Gene 19636 (Tetrahymena)

19636

Species: Tetrahymena
Alias: PreTt19636, 59.m00274, 19636, 3680.m00131, TTHERM_00487050, 658
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
19636.AA Protein None 2048 None Fasta, JSON
19636.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
19636.NA RNA None 6150 None Fasta, JSON

Protein domain

Protein domains of 19636.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19636.AA Aur 1483-1735 47 7.29999999999e-211 563.03 In-house 1-257 (257) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-257/257
Sequence Identity: 47% (121 aa)

FYFVKKLGKGKHSEVFLAQDKKTGFLFAVKQIHKEDMISMGMEEQFSNEIKIQMSLNHPNIIRLYGFYQDEYYFYLLMEYAPGGEIYRYQKTLPDGRFTE
|.. |.|||||...|.||..|||.|.|| |...||......||.|. .|||||..||||||...||...|....||..|||||||.|.... .|..||.|
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

TEAAFYLYQLANALRYLHSRNVIHRDIKPENLLIS--NGVVKLADFGYSRVCDFKSTRSTFCGTLDYLSPQVVKGQEYNHDVDVWAFGVMCYEFLQGIAP
 .||.| ||..|||.|.||.|.|||||||||.|..  ||..|..|||.| .|.... |.||||||||..|..|.||...| ||.|..||.|||...| .|
QRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPP

FYE-KSKDDTLDKIQ-SGKYSFIKPISEEAKTLIQVLLDSESKNRVSINDVCRCSWL
|.. ...| |.|.|.  ....| ..||.||| ||. .|....|.|......... | 
FESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 19636.AA AGC 1483-1735 23 4.1e-108 280.08 In-house 1-395 (395) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-395/395
Sequence Identity: 23% (94 aa)

FYFVKKLGKGKHSEVFLAQDK------KTGFLFAVKQIHKED--------MISMGMEEQ-------FSNEIKIQMSLN----------HPNIIR-LYGFY
| |.| .|||  ..|.|...|       || ..|.| . |..        |. . | |.       . .| .| . .|          ||.|.. |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEYY--FYLLMEYAP---------GG-EIYRYQKTL-PDGRFTETEAAFYLYQ-------LANALRYLHS-RNVIHRD-IKPENLLISN-GVVKLADFG
||. .   |..|||.|         || | . ...     |||.| .| ||. .       .. || |||| ...|||| .||||.|. . | .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

YSRVCDFKS---------------------------------------------------TRSTFCG--TLDYLSPQVVKGQEYNHDVDVWA--FGVMCY
 . .   .                                                    . .||||  | .|..| ..    |.. .| |.  .|.. |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFLQGIAPFYEKS----------KDDTLDKIQ------SGKYSFI----------KPISEEAKTLIQVLLDSESKNRVS----------INDVCRCSWL
|.| |. ||| ..          .... .||.      . |  |           . .|.||| ||. ||  . ..|            .... .  | 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 19636.AA CAMK 1488-1735 22 1e-94 305.58 In-house 1-425 (425) Show / Hide 
Range on Protein: 1488-1735
Range on HMM: 1-425/425
Sequence Identity: 22% (96 aa)

KLGKGKHSEVFLAQDKKTG------------FLFAVKQIHKEDMIS-------------------------MGMEEQFSNEIKIQMS-------LNHPNI
.||.|  ..|.|...|.|.              .|.| | |. . .                           ..... .||.| ..       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRLYGFYQD-------------------EYYFYLLM---EYAPGG----EIYRYQKTLPD-------------GRFTETEAAFYLYQLANALRYLHSRNV
|.|| .|.|                   . ..|. |   ||..||    ... | .  ..             ||||| ||..|  |.. |..|.||.|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPENLLI-SN-----------------GVVKLADFGYSRVCDF------------------------KSTRSTFCGTLDYLS-PQVVKG------
.|||.||||.|. .|                 . .|..||| ....|                             .|||||. | . | |..|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QEYNHDVDVWAFGVMCYEFLQGIAPFYEK-------------SKDDTLDKIQSGKYSFIKP----------------ISEE--------AKT
        . |.  .|.|. ||..|  | |  |||..             .  ... ||..|||.|. |                ||.|        .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIQVLLDSESKNRVSINDVCRCSWL
||. .|  . ..| .| .. .  |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 19636.AA S_TKc 1483-1735 32 1.8e-88 301.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-231/231
Sequence Identity: 32% (86 aa)

FYFVKKLGKGKHSEVFLAQDKKTGFLFAVKQIHKEDMISMGMEEQFSNEIKIQMSLNHPNIIRLYGFYQDEYYFYLLMEYAPG--GEIYRYQKTLPDGR-
. ...|.|||  ..|.....|||| ..|.|.|.          |.. .||.| .. .||||..||...||  ..|. |||..|  |. ..| |  . .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTETEAAFYLYQLANALRYLHSRNVIHRDIKPENLLISNGVVKLADFGYSRVCDFKSTRSTFCGTLDYLSPQVVKGQEYNH-DVDVWAFGVMCYEFL
   |.| .|.||.||...|| |.||...||||.||||.|... ..|..||| .|.       .|||||..|..| |.    |..  .|.|..|.. ||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

QGIAPFYEKSKDDTLDKIQSGKYSFIKPISEEAKTLIQVLLDSESKNRVSINDVCR-------CSWL
 |  ||.    . ...||           |.||| .|. .|. . ..| .. .. .         |.
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19636.AA Ciliate-E2 1483-1735 24 7.8e-83 281.5 In-house 1-365 (365) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-365/365
Sequence Identity: 24% (91 aa)

FYFVKKLGKGKHSEVFLAQDKKTG-----------------------FLFAVKQIHKEDMISMGMEEQFSNEIK----------IQMSLNHPNIIRLYGF
. |.||.|.| .. |......|..                       ...|.|...| . ... .|..  .||.          |. .|||||||..| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YQ--DEYYFYLLMEYAPGGEIYRYQK-----------TLPDGRFTETEAAFYLYQLAN---------------ALRYLHSRN-VIHRDIKPENLLISNGV
.|  |. ..|| |||. ||. . | |               ..||| |.... .|...               ||.||||.| .|||||||||.|.    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

VKLADFGYSRVCDFKSTRST--------------------------------FCGTLDYLSPQVVKGQE---------YNHDVDVWAFGVMCYEFLQGIA
.|..|||.|. .| .. . |                                .|||. |..|....|..         |.. .|.|..||. ||.| |  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFYEKSKDDTLDKIQSGKYSFI------------------KPISEEAKTLIQV----LLDSESKNRVS-INDVCRCSWL
||        ...|. .|..|                   | .|.|.| ||.     .|. . ..| . ....    |.
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19636.AA Pkinase 1483-1735 32 1.9e-80 278.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-293/293
Sequence Identity: 32% (95 aa)

FYFVKKLGKGKHSEVFLAQDKKTGFLFAVKQIHKEDMISMGMEEQFS-NEIKIQMSLNHPNIIRLYGFYQDEYYFYLLMEYAPGG----EIYRYQKTLPD
. ...|.|.|  ..|.....|.|| ..|||.| |..  |   .. .  .||.|  .||||||.|||....|. . |. |||..||    . ..| .|  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--TETEAAFYLYQLANALRYLHSRNVIHRDIKPENLLIS-NGVV----KLADFGYSRV--CDFKSTRSTFCGTLDYLSPQVVK-GQEYNHDVDVWAF
|.|  .| |. ||.||.. .| |.||...||||.||||.||. ||..    |..||| ...     .|  .|||||..|..| |.. ||.| . ||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVMCYEFLQGIAPFYEK------SKDDTLDKIQSGKYSFIKPIS---------------------EEAKTLIQVLLDSESKNRVSINDVCRCSWL
|...||.| |  ||...      ...  ...| .....|  | .                     ||.| .|  .|.   | | .. ...   |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 19636.AA CAMKL 1483-1735 30 1.1e-77 247.52 In-house 1-297 (297) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-297/297
Sequence Identity: 30% (91 aa)

FYFVKKLGKGKHSEVFLAQD-KKTGFLFAVKQIHKEDMISMGMEEQF------------SNEIKIQMSLN---HPNIIRLYGFYQDEYY------FYLLM
. ..| ||||  ..| ||.. . ||   |.| |.|. .      ..               ||.|...||   |||||.||  .... .      .|| |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAPGGE--IYRYQKTLPD--GRFTETEAAFYLYQLANALRYLHSRNVIHRDIKPENLLIS-NG--VVKLADFGYSRVCD-F----KSTRSTFCGTLDYL
||..|||   . | .  ..  ||..| || .|  |.  |. |.||....||||||||.|.. ||  ..|..||| |  ..        . .||||.. | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPQVVKG--QEYN-HDVDVWAFGVMCYEFLQGIAPFYEK--------SKDDTLDKIQSGKYSF-IK-PISEEAKTLIQVLLDSESKNRVSINDVCRCSWL
.| ...|  ..|.   ||.|. ||. |  . |  || .          .   . || .| | . |   .| ... ||. .|    . | .| .. .  |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 19636.AA MARK 1483-1735 36 3.6e-74 241.89 In-house 1-262 (262) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-262/262
Sequence Identity: 36% (96 aa)

FYFVKKLGKGKHSEVFLAQDKKTGFLFAVKQIHKEDMISMGMEEQFSNEIKIQMSLNHPNIIRLYGFYQ--DEYY-FYLLMEYAPGGEIYRYQKTLPDGR
. ..| .|.| ...| ||..|.||  .|.| . |...      . .  ||.| ..|.|||||.|.   .  .|   .|| ||||.||| | | |  |.||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FTETEAAFYLYQLANALRYLHSRNVIHRDIKPENLLI-SNG--VVKLADFGYSRVCDFKSTRSTFCGTLDYLSPQVVKGQEYN-HDVDVWAFGVMCYEFL
 .| ||  .  |.  |. |.||.|..||||||||.|| .||   .|..|||.|. .   .  .|||||. | .|.......|.   ||.|. ||  |  .
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

QGIAPFYEKS--KDDTLDKIQSGKYSFIKPISEEAKTLIQVLLDSESKNRVSINDVCRCSWL
.|  || ...    .   ||..|||..   .| |.. ||| ||    . | .| .. . .|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 19636.AA CAMK-Unique 1483-1735 21 5.3e-73 240.27 In-house 1-363 (363) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-363/363
Sequence Identity: 21% (78 aa)

FYFVKKLGKGKHSEVFLAQDKKTGFLFAVKQIHKEDMISMGMEEQ-----------------FSNEIKIQMSLNHPNIIRLYGF----YQDEY-------
  ... .|.|  ..|. ..|..|| ..|.| . |..  .  . .|                 . .|. |  ...|||||.||..    ..|.        
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------YFYLLMEYAPGGEIYRYQKTL------------------PDGRFTE--TEAAFYLYQLANALRYLHSRNVIHRDIKPENLLISNG-------
        |.|..|||..||. . .   .                    |.|.|  ....|.  .|. |. |.|| ...|||.|.||.....        
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------VVKLADFGYSRVCDFKSTRS---TFCGTLDYLSP--------------QVVKGQEYNHDV----DVWAFGVMCYEFLQGIAPFYEKSKD-
           .||.||| ..  . .  ..   |.|||..|..|              .|...| |   .    | |. ||. |. | |. ||.. ..| 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------DTLDKIQSGKY-SFIKP-------ISEEAKTLIQVLLDSESKNRVSINDVCRCSWL
        ....| .|.| .| ..       ||.||| ... .. .. . |.|..     .|.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 19636.AA Ciliate-E2-Unclassified 1483-1735 25 6.4e-73 248.56 In-house 1-352 (352) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

FYFVKKLGKGKHSEVFLAQDKKTGFLFAVKQIHKEDMIS----MGMEEQFSNEIKIQMSLN-----------------HPNIIRLYGFYQ--DEYYFYLL
. ..|..|.| ...|...|.||.....| |...|  ...    | .. ...||.|. ....                 ||...... ||.  |. ..|. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYAPGGEIYRYQKTLPD---------------GRFTETEAA-----FYLYQLANALRYLHSRN-VIHRDIKPENLLISNG----VVKLADFGYSR----
|||..||.   | |  .                 .||| .|.     ||..|. ..| |||. | .|||||||||.|..|.     .|..||| |.    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

VCDFKSTR-------------STFCGTLDYL----SPQVVKGQEYNHD----VDVWAFGVMCYEFLQGIAPFYEKSKDD----------------TLDKI
  ... |.             .|||||. |.    .| | .||.|.|     .|.|..|| .||.| |  ||| .....                 ...|
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

QSGKYSFIK--------PISEEAKTLIQ----VLLDSESKNRVSINDVCRCSWL
. ....| |         .|.||| .|.     .|.   ..| ......   |.
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 19636.AA RSK 1486-1735 30 2.7e-72 246.51 In-house 1-278 (278) Show / Hide 
Range on Protein: 1486-1735
Range on HMM: 1-278/278
Sequence Identity: 30% (86 aa)

VKKL---GKGKHSEVFLAQDKKTGFLFAVKQIHKEDMISMGM-EEQFSNEIKIQMSLN-HPNIIRLYGFYQDEYYFYLLMEYAPGGEIYRYQKTLPD-GR
.| |   |.||.. .   ....|| ..|.|...|  ..      .    |..| .  . ||.|..|.  .|.| ..|| ||| .||| ..  ..    | 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTETEAAFYLYQLANALRYLHSRNVIHRDIKPENLLISN----GVVKLADFGYSRV--CDFKSTRSTFCGTLDYLSPQVVK---GQE-YNHDVDVWAFGV
|.|.||.||..... |...||.. .||||.|||| |  .    | .|| ||| ..   ||...   |||.|..|. | ..|   .|. ... .|.| .||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

MCYEFLQGIAPFYE---KSKDDTLDKIQSGKYSFIKP----ISEEAKTLIQVLLDSESKNRVS-----INDVCRCSWL
  || | |  ||.    .........||.||.|.  |    .|.||| ||. .|  . ..| .     .... . .|.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 19636.AA ULK 1483-1735 28 3.2e-69 236.3 In-house 1-329 (329) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-329/329
Sequence Identity: 28% (93 aa)

FYFVKKLGKGKHSEVFLAQDKKT----GFLFAVKQIHKEDMISMG-------MEEQFSNEIKIQMSLN--------HPNIIRLYGFYQDE--YYFYLLME
..  ..||||    |. . .|||    . ..|.|.| |. |.          | ... |||||.  |.        ||||..|| ....    ..|. ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAPGGEIYRYQKTLPD--------GRFTETEAAFYLYQLANALRYLHSRNVIHRDIKPENLLISNG-------------VVKLADFGYSRVCD-F---KS
| .||    | |.           .|..| ||  ...|..|....||..|.|||||||.| ||.||             |.|.|||| ....| .   . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

TRSTFC------GTLDYLSPQVVK----GQEYN-HDVDVWAFGVMCYEFLQGIAPFYEKSKDDTL-----DK----------IQSGKYSFI-----KPIS
   |.       ||  | .||...    ...|. . .|.| .|.. || | |  |||.  . |.      .           |.. .  |      ..||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

EEAKTLIQVLLDSESKNRVSINDVCRCSWL
.| | ||. .|  . | | |. ..    |.
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 19636.AA Pkinase_Tyr 1483-1627 35 2e-22 76.57 Pfam 1-156 (270) Show / Hide 
Range on Protein: 1483-1627
Range on HMM: 1-156/270
Sequence Identity: 35% (57 aa)

FYFVKKLGKGKHSEVFLAQDK----KTGFLFAVKQIHKEDMISMGME---EQFSNEIKIQMSL-NHPNIIRLYGFYQ-DEYY--FYLLMEYAPGGEIYRY
  | ||||.|   ||...  |    .|.   ||| . ||   .|  .   | | .|.|| ..| .||||.||||    ..     |. |||.|.|  . |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

QKTL--PDGRFTETEAAFYLYQLANALRYLHSRNVIHRDIKPENLLIS-NGVVKLADFG
 ..   .....|  .   . .| |... ||.|.| ||||.   | |.. |.||| .|||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 19636.AA TyrKc 1483-1735 22 6e-22 80.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 1483-1735
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FYFVKKLGKGKHSEVFLAQDKKTGFLFAVKQIHKEDMISMGMEEQFSNEIKIQMSL--NHPNIIRLYGFYQDE-------YYFYLLMEYAPGGEIYRYQK
  . |||| |   ||.... |      ||| ....       .| | .|..| ..|  .||||.||||   ..          ...|||.|.|    | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

TLPDGRFTETEAAFYLYQLANALRYLHSRNVIHRDIKPENLLISNGV-VKLADFGYSRVCDFK--------STRSTF--CGT----LDYLSPQVVKGQEY
   .  ..  .   . .| |.  .||||.|.||||.   | |....  || .||| ||  . .          |..   .|     .  ..| . .  ..
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NHDVDVWAFGVMCYEFL-QGIAPFYE-----KSKDDTLDKIQSGKYSFIKPI---------SEEAKTLIQVLLDSESKNRVSINDVCRCSWL
..  |||.|||...| .  |  | ..     .| .. . ....|..  . |          ..|  ....   . . ..| . ...  .. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 19636.AA Pkinase_Tyr 1657-1696 27 0.002048 12.19 Pfam 190-232 (270) Show / Hide 
Range on Protein: 1657-1696
Range on HMM: 190-232/270
Sequence Identity: 27% (12 aa)

EYNHDVDVWAFGVMCYEFLQ-GIAP-FYEKSKDDTLDKI-QSG
....  |||.||| ..| .  |  | ... |  . ...| ..|
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
FA_hydroxylase 19636.AA FA_hydroxylase 1892-2008 22 7.1e-23 87.12 Pfam 1-129 (129) Show / Hide 
Range on Protein: 1892-2008
Range on HMM: 1-129/129
Sequence Identity: 22% (30 aa)

FFILLFFHDFCFYWSHR-FFH--QKF--IYPYI-HKIHH--QYYQNVCI---AGQY--FHP-LEFIITILLPT-FILVKYLG--SYLHFSTLCMWIFVMG
........||.||| || ..|   ..   . .. ||.||  .. .   .   .. .  ||| .|.|.  .... ...   .      | ...  |.|.|.
WVLCFLWWDFWFYWWHRYLMHWRWPWYFLWRRFYHKVHHQPSDEHPNWWPWRTAFRHWFHPVFEYILW-FFWIWLPC--WIFMAPGHHPWMFWIWFFFMY

VNAVEEHSGYDFPWSPFNISDFNVSAQFHDFHHS
..... |..|  .|.|   . . |....|. |||
FWYFWIHCNY--HWWPWWLRWWFVTPRHHRWHHS