Gene 28968 (Tetrahymena)

28968

Species: Tetrahymena
Alias: PreTt28968, 3812.m02656, 960, 28968, 77.m00180, TTHERM_00576770
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: RCK

Sequence

Name Sequence Type Origin Length Description Download
28968.AA Protein None 576 None Fasta, JSON
28968.kin_dom Protein Kinase Domain None 283 None Fasta, JSON
28968.NA RNA None 1731 None Fasta, JSON

Protein domain

Protein domains of 28968.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28968.AA RCK 4-286 54 1.6e-201 645.54 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-298/298
Sequence Identity: 54% (161 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKRKYRNWDECMSLREVKSLRKMN-HPNLVKLKEVLQIKD--ELMLVFEYVDLNLYQMYMTYKEKKTQI
||..|.|||||||.|.||.|||.||||||||||.|...|.|||.|||.|||||.| |||..|||||....|  .|..||||.| |||||....||... .
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PESV--IKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMS--------SLNVKVCDFGLAREVRCRPPFTEYVSTRWYRAPEILLHSQNYNSPIDVFAL
||..  ||.|.|||..||. .|..|.|||||||||.....|        . ..|..||||.||.| .||.|.|||||||||||.||....||||.|..|.
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCIMAELYNLQPLFSGQNEVDQFYKIVSVLGTP--QNWNEGAKLAQKLQLTIPKKEPLPLPQVVPRASLDALQLLGDMLQYDPMKRPTAIQITKYPYF
||||.||| |.||| |..|.|| .||..|.|||  . |..| |||.......|.... ||.|..|..| |...|. .|||.|| ||.|| |. ..|||
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 28968.AA MAK 4-286 44 2.7e-158 507.83 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-352/352
Sequence Identity: 44% (159 aa)

YQLVKNLGDGTYGTVFKAIN------------------------------KENGEIVAIKKMKRKYRNWDECMSLREVKSLRKMN-HPNLVKLKEVLQ--
||..| |||||||.| .|.                               ...||.||||.||.|.  |.|||.|||||||.|.| |||.||||||.   
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

IKDELMLVFEYVDLNLYQMYMTYKEKKT-QIPESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMS----------------SLNVKVCDFGLARE
  |.| .||||   |||||    |. ..   ||.||. |.|||  ||  .|  |.||||.||||.... .                   .|. |||||||
ENDHLYFVFEYMKENLYQM---MKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLARE

VRCRPPFTEYVSTRWYRAPEILLHSQNYNSPIDVFALGCIMAELYNLQPLFSGQNEVDQFYKIVSVLGTP--QN----------------WNEGAKLAQK
.| .||.| |||||||||||.||.| .|.||||. |.|||||||| . ||| | .|.|| .||..|||||  .                 | .| .|| .
IRSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHM

LQLTIPKKEP---LPLPQVVPRASL-DALQLLGDMLQYDPMKRPTAIQITKYPYF
. .. |. .|    || ...|..|. ||..|. ||||.|| ||||| |  |||||
MNFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 28968.AA CMGC 4-286 25 7.6e-122 402.46 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

YQLVKNLGDGTYGTVFKAIN--------------KENGEIVAIKKMK-RKYRNWDEC----------MSLREVKSLRKMN-----------------HPN
|. .| .| ||||.|.|...              .|..|||||||.| ..   ....          ..|||.| |...|                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVKLKEVLQIKD-----------------ELMLVFEYVDLNLYQMYMTYKE-----KKTQIPESV------------IKKII------YQIALGLD--SL
.|||..... |.                 .| |||||.| .|||.   ..      ..   .| .            ||...      |||  ||.   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HNTG--YFHRDLKPENLLVNMSSLN-------------------VKVCDFGLAREVRCRP----------------------PFTEYVSTRWYRAPEILL
|  .   .||||||||.|.|    .                   .|.||||||| .  ..                      |.|.||.|||||||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

HS---------QNYNSPIDVFALGCIMAELYN--------LQPLFSGQNE-----------VDQFYKIVSVLGTP----------------QN-------
 .         ..|..|||. ..|||.||.|.        ..||| |..|           .|| .||. |||||                ..       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

-------------------WNEGAKLAQKLQLTIPKKEPLPLPQVVPR-----------------------------------ASLDALQLLGDMLQYDP
                   |.|.|.....  .. |.. | |. ...|.                                   .. .|. ||  ||||||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

MKRPTAIQITKYPYF
 ||.|| |. . |||
DKRITAEQALQHPYF
Kinase 28968.AA S_TKc 4-286 29 2.5e-91 310.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 29% (88 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKRKYRNWDECMSLREVKSLRKMNHPNLVKLKEVLQIKDELMLVFEYVDL---NLYQMYMTYKEKKTQ-
|.... .| |..|.|.|...|. |.|||||..|        .. .||.. |.| .|||.|||..| |  |.| .|.||.|    .|...   .. .... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLAREVRCRPPFTEYVSTRWYRAPEILLHSQNYNS-PIDVFALGCIMAEL
 .|| ......|||...|. .|. |  ||||||||.|..    ..|.|||||||..      | .. |.||.|||.|     |.  ..|. ..|||..|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

YNLQPLFSGQNEVDQFYKIVSVLGTPQNWNEGAKLAQKLQLTIPKKEPLPLPQVVPRASLDALQLLGDMLQYDPMKRPTAIQITK-------YPYF
.  .|.|.   .... .|..                                      | .|....  .||.|| ||||| .. .        |.|
LCGYPPFP---QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28968.AA CDC2 4-286 36 1.4e-90 278.57 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-301/301
Sequence Identity: 36% (113 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKRKYRNWDE---CMSLREVKSLRKMN-HPNLVKLKEVLQIKDELMLVFEYVDLNLYQMYMT-YKEKKT
|| .. .| |||| |.|..... ..|||.|| . .. . ..     ..||   | ... |||.|||..|. .   | .||||.| .|   ||  .. |..
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDL-KKYMDMSIPKNK

QIPESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLAREVRCRPPFTEYV-----STRWYRAPEILLHSQNYNSPIDVFALGCI
..|....|...|||  |.. .|  . .|||||| |.|.. .   .|. |||||| .    |  .|       |.||||||||| .. |. |.|. ..|||
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGI--PIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

MAEL---YNLQPLFSGQNEVDQFYKIVSVLGTP--QNWNEGAKLAQKLQLTIPKKEPLPLPQVVPR-------ASLD--ALQLLGDMLQYDPMKRPTAIQ
.||.    .  |||.|. | || .||  .||||  |.| .| .  .  . | |. .|  | ...|.         ||  ...||  |||||| || .| .
FAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTW-PGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKE

ITKYPYF
. . |||
ALQHPYF
Kinase 28968.AA CDK 4-286 34 1.6e-86 276.86 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-284/284
Sequence Identity: 34% (111 aa)

YQLVKNLGDGTYGTVFKAINKENG-----EIVAIKKMK---RKYRNW-DECMS---LREVKSLRKMNHPNLVKLKEVLQIK-----------DELMLVFE
|. .. .| ||||.|.||..|..|     .|||.|| .    . |.  .| ..   .||.. |... ||| |||..|   |             | .|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

YVDLNLYQMYMTYKEKKTQIPESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSL----NVKVCDFGLAREVR-------CRPPFTEYVSTRWY
|.|  |.. ||             || ...|.  ||. .|  .  |||||| |.|.|         .|. ||||||.          . ..|  | |.||
YMDHDLKK-YMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPEILLHSQNYN--SPIDVFALGCIMAELYN---LQPLFSGQNEVDQFYKIVSVLGTP--QNWNEGAKLAQKLQLTIPKKEPLPLPQVVPRASLDALQL
||||.|| |..|.   |||. ..|||.||...    .||| |..| ||  ||  ..|||  .|| .  ||                            .|
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DL

LGDMLQYDPMKRPTAIQITKYPYF
|  ||.||| || .| |  . |||
LNKMLCYDPKKRISAEQALQHPYF
Kinase 28968.AA Pkinase 4-286 28 5.5e-84 290.11 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKRKYRNWDECMSLR---EVKSLRKMNHPNLVKLKEVLQIKDELMLVFEYVDL-----NLYQMYMTYKE
|.... .| |..|.|.|...| .|.|||.|..|.. .........|   |.. ....|||| |.|... . ||.. .|.||..       |. . .|  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KKTQI--PESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNV----KVCDFGLARE--VRCRPPFTEYVSTRWYRAPEILLHSQNYNSPIDV
... .  .| ..|...|||. ||. .|. |  ||||||||.|.. .  ..    |.||||||.       . .| .. |.||.|||.....| | ...|.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FALGCIMAELYNLQPLFSGQ----NEVDQFYKIVSVLGTPQNWNEGAK----LAQKLQLTIPKKEPLPLPQVVPRASLDALQLLGDMLQYDPMKRPTAIQ
...|||..|... .|.|.|.    | .|| ..|. ..|.|  ...  .    .   ..    .    . .......| ...... ..|..|| ||||| |
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

ITKYPYF
| . |.|
ILQHPWF
Kinase 28968.AA MAPK 4-286 33 2.8e-76 259.74 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-328/328
Sequence Identity: 33% (110 aa)

YQLVKNLGDGTYGTVFKAINKE------NGEIVAIKKMKRKYRNWDECM-SLREVKSLRKM-NHPNLVKLKEVLQIK-----------DELMLVFEYVDL
||..|..| | ||.|..|| |.      .|..|||||. |  .|   |   .||.| || . .|.| .||..... .           ... .|.|. . 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLYQMYMTYKEKKTQIPESVIKKIIYQIALG--LDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLAREVRCR-------PPF--------TEYVSTR
.|.|   . .    .  .  |. ..|||  |  |  .|  .  ||||||.|.||| .   .|.||||||| .          . .        ||||.||
DLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVN-ENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPEILLH--SQNYNSPIDVFALGCIMAELYN-LQPLFSGQNEVDQFYKIVSVLGTPQNWNE---G-AKLAQKLQLTI---PKKEPLPLPQVVPR---
|||||||.|   ...|.  .|. ..|||.||...  .||| |.. .||. .|..|||||        .  . | ..       ||. . |. .. |    
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-ASLDALQLLGDMLQYDPMKRPTAIQITKYPYF
 |. .|. ||  ||. ||.|| |. .    |||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 28968.AA MOK 4-286 36 4.8e-74 231.34 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-283/283
Sequence Identity: 36% (105 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKRKYRNWDECMSLREVKSLRKMN-HPNLVKLKEVL--QIKDELMLVFEYVDLNLYQMYMTYKEKKTQI
|. .  .|.||.  | |     .|.  | |.||...   ..  .|||.. .|..| |||...|.||.      .| |. | .|.|.| .    . ..  .
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYEL---IRGRRHYL

PESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLAREVRCRPPFTEYVSTRWYRAPEILLHSQNYNSPIDVFALGCIMAELYNL
|.  |.. .||.   || .|  | |||| ||||.|.    |  |. |||  | |  . |.|||.||||||||| ||    |   .|... ||.  |.  |
PQKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDHL--KLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASL

QPLFSGQNEVDQFYKIVSVLGTP-QNWNEGAK-LAQKLQLTIPKKEPLPLPQVVPRASLDALQLLGDMLQYDPMKRPTAIQITKYPYF
.||| | |||||  ||  |.||| |   .  |  .  ..   | |    .....| ..  .|...  |  |||  | || |. . |||
HPLFPGVNEVDQISKIHDVMGTPCQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase 28968.AA CDKL 4-222 41 6e-73 248.67 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-222
Range on HMM: 1-218/286
Sequence Identity: 41% (92 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKR-KYRNWDECMSLREVKSLRKMNHPNLVKLKEVLQIKDELMLVFEYVDLNLYQMYMTYKEKKTQIPE
|     .| | ||.|.|  |||.|.|||||| |  ..        .||.| |. . |.|.| |.|| . | .| |||||.| ..       .|. . ..|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHE---LEEYPNGVDE

SVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLAREVRCRPP--FTEYVSTRWYRAPEILLHSQNYNSPIDVFALGCIMAELYNL
.|..|...||  ... .|.    ||| ||||.|.. ..  || ||||.||     |    |.|| |||||||| |.    | .|.|. |.||.|||.   
HVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDG

QPLFSGQNEVDQFYKIVSVLGT
|||. ||...||.|.|. .||.
QPLWPGQSDIDQLYHIQKCLGP
Kinase 28968.AA CDK5 4-286 36 9.2e-73 229.1 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 36% (109 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKRKYRNWDE---CMSLREVKSLRKMNHPNLVKLKEVLQIKDELMLVFEYVDLNLYQMYMTYKEKKTQI
|. .  .|.||||||.|| ||| .||||.|.   .  . ||   .  .||.  |. . |.| | |  |.     | ||||..|  |   ||   .   ..
YEKMEKIGEGTYGTVYKARNKETHEIVALKRV--RLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDL-KKYMDSCNG--EM

PESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLARE----VRCRPPFTEYVSTRWYRAPEILLHSQNYNSPIDVFALGCIMAE
   .|| ..||   ||   |.    |||||| |||.|    . |  ||||||     |||   ..  | | |||.| .|. |. |. .||.   |||.||
DMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNG-ELKLADFGLARAFGIPVRC---YSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

LY-NLQPLFSGQNEVDQFYKIVSVLGTP--QNWNEGAKLAQ-K-LQLTIPKKEPLP-LPQVVPRASLDALQLLGDMLQYDPMKRPTAIQITKYPYF
.  ...||| | .. ||  .|  ..|||   .|   .|| . | .    |. .. . . |.||. .   . ||. |||..| .| .| .  . |||
MANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 28968.AA CDK4 4-286 38 5.3e-68 232.23 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-290/290
Sequence Identity: 38% (114 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKRKYRNW--DECMS-LREV---KSLRKMNHPNLVKLKEVLQIKDELM------LVFEYVDLNLYQMYM
||.|  .| | ||||..|   ..| .|| |. .    .      || .||.   . | ...||| |||..| .  |         .||| .|  |     
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDL----H

TYKEKKTQ--IPESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLAREVRCRPPFTEYVSTRWYRAPEILLHSQNYNSPIDVFA
|| .|  .  .|.  ||..  |.  |.| ||     ||||||.|.||. |.  ||  ||||||.      .|  | | ||||||.|| |  ||.|.|  .
TYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVT-SDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSY-YNTPVDMWS

LGCIMAELYNLQPLFSGQNEVDQFYKIVSVLGTP--QNWNEGAKLAQKLQLTIPKKEPLPLPQVVPRASLDALQLLGDMLQYDPMKRPTAIQITKYPYF
.|||.||.|. .||| ||.|.||  ||  | |.|  . |     |.       | . | |.  ..|  .  ...||  || |.. ||..| |  . |||
VGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWD---HFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 28968.AA Pkinase_Tyr 4-154 29 1.3e-17 60.27 Pfam 1-161 (270) Show / Hide 
Range on Protein: 4-154
Range on HMM: 1-161/270
Sequence Identity: 29% (48 aa)

YQLVKNLGDGTYGTVFKAINK----ENGEIVAIKKMKRKYRNWD--ECMSLREVKSLRKM-NHPNLVKLKEVLQ-IKDE--LMLVFEYVDL-NLYQMYMT
 .. | || | .|.|.|.. |    ...  ||.|..| ..   .    . .||.| .... .|||.|.|  |    ..   ...|.||. . .|.    .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

YKEKKTQIPESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLAREV
 .| | ... . . .. .||| |.. |.. .. ||||   | ||. ... ||.||||||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT-ENNVVKICDFGLARDI
Kinase 28968.AA TyrKc 4-286 22 1.1e-14 14.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

YQLVKNLGDGTYGTVFKAINKENGEIVAIKKMKRKYRNWDECMSLREVKSLRKM--NHPNLVKLKEVLQIK-------DELMLVFEYVDLNLYQMYMTYK
 .| | || | .|.|.|.. |   . ||.|..|       . . .|| . ..|   .|||.|.|  |   .       . ||.|.||...   . |  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

EKKTQIPESVIKKIIYQIALGLDSLHNTGYFHRDLKPENLLVNMSSLNVKVCDFGLAREVRCR-------PPFT------EY--VSTRWYRAPEILLHSQ
..|  .. .   .. .||| | . ||  .. ||||   | ||.     ||..||||.|..             .      .   .  ||. ||| . .. 
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECINYGK

NYNSPIDVFALGCIMAELYNL-QPLFSGQ----NEVDQFYKIVSVLGTPQNWNE----GAKLAQKLQLTIPKKEPLPLPQVVPRASLDALQLLGDMLQYD
 ...  ||.. |  | |.. . |.  .|.     . .. .. |   . .    .                            .... .  |.  .  ..|
-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------F-VCCPDEMYQIMKQCWHED

PMKRPTAIQITKYPYF
| .|||  .|  . .|
PEDRPTFSEI--HECF
Kinase 28968.AA CDKL 243-286 33 2.8e-07 20.94 In-house 242-286 (286) Show / Hide 
Range on Protein: 243-286
Range on HMM: 242-286/286
Sequence Identity: 33% (15 aa)

KEPLPLPQVVPRAS-LDALQLLGDMLQYDPMKRPTAIQITKYPYF
... ||.. .| .|   || ..  .|. || .|.|. | .. |||
EHMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF