Gene 13032 (Tetrahymena)

13032

Species: Tetrahymena
Alias: TTHERM_00058470, 4.m00431, PreTt13032, 456, 3707.m00076, 13032
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E5

Sequence

Name Sequence Type Origin Length Description Download
13032.AA Protein None 524 None Fasta, JSON
13032.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
13032.NA RNA None 1575 None Fasta, JSON

Protein domain

Protein domains of 13032.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13032.AA Ciliate-A1 60-316 42 8.20000000001e-159 533.89 In-house 1-301 (301) Show / Hide 
Range on Protein: 60-316
Range on HMM: 1-301/301
Sequence Identity: 42% (127 aa)

KFSERLLGKGGTSVVLRAENIQGQK--LALKILKCSTKEQYLNNLQEYRLMKQTNSNYVIKVNELLEYRTNNKLIQFLAMEKCLYNLQSQLCGGKK-MKK
   . |..||...||.||..||.||  |..||..|...|||.||.||||..||.|.|.|||....|.|.||||...|..||.|.|......|.... |||
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQNDYMKK

DQIYEICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDNKWKFIDLGLSQVLPQNQDCCDDV-----------------QGLTRYYCSPEQYQLFY---KL
..|||||.....|....|..||||.|.||.||...||.|||..|||.|..|.|||||||||                 .|...||.||||||..|   ..
EEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMF

SKAKIGKQSDIYSLGLVFLELTG-----------VKIPEAQIQETK----------LKKINFEQMFNPEFEEINILLNKMLQYNPENRCSLSQIKSYLDQ
...||.||||.||||.....|..           |.|.....|...          .|||.|..|..|.|||...|..||.||.|.|||||.|....| .
IENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKKIIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCIDCLYI

L
.
F
Kinase 13032.AA Ciliate-E5 62-258 32 4.8e-85 276.73 In-house 3-271 (271) Show / Hide 
Range on Protein: 62-258
Range on HMM: 3-271/271
Sequence Identity: 32% (88 aa)

SERLLGKGGTSVVLRAENIQGQKLALKIL-KCSTKEQYLNNLQEYRLMKQTNSNYVIKVNELLEYRTNNKLIQFLAMEKCLYNLQSQL----CGGKKMKK
. ..|||||  .|....  . .|.. .   ||.. .|.  |..|. ..|| ||...||| ....|.. |. .||. ||.|...| ..|       |  | 
ENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMKWQKH

DQIYEICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDNKWKFIDLGLS---------QVLPQNQD-----------------------------------
 .||.||| | |||  .| .||.||||||.||.|| |||||.||.|.|          ..  . .                                   
QDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKNRKK

------CCDDVQGLTRYYCSPEQYQLFYKLS-----------------KAKIGKQSDIYSLGLVFLELT
         .  |.|. |.||||||...  .                 | || |||||||||.||||||
LRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT
Kinase 13032.AA Ciliate-B2 59-251 29 2.8e-37 85.18 In-house 1-197 (197) Show / Hide 
Range on Protein: 59-251
Range on HMM: 1-197/197
Sequence Identity: 29% (60 aa)

YKFSERLLGKGGTSVVLRAE----NIQGQKLALKILKC--STKEQYLNNLQEYRLMKQTNSNYVIKVNELLEYRTNNKLIQFLAMEKCLYNLQSQLC---
|   .  ..|||  ..        . . | ||.||.     . .. ..  .|.  ||  . |  |.| .....   |. |. | |||| . |.. |    
YYLCK-YINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQ--HEIKIMKMFEYN--INVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQ

-GGKKMKKDQIYEICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDNKWKFIDLGLSQVLPQNQDCCDDVQGLTRYYCSPEQYQLF-YKLSKAKIGKQSDI
   |. ..  .| .   |  ||  ..  ||||||||| || .   .. .. | | | .  .||     . |.| .| |||| . .  . .  .|  ||||
KQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGISSIKKDNQQI--KIKGFTKKYASPEQMECDHNQTFVTNIDFQSDI

YSLG
||.|
YSMG
Kinase 13032.AA S_TKc 60-313 19 1e-30 109.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 60-313
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)

KFSERLLGKGGTSVVLRAENIQ-GQKLALKILKCSTKEQYLNNLQEYRLMKQTNSNYVIKVNELLEYRTNNKLIQFLAMEKCLY---NLQSQLCGGKK--
    |..|||. ..| .. ..  |.. |.||.|        . ..| ...|. .  ...|  .  .         .. || |     .| . ..  ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----MKKDQIYEICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDNKWKFIDLGLSQVLPQNQDCCDDVQGLTRYYCSPEQYQLFYKLSKAKIGK-QSDIY
    .   ..  ..  . ..|  .|...|.| |.|| || |      | .| ||. .|        . .  |..|..||           . ||  .|..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---------GYGKCKCDWW

SLGLVFLELTGVKIPEAQIQETKLKKINFEQMFNPEFEEINILLNKMLQYNPENRCSLSQIKS---------YL
|.| .. |.   . |    ... .|||          .|   ...|.||..||.| .  ..           ..
SCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 13032.AA Ciliate-E1 66-248 27 4.4e-29 91.96 In-house 1-202 (202) Show / Hide 
Range on Protein: 66-248
Range on HMM: 1-202/202
Sequence Identity: 27% (57 aa)

LGKGGTSVVLRA--ENIQGQKLALKILKCS---TKEQYLNNLQEYR-LMKQTN-SNYVIKVNELLEYRTNNKLIQFLAMEKCLYNLQSQLC---------
.|.|. |.|..|  .| . .. |.|| .|    ..........||  .||  .   |.|.. . ..    . .|. . .|.| ..|. .|          
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI--DQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

----GGKKMKKDQIYEICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDNKWKFIDLGLSQVLPQNQDCCDDVQGLTRYYCSPEQYQ---LFYKLSKAKIG
      .... .|. .|  .| .||. || .||.|.|||| ||.   ... .. |.|.|..|  ||.   .. | | ||..||||.   . .   . ||.
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKIN

KQSDIY
..||||
YKSDIY
Kinase 13032.AA Ciliate-E3 61-258 31 9.3e-24 71.19 In-house 2-202 (202) Show / Hide 
Range on Protein: 61-258
Range on HMM: 2-202/202
Sequence Identity: 31% (67 aa)

FSERLLGKGGTSVVLRAENIQG-QKLALKILKCSTKEQ------YLNNLQEYRLMKQTNSNYVIKVNELLEYRTNNKLIQFLAMEKCLY-NLQSQLCGGK
.  ..||.|. ..| .| . |  |. | | . |. .             ||  . .| || .| |. . . |  .||.| |. .| |   .|.  .   |
TVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQY-YDQQNKMI-FIVQEYCSNGDLYHYI---K

KMKKDQ--IYEICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDN---KWKFIDLGLSQVLPQNQDCCDDV-QGLTRYYCSPEQYQLFYKLSKAKIGKQSD
.  | |  ||.||  ...|.  .| .|| | |||| || ..  |     |. |.|.|  | .|        ||.| .| .|||      . ...| | ||
QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ------NDQQQISKESD

IYSLGLVFLELT
.||.| ||..| 
YYSVGAVFCQLC
Kinase 13032.AA Pkinase 59-313 17 2.4e-21 76.56 Pfam 1-293 (293) Show / Hide 
Range on Protein: 59-313
Range on HMM: 1-293/293
Sequence Identity: 17% (55 aa)

YKFSERLLGKGGTSVVLRAENIQGQK-LALKIL-KCSTKEQYLNNLQ---EYRLMKQTNSNYVIKVNELLEYRTNNKLIQFLAMEKCLY-----NLQSQL
|.. .| .|.|. ..| .. ..  .|  |.||. |...|.. . ..    | ..||  |. ....  .  |.  ....   . || |        | . .
YHI-GRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIY--MVMEYCEGGLYVMDLFDYI

C--GGKKM--KKDQIYEICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDNKW----KFIDLGLSQVL-PQNQDCCDDVQGLTRYYCSPEQYQLFYKLSKA
    ....    ...  ... . .||  .|...|.| |.|| || .  ..      | .| ||. ..   |.  .... | |..|..||  .     .  
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEVIR-----GGQ

KIGKQSDIYSLGLVFLELTGVKIPEAQI-------QETKLKKINFEQMFNPEF-----------------------EEINILLNKMLQYNPENRCSLSQI
..|. .|..|.|... |.   . |  .        |  ....|   .   ...                       ||   .....|...|. |..  ||
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

KSY--L
.    .
LQHPWF
Kinase 13032.AA Ciliate-E2 59-310 20 2.6e-20 66.41 In-house 1-360 (365) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-360/365
Sequence Identity: 20% (76 aa)

YKFSERLLGKGGTSVVLRAEN------------------------IQGQKLALKILKCSTKEQYLNNLQEYR-------------LMKQTNSNYVIKVNE
|||  ...|.|. ..| ....                         .... |.||.| . .|| .. ....|             ...| |....||  |
YKF-IKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

LLEYRTNNKLIQFLAMEKCLY-NLQS-----QLCGGKK------MKKDQIYEICLHLTK---------------GLSSLHKQN-ILHLDIKPGNIVLGFD
  .  ..|..  .| || | . .|..     ... ...      ..  .| .|  ....               .| .||..| |.| |||| ||..   
CFQEKDDNNI--YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---

NKWKFIDLGLS-QVLPQNQDCCDDVQGL------------------------------TRYYCSPEQYQ-LFYK--LSKAKIGKQSDIYSLGLVFLELTG
   | ||.||| .. ..||.. .  |.                               | .| .|| ..   |     .   ....||.||| .. |.  
--IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

VKIPEAQIQETKLKKINFEQM---------------FNPEFEEINILLNK----MLQYNPENRCS-LSQIK
 | |   .|. | .||.| .                ..   .|   |..|    |||..||.| .  .||.
GKPPF--QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase 13032.AA Ciliate-C8 69-254 23 2.8e-17 58.7 In-house 1-238 (238) Show / Hide 
Range on Protein: 69-254
Range on HMM: 1-238/238
Sequence Identity: 23% (57 aa)

GGTSVVLRAENIQG-QKLALKILKCSTKEQYLN----NLQEYRLMKQTNSNYVIKVNE--LLEYRTNNKL-----------------IQFLAMEKCLYN-
|....||.|.|..  .| |||...|. |.|         .. ..|.. .. .|..|     |.  .. .                     . ||||  | 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LQSQLCGGKKMKKDQIY-------EICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDNKW----KFID------LGLSQVLPQNQDCCDDVQ--GLTRY
 |.. .   ....|.|.|       .|      ... ||  ||.| |||| |. . ||..     |  |      .|..  ||.|..   . .  |   |
NLKQYF---DRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQY

----------YCSPEQYQLFYKLSKAKIGKQSDIYSLGLVF
          |. ||...  ..       |.||.||.|||.
IEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 13032.AA TKL 157-313 16 1.6e-16 56.0 In-house 132-364 (364) Show / Hide 
Range on Protein: 157-313
Range on HMM: 132-364/364
Sequence Identity: 16% (38 aa)

DQIYEICLHLTKGLSSLHKQN--------ILHLDIKPGNIVLGFDNK--------------WKFIDLGLSQVLPQNQDCCDD------------------
.|.  ..|   .|.. || .|        |.| |.|. || .  ...               |  |.|||... |...  |                   
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

VQGLTRYYCSPEQYQLFYKLSKA----------KIGKQSDIYSLGLVFLELTGVKIPEAQIQET------------KLKKINFEQMFNP-----------
 |. | ....||  .   .....          .  ...|.|| |.|. |.   ..|.... .             ..   ....   |           
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCP

---EFEEINILLNKMLQYNPENRCSLSQIKSYL
     ...  |. .  ...||.| | ..|...|
CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 13032.AA Ciliate-E2-Unclassified 59-310 19 1.7e-16 53.71 In-house 1-347 (352) Show / Hide 
Range on Protein: 59-310
Range on HMM: 1-347/352
Sequence Identity: 19% (70 aa)

YKFSERLLGKGGTSVVLRAENIQGQKLA-----LKILKCSTKEQYLN-NLQEYRLMKQTNSNY--------------------VIKVNELLEYRTNNKLI
||. .  .|.|| ..| ...... . ..     .|  .   . |..| . .. . ||. |..                      ..|... . .. ... 
YKIIK-QIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNI-

QFLAMEKCLYNLQSQLCG------------GKKMKKDQIY-----------EICLHLTKGLSSLHKQN-ILHLDIKPGNIVLGFDN---KWKFIDLGLSQ
 .. ||.| ..  .| .             ...||...|             .. .. .||..||..| |.| |||| ||..  ..   . | ||.|.| 
-YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISK

VLPQNQDCCDDVQ---------------GLTRYYC----SPEQYQL-FYKLSKAKIGKQSDIYSLGLVFLELTGVKIPEAQIQETK--------------
 . ||..|  . |                 | .|     .|| .|   |  |||   ...||.||| .. |.   . |  . ....              
KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYR

--LKKINFEQMFN-PEFEE------IN----ILLN----KMLQYNPENRCSLSQIK
  |... ... .. |.|..      ..     ..|    |||..||..| ...||.
KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase 13032.AA STE 149-303 20 1.1e-14 48.36 In-house 144-345 (359) Show / Hide 
Range on Protein: 149-303
Range on HMM: 144-345/359
Sequence Identity: 20% (44 aa)

CGGKKMKKDQIYEICLHLTKG-LSSLHKQNILHLDIKPGNIVLGFDNKWKFIDLGLSQVLPQNQD----------------CCDDVQGLTRYYCSPEQYQ
. ..... .||  ||  . || |. ||...| | ||||.|| |      | .| |..  | .. .                 .. . |    . .||  |
H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQ

LFYKLSK-AKIGKQSDIYSLGLVFLELTGVKIPEAQIQETK-LKKINFEQ-------------MFNPEF------------------------EEINILL
   .  .  . . ..||.|||.. .|.   | | .  . .. .  |.|..                | .                        .| .  .
QNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFI

NKMLQYNPENR
|| ||..|..|
NKCLQKDPNKR
Kinase 13032.AA TyrKc 60-313 15 1.3e-07 -99.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 60-313
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

KFSERLLGKGGTSVVLRAENIQGQKLALKILKCSTKEQYLNNLQEYRLMKQT--NSNYVIK-----VNE------------LLEYRTNNKLIQFLAMEKC
   .. || |   .| ... .  .. | | || ..       ..| |.|..   .   ...     . .            ..||  .  | ..|   . 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

LYNLQSQLCGGKKMKKDQIYEICLHLTKGLSSLHKQNILHLDIKPGNIVLGFDNKWKFIDLGLSQVLPQN--------QDCCD---DVQG-LTRYYCSPE
              . ..  ..|.   .| . ||..|. | |.   |. .| ..  |  | |||  .                   .  . |    ..||
K------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

QYQLFYKLSKAKIGKQSDIYSLGLV---FLELTGVKIPE-----AQIQETKLKKINFEQMFNPEF----------EEINILLNKMLQYNPENRCSLSQIK
         . |   .||..| | .    . . .   |.        ||   .  . . |  |.           .|.  .  .  ...||.|.. |.|.
CI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

SYL
...
ECF
Kinase 13032.AA STE 61-118 17 8.9e-07 20.1 In-house 1-94 (359) Show / Hide 
Range on Protein: 61-118
Range on HMM: 1-94/359
Sequence Identity: 17% (16 aa)

FSE-RLLGKGGTSVVLRAENI----------------QGQKLALKILKCSTK-----------------EQYLNNLQEYRLMKQTN--SNYVIK
.   . .|||.. .| .| |.                .|.  | |... ...                 |.  . |.| ..||. |  . ...|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK
Kinase 13032.AA TKL 66-91 22 0.339468 0.07 In-house 1-35 (364) Show / Hide 
Range on Protein: 66-91
Range on HMM: 1-35/364
Sequence Identity: 22% (8 aa)

LGKGGTSVVLRAENIQ---------GQKLALKILK
.|.|| ..| ...  .         |.  | |..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFK