Gene 15246 (Tetrahymena)

15246

Species: Tetrahymena
Alias: TTHERM_00926910, 166.m00053, PreTt15246, 875, 15246
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
15246.AA Protein None 1647 None Fasta, JSON
15246.kin_dom Protein Kinase Domain None 252 None Fasta, JSON
15246.NA RNA None 4944 None Fasta, JSON

Protein domain

Protein domains of 15246.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15246.AA Aur 1372-1623 55 4e-225 601.43 In-house 1-257 (257) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-257/257
Sequence Identity: 55% (143 aa)

FQIGKCLGRGRFGNVYLSRHKLTNMLFAIKQISKKNLIESCMEKQLQQEIKIQTYLNHPNVLKMHGFFDDSQKIYLILELASHGDIYKEIKREANKKFTE
|.|||.||.|.||||||.||| |...||.|...|......|||.||..|||||..|||||.|||.|.| |.|.|||||| |..|..|||.....||.|.|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

EKAANYIRQVCEGLIYLHSQGIIHRDIKPENILNS--YGVLKLSDFGWSIYT--EEKRMTFCGTLDYVSPEVVSGKDYDFKVDIWSIGVLTYELITGKPP
..||.|..|.|..|.|.||..||||||||||||..  .|..|..|||||...  ...||||||||||..||.|.|...|.|||||..|||.|||..|.||
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FENRQNHNEAYQKIL-MVKYDFPNYISKEAKDFMSKLLVGDPNKRISLETALNHEWI
||...||.| |..|. .|...||..|||||||..||.|. ||..|..|. ..|| ||
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 15246.AA AGC 1372-1623 25 1.1e-110 286.92 In-house 1-395 (395) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-395/395
Sequence Identity: 25% (103 aa)

FQIGKCLGRGRFGNVYLSRHK------LTNMLFAIKQISKKN-LIESC--MEKQLQQE------------IKIQTYLN----------HPNVLK-MHGFF
|.. |..|.| || ||| |.|       |. ..|.| ..||   ..    |... . |             .| . .|          ||.. | .|  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDSQK--IYLILELAS--------HGD-IYKEIKRE--ANKKFTEEKAANYIRQ-------VCEGLIYLHS-QGIIHRD-IKPENIL-NSYGVLKLSDFG
 | ..  .|...|...         |.  .  ....   ...|.|| |  |. .       .. .| |||| .|||||| .|||||| .. | .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

WSIYTE-----------------------------------------------------EKRMTFCG--TLDYVSPEVVSGKDYDFKVDIWS--IGVLTY
 .                                                         ..  ||||  | .|..||..    |.. .|.||   |.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELITGKPPFENRQ---------NHNEAYQKIL--------MVKYDFP--------NYISKEAKDFMSKLLVGDPNKRIS----------LETALNHEWI
|..||.||| . .         |..| .|||.         ||..||         ..|.||||...|||. ||.||.            |   ||.| 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 15246.AA CAMK 1377-1623 25 7.1e-104 335.65 In-house 1-425 (425) Show / Hide 
Range on Protein: 1377-1623
Range on HMM: 1-425/425
Sequence Identity: 25% (108 aa)

CLGRGRFGNVYLSRHKLTN------------MLFAIKQISKKNLIE-------------------------SCMEKQLQQEIKIQTY-------LNHPNV
 ||||.|| |.| .||.|.              .||| |.|| | .                          ...|....||.|          |.|||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKMHGFFDD-------------------SQKIYLIL---ELASHG----DIYKEIKREAN-------------KKFTEEKAANYIRQVCEGLIYLHSQGI
.|.. ...|                    ...|...   |..| |    |..  |..  .             ..|||. |. |.||.|... |.||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENILNSY------------------GVLKLSDFGWSIYTEE--------------------------KRMTFCGTLDYVS-PEVVSGKD----
.|||.|||||| ..                  . .|..||| ... ..                          |  |||||. |.. |||..||     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YDFKVDIWSIGVLTYELITGKPPFENR------------QNHNEAYQKILMVKYDFPNY----------------ISKE--------AKD
          |..|.|.||.||..| . .|.|||.              .| .| ..||.  ||||| .                ||.|        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FMSKLLVGDPNKRISLETALNHEWI
. .|.|. ||.||...| .|||.|.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15246.AA S_TKc 1372-1623 35 1.2e-101 344.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-231/231
Sequence Identity: 35% (95 aa)

FQIGKCLGRGRFGNVYLSRHKLTNMLFAIKQISKKNLIESCMEKQLQQEIKIQTYLNHPNVLKMHGFFDDSQKIYLILELASH--GDIYKEIKREANKK-
..|.. .|.| || ||. ||| |. ..|||.|.          .....||.|    .|||. |....|.| ...|...|....  || .. ||.   .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTEEKAANYIRQVCEGLIYLHSQGIIHRDIKPENILNSYGVLKLSDFGWSIYTEEKRMTFCGTLDYVSPEVVSGKDYDF-KVDIWSIGVLTYELITG
   |.|  |. |..|.|..| |.||.||||||.|||||| .  ..|..||| .       .|||||..|..|||.    |.. |.|.||.|.. ||...|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

KPPFENRQNHNEAYQKILMVKYDFPNYISKEAKDFMSKLLVGDPNKRISLETALN-------HEWI
.|||.   .... ..||.          |.|||||..|.|. ||.||..   ||.       |.|.
YPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15246.AA Pkinase 1372-1623 32 6.7e-98 336.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

FQIGKCLGRGRFGNVYLSRHKLTNMLFAIKQISKKNLIESCMEKQLQQ--EIKIQTYLNHPNVLKMHGFFDDSQKIYLILELASHG----DIYKEIKREA
..||...|.| || ||. .|| |. ..|.|.|.|.  ..|......    ||.|   |||||.......| |...||...|.. .|    | .  |....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NKKF--TEEKAANYIRQVCEGLIYLHSQGIIHRDIKPENILNS-YGVL----KLSDFGWS----IYTEEKRMTFCGTLDYVSPEVVS-GKDYDFKVDIWS
...|  .|. . .|..|...|| |.||.||||||.|||||| .  |..    |..||| .    .   .  .|||||..|..|||.  |..|. |||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

IGVLTYELITGKPPFENR-----QNHNEAYQKILMVKYDFPNYIS---------------------KEAKDFMSKLLVGDPNKRISLETALNHEWI
.|.. ||...|.||| ..      .... ...|.. ...|. . .                     .|.|||....|  ||.||.. | .|.|.|.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15246.AA CAMK1 1372-1623 37 6.3e-96 279.34 In-house 1-276 (276) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-276/276
Sequence Identity: 37% (104 aa)

FQIGKCLGRGRFGNVYLSRHKLT---NMLFAIKQIS-KKNLIESCME--KQLQQEIKIQT---YLNHPNVLKMHGFFDDSQKIYLILELASHGDIYKEIK
...|| .||| |. |||  || |   .  .||| |. ||.. .. |   ..|..|| | .    ..|||. |.. ....  ..||..|| . |..   | 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI-

REANKKFTEEKAANYIRQVCEGLIYLHSQGIIHRDIKPENIL---NSYG-VLK--LSDFGWSIYTEEKR---MTFCGTLDYVSPEVVSG---KDYDFKVD
   ....||..|.. ..|... . |.||.|| |||.||||.|   .. .  .|  ..||| | .....     | |||..|| |||. .   | || ..|
-VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

IWSIGVLTYELITGKPPFENRQNHNEAYQKILMVKYDFPNY----ISKE-AKDFMSKLLVGDPNKRISLETALNHEWI
.||||| || | .| |||     .|| ..||.  .|.||.     ||.. |||| ...|. ||.||.. | .||| ||
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 15246.AA CAMKL 1372-1623 34 1.6e-94 302.05 In-house 1-297 (297) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-297/297
Sequence Identity: 34% (102 aa)

FQIGKCLGRGRFGNVYLSRH-KLTNMLFAIKQISKKNLI-ESCMEKQ-----------LQQEIKIQTYLN---HPNVLKMHGFFDDSQK------IYLIL
..||| ||.| || | | .| ..|.   ||| | || .  . .|.|            ...||.|.  ||   |||. |..  ......      |||..
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELASHGD--IYKEIKREANKK--FTEEKAANYIRQVCEGLIYLHSQGIIHRDIKPENILNS-YG--VLKLSDFGWSIY-T------EEKRMTFCGTLDYV
|..| |.   .  |... ...  ..|. |  | ||..... |.||.||.|||||||||| .  |  ..|..||| |.. .      ..| .||||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEVVSG--KDYD-FKVDIWSIGVLTYELITGKPPFENRQ-------NHNEAYQKILMVKYDFP--NYISKEAKDFMSKLLVGDPNKRISLETALNHEWI
.||...|  |.|| .||||||.||. | ...|. ||..         |. . | ||    | .|  ...| ...|. .|.|. .|.||....  .||.| 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 15246.AA Ciliate-E2 1372-1623 28 1.6e-90 307.04 In-house 1-365 (365) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-365/365
Sequence Identity: 28% (107 aa)

FQIGKCLGRGRFGNVYLSRHKLT-----------------------NMLFAIKQISKKNLIESCMEKQLQQEIK----------IQTYLNHPNVLKMHGF
. . |..|.| || ||. .....                       ....|.|...|.....  .|... .||.          |.  |||||..||. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--DSQKIYLILELASHGDIYKEIK-----------REANKKFTEEKAANYIRQVCE---------------GLIYLHSQG-IIHRDIKPENILNSYGV
|   | ..|||..|....|| .. ||             . |.|||........|...               .| ||||.. ||||||||||||     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

LKLSDFGWS-----------------IYTEEKRMT------------------FCGTLDYVSPEVVSGKD---------YDFKVDIWSIGVLTYELITGK
.|..||| |                 .|.. | .|                  .|||. |..||...||.         ||.|.||||.||. ||...||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFENRQNHNEAYQKILMVKYDFP------------------NYISKEAKDFMSK----LLVGDPNKRIS-LETALNHEWI
|||         .|.|.  |.|||                  ...|.|.||...|    .|. ||.|||.  | .|||.|.
PPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 15246.AA MARK 1372-1623 40 1.8e-87 286.02 In-house 1-262 (262) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-262/262
Sequence Identity: 40% (105 aa)

FQIGKCLGRGRFGNVYLSRHKLTNMLFAIKQISKKNLIESCMEKQLQQEIKIQTYLNHPNVLKMHGFFD--DSQK-IYLILELASHGDIYKEIKREANKK
. ..|..| | .. |.| .||.|.  .||| . |..| . .  | .. ||.|   |.|||. |..  ..  ..|. ||||.|.|| |. |  ||   | .
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FTEEKAANYIRQVCEGLIYLHSQGIIHRDIKPENIL-NSYG--VLKLSDFGWSIYT--EEKRMTFCGTLDYVSPEVVSGKDYD-FKVDIWSIGVLTYELI
 .|| |  . ||..... |.||..|.||||||||||  . |    |..|||.||    ..|  |||||. | .||....|.|| .|||||| ||. | ..
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

TGKPPFE-NRQNHNEAYQKILMVKYDFPNYISKEAKDFMSKLLVGDPNKRISLETALNHEWI
.|. ||.   |. .| |.|||  |||.| ..|||.... ..||. .|..|...|  ..|.|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 15246.AA PLK 1372-1623 36 1.2e-81 265.72 In-house 1-258 (258) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-258/258
Sequence Identity: 36% (94 aa)

FQIGKCLGRGRFGNVYLSRHKLTNMLFAIKQISKKNLIESCMEKQLQQEIKIQTYLNHPNVLKMHGFFDDSQKIYLILELASHGDIYKEIKREANKKFTE
...|. ||.| |  .|  ..  |.  .||| ..|. .. . . . ..|||.|.  |.|||..|.| || |.. .|. ||......    .||   |..||
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRR-AKRLTE

EKAANYIRQVCEGLIYLHSQGIIHRDIKPENI-LNSYGVLKLSDFGWSI---YTEEKRMTFCGTLDYVSPEVVSGKD--YDFKVDIWSIGVLTYELITGK
. .  |..|...|| |||...|||||.|. |. ||.  ..|. ||| .    | .|...|.|||  |..|||. |.   ....||.||.|.  | |..||
PEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGK

PPFENRQNHNEAYQKILMVKYDFPNY--ISKEAKDFMSKLLVGDPNKRISLETALNHEWI
||||  .. .| |..| . .| ||..  ||.||||.  |.|  .| .|....  |.|.. 
PPFET-KDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 15246.AA RSK 1375-1623 33 1.8e-77 263.71 In-house 1-278 (278) Show / Hide 
Range on Protein: 1375-1623
Range on HMM: 1-278/278
Sequence Identity: 33% (92 aa)

GKCLGRGRFGNVYLSRHK---LTNMLFAIKQISKKNLIESCM-EKQLQQEIKIQTYLN-HPNVLKMHGFFDDSQKIYLILELASHGDIYKEIKREANK-K
 | ||.| .| |.| | .    |....| |...|. .. .    .   .|..|    . ||.. . |  |.. .|.|||.|. . |. .. ...|  .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEKAANYIRQVCEGLIYLHSQGIIHRDIKPENIL-NS---YGVLKLSDFGWSIYT----EEKRMTFCGTLDYVSPEVVS----GKDYDFKVDIWSIGV
|.|. |. |....   . .||.|||||||.|||||| ..    | .||.||| . ..    ... ||||.|..|. ||..     .. .|  .|.|| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYELITGKPPFEN-RQ-NHNEAYQKILMVK--YDFP--NYISKEAKDFMSKLLVGDPNKRIS-----LETALNHEWI
| ||. ||.||| . .. |..|  ..|.  |   ..|  .|.|.||||. .|.|  ||.||..     .|  ..|.|.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 15246.AA ULK 1372-1623 30 2.9e-77 263.02 In-house 1-324 (324) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-324/324
Sequence Identity: 30% (99 aa)

FQIGKCLGRGRFG-NVYLSRHKLT---NMLFAIKQISKKNLIESCME-------KQLQQEIKIQTYLN---HPN--VLKMHGFFDDS--QKIYLILELAS
... .||| | ||  ||  |.| |   | ..|.|.|.||.....  |       ..|..||.|.  |.   |||  . |.. .| .|    ||.|.|.  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

HGDIYKEIKRE-------ANKKFTEEKAANYIRQVCEGLIYLHSQGIIHRDIKPENILNSYG-------------VLKLSDFGWSIYTEE------KRMT
.||  . ||.         .|...|..| ....| |.|. .||...||||||||.||| . |             |||..||| .   ..      ...|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

FC------GTLDYVSPEVVS----GKDYD-FKVDIWSIGVLTYELITGKPPFENRQNHNEA------------YQKILMVK--YDFP-----NYISKEAK
..      ||  | .|....    .|.|. .|.||||.|.. ||...||.||... . ..             . .|.. .   .||     . ||.| |
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQ-QIYIKNQPIQFPKPPKDPKISPECK

DFMSKLLVGDPNKRISLETALNHEWI
|. ...|. |...||| |  .||.|.
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 15246.AA Pkinase_Tyr 1372-1498 28 8.9e-25 84.53 Pfam 1-137 (270) Show / Hide 
Range on Protein: 1372-1498
Range on HMM: 1-137/270
Sequence Identity: 28% (41 aa)

FQIGKCLGRGRFGNVYLSRHK----LTNMLFAIKQISKKNLIESCMEKQ-----LQQEIKIQTYL-NHPNVLKMHGFFD-DSQK--IYLILELASHGDIY
 ..|| ||.| ||.||. . |     |..  |.| . |    |..|..|     . .|.|| . | .|||.....|    ...   ||...|.. ||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KEIKRE--ANKKFTEEKAANYIRQVCEGLIYLHSQGIIHRDI
.  ..    ....| .   .. .|...|. ||.|...||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 15246.AA TyrKc 1372-1623 21 5.6e-17 51.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 1372-1623
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FQIGKCLGRGRFGNVYLSRHKLTNMLFAIKQISKKNLIESCMEKQLQQEIKIQTYL--NHPNVLKMHGFFDDS-------QKIYLILELASHGDIYKEIK
 . || ||.| || ||. . |   .  |.| . .        .. . .|..| . |  .|||.....|   ..       . .....|...|||  . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

REANKKFTEEKAANYIRQVCEGLIYLHSQGIIHRDIKPENILNSYGV-LKLSDFGWSIYTEEK-------RMTFCGT---LD------YVSPEVVSGKDY
.  .| .. ..  ..  |...|  ||||...||||.   |.| . .   | |||| | . ...        .    .    .        .||.   . .
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DFKVDIWSIGVLTYELIT-GKPPFENR----QNHNEAYQKILMV-KYDFPNY--------ISKEAKDFMSKLLVGDPNKRISLETALNHEWI
 .| |.|| ||. .|. | |..| ..      .  |.....      . | .         ..|  . |..    ||..| . ..   || .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 15246.AA Pkinase_Tyr 1536-1581 33 0.001693 12.47 Pfam 182-228 (270) Show / Hide 
Range on Protein: 1536-1581
Range on HMM: 182-228/270
Sequence Identity: 33% (16 aa)

SPEVVSGKDYDFKVDIWSIGVLTYELIT-GKPP-FENRQNHNEAYQKI
.||. . . .  | |.|| ||| .|..| |. | ...    .| |..|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYI