Gene 27248 (Tetrahymena)
27248
Sequence
Protein domains of 27248.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 27248.AA | RCK | 30-279 | 44 | 5.4e-161 | 514.81 | In-house | 34-298 (298) | Show / Hide |
Range on Protein: 30-279 Range on HMM: 34-298/298 Sequence Identity: 44% (118 aa) KKCSTWEECISIRQVKVLRVLN-HPNIIKIKEIIRQDK--QLFLVFEYFETNLSQYYQSFADSRKKISEEQ--IKKIIYQIALALNQCHLNGIMHRDLSP .|...||||.. | .|.||.|| ||||||.||.||... ||..||||...||.|....|...||...|.| ||.|.|||...|...| .|..||||.| QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKP ENIYVTK---------QNRIKVGQFSNA-EFQNKHNNTAYVTSRYYESPESILKQ-QQNTKIDIWALGCIMGELYCLNPLFAGNSEIDQLMQILKIIGIP |||..|. |..||...|... |...|...|.||..|.|..|| .|.. ..|...||||.|||| |||.|.|||.|.|||||...|.|..|.| ENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTP NHKEYPEFHTLCQQKQIKILPSHESMKLPSIIPQASSEAIDLLFKMLNINPSKRISIQAVLQHPFF |.|..|....|..|..... ... .|.|...||..|...|.|..|||...|.|||..|..||||.| NKKDWPDGYKLASQMNFNFPQCK-GMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF |
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| Kinase | 27248.AA | CMGC | 29-279 | 20 | 2.2e-89 | 293.83 | In-house | 48-513 (513) | Show / Hide |
Range on Protein: 29-279
Range on HMM: 48-513/513
Sequence Identity: 20% (96 aa)
NKKCSTWEEC----------ISIRQVKVLRVLN-----------------HPNIIKIKEIIRQDK-----------------QLFLVFEYFETNLSQYYQ
|.. ..... ...| .| |. || |.||.|...|.. .. .|.||||| ...| || .
NPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIK
SFAD-----SRKKISEEQ------------IKKII------YQIALALN--QCHLNG--IMHRDLSPENIYVTKQNR--------------------IKV
. . ... || . ||... ||| .|. || .. |.|||| |||| ...... .|.
NNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKI
GQFSNAEFQNKH-----------------------NNTAYVTSRYYESPESILKQQQN----------TKIDIWALGCIMGELYC--------LNPLFAG
. | .| . ..| .| || .|.| .|| .| .. |.||.|..|||..|.| . ||| |
CDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPG
NSE-----------IDQLMQILKIIGIPN---------------HKEYPE---------------------FHTLCQQKQIKI---LPSHESMKLPSIIP
.|| |||| .| |..| |. .|.|. ... ....|.. .| . .. ...|
HSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFP
Q-----------------------------------ASSEAIDLLFKMLNINPSKRISIQAVLQHPFF
....||||| ||| ..|.|||... ||||.|
WHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
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| Kinase | 27248.AA | MAK | 30-279 | 35 | 5.5e-74 | 234.79 | In-house | 64-352 (352) | Show / Hide |
Range on Protein: 30-279 Range on HMM: 64-352/352 Sequence Identity: 35% (103 aa) KKCSTWEECISIRQVKVLRVLN-HPNIIKIKEIIR--QDKQLFLVFEYFETNLSQYYQSFADSRK-KISEEQIKKIIYQIALALNQCHLNGIMHRDLSPE || ..||||...| || |. || ||||.|.||.|| . .|..|||| . || ||. | .. .| |. |.||| .| | .| |||. || KKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDSENDHLYFVFEYMKENL---YQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPE NIYVTKQ-----------------NRIKVGQFSNA-EFQNKHNNTAYVTSRYYESPESILKQQQ-NTKIDIWALGCIMGELYCLNPLFAGNSEIDQLMQI || .. .||. | | | .| |.|| | | .|| |. . . ||.||.|||| ||| . ||| | |||||. | NIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKI LKIIGIPNHKE----------------YPEFHTLCQQKQIKILPSHES---MKLPSIIPQASS-EAIDLLFKMLNINPSKRISIQAVLQHPFF ....| |. .. |. | . . .| . | | ..||..|. .||.|. .||. .| || | ...|.| CQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNFR-FPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF |
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| Kinase | 27248.AA | CDC2 | 40-279 | 35 | 7e-61 | 185.62 | In-house | 47-301 (301) | Show / Hide |
Range on Protein: 40-279 Range on HMM: 47-301/301 Sequence Identity: 35% (91 aa) SIRQVKVLRVLN-HPNIIKIKEIIRQDKQLFLVFEYFETNLSQYYQSFADSRKKISEEQIKKIIYQIALALNQCHLNGIMHRDLSPENIYVTKQNRIKVG .|| | |. ||||.|....| | . |..|||| . .| .| ..|..... .|...||| ... || ..|||||| | || . |. .||.. AIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIA QF--SNAEFQNKHNNT--AYVTSRYYESPESILKQQQ-NTKIDIWALGCIMGEL---YCLNPLFAGNSEIDQLMQILKIIGIPNHKEYPEFHTLCQQKQI | . | .. . | | . | .|| | ... .| .|.|..|||. |. |||.| |||||| .| .|.| || ...|. | |. DFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN- KILPSHESMKLPSIIPQ---------ASSEAIDLLFKMLNINPSKRISIQAVLQHPFF | . .| .|.|. . |.|||| .|| ..|.||||... ||||.| -TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF |
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| Kinase | 27248.AA | CDK | 38-279 | 29 | 2.8e-60 | 191.51 | In-house | 53-284 (284) | Show / Hide |
Range on Protein: 38-279 Range on HMM: 53-284/284 Sequence Identity: 29% (80 aa) CISIRQVKVLRVLNHPNIIKIKEIIRQD-----------KQLFLVFEYFETNLSQYYQSFADSRKKISEEQIKKIIYQIALALNQCHLNGIMHRDLSPEN . .|| .. |. | ||||.|..... .. . |..|||| .. |..| || ...|. .|. || |.|||||| | | ITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQN IYVTKQNR-----IKVG------QFSN---AEFQNKHNNTAYVTSRYYESPESIL-KQQQN--TKIDIWALGCIMGELYC---LNPLFAGNSEIDQLMQI | .... .|.. |.. . . | | . | .|| | .. . | ||.|..|||..|... ||| |.|||||| | ILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKI LKIIGIPNHKEYPEFHTLCQQKQIKILPSHESMKLPSIIPQASSEAIDLLFKMLNINPSKRISIQAVLQHPFF .|.| |. . |.. | ||| ||| .|.|||| .. ||||.| FRICGTPTEDNWPGVTKLPDY--------------------------DLLNKMLCYDPKKRISAEQALQHPYF |
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| Kinase | 27248.AA | CDKL | 39-279 | 34 | 1.2e-56 | 192.24 | In-house | 44-286 (286) | Show / Hide |
Range on Protein: 39-279 Range on HMM: 44-286/286 Sequence Identity: 34% (85 aa) ISIRQVKVLRVLNHPNIIKIKEIIRQDKQLFLVFEYFETNLSQYYQSFADSRKKISEEQIKKIIYQIALALNQCHLNGIMHRDLSPENIYVT-KQNRIKV | | .| |. | |.|| ..|. |. . |.||||| . ... . . . . |....|...|| |.|.|| . . ||| ||||..| |. ..| IAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEE---YPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKL GQFSNAEFQNKHN--NTAYVTSRYYESPESILK-QQQNTKIDIWALGCIMGELYCLNPLFAGNSEIDQLMQILKIIG--IPNHKEYPEFHTLCQQKQIKI . | | .| . | || | | .|| .. | . .||||.||.|.|. .||. | |.|||| | | .| || |.| | . . .|. CDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEI--FSKNPFFHGMKF LPSHESMK-LPSIIPQAS-SEAIDLLFKMLNINPSKRISIQAVLQHPFF | | |. |.. |..| ..|.|.. |.| ..|..|.. . ..||.| -PEIEHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF |
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| Kinase | 27248.AA | MAPK | 41-279 | 29 | 2.6e-54 | 186.19 | In-house | 52-328 (328) | Show / Hide |
Range on Protein: 41-279 Range on HMM: 52-328/328 Sequence Identity: 29% (82 aa) IRQVKVLRVL-NHPNIIKIKEIIRQD-----------KQLFLVFEYFETNLSQYYQSFADSRKKISEEQIKKIIYQIALA--LNQCHLNGIMHRDLSPEN .| .| || . .|.||||...|.. . ... .|.|. ||.| | .| . |.. |. ..||| . | | .. |||| |.| YREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSN IYVTKQNRIKVGQF----SNAEFQNKHNN------------TAYVTSRYYESPESILK---QQQNTKIDIWALGCIMGELYC-LNPLFAGNSEIDQLMQI | |.. |.. | | . ....|.. | ||. |.| .|| .| . ....|.|..|||..|.. ||| |.. |||. .| ILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLI LKIIGIPNHKEYPEFH-TLCQQKQIKIL---PSHESMKLPSIIPQ----ASSEAIDLLFKMLNINPSKRISIQAVLQHPFF ....| | . . |. | | . . ...| |...|||||.||| ..|.|||... ||||.| MEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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| Kinase | 27248.AA | Pkinase | 44-279 | 29 | 2.6e-52 | 184.89 | Pfam | 51-293 (293) | Show / Hide |
Range on Protein: 44-279 Range on HMM: 51-293/293 Sequence Identity: 29% (74 aa) VKVLRVLNHPNIIKIKEIIRQDKQLFLVFEYFETNLSQYYQSF----ADSRKKI--SEEQIKKIIYQIALALNQCHLNGIMHRDLSPENIYVTKQNRI-- ..... ||||||...... . .. . .|.|| | |. | ....... ||...|...|||. .|. || .||.|||| |||| . ... | IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA --KVGQFSNAE---FQNKHNNTAYVTSRYYESPESIL-KQQQNTKIDIWALGCIMGELYCLNPLFAGN----SEIDQLMQILKIIGIPNHKEYPEFHTLC |.. | |. |.. .| .. ...| .|| |. | .|.|.|..|||. |..| .|.| | . .||. | .| | |.| ..|. .. CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSIS QQKQIKILPSHESMKLPSIIPQASSEAIDLLFKMLNINPSKRISIQAVLQHPFF . ... . | . . .|.|..|.. ..|. .|.||.... .||||.| YFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| S_TKc | 27248.AA | S_TKc | 1-279 | 24 | 4.1e-49 | 170.4 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-279 Range on HMM: 1-231/231 Sequence Identity: 24% (72 aa) MTLGYH----QYGSYYRAESLENGEMHLIEEHNKKCSTWEECISIRQVKVLRVLNHPNIIKIKEIIRQDKQLFLVFEYFET---NLSQYYQSFAD--SRK ... . .|. |.. . |. | . . . .| ...|. .||||.|...... . |..|.|| .. .| .| .. |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF KISEEQIKKIIYQIALALNQCHLNGIMHRDLSPENIYVTKQNRIKVGQFSNAEFQNKHNNTAYVTSRYYESPESILKQQQNT-KIDIWALGCIMGELYCL ...| ......|||..||. || .||.|||| |||| ... .||.. | | . | .. ...| .|| . . .. |.|.|..|||. |..| PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG NPLFAGNSEIDQLMQILKIIGIPNHKEYPEFHTLCQQKQIKILPSHESMKLPSIIPQASSEAIDLLFKMLNINPSKRISIQAVLQ-------HPFF |.| |.....|.|| |.||.|.. |.|. .|.||... .|| ||.| YPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 27248.AA | ERK7 | 42-279 | 31 | 4.2e-45 | 152.04 | In-house | 47-292 (292) | Show / Hide |
Range on Protein: 42-279 Range on HMM: 47-292/292 Sequence Identity: 31% (78 aa) RQVKVLRVLN-HPNIIKIKEIIR--QDKQLFLVFEYFETNLSQYYQSFADSRKKISEEQIKK-IIYQIALALNQCHLNGIMHRDLSPENIYVTKQNRIKV | . |. .. |||||.. ..|| |. ..||||. || | . . .| .. |. |.||. |. | ..|||| | || . . ..|| REIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIR-----KGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKV GQF------SNAE--FQNKHNNTAYVTSRYYESPESILKQQQNTK-IDIWALGCIMGELYCLNPLFAGNSEIDQLMQILKIIGIPNHKEYPEFHTLCQQK | .. | ... | || | | .|| | .. || .| | .|||.||. |.|.|.| ..|. .||..|. | ... . . CDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWN QIKILPSHESMKLPSIIPQASSEAIDLLFKMLNINPSKRISIQAVLQHPFF .. ..... .| ..||.. .||||| ..| || ||.... ||||. MLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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| Kinase | 27248.AA | CDK4 | 45-279 | 31 | 8e-45 | 151.61 | In-house | 55-290 (290) | Show / Hide |
Range on Protein: 45-279 Range on HMM: 55-290/290 Sequence Identity: 31% (76 aa) KVLRVLNHPNIIKIKEI---IRQDK---QLFLVFEYFETNLSQYYQSFADSRKKISEEQIKKIIYQIALALNQCHLNGIMHRDLSPENIYVTKQNRIKVG . | ..||||.| ... .. | . .||| . |..| . .....||.. |. .. | . | |||| |.|| || . ..| RHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLDKCPPP--GMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLA QFSNA-EFQNKHNNTAYVTSRYYESPESILKQQQNTKIDIWALGCIMGELYCLNPLFAGNSEIDQLMQILKIIGIPNHKEYPEFHTLCQQKQIKILPSHE | | .. .. | | | .|| | . || .|.|..|||. |.|| ||| |.|| ||| .|....| | .. | | . |. DFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDH----FPQRH SMKLPSIIPQASSEAIDLLFKMLNINPSKRISIQAVLQHPFF .. .. |. . ..||| ||| |..||.| . ||||.| PRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF |
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| Kinase | 27248.AA | CDK5 | 172-279 | 38 | 1.1e-34 | 106.67 | In-house | 177-287 (287) | Show / Hide |
Range on Protein: 172-279 Range on HMM: 177-287/287 Sequence Identity: 38% (43 aa) NTKIDIWALGCIMGELY-CLNPLFAGNSEIDQLMQILKIIGIPNHKEYPEFHTLCQQK-QIKILPSHESMK-LPSIIPQASSEAIDLLFKMLNINPSKRI .| ||.| |||. |. . ||| ||.. |||..| ||.| |. . | | . | ... .|... . . .|.|. ... ||| ||| .|| .|| STSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRI SIQAVLQHPFF | .| |.||.| SAKAALHHPYF |
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| Kinase | 27248.AA | CDK5 | 38-140 | 32 | 3e-21 | 63.44 | In-house | 43-142 (287) | Show / Hide |
Range on Protein: 38-140 Range on HMM: 43-142/287 Sequence Identity: 32% (33 aa) CISIRQVKVLRVLNHPNIIKIKEIIRQDKQLFLVFEYFETNLSQYYQSFADSRKKISEEQIKKIIYQIALALNQCHLNGIMHRDLSPENIYVTKQNRIKV . || . .|. | |.||. . .| .| | ||||. | | |. . ... . || ..|| | || . ..|||| | | . |. | STAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG---EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKL GQF . | ADF |
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| TyrKc | 27248.AA | TyrKc | 25-279 | 14 | 2.7e-08 | -88.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 25-279 Range on HMM: 1-280/280 Sequence Identity: 14% (44 aa) IEEHNK-----------------------KCSTWEECISIRQ-VKVLRVL--NHPNIIKIKEIIRQD-------KQLFLVFEYFET-NLSQYYQSFADSR |. | | .. ... .... | .||||... ...|. ..|..|.|| . .| .| .. . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK- KKISEEQIKKIIYQIALALNQCHLNGIMHRDLSPENIYVTKQNRIKVGQFSNAEFQNKH-----NNTAYVT-----SR-----YYESPESILKQQQNTKI .. .. .. .||| . | ... |||| |. |......|.. | . . . . |.. .. .||.| . .|| --LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS DIWALGCIMGELYCLNPLFAGN-----SEIDQLMQILKIIGIPNHKEYPEFHTLCQQKQIKILPSHESMKLPSIIPQASSEAIDLLFKMLNINPSKRISI |.|. | | |.. . . . ..... .| . . .... . . . ...| .. . . .|..| . DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-----------------F--VCCPDEMYQIMKQCWHEDPEDRPTF QAVLQHPFF ... | .| SEI--HECF |
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