Gene 5973 (Tetrahymena)

5973

Species: Tetrahymena
Alias: TTHERM_00334280, PreTt05973, 3689.m00008, 34.m00210, 1084, 5973
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Aur

Sequence

Name Sequence Type Origin Length Description Download
5973.AA Protein None 739 None Fasta, JSON
5973.kin_dom Protein Kinase Domain None 262 None Fasta, JSON
5973.NA RNA None 2220 None Fasta, JSON

Protein domain

Protein domains of 5973.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5973.AA Aur 33-294 45 2.3e-186 497.05 In-house 1-257 (257) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-257/257
Sequence Identity: 45% (122 aa)

FQVLDRLGKGAFGKVYKTKLQKTGQIFALKQMEKQQILKQGMVKQIQTEVKVMYSLDHPNIIKLYNHFEEDAYIYLMIEYASGGQLWQKLTKE--GRFDE
|..   ||||.||.||  .  ||..|||||.|.|.|| |..|..|.. |.|....|.||||.|.|..|..| .|||..|||.||.|...|.|.  .||||
FEIGKPLGKGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDE

NTVKRYMADIILAVEYLHSQNPPIIHRDIKPENLILD-ENGRVKLVDFGWSNFKNR--LRMTYCGTLDYLAPEMILELGHDEKLDIWSLGVLIFELITGK
..  .||..|..|..|.||.|  ||||||||||..|| .|| .|. |||||.....   |||.||||||..|||. . .||.| |||.||||..||..|.
QRAAKYMYQICNALDYCHSKN--IIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGC

APFAPKVENANIDQNQARQILEDNIL-KVKLDYPNDFPQLAKDLVNNLCKKEPNQRKTLPEIKKHPWF
.||...         . ..   |.|. ||....|. ... ||||........|.|| || .|..|||.
PPFESN---------ENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 5973.AA AGC 33-294 26 7.79999999999e-115 297.87 In-house 1-395 (395) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-395/395
Sequence Identity: 26% (110 aa)

FQVLDRLGKGAFGKVYKTKLQ------KTGQIFALKQMEKQQ---ILKQGMVKQIQTE------------VKVMYSLD----------HPNIIK-LYNHF
|..|  .|||.|||||  .         ||...|.| ..|.    |.|. ||....||             ...  ..          ||.|.| |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EEDAY--IYLMIEYAS---------GG-QLWQKLT---KEGRFDENTVKRYMAD-------IILAVEYLHS-QNPPIIHRD-IKPENLILDENGRVKLVD
. . .  .|.  ||..         ||  |.. |    |||||||.... |.|        |.||.||||| ..  ||||| .||||. |||.| .||.|
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMG--IIHRDYLKPENILLDEDGHIKLTD

FGWSNF-----------------------------------------------------KNRLRMTYCG--TLDYLAPEMILELGHDEKLDIWS--LGVL
|| .                                                       |. .  | ||  | .|.|||..    ..   |.||  ||.|
FGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCL

IFELITGKAPFAPKVENANIDQNQ-------ARQILEDNIL------KVKLDYP----------NDFPQLAKDLVNNLCKKEPNQRKT----------LP
..|..||. ||       . |..|        .  . ..|.      . |. .|            | . ||||.. |..|.|..| .            
MYEMLTGYPPF-------YGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAE

EIKKHPWF
|||.||||
EIKNHPWF
Kinase 5973.AA S_TKc 33-294 33 1.1e-94 321.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

FQVLDRLGKGAFGKVYKTKLQKTGQIFALKQMEKQQILKQGMVKQIQTEVKVMYSLDHPNIIKLYNHFEEDAYIYLMIEYASG--GQLWQKLTKEGR---
...|. .|||||||||| .  |||.|.|.|..           ..|. |.... . .||||.||| .|..  ..|.  ||..|  | | . . | ||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDENTVKRYMADIILAVEYLHSQNPPIIHRDIKPENLILDENGRVKLVDFGWSNFKNRLRMTYCGTLDYLAPEMILELGHDE-KLDIWSLGVLIFEL
   |.| ....||. |..|.||.||..  |||||.||||. |||  ..|. ||| . .     .|.|||..|.|||..   |..  | |.||.|....|.
RFPFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ITGKAPFAPKVENANIDQNQARQILEDNILKVKLDYPNDFPQLAKDLVNNLCKKEPNQRKTLPEIKK-------HPWF
..|. ||         ....  ...               .. |||.......|.|..| |  |. .       ||||
LCGYPPFP--------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5973.AA Pkinase 33-294 30 3e-90 310.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-293/293
Sequence Identity: 30% (92 aa)

FQVLDRLGKGAFGKVYKTKLQKTGQIFALKQMEKQQILKQGMVKQIQ-TEVKVMYSLDHPNIIKLYNHFEEDAYIYLMIEYASGG----QLWQKLT--KE
.... ..|.|.||.||| . ..||.|.|.|...|. . ..  .  .  .|...| .|.||||..||  ||.. .||.  ||. ||     |.  ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--DENTVKRYMADIILAVEYLHSQNPPIIHRDIKPENLILDENGRV----KLVDFGWS----NFKNRLRMTYCGTLDYLAPEMIL-ELGHDEKLDIW
|.|  .|...|.||  |. ..||.||.   |||||.||||. .|.|| .    |. ||| .    . .|.  .|.|||..|.||| |.   ... | |.|
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGVLIFELITGKAPFAPKVENANIDQNQARQILEDNILKVKLDYPNDFP-------------------QLAKDLVNNLCKKEPNQRKTLPEIKKHPWF
|.|....|...|. ||  .. .     .|   | ..   ... |.|.. .                   . .||.......| |..| | ..|..||||
SCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5973.AA CAMK 38-294 22 4.6e-89 287.07 In-house 1-425 (425) Show / Hide 
Range on Protein: 38-294
Range on HMM: 1-425/425
Sequence Identity: 22% (98 aa)

RLGKGAFGKVYKTKLQKTG------------QIFALKQMEKQQILK-------------------------QGMVKQIQTEVKVMYS-------LDHPNI
 ||.|.||||.. .  .|.            | .| | ..|... .                         . . |... |...| .       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYNHFEE-------------------DAYIYLMI---EYASGG----QLWQKLTKE---------------GRFDENTVKRYMADIILAVEYLHSQNP
|||| ..|                    | ..|.     ||.|||     | .....                |||.|  ..||.  |. ||.|.||.| 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

PIIHRDIKPENLILDEN-----------------GRVKLVDFGWSNFKNR--------------------------LRMTYCGTLDYLA-PEMIL-----
 |.|||.||||. ||.|                 . .|..||| .|....                          .  |.|||. | | ||...     
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------ELGHDEKLDIWSLGVLIFELITGKAPFAPKVENANIDQNQAR-----QILEDNILKVKLD-YPNDFP-----------------------Q
         . ....| |.||.||. . . .|. ||  . .|  .. .. .     . |  .|.| | | .|  |.                       |
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-DE-WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQ

LAKDLVNNLCKKEPNQRKTLPEIKKHPWF
 .|||.... ...|..| |. ....|||.
ECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5973.AA RSK 36-294 36 2.5e-84 286.44 In-house 1-278 (278) Show / Hide 
Range on Protein: 36-294
Range on HMM: 1-278/278
Sequence Identity: 36% (106 aa)

LDRLGKGAFGKVYKTKLQ---KTGQIFALKQMEKQQILKQGM-VKQIQTEVKVMYSLD-HPNIIKLYNHFEEDAYIYLMIEYASGGQLWQKLTKEGR---
|  ||.|..|||.  .     .||||.| |. .|  | .    ..   ||....     ||.|..|.  |... ..||  || .|| |  .| ||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDENTVKRYMADIILAVEYLHSQNPPIIHRDIKPENLILDE---NGRVKLVDFGWSNF-KNR---LRMTYCGTLDYLAPEMIL----ELGHDEKLDIWSL
|.|.... ||| |.||||.||.|   |||||.|||| ..|.   .|..||.||| .   ...   . ||.|.|..|.||||.     . |||.  |.|||
FSEDEACFYMAEIVLAVEHLHQQG--IIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLIFELITGKAPFAPKVENANIDQNQARQILEDNILKVK--LDYP--NDFPQLAKDLVNNLCKKEPNQRKT-----LPEIKKHPWF
|||..|. ||. ||.   .      |.. .|. ..|.| |  |. |  .   | ||||.. . ...|..| .     . |||.||||
GVLMYEMLTGCPPFQG-PND-----NNRKEIM-KRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 5973.AA CAMKL 33-294 32 6.7e-84 267.62 In-house 1-297 (297) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-297/297
Sequence Identity: 32% (97 aa)

FQVLDRLGKGAFGKVYKTKL-QKTGQIFALKQMEKQQILKQGMVKQ------------IQTEVKVMYSLD---HPNIIKLYNHFEEDAY------IYLMI
..... ||||.||||   .  . ||.  | | ..|. | .   .|.            |. |.. | .|.   |||||||| ..| . .      |||  
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYASGGQ--LWQKLTKE----GRFDENTVKRYMADIILAVEYLHSQNPPIIHRDIKPENLILDENG--RVKLVDFGWSNF---K----NRLRMTYCGTLD
||.|||   | ... |.    ||..|.  .||   |. ||.|.||..  |.||||||||. |||||   .|..||| ||.   .    ... .| ||.. 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YLAPEMILE--LGHD-EKLDIWSLGVLIFELITGKAPF-APKVENANIDQNQARQILEDNILKVKLDYPNDFPQLAKDLVNNLCKKEPNQRKTLPEIKKH
| |||...     .|  | ||||.||. . ...|. || .. ..  ... |. .  ......  . . ... .  ..||   . .. |..| |. .|..|
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-KQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWF
||.
PWM
Kinase 5973.AA Ciliate-E2 33-294 26 7.3e-82 278.28 In-house 1-365 (365) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-365/365
Sequence Identity: 26% (102 aa)

FQVLDRLGKGAFGKVYKTKL-----------------------QKTGQIFALKQMEKQQILKQGMVKQIQ----------TEVKVMYSLDHPNIIKLYNH
. ..  .|.|.||.||| |                        . ...|.|.|.|.|.||  . ....|            | ... .|.||||||.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--EDAYIYLMIEYASGGQLWQKLT------------KEGRFDENTVKRYMADIIL---------------AVEYLHSQNPPIIHRDIKPENLILDENG
|.   | .|||  ||..|| |.. .             . ..|.|. .|..|. |.                |.|||||.|. ||||||||||...    
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF----

RVKLVDFG-------------------WSNFKN----------------RLRMTYCGTLDYLAPEMILELG---------HDEKLDIWSLGVLIFELITG
 .|..|||                   |  | .                 .  |.|||. |.|||..   .         .|.| |||||||...|...|
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KAPFAPKVENANIDQNQARQILEDNILKVKLDYP------------------NDFPQLAKDLVNN----LCKKEPNQRKT-LPEIKKHPWF
| ||                  ...|.. |.|.|                  .. .| .||| ..    . .|.|..| |   .|..||||
KPPF------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 5973.AA Ciliate-E2-Unclassified 33-294 30 1.8e-81 276.94 In-house 1-352 (352) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-352/352
Sequence Identity: 30% (107 aa)

FQVLDRLGKGAFGKVYKTKLQKTGQIFALKQMEKQQILKQGMVKQ--------IQTEVK--------------VMYSLDHPNIIKLYNHFEEDAYIYLMI
. ..  .|.|.|||||| .  |..|..|.|.| |.|| ||  ...        .. . |               .....||.|.|.. .|. . .||.  
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYASGGQLWQKLTKE-----------------GRFDENTVK-----RYMADIILAVEYLHSQNPPIIHRDIKPENLILDENG---RVKLVDFGWS-----
||. || ||| ..|                   .|.|. .|     .|.| |... ||||..|  ||||||||||...|.||   ..|. ||| |     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-------------NFKNRLRMTYCGTLDYL----APEMILELGHD----EKLDIWSLGVLIFELITGKAPFAPKVENA-------NIDQNQARQILEDNI
             ..|. .  | |||. |.    |||.. . ..|    .| |||||||...|...|. ||  . ..        .| .|  |..|..||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNI

LKVKLDYPN--------DFPQLAKDLVN----NLCKKEPNQRKTLPEIKKHPWF
.. ....|.        . .. |||..|     . || ||.| |...|..||||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 5973.AA AktR 33-294 38 3.6e-76 259.38 In-house 1-268 (268) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-268/268
Sequence Identity: 38% (106 aa)

FQVLDRLGKGAFGKVYKTKLQ-KTGQIFALKQMEKQQILKQGMVKQIQTEVKVMY-SLDHPNIIKLYNHFEEDAYIYLMIEYASGGQLWQKLTKEGRFDE
|.|.  ||||||||||  .   ......|.|   |. | .. . ....|| ..|    .|| |.||.  |. . .... .||  || | | | |...|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

NTVKRYMADIILAVEYLHSQ-NPPIIHRDIKPENLILDENGRVKLVDFGWSN--FKN-RLRMTY--CGTLDYLAPEMILE-LGHDEKLDIWSLGVLIFEL
.... |.| |.||.||||.. |  || ||.||||. |||.| ||..||| |.  |.. .  ..|  |||  |.|||||..  ||.   |.|..|..|.|.
EQARFYFAQILLALEYLHQHMN--IIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

ITGKAPFAPKVENANIDQNQARQILEDNILK-VKLDYPNDFPQLAKDLVN-NLCKKEPN-----QRKTLPEIKKHPWF
.||  ||         ..|| . ..  .|   .| .|| .| . .|||..  | .| ||     ....  |||.||||
VTGCPPFY--------HKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 5973.AA MARK 33-294 38 4.6e-75 244.82 In-house 1-262 (262) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-262/262
Sequence Identity: 38% (104 aa)

FQVLDRLGKGAFGKVYKTKLQKTGQIFALKQMEKQQILK-QGMVKQIQTEVKVMYSLDHPNIIKLYNHFE--EDAY-IYLMIEYASGGQLWQKLTKE--G
. .|  .|.|...||..   ..||. .|.| .||... . | | | .. |...| .|||||||||.  .|  .    |||  |||||| | . . .   |
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWM-KNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

RFDENTVKRYMADIILAVEYLHSQNPPIIHRDIKPENLILDENG--RVKLVDFGWSNFK--NRLRMTYCGTLDYLAPEMILELGHD-EKLDIWSLGVLIF
|  |.  .|.   |. ||.|.||.|  |.||||||||. .||||   .|. |||.|.    ...  | |||. | |||..|    |  | |||||||. .
RLHEEEARRIFRQIVSAVNYCHSKN--IVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLY

ELITGKAPFAPKVENANIDQNQARQILEDNILKVKLDYPNDFPQLAKDLVNNLCKKEPNQRKTLPEIKKHPWF
 ...|. ||         ...|    |. .||. | |.|   .  ...|.. | .  |..| |. || ||||.
FMVCGYFPFD--------GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 5973.AA STE 33-294 26 2.6e-71 243.2 In-house 1-359 (359) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-359/359
Sequence Identity: 26% (99 aa)

FQVLDRLGKGAFGKVYKTKLQK---------------TGQIFALKQMEKQQILK--------------QGMVKQIQTEVKVMYSLD--HPNIIKLYNHFE
.. ....||||||.||| .  |               ||.|.| |||....  .              .  ..||. |.|.|  ..  ||||.| | ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EDA-------YIYLMIEYASGGQLWQKLT------KE--------GRFDENTVKRYMADIILA-VEYLHSQNPPIIHRDIKPENLILDENGRVKLVDFGW
 .        ....  || .|| | . .       |.        .||.|. ....  .|. .  .||||..  |||||||| |  |     |||.||| 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

SNFKNR-------------------LRMTYCGTLDYLAPEMILE------LGHDEKLDIWSLGVLIFELITGKAPF---APKVENANIDQN--------Q
.   .                     | | .||  . |||.|.        |.|.| |||||| .| |..||| |.    |     .| .|        |
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

ARQILEDNILKVKLD---------------YPNDFPQLAKDLVNNLCKKEPNQRKTLPEIKK--HPWF
  .|..... . . .               ||  . .  || .|. ..|.||.| |  .  |  ||..
L-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 5973.AA TyrKc 33-294 22 3.7e-15 22.46 SMART 1-280 (280) Show / Hide 
Range on Protein: 33-294
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FQVLDRLGKGAFGKVYKTKLQKTGQIFALKQMEKQQILKQGMVKQIQTEVKVMYSL--DHPNIIKLYNHFEED-------AYIYLMIEYASGGQLWQKLT
 . .. || ||||.||| ..    .  | | . .        .. .  | ..| .|  .||||..||    ..         ...  ||...| | . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KEGR-FDENTVKRYMADIILAVEYLHSQNPPIIHRDIKPENLILDENGRVKLVDFGWSNFKNRL-------RMTYCGT---LD------YLAPEMILELG
| .. .   .   .. .|    |||||.  ..||||.   |  ..||..||  ||| | .            .    .    .       .||| | .  
KHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HDEKLDIWSLGVLIFELIT-GKAPFAPKVENANIDQNQARQILEDNILKVKLDY------PNDFPQLAKDLVNNLCKKEPNQRKTLPEIKKHPWF
  .| |.|| ||...|. | |. |    ...  ..  .... ...     . ..      .   . . . .    .. .|..| |  ||  |  |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 5973.AA Pkinase_Tyr 33-178 30 1.1e-13 46.92 Pfam 1-156 (270) Show / Hide 
Range on Protein: 33-178
Range on HMM: 1-156/270
Sequence Identity: 30% (49 aa)

FQVLDRLGKGAFGKVYKTKLQ----KTGQIFALKQMEKQQILKQGM--VKQIQTEVKVMYSL-DHPNIIKLYNHFE-EDAY--IYLMIEYASGGQLWQKL
 . .  ||.||||.||| ..     .|..  | | . |.    .     .    |.|.| .| .||||..||     ..    ||.  ||. .| |   |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

TK----EGRFDENTVKRYMADIILAVEYLHSQNPPIIHRDIKPENLILDENGRVKLVDFG
 |    .....  .   . ..|  . |||.|.|  .||||.   |  ..||. ||  |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFG
Kinase 5973.AA Pkinase_Tyr 212-231 45 0.051733 7.44 Pfam 196-217 (270) Show / Hide 
Range on Protein: 212-231
Range on HMM: 196-217/270
Sequence Identity: 45% (10 aa)

DIWSLGVLIFELIT-GKAP-FA
|.|| |||..|..| |. | ..
DVWSFGVLMWEIFTYGEQPTYP