 100-292/292
Sequence Identity: 38% (74 aa)

ISVKFYMYQLLKAIDHMHKKGIFHRDIKPENILLLGD-HVKLADFGSCKGIYSEH-------PYTEYISTRWYRAPECLLTDGYYSSKMDLWGVGCVMFE
| ... |||||.|| .||   . |||.|| ||||  . .||..|||    | .           |||. |||||||| ||    |    |.|..||.. |
IHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGE

VMSLFPLFPGNDELDQAHKIHNVLGTPNPKILEQFQKH-ATHMELNFPPKKGTGIEKLAPHIPKDCVDLIYKLLCYDPEERINAEQALQHPYF
 .   |.|||.  ..|  || .... |  . .|  . | |  |  . . .|   .... |. ..| .||. .||.. |..|. ||||||||| 
MLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 13065.AA MOK 4-109 56 4.5e-48 148.48 In-house 1-106 (283) Show / Hide 
Range on Protein: 4-109
Range on HMM: 1-106/283
Sequence Identity: 56% (60 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIKCMKNHFNSIEQVQRLKEIQALRKVSPHPHIIKLIEVLYDEPTGRLALVFELMDQNLYEAIRGKKQYLNQQ
|| . | ||||||||.| |||..| . | | || ||.|||||. |.||||.|...||| |..| ||..|  || |||. |||| |.|| |||.. || |.
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

KLNKHI
|. . .
KIMHYM
Kinase 13065.AA MAK 4-100 28 4.1e-26 79.75 In-house 1-128 (352) Show / Hide 
Range on Protein: 4-100
Range on HMM: 1-128/352
Sequence Identity: 28% (36 aa)

YKLLSKKGEGTFSEVLKAQS------------------------------LKEGKFVAIKCMKNHFNSIEQVQRLKEIQALRKVSPHPHIIKLIEVLYDE
| .. . | ||. .|..|..                               . |  |||| ||  | | |   .| |. .|.| . ||.|.|| ||. | 
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

PTGRLALVFELMDQNLYEAIRGKKQ-YL
    | .||| | .|||. . . .  ..
ENDHLYFVFEYMKENLYQMMKDRDRRHF
Kinase 13065.AA TyrKc 4-320 18 1.8e-14 11.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-320
Range on HMM: 1-280/280
Sequence Identity: 18% (64 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIKCMKNHFNSIEQVQRLKEIQALRKV-SPHPHIIKLIEVLYDE-----PTGRLALVFELMDQ-NLYEAIRGK
 .|. | ||| | || |..       ||.|..|..     .   ..|.. ..|.   ||.|..|. |  ..       . | .|.|.|.  .| . .| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KQYLNQQKLNKHIKGEKRPAYYLSQRINNQKFDIFKVTIPISVKFYM-YQLLKAIDHMHKKGIFHRDIKPENILLLGDH-VKLADFGSCKGIYSE-----
.                                     .. . . .. .|  .  .. |.|.. |||.   |.|.  .| || .||| .. ||..     
RPK-----------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGE

-HPYT-------EY--ISTRWYRAPECLLTDGYYSSKMDLWGVGCVMFEVMSLFPLFPGNDEL--DQAHKIHNVLGTP--NPKILE----QFQKHATHME
 . |        .   .  ||. ||||.  .| ...| | |  | .|.|....    . ....    .  ... . .    |.  .              
SKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------

LNFPPKKGTGIEKLAPHIPKDCVDLIYKLLCYDPEERINAEQALQHPYF
               .. |..  ... .   .|||.| . ..   | .|
--------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 13065.AA ERK7 4-96 32 1.1e-10 32.42 In-house 1-95 (292) Show / Hide 
Range on Protein: 4-96
Range on HMM: 1-95/292
Sequence Identity: 32% (31 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIKCMKNHFNSIEQVQR-LKEIQALRKVSPHPHIIKLIEVLYDEPTGRLALVFELMDQNLYEAIR-GK
|..... | | .  | ||   . .. ||.| .   |      ||  .||  |.    || ||.||.|.  .    . |||| |.  |   || |.
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGN
Kinase 13065.AA Pkinase_Tyr 4-232 21 4.8e-10 34.65 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-232
Range on HMM: 1-210/270
Sequence Identity: 21% (53 aa)

YKLLSKKGEGTFSEVLKAQSL----KEGKFVAIKCMKNHFNSIE--QVQRLKEIQALRKVSPHPHIIKLIEVLY--DEPTGRLALVFELMDQ-NLYEAIR
 ... | ||| | || |.       ...  ||.|..|..  . .  .   ..|.. ...   ||.|..|. | .  .||  .. .|.|.|   .|..  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLR

GKKQYLNQQKLNKHIKGEKRPAYYLSQRINNQKFDIFKVTIPISVKFYMYQLLKAIDHMHKKGIFHRDIKPENILLL-GDHVKLADFGSCKGI-----Y-
 ..                               |  ..|..     . .|  |. .. . |.. |||.   |.|.  . .|| .||| .. |     | 
KHR------------------------------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYY

SEHPYTEYISTRWYRAPECLLTDGYYSSKMDLWGVGCVMFEVMSL
  .  .  .  .|. ||||. .   ...| | |  | .|.|....
RKRGGGK-LPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTY
Kinase 13065.AA MAPK 4-90 28 8.6e-08 22.78 In-house 1-103 (328) Show / Hide 
Range on Protein: 4-90
Range on HMM: 1-103/328
Sequence Identity: 28% (29 aa)

YKLLSKKGEGTFSEVLKAQSLK------EGKFVAIKCMKNHFNSIEQVQR-LKEIQALRKVSPHPHIIKLIEVLYDE-----PT----GRLALVFELMDQ
|..|.. |.| .  | .|   .      .||.|||| . . |..    .| . ||  ||    |. ||||..... |     ..      . .|.|||. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLY
.|.
DLH
Kinase 13065.AA CDKL 4-89 33 0.006668 5.76 In-house 1-84 (286) Show / Hide 
Range on Protein: 4-89
Range on HMM: 1-84/286
Sequence Identity: 33% (29 aa)

YKLLSKKGEGTFSEVLKAQSLKEGKFVAIKCMKN-HFNSIEQVQRLKEIQALRKVSPHPHIIKLIEVLYDEPTGRLALVFELMDQNL
|  |.| |||    |.|      |. ||||  |    . ..    . ||  |.    |. |  ||||      ..| |||| .| ..
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLK-HENIVNLIEVF--RRKRKLHLVFEYCDHTV