Gene 22526 (Tetrahymena)

22526

Species: Tetrahymena
Alias: 627, 3686.m00073, PreTt22526, 56.m00230, 22526, TTHERM_00471120
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: CAMKK
Subfamily: CAMKK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
22526.AA Protein None 276 None Fasta, JSON
22526.kin_dom Protein Kinase Domain None 270 None Fasta, JSON
22526.NA RNA None 828 None Fasta, JSON

Protein domain

Protein domains of 22526.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22526.AA CAMKK-Unclassified 1-270 31 4.8e-115 376.34 In-house 15-392 (392) Show / Hide 
Range on Protein: 1-270
Range on HMM: 15-392/392
Sequence Identity: 31% (119 aa)

VKLCIEKST-----GKKLALKKFHKNILKKKTKMTKDELGNVYYKSQWENVETEIELMKKFNHPNVTMIDSIIYHDSQSKLYL--IIDYCEYGDVLKWD-
||| . . |      |..| | | |. ||||    .|. .   .| .  .|  ||. ||| .|||.     .|    ..|.|.  ...||..|....|| 
VKLATRRYTTDDGVQKQFAIKVFKKQKLKKKKFIYNDNAFTMKMKNRLHLVQQEIAIMKKLWHPNICKLYEVIDDPDNDKIYMGQVMEYCQMGQIMSWDY

-EKTLK--------------------FSHLQIPQAG-------------------------SIDYLQKIMLESCLALQYLHQQN----------------
 .....                    |......|.|                         ...||.|.....|..|||.|..|                
WKQDYQPNDGEIEYFFQTQTEYKPDQFCCQYYNQNGKLHNRQNQKICLFSNQILEMKPYKMHEQYLKKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKI

-----IIHRDIKPQNILLTHELK-----IKLCDFGLAVKLSSDNHR-IKGTEGTYHFMAPESLSDSNQKNGYDG-----------------------KKA
     ||||||||||||..|| .     .|..|||..|........ .|...|||.|||||..|..|.|..|..                       |||
DHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKA

DIWSLGVTFYCMVYLKLPFYHDNLMELFE-MIQNKE----PKYDKKMQTHDLLDLLQKILVKDPSKRLGLNEIINHSFF
||||||||||||||..|||.|.||.|||. ||..||    | | ...  | ..||.|| . |.| ||. .  ...| .|
DIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHC-SHEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase 22526.AA CAMKK 1-270 28 7.6e-110 349.91 In-house 15-396 (396) Show / Hide 
Range on Protein: 1-270
Range on HMM: 15-396/396
Sequence Identity: 28% (107 aa)

VKLCIEKST-GKKLALKKFHK----NILKKKTKMTKDELGNVYY---------KSQWENVETEIELMKKFNHPNVTMIDSIIYHDSQSKLYLI-IDYCEY
||| . . . .|. | | | |    . ||||..  .|. ..  .         ..  ..|. ||. ||| ||||.     .|    . |.|.. ..|||.
VKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQNDKIYMVQMEYCER

GDVLKWD--EKTLK--------------------FSHLQIPQAG---------------SIDYLQKIMLESCLALQYLH-QQN-----------------
|....|.  .....                    ||... .|..               ..||..|........|.||| .|.                 
GQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHF

--IIHRDIKPQNILLTHEL---KIKLCDFGLAVKLSSDNHRIKG-----------TEGTYHFMAPESLSDSNQKNG-----------YDGKKADIWSLGV
  ||||||||||||...|    ..|..||| .............           |.||..|||||..|..|||..           |.||.||||.|||
QDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGKAADIWALGV

TFYCMVYLKLPFYHDNLMELFE---MIQNKEPKYDK------------KMQTHDLLDLLQKILVKDPSKRLGLNEIINHSFF
|.||.|..|.||.|.|||.|..   .|.|...|. .               ..|| ||... | |.| ||. . .|..| ..
TLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase 22526.AA S_TKc 1-270 28 7.3e-67 229.37 SMART 15-231 (231) Show / Hide 
Range on Protein: 1-270
Range on HMM: 15-231/231
Sequence Identity: 28% (80 aa)

VKLCIEKSTGKKLALKKFHKNILKKKTKMTKDELGNVYYKSQWENVETEIELMKKFNHPNVTMIDSIIYHDSQSKLYLIIDYCEY--GDVLKWDEKTLK-
|..|..|.||.. |.|. .                        |... ||...|| .|||.  .  ....   ..||.. .||.   ||...  .|  . 
VYKCRHKKTGRIVAIKIIK------------------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FSHLQIPQAGSIDYLQKIMLESCLALQYLHQQNIIHRDIKPQNILLTHELKIKLCDFGLAVKLSSDNHRIKGTEGTYHFMAPESLSDSNQKNGYD
     |.  ..         ...| . |.||.|.|...|||||.||.||||..   ||.|||||| .|       .   || ..|||| |       ||.
GLRFPFPE-HA---------RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-------GYG

GKKADIWSLGVTFYCMVYLKLPFYHDNLMELFEMIQNKEPKYDKKMQTHDLLDLLQKILVKDPSKRLGLNEIIN-------HSFF
..|.|.||.|...| |.. . ||.  .....|..|            .....|...|.|.|||.||..  |. .       | .|
KCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22526.AA CAMK 1-270 21 1.4e-61 196.94 In-house 10-425 (425) Show / Hide 
Range on Protein: 1-270
Range on HMM: 10-425/425
Sequence Identity: 21% (92 aa)

VKLCIEKSTG------------KKLALKKFHKNILKKKTK--------MTKDELGNVYYK---SQWENVETEIELMKK-------FNHPNVTMIDSIIYH
|||||.|.|.            .| | |   |. ||.|..        . | . .. | .   .  .||. |||.|||        .|||.  .  ..  
VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYED

DS-----------------QSKLYLII---DYCEYG----DVLKWDEKTLKFSHLQIPQAGSI-------DYL-----QKIMLESCLALQYLHQQNIIHR
..                 ....|..    .||. |    |.. .  .  ...         .        ..     ....   | |..|.|..||.||
PHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF------DQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHR

DIKPQNILLTHE-----------------LKIKLCDFGLAVKLSS-----------------------DNHRIKGTEGTYHFMA-PESLSDSNQK-----
|.|| ||||..                   .||..|||.| |. .                       ...  |   || ..|| || |. . ..     
DLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNA

----NGYDGKKADIWSLGVTFYCMVYLKLPFYHD-------------NLMELFEMIQNKEPKYDKKMQTH-----------------------DLLDLLQ
    . |.|.|.|.||.||  | |.  ..|||.|             |. ||||.|.. .  .. .. ..                       .  ||..
TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIR

KILVKDPSKRLGLNEIINHSFF
|.|..||.||. . .. || ..
KMLQVDPEKRMTIEQCLNHPWM
Kinase 22526.AA Pkinase 1-270 26 3.1e-61 214.55 Pfam 15-293 (293) Show / Hide 
Range on Protein: 1-270
Range on HMM: 15-293/293
Sequence Identity: 26% (83 aa)

VKLCIEKSTGKKLALKKFHKNILKKKTKMTKDELGNVYYKSQWENVETEIELMKKFNHPN-VTMIDSIIYHDSQSKLYLIIDYCEYG----DVLKWDE--
|..|..|.|||. |.|.. |   |.. ..|.  |             .||..||..|||| |...|.  .    ...|.. .||| |    |   . .  
VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-------------SEIQIMKRLNHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFDYISTW

KTLKFSHLQIPQAGSIDYLQKIMLESCLALQYLHQQNIIHRDIKPQNILLTHELKI----KLCDFGLAVKL-SSDNHRIKGTEGTYHFMAPESLSDSNQK
.  .|. .      | . ....|.. . .|.|.|...|||||.||.|||. ..  |    |.|||||| ..    |.  ..  ||...|||| .     .
RHGCFY-F------SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----G

NGYDGKKADIWSLGVTFYCMVYLKLPFYHD------NLMELFEMIQNKEPKYDKK--------------------MQTHDLLDLLQKILVKDPSKRLGLN
. |.|.|.|.||.|...|.|.  ..||...      . |.....|  .....|                       .. ...|.. ..| |||.||..  
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

EIINHSFF
.| .| .|
QILQHPWF
Kinase 22526.AA AGC 1-270 23 1.2e-60 154.49 In-house 15-395 (395) Show / Hide 
Range on Protein: 1-270
Range on HMM: 15-395/395
Sequence Identity: 23% (99 aa)

VKLCIEK------STGKKLALKKFH---KNILKK--KTKMTKDELGNVYYKSQWEN---VETEIELMKKFN----------HPNVTMIDSIIYHDSQS--
| |. .|      .|||  |.|.     | ..||  . ..|. | . .       .   |  | . ..| |          ||...    | ..  |.  
VYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQ------DQGYVWEERNILEKCNHTHNHPIKSHHPFIVK---ILHYSFQDKD

K--LYLIIDYCE--------YGD-VL-----------KWDEKTLKFSHLQ---IPQAGSIDYLQKIMLESCLALQYLHQ-QNIIHRD-IKPQNILLTHEL
.  ||.. .|..         |.  |           . ||.. .|   .   |  .           . .|||.|||. ..||||| .|| ||||... 
HTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKI-CG-----------CIVLALEYLHSHMGIIHRDYLKPENILLDEDG

KIKLCDFGLAVKLSSDN--------------------------------------------------HRIKGTEG--TYHFMAPESLSDSNQKNGYDGKK
 |||.||||. .. .|.                                                  .| .   |  | ..|||| |          || 
HIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKA

ADIWS--LGVTFYCMVYLKLPFYHDN----------LMELFEMIQ------NKEPKYD----------KKMQTHDLLDLLQKILVKDPSKRLG-------
.|.||  ||. .| |.. . |||.||           ||.|. |.      |...|..          ... . .. ||..| |.|||.||||       
CDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWF-SPEAKDLIKKLLCKDPEKRLGCGGNDFG

---LNEIINHSFF
    .|| || .|
DKGAEEIKNHPWF
Kinase 22526.AA Ciliate-E2 1-270 24 2e-55 188.71 In-house 15-365 (365) Show / Hide 
Range on Protein: 1-270
Range on HMM: 15-365/365
Sequence Identity: 24% (89 aa)

VKLCIEKSTGKKLALKKFHKNILKKKT----KMTKDELGNVYY-KSQWENVETEIELMKKFN----------------HPNVTMIDSIIYHDSQSKLYLI
|..|  ....|. |.|..  ... . .    | .. .    .. |.| |... || .|.. |                |||.  .    .  .....||.
VYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLV

IDYCEYGDVLKWDE--KTLKFSHLQIPQAGSIDYLQK--IMLESCL---------------ALQYLHQQN-IIHRDIKPQNILLTHELKIKLCDFGLAVK
 .||..|| ... .  |. ....... . ....  .   || . .                ||.|||..| ||||||||.|||.     ||..||||. |
MEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKK

LSSDN-------------------------------HRIKGTEGTYHFMAPESLSDSN-----QKNGYDGKKADIWSLGVTFYCMVYLKLPFYHDNLMEL
.. ||                               . .. . ||...|||| |.  .     ...||| .|.|||||||..|.|.. |.||        
YDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD-YKCDIWSLGVILYEMLFGKPPF--------

FEMIQNKEPKYD-----------------KKMQTHDLLDLLQK----ILVKDPSKRLG-LNEIINHSFF
.. |.... ...                 .|  . .  ||..|    .|.|||.||..  ..|.|| .|
QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22526.AA Ciliate-E2-Unclassified 1-270 26 1.2e-48 166.85 In-house 15-352 (352) Show / Hide 
Range on Protein: 1-270
Range on HMM: 15-352/352
Sequence Identity: 26% (92 aa)

VKLCIEKSTGKKLALKKFHKNILKK-KTKMTKDELGNV----YYKSQWENVETEIE-LMKK--FNHPNVTMIDSIIYHDSQSKLYLIIDYCEYGDVLKWD
|..|..|..... |.|  .|.. .| | .|.|||. |       |.   ...  .. .|.    |||.   .  . .  .. ..|.. .|||.|| ... 
VYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-KYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYI

EKTLK-----------------FSHLQIP---QAGSIDYLQKIMLESCLALQYLHQQN-IIHRDIKPQNILLTHEL---KIKLCDFGLAVKLSSD-----
.|  |                 |.  |.    .       .... . ...|.|||..| ||||||||.|||.. .    .||..|||.. |. ..     
KKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA-------KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDT

----------NHRIKGTEGTYHFM----APESLSDSNQKNGYDG---KKADIWSLGVTFYCMVYLKLPFYHDNLME----------------LFEMIQNK
          ..... . ||. .|    ||| |    |...||.   .|.||||||| .|.|.. ..|||  |  .                |.. |..|
NQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL----QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

EPKYDK--K----MQTHDLL-----DLLQKILVKDPSKRLGLNEIINHSFF
.....|  .    .. ..       |||||.|.|.|.||.....|.|| .|
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 22526.AA CAMKL 122-270 32 4.9e-48 151.3 In-house 139-297 (297) Show / Hide 
Range on Protein: 122-270
Range on HMM: 139-297/297
Sequence Identity: 32% (54 aa)

ALQYLHQQNIIHRDIKPQNILLTHEL--KIKLCDFGLAVKLSS----DNHRIKGTEGTYHFMAPESLSDSNQKNGYDGKKADIWSLGVTFYCMVYLKLPF
|..|.|...|.|||||| ||||..    .||..|||.. .       ...  |   |....|||| ...   .  |||.|.||||.||. | ||. .|||
AVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGN--NKPYDGPKVDIWSCGVILYAMVCGYLPF

YHDNL-------MELFEMIQNKEPKYDK--KMQTHDLLDLLQKILVKDPSKRLGLNEIINHSFF
  |..         ... ....  .|.   .    |. ||..|.|...|.||  . .| || ..
DDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 22526.AA ULK 120-270 28 1.5e-43 149.92 In-house 140-329 (329) Show / Hide 
Range on Protein: 120-270
Range on HMM: 140-329/329
Sequence Identity: 28% (54 aa)

CLALQYLHQQNIIHRDIKPQNILLTHELK------------IKLCDFGLAVKLSSD---NHRIKGTE------GTYHFMAPESLSDSNQKNGYDGKKADI
. ....||..|||||||||||||..                .|..|||.| ....|   .  .. .       ||  .|||. |..   .  |. .|.||
LNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDI

WSLGVTFYCMVYLKLPFYHDNLMELF-----EM----------IQNKEPKYDK----KMQTHDLLDLLQKILVKDPSKRLGLNEIINHSFF
||||. || |.| | |||    ....     .           |... ....|    .    .. ||... |..|...|    |..|| .|
WSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 22526.AA MARK 122-270 35 4.9e-43 138.61 In-house 116-262 (262) Show / Hide 
Range on Protein: 122-270
Range on HMM: 116-262/262
Sequence Identity: 35% (54 aa)

ALQYLHQQNIIHRDIKPQNILLTHEL--KIKLCDFGLAVKLSSDNHRIKGTEGTYHFMAPESLSDSNQKNGYDGKKADIWSLGVTFYCMVYLKLPFYHDN
|..|.|..||.||||||.|||. ..   .||..|||....  ... . .   ||. .|||| .    .|  |||.|.|||||||  | ||  ..||  |.
AVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQ-KLNTFCGTPPYMAPEIF----LKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDT

--LMELFEMIQNKEPKYDKKMQTHDLLDLLQKILVKDPSKRLGLNEIINHSFF
  . ||.. |.. ....  .   ... .|.|..|. .|..|  . || .|...
QDYKELYKKILRGKYDIPCH-VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 22526.AA ULK 120-270 29 3.4e-42 146.51 In-house 136-324 (324) Show / Hide 
Range on Protein: 120-270
Range on HMM: 136-324/324
Sequence Identity: 29% (56 aa)

CLALQYLHQQNIIHRDIKPQNILLTHELK------------IKLCDFGLAVKLSSDN---HRIKGTE------GTYHFMAPESLSDSNQKNGYDGKKADI
| ....||..|||||||||||||...               .|..|||.| .. ..|     .. .       ||  .|||. |..   .  |. .|.||
CNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDI

WSLGVTFYCMVYLKLPFYHDNLMELF----EM----------IQNKEPKYDKKM---QT-HDLLDLLQKILVKDPSKRLGLNEIINHSFF
||||. || |.| | ||. .  ....    ..          |.|.  ...|.    .   .. ||... |..|...|    ||.|| .|
WSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 22526.AA TyrKc 22-270 19 1.3e-14 13.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-270
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

ILKKKT--------------------KMTKDELGNVYYKSQWENVETEIELMKKF--NHPNVTMIDSIIYHD-----SQSKLYLIIDYCEYGDVLKWDEK
| ..|.                    || |..          |    |...|.|.  .|||.  .  .. ..     .   |...  |...|| ..   |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TLKFSHLQIPQAGSIDYLQKIMLESCLALQYLHQQNIIHRDIKPQNILLTHELKIKLCDFGLAVKLSSD--------NHRIK---GTE--GTYHFMAPES
. .          . . | ....  .   .|||..|.||||.   |.|..... .| .||||. .. .|          | |   |.     .  ||||.
HRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LSDSNQKNGYDGKKADIWSLGVTFYCMVYL-KLPFYH-----DNLMELFEMIQNKEPKYDKKM--------QTHDLLDLLQKILVKDPSKRLGLNEIINH
.     . |    | |.|| ||. . .  . . | .       .  |..| ... .     .          . .. .. ..    ||..|   .||  |
I-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

SFF
..|
ECF
Kinase 22526.AA CAMKL 1-91 27 1e-11 33.49 In-house 15-113 (297) Show / Hide 
Range on Protein: 1-91
Range on HMM: 15-113/297
Sequence Identity: 27% (28 aa)

VKLCIE-KSTGKKLALKKFHKNILKKKTKMTKDELGNVYYKSQWENVETEIELMKKFN---HPNVTMIDSIIYHDSQ----SKLYLIIDYCEYGD--VLK
|||..  . ||.| | |  .|. ......|.|  .|.   .|   ... ||..||..|   |||.  .  .|. ..     .|.||.  ||. |.   . 
VKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFD

W
.
Y
Kinase 22526.AA Pkinase_Tyr 120-157 44 1.1e-09 33.44 Pfam 121-158 (270) Show / Hide 
Range on Protein: 120-157
Range on HMM: 121-158/270
Sequence Identity: 44% (17 aa)

CLALQYLHQQNIIHRDIKPQNILLTHELKIKLCDFGLA
. ...||...|.||||.   |.|.|.....| ||||||
AKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 22526.AA MARK 42-91 38 1.3e-07 21.12 In-house 41-92 (262) Show / Hide 
Range on Protein: 42-91
Range on HMM: 41-92/262
Sequence Identity: 38% (20 aa)

QW-ENVETEIELMKKFNHPNVTMIDSIIYHDSQSK-LYLIIDYCEYGDVLKW
|| .||. |||.||| .|||..    .|  |  .. .||| .|.. |... .
QWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDY
Kinase 22526.AA ULK 42-87 33 7.8e-07 20.34 In-house 53-103 (324) Show / Hide 
Range on Protein: 42-87
Range on HMM: 53-103/324
Sequence Identity: 33% (18 aa)

QWENVETEIELMKKFN---HPN---VTMIDSIIYHDSQS-KLYLIIDYCEYGD
.|.. . ||..|||..   |||   | ..|  .. .|..  .|.| .||. ||
MWQLLKNEIQIMKKLKELKHPNHHIVKLYD--WFETSNHNNIYIIMEYCNGGD
Kinase 22526.AA ULK 17-87 22 0.000143 11.98 In-house 25-106 (329) Show / Hide 
Range on Protein: 17-87
Range on HMM: 25-106/329
Sequence Identity: 22% (19 aa)

KFHKNILKKKTKMTKDELGNVYYKSQ----WENVETEIELMKKFN----HPN-----VTMIDSIIYHDSQS-KLYLIIDYCEYGD
. ..|.. .  .. |... . .. ..    |. .. ||..||| .    |.|     | ..|  .. .|..  .|.| .||. ||
D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD--WFETSNHNNIYIIMEYCNGGD
Kinase 22526.AA Pkinase_Tyr 40-90 23 0.004475 11.04 Pfam 42-96 (270) Show / Hide 
Range on Protein: 40-90
Range on HMM: 42-96/270
Sequence Identity: 23% (13 aa)

KSQ--WENVETEIELMKKF-NHPNVTMIDSIIYHDSQS-KLYLIIDYCEYGDVLK
..|  .|    |...||.. .|||.     ........ ..|..  |...|| |.
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD